Sfoglia per Autore
Development of new hydroxypyrazole-based inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH)
2014-01-01 A.C. Pippione; A. Giraudo; I. Galleano; U.J. Nilsson; I. Fritzson; A.P. Sundin; S. Al-Karadaghi; D. Boschi; M.L. Lolli
Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by a Scaffold Hopping Bioisosteric approach using Hydroxylated Pentaatomic Heterocycles
2016-01-01 Sainas, Stefano; Pippione, Agnese Chiara; Carnovale, IRENE MARIA; Giraudo, Alessandro; Giorgis, Marta; Braga Rodolpho Campos, ; Andrade Carolina Horta, ; Piccinini, Marco; Lupino, Elisa; Guedes, Rita; AL KARADAGHI, Salam; Boschi, Donatella; Lolli, Marco Lucio
Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by a Scaffold Hopping Bioisosteric approach using Hydroxylated Pentatomic Heterocycles
2016-01-01 Sainas Stefano; Pippione Agnese Chiara; Carnovale Irene Maria; Giraudo Alessandro; Giorgis Marta; de Campos Braga Rodolpho; Andrade Carolina H; Villella Noemi; Friemann Rosmarie; Piccinini Marco; Lupino Elisa; Al-karadaghi Salam; Boschi Donatella;Lolli Marco Lucio
Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by a Scaffold Hopping Bioisosteric approach using Hydroxylated Pentatomic Heterocycles
2016-01-01 Stefano Sainas, Agnese Chiara Pippione, Irene Maria Carnovale, Alessandro Giraudo, Marta Giorgis, Rodolpho B. Braga, Carolina H. Andrade, Noemi Villella, Marco Piccinini, Elisa Lupino, Rosmarie Friemann, Salam Al-Kadaraghi, Donatella Boschi, Marco L. Lolli
Design, synthesis, and biological evaluation of flufenamic acid derived bioisosteres as inhibitors of aldo-keto reductase 1C3 (AKR1C3) expressed in prostate cancer
2016-01-01 Lolli, Marco; Cena, Clara; Giraudo, Alessandro; Marini, Elisabetta; Pippione, Agnese; Oliaro-Bosso, Simonetta; Ferrante, Terenzio; Sadiq, Maria; Pors, Klaus; Boschi, Donatella; Braga, Rudolpho; Andrade, Carolina.
NEW HYDROXYAZOLES INHIBITORS OF AKR1C3 OBTAINED FROM NSAIDS BY SCAFFOLD HOPPING APPROACH AGAINST CASTRATE RESISTANT PROSTATE CANCER
2016-01-01 Boschi, Donatella; Pippione, Agnese Chiara; Giraudo, Alessandro; Carnovale, Irene Maria; Zorniotti, Sonia; Oliaro-Bosso, Simonetta; Ferrante, Terenzio; Marini, Elisabetta; Pors, Klaus; Festuccia, Claudio; Monache, Simona Delle; Zaffaroni, Nadia; Braga, Rodolpho Campos; Lucio Lolli, Marco
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NOVEL AMