Sfoglia per Autore
INHIBITION OF MEK AND PI3K/MTOR SUPPRESSES TUMOR GROWTH BUT DOES NOT CAUSE TUMOR REGRESSION IN PATIENT-DERIVED XENOGRAFTS OF RAS-MUTANT COLORECTAL CARCINOMAS
2012-01-01 Giorgia Migliardi; Francesco Sassi; Davide Torti; Francesco Galimi; Eugenia R. Zanella; Michela Buscarino; Dario Ribero; Andrea Muratore; Paolo Massucco; Alberto Pisacane; Mauro Risio; Lorenzo Capussotti; Silvia Marsoni; Federica Di Nicolantonio; Alberto Bardelli; Paolo M. Comoglio; Livio Trusolino*; Andrea Bertotti* (*Co-Senior Authors)
Sustained Inhibition of HER3 and EGFR Is Necessary to Induce Regression of HER2-Amplified Gastrointestinal Carcinomas
2015-01-01 Leto, Simonetta M.; Sassi, Francesco; Catalano, Irene; Torri, Valter; Migliardi, Giorgia; Zanella, Eugenia R.; Throsby, Mark; Bertotti, Andrea; Trusolino, Livio
The genomic landscape of response to EGFR blockade in colorectal cancer
2015-01-01 Bertotti, Andrea*; Papp, Eniko; Jones, Siân; Adleff, Vilmos; Anagnostou, Valsamo; Lupo, Barbara; Sausen, Mark; Phallen, Jillian; Hruban, Carolyn A.; Tokheim, Collin; Niknafs, Noushin; Nesselbush, Monica; Lytle, Karli; Sassi, Francesco; Cottino, Francesca; Migliardi, Giorgia; Zanella, Eugenia R.; Ribero, Dario; Russolillo, Nadia; Mellano, Alfredo; Muratore, Andrea; Paraluppi, Gianluca; Salizzoni, Mauro; Marsoni, Silvia; Kragh, Michael; Lantto, Johan; Cassingena, Andrea; Li, Qing Kay; Karchin, Rachel; Scharpf, Robert; Sartore-Bianchi, Andrea; Siena, Salvatore; Diaz, Luis A.; Trusolino, Livio*; Velculescu, Victor E*. (*Co-Senior e Corresponding Authors)
Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer
2017-01-01 Isella, Claudio; Brundu, Francesco; Bellomo, Sara E.; Galimi, Francesco; Zanella, Eugenia; Porporato, Roberta; Petti, Consalvo; Fiori, Alessandro; Orzan, Francesca; Senetta, Rebecca; Boccaccio, Carla; Ficarra, Elisa; Marchionni, Luigi; Trusolino, Livio; Medico, Enzo; Bertotti, Andrea
Patient-derived xenografts and matched cell lines identify pharmacogenomic vulnerabilities in colorectal cancer
2019-01-01 Lazzari L.; Corti G.; Picco G.; Isella C.; Montone M.; Arcella P.; Durinikova E.; Zanella E.R.; Novara L.; Barbosa F.; Cassingena A.; Cancelliere C.; Medico E.; Sartore-Bianchi A.; Siena S.; Garnett M.J.; Bertotti A.; Trusolino L.; Di Nicolantonio F.; Linnebacher M.; Bardelli A.; Arena S.
Systems analysis of protein signatures predicting cetuximab responses in KRAS, NRAS, BRAF and PIK3CA wild-type patient-derived xenograft models of metastatic colorectal cancer
2020-01-01 Lindner A.U.; Carberry S.; Monsefi N.; Barat A.; Salvucci M.; O'Byrne R.; Zanella E.R.; Cremona M.; Hennessy B.T.; Bertotti A.; Trusolino L.; Prehn J.H.M.
Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype
2020-01-01 Lupo, Barbara; Sassi, Francesco; Pinnelli, Marika; Galimi, Francesco; Zanella, Eugenia R.; Vurchio, Valentina; Migliardi, Giorgia; Gagliardi, Paolo Armando; Puliafito, Alberto; Manganaro, Daria; Luraghi, Paolo; Kragh, Michael; Pedersen, Mikkel W.; Horak, Ivan D.; Boccaccio, Carla; Medico, Enzo; Primo, Luca; Nichol, Daniel; Spiteri, Inmaculada; Heide, Timon; Vatsiou, Alexandra; Graham, Trevor A.; Élez, Elena; Argiles, Guillem; Nuciforo, Paolo; Sottoriva, Andrea; Dienstmann, Rodrigo; Pasini, Diego; Grassi, Elena; Isella, Claudio; Bertotti, Andrea; Trusolino, Livio
Implementing systems modelling and molecular imaging to predict the efficacy of BCL-2 inhibition in colorectal cancer patient-derived xenograft models
2020-01-01 O'Farrell A.C.; Jarzabek M.; Lindner A.U.; Carberry S.; Conroy E.; Miller I.S.; Connor K.; Shiels L.; Zanella E.R.; Lucantoni F.; Lafferty A.; White K.; Villamandos M.M.; Dicker P.; Gallagher W.M.; Keek S.A.; Sanduleanu S.; Lambin P.; Woodruff H.C.; Bertotti A.; Trusolino L.; Byrne A.T.; Prehn J.H.M.
Molecular Subtyping Combined with Biological Pathway Analyses to Study Regorafenib Response in Clinically Relevant Mouse Models of Colorectal Cancer
2021-01-01 Lafferty, Adam; O'Farrell, Alice C; Migliardi, Giorgia; Khemka, Niraj; Lindner, Andreas U; Sassi, Francesco; Zanella, Eugenia R; Salvucci, Manuela; Vanderheyden, Evy; Modave, Elodie; Boeckx, Bram; Halang, Luise; Betge, Johannes; Ebert, Matthias P A; Dicker, Patrick; Argilés, Guillem; Tabernero, Josep; Dienstmann, Rodrigo; Medico, Enzo; Lambrechts, Diether; Bertotti, Andrea; Isella, Claudio; Trusolino, Livio; Prehn, Jochen H M; Byrne, Annette T
Chromatin Velocity reveals epigenetic dynamics by single-cell profiling of heterochromatin and euchromatin
2022-01-01 Tedesco, Martina; Giannese, Francesca; Lazarević, Dejan; Giansanti, Valentina; Rosano, Dalia; Monzani, Silvia; Catalano, Irene; Grassi, Elena; Zanella, Eugenia R; Botrugno, Oronza A; Morelli, Leonardo; Panina Bordignon, Paola; Caravagna, Giulio; Bertotti, Andrea; Martino, Gianvito; Aldrighetti, Luca; Pasqualato, Sebastiano; Trusolino, Livio; Cittaro, Davide; Tonon, Giovanni
Towards precision oncology with patient-derived xenografts
2022-01-01 Zanella, Eugenia R; Grassi, Elena; Trusolino, Livio
Synthetic Lethal Interaction with BCL-XL Blockade Deepens Response to Cetuximab in Patient-Derived Models of Metastatic Colorectal Cancer
2023-01-01 Leto, Simonetta M; Ferri, Martina; Sassi, Francesco; Zanella, Eugenia R; Cottino, Francesca; Vurchio, Valentina; Catalano, Irene; Ferrero, Alessandro; Zingaretti, Caterina C; Marchio', Caterina; Grassi, Elena; Trusolino, Livio; Bertotti, Andrea
Phosphoproteomics of patient-derived xenographs identifies targets and markers associated with sensitivity and resistance to EGFR blockade in colorectal cancer
2023-01-01 Beekhof, Robin; Bertotti, Andrea; Böttger, Franziska; Vurchio, Valentina; Cottino, Francesca; Zanella, Eugenia R; Migliardi, Giorgia; Viviani, Marco; Grassi, Elena; Lupo, Barbara; Henneman, Alex A; Knol, Jaco C; Pham, Thang V; de Goeij-de Haas, Richard; Piersma, Sander R; Labots, Mariette; Verheul, Henk M W; Trusolino, Livio; Jimenez, Connie R
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| INHIBITION OF MEK AND PI3K/MTOR SUPPRESSES TUMOR GROWTH BUT DOES NOT CAUSE TUMOR REGRESSION IN PATIENT-DERIVED XENOGRAFTS OF RAS-MUTANT COLORECTAL CARCINOMAS | 2012 | Giorgia Migliardi; Francesco Sassi; Davide Torti; Francesco Galimi; Eugenia R. Zanella; Michela Buscarino; Dario Ribero; Andrea Muratore; Paolo Massucco; Alberto Pisacane; Mauro Risio; Lorenzo Capussotti; Silvia Marsoni; Federica Di Nicolantonio; Alberto Bardelli; Paolo M. Comoglio; Livio Trusolino*; Andrea Bertotti* (*Co-Senior Authors) | |
| Sustained Inhibition of HER3 and EGFR Is Necessary to Induce Regression of HER2-Amplified Gastrointestinal Carcinomas | 2015 | Leto, Simonetta M.; Sassi, Francesco; Catalano, Irene; Torri, Valter; Migliardi, Giorgia; Zanella, Eugenia R.; Throsby, Mark; Bertotti, Andrea; Trusolino, Livio | |
| The genomic landscape of response to EGFR blockade in colorectal cancer | 2015 | Bertotti, Andrea*; Papp, Eniko; Jones, Siân; Adleff, Vilmos; Anagnostou, Valsamo; Lupo, Barbara; Sausen, Mark; Phallen, Jillian; Hruban, Carolyn A.; Tokheim, Collin; Niknafs, Noushin; Nesselbush, Monica; Lytle, Karli; Sassi, Francesco; Cottino, Francesca; Migliardi, Giorgia; Zanella, Eugenia R.; Ribero, Dario; Russolillo, Nadia; Mellano, Alfredo; Muratore, Andrea; Paraluppi, Gianluca; Salizzoni, Mauro; Marsoni, Silvia; Kragh, Michael; Lantto, Johan; Cassingena, Andrea; Li, Qing Kay; Karchin, Rachel; Scharpf, Robert; Sartore-Bianchi, Andrea; Siena, Salvatore; Diaz, Luis A.; Trusolino, Livio*; Velculescu, Victor E*. (*Co-Senior e Corresponding Authors) | |
| Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer | 2017 | Isella, Claudio; Brundu, Francesco; Bellomo, Sara E.; Galimi, Francesco; Zanella, Eugenia; Porporato, Roberta; Petti, Consalvo; Fiori, Alessandro; Orzan, Francesca; Senetta, Rebecca; Boccaccio, Carla; Ficarra, Elisa; Marchionni, Luigi; Trusolino, Livio; Medico, Enzo; Bertotti, Andrea | |
| Patient-derived xenografts and matched cell lines identify pharmacogenomic vulnerabilities in colorectal cancer | 2019 | Lazzari L.; Corti G.; Picco G.; Isella C.; Montone M.; Arcella P.; Durinikova E.; Zanella E.R.; Novara L.; Barbosa F.; Cassingena A.; Cancelliere C.; Medico E.; Sartore-Bianchi A.; Siena S.; Garnett M.J.; Bertotti A.; Trusolino L.; Di Nicolantonio F.; Linnebacher M.; Bardelli A.; Arena S. | |
| Systems analysis of protein signatures predicting cetuximab responses in KRAS, NRAS, BRAF and PIK3CA wild-type patient-derived xenograft models of metastatic colorectal cancer | 2020 | Lindner A.U.; Carberry S.; Monsefi N.; Barat A.; Salvucci M.; O'Byrne R.; Zanella E.R.; Cremona M.; Hennessy B.T.; Bertotti A.; Trusolino L.; Prehn J.H.M. | |
| Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype | 2020 | Lupo, Barbara; Sassi, Francesco; Pinnelli, Marika; Galimi, Francesco; Zanella, Eugenia R.; Vurchio, Valentina; Migliardi, Giorgia; Gagliardi, Paolo Armando; Puliafito, Alberto; Manganaro, Daria; Luraghi, Paolo; Kragh, Michael; Pedersen, Mikkel W.; Horak, Ivan D.; Boccaccio, Carla; Medico, Enzo; Primo, Luca; Nichol, Daniel; Spiteri, Inmaculada; Heide, Timon; Vatsiou, Alexandra; Graham, Trevor A.; Élez, Elena; Argiles, Guillem; Nuciforo, Paolo; Sottoriva, Andrea; Dienstmann, Rodrigo; Pasini, Diego; Grassi, Elena; Isella, Claudio; Bertotti, Andrea; Trusolino, Livio | |
| Implementing systems modelling and molecular imaging to predict the efficacy of BCL-2 inhibition in colorectal cancer patient-derived xenograft models | 2020 | O'Farrell A.C.; Jarzabek M.; Lindner A.U.; Carberry S.; Conroy E.; Miller I.S.; Connor K.; Shiels L.; Zanella E.R.; Lucantoni F.; Lafferty A.; White K.; Villamandos M.M.; Dicker P.; Gallagher W.M.; Keek S.A.; Sanduleanu S.; Lambin P.; Woodruff H.C.; Bertotti A.; Trusolino L.; Byrne A.T.; Prehn J.H.M. | |
| Molecular Subtyping Combined with Biological Pathway Analyses to Study Regorafenib Response in Clinically Relevant Mouse Models of Colorectal Cancer | 2021 | Lafferty, Adam; O'Farrell, Alice C; Migliardi, Giorgia; Khemka, Niraj; Lindner, Andreas U; Sassi, Francesco; Zanella, Eugenia R; Salvucci, Manuela; Vanderheyden, Evy; Modave, Elodie; Boeckx, Bram; Halang, Luise; Betge, Johannes; Ebert, Matthias P A; Dicker, Patrick; Argilés, Guillem; Tabernero, Josep; Dienstmann, Rodrigo; Medico, Enzo; Lambrechts, Diether; Bertotti, Andrea; Isella, Claudio; Trusolino, Livio; Prehn, Jochen H M; Byrne, Annette T | |
| Chromatin Velocity reveals epigenetic dynamics by single-cell profiling of heterochromatin and euchromatin | 2022 | Tedesco, Martina; Giannese, Francesca; Lazarević, Dejan; Giansanti, Valentina; Rosano, Dalia; Monzani, Silvia; Catalano, Irene; Grassi, Elena; Zanella, Eugenia R; Botrugno, Oronza A; Morelli, Leonardo; Panina Bordignon, Paola; Caravagna, Giulio; Bertotti, Andrea; Martino, Gianvito; Aldrighetti, Luca; Pasqualato, Sebastiano; Trusolino, Livio; Cittaro, Davide; Tonon, Giovanni | |
| Towards precision oncology with patient-derived xenografts | 2022 | Zanella, Eugenia R; Grassi, Elena; Trusolino, Livio | |
| Synthetic Lethal Interaction with BCL-XL Blockade Deepens Response to Cetuximab in Patient-Derived Models of Metastatic Colorectal Cancer | 2023 | Leto, Simonetta M; Ferri, Martina; Sassi, Francesco; Zanella, Eugenia R; Cottino, Francesca; Vurchio, Valentina; Catalano, Irene; Ferrero, Alessandro; Zingaretti, Caterina C; Marchio', Caterina; Grassi, Elena; Trusolino, Livio; Bertotti, Andrea | |
| Phosphoproteomics of patient-derived xenographs identifies targets and markers associated with sensitivity and resistance to EGFR blockade in colorectal cancer | 2023 | Beekhof, Robin; Bertotti, Andrea; Böttger, Franziska; Vurchio, Valentina; Cottino, Francesca; Zanella, Eugenia R; Migliardi, Giorgia; Viviani, Marco; Grassi, Elena; Lupo, Barbara; Henneman, Alex A; Knol, Jaco C; Pham, Thang V; de Goeij-de Haas, Richard; Piersma, Sander R; Labots, Mariette; Verheul, Henk M W; Trusolino, Livio; Jimenez, Connie R |
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