Sfoglia per Autore
PROBING THE BICYCLIC HYDROXYPYRAZOLO[1,5-a]PYRIDINE SCAFFOLD AS A CARBOXYLIC ACID BIOISOSTERE IN THE GABAa RECEPTOR SYSTEM
2012-01-01 Ducime Alex; Nielsen Birgitte; Lolli Marco L. ;Frølund Bente
Probing the bicyclic hydroxypyrazolo[1,5-a]pyridine scaffold as a carboxylic acid bioisostere in theGABAA receptor system
2012-01-01 A. Ducime; B. Nielsen; B. Frølund; M. L. Lolli
Hydroxypyrazolo[1,5-a]pyridine as a fluorescent carboxylic acid isostere: introducing GABAA receptor system affinities in the scaffold
2013-01-01 A. Ducime; B. Nielsen; D. Boschi; B. Frølund; M. L. Lolli
Hydroxypyrazolo[1,5-a]pyridine as a fluorescent carboxylic acid isostere: probing first MedChem bioisosteric applications
2013-01-01 A. Ducime
SUBSTITUTED 4-HYDROXY-1H-1,2,3-TRIAZOLES: SYNTHESIS AND BIOISOSTERIC APPLICATIONS
2014-01-01 Agnese C. Pippione; Antonella Federico; Stefano Sainas; Alex Ducime; Marco L. Lolli; Donatella Boschi
TOWARD A BIOISOSTERIC ALKAEST – APPLICATION TO THE BIOISOSTERIC MODULATION OF IMD-0354
2014-01-01 Marco L. Lolli; Alex Ducime; Antonella Federico; Agnese Chiara Pippione; Stefano Sainas; Alessandro Barge; Katia Martina; Donatella Boschi; Elisa Lupino; Marco Piccinini; Michael Kubbutat; Christoph Schächtele; Jean Marie Contreras; Christophe Morice; Joel Sussman; Yoav Peleg; Bjorn Walse; Salam Kadaraghi
Towards a Bioisosteric Alkaest: application to the bioisosteric modulation of IMD-0354
2014-01-01 Lolli Marco L.; Federico Antonella; Ducime Alex; Pippione Agnese; Sainas Stefano; Barge Alessandro; Martina Katia; Boschi Donatella; Lupino Elisa; Piccinini Marco; Kubbutat Michael; Contreras Jean Marie; Morice Christophe; Sussman Joel; Peleg Yoav; Walse Bjorn; Al-Kadaraghi Salam
Discovery and optimization of new OvCHT1 inhibitors based on the 4-hydroxy-1H-1,2,3-triazole ring
2014-01-01 A. Ducime; A. C. Pippione; A. Moreo; A. Piccinelli; M. Gooyit; K. D. Janda; D. Boschi; M. L. Lolli
Synthesis and Structural Characterization of Regio Substituted 4-Hydroxy-1H-1,2,3-triazols as Possible Tool in Bioisosteric Applications
2014-01-01 A Federico; S.Sainas; A. Ducime;K. Martina; F. Bosca; D. Boschi; M.L. Lolli.
Substituted 4-hydroxy-1,2,3-triazoles: synthesis, characterization and first drug design applications through bioisosteric modulation and scaffold hopping approaches
2015-01-01 Pippione, Agnese C; Dosio, Franco; Ducime, Alex; Federico, Antonella; Martina, Katia; Sainas, Stefano; Frølund, Bente; Gooyit, Major; Janda, Kim D.; Boschi, Donatella; Lolli, Marco L.
4-Hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-κB cascade
2017-01-01 Pippione, Agnese C.; Federico, Antonella; Ducime, Alex; Sainas, Stefano; Boschi, Donatella; Barge, Alessandro; Lupino, Elisa; Piccinini, Marco; Kubbutat, Michael; Contreras, Jean-Marie; Morice, Christophe; Al-Karadaghi, Salam; Lolli, Marco L.
N-Acetyl-3-aminopyrazoles block the non canonical NF-kB cascade by selectively inhibiting NIK
2018-01-01 Agnese C. Pippione, Stefano Sainas, Antonella Federico, Elisa Lupino, Marco Piccinini, Michael Kubbutat, Jean-Marie Contreras, Christophe Morice, Alessandro Barge, Alex Ducime, Donatella Boschi, Salam Al-Karadaghi, Marco L. Lolli
Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors
2018-01-01 Sainas, Stefano; Pippione, Agnese C; Lupino, Elisa; Giorgis, Marta; Circosta, Paola; Gaidano, Valentina; Goyal, Parveen; Bonanni, Davide; Rolando, Barbara; Cignetti, Alessandro; Ducime, Alex; Andersson, Mikael; Järvå, Michael; Friemann, Rosmarie; Piccinini, Marco; Ramondetti, Cristina; Buccinnà, Barbara; Al-Karadaghi, Salam; Boschi, Donatella; Saglio, Giuseppe; Lolli, Marco L
Regioselective N‐Alkylation of Ethyl 4‐Benzyloxy‐1,2,3‐triazolecarboxylate: A Useful Tool for the Synthesis of Carboxylic Acid Bioisosteres
2019-01-01 Sainas, Stefano; Pippione, Agnese C.; Giraudo, Alessandro; Martina, Katia; Bosca, Federica; Rolando, Barbara; Barge, Alessandro; Ducime, Alex; Federico, Antonella; Grossert, Stuart J.; White, Robert L.; Boschi, Donatella; Lolli, Marco L.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| PROBING THE BICYCLIC HYDROXYPYRAZOLO[1,5-a]PYRIDINE SCAFFOLD AS A CARBOXYLIC ACID BIOISOSTERE IN THE GABAa RECEPTOR SYSTEM | 2012 | Ducime Alex; Nielsen Birgitte; Lolli Marco L. ;Frølund Bente | |
| Probing the bicyclic hydroxypyrazolo[1,5-a]pyridine scaffold as a carboxylic acid bioisostere in theGABAA receptor system | 2012 | A. Ducime; B. Nielsen; B. Frølund; M. L. Lolli | |
| Hydroxypyrazolo[1,5-a]pyridine as a fluorescent carboxylic acid isostere: introducing GABAA receptor system affinities in the scaffold | 2013 | A. Ducime; B. Nielsen; D. Boschi; B. Frølund; M. L. Lolli | |
| Hydroxypyrazolo[1,5-a]pyridine as a fluorescent carboxylic acid isostere: probing first MedChem bioisosteric applications | 2013 | A. Ducime | |
| SUBSTITUTED 4-HYDROXY-1H-1,2,3-TRIAZOLES: SYNTHESIS AND BIOISOSTERIC APPLICATIONS | 2014 | Agnese C. Pippione; Antonella Federico; Stefano Sainas; Alex Ducime; Marco L. Lolli; Donatella Boschi | |
| TOWARD A BIOISOSTERIC ALKAEST – APPLICATION TO THE BIOISOSTERIC MODULATION OF IMD-0354 | 2014 | Marco L. Lolli; Alex Ducime; Antonella Federico; Agnese Chiara Pippione; Stefano Sainas; Alessandro Barge; Katia Martina; Donatella Boschi; Elisa Lupino; Marco Piccinini; Michael Kubbutat; Christoph Schächtele; Jean Marie Contreras; Christophe Morice; Joel Sussman; Yoav Peleg; Bjorn Walse; Salam Kadaraghi | |
| Towards a Bioisosteric Alkaest: application to the bioisosteric modulation of IMD-0354 | 2014 | Lolli Marco L.; Federico Antonella; Ducime Alex; Pippione Agnese; Sainas Stefano; Barge Alessandro; Martina Katia; Boschi Donatella; Lupino Elisa; Piccinini Marco; Kubbutat Michael; Contreras Jean Marie; Morice Christophe; Sussman Joel; Peleg Yoav; Walse Bjorn; Al-Kadaraghi Salam | |
| Discovery and optimization of new OvCHT1 inhibitors based on the 4-hydroxy-1H-1,2,3-triazole ring | 2014 | A. Ducime; A. C. Pippione; A. Moreo; A. Piccinelli; M. Gooyit; K. D. Janda; D. Boschi; M. L. Lolli | |
| Synthesis and Structural Characterization of Regio Substituted 4-Hydroxy-1H-1,2,3-triazols as Possible Tool in Bioisosteric Applications | 2014 | A Federico; S.Sainas; A. Ducime;K. Martina; F. Bosca; D. Boschi; M.L. Lolli. | |
| Substituted 4-hydroxy-1,2,3-triazoles: synthesis, characterization and first drug design applications through bioisosteric modulation and scaffold hopping approaches | 2015 | Pippione, Agnese C; Dosio, Franco; Ducime, Alex; Federico, Antonella; Martina, Katia; Sainas, Stefano; Frølund, Bente; Gooyit, Major; Janda, Kim D.; Boschi, Donatella; Lolli, Marco L. | |
| 4-Hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-κB cascade | 2017 | Pippione, Agnese C.; Federico, Antonella; Ducime, Alex; Sainas, Stefano; Boschi, Donatella; Barge, Alessandro; Lupino, Elisa; Piccinini, Marco; Kubbutat, Michael; Contreras, Jean-Marie; Morice, Christophe; Al-Karadaghi, Salam; Lolli, Marco L. | |
| N-Acetyl-3-aminopyrazoles block the non canonical NF-kB cascade by selectively inhibiting NIK | 2018 | Agnese C. Pippione, Stefano Sainas, Antonella Federico, Elisa Lupino, Marco Piccinini, Michael Kubbutat, Jean-Marie Contreras, Christophe Morice, Alessandro Barge, Alex Ducime, Donatella Boschi, Salam Al-Karadaghi, Marco L. Lolli | |
| Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors | 2018 | Sainas, Stefano; Pippione, Agnese C; Lupino, Elisa; Giorgis, Marta; Circosta, Paola; Gaidano, Valentina; Goyal, Parveen; Bonanni, Davide; Rolando, Barbara; Cignetti, Alessandro; Ducime, Alex; Andersson, Mikael; Järvå, Michael; Friemann, Rosmarie; Piccinini, Marco; Ramondetti, Cristina; Buccinnà, Barbara; Al-Karadaghi, Salam; Boschi, Donatella; Saglio, Giuseppe; Lolli, Marco L | |
| Regioselective N‐Alkylation of Ethyl 4‐Benzyloxy‐1,2,3‐triazolecarboxylate: A Useful Tool for the Synthesis of Carboxylic Acid Bioisosteres | 2019 | Sainas, Stefano; Pippione, Agnese C.; Giraudo, Alessandro; Martina, Katia; Bosca, Federica; Rolando, Barbara; Barge, Alessandro; Ducime, Alex; Federico, Antonella; Grossert, Stuart J.; White, Robert L.; Boschi, Donatella; Lolli, Marco L. |
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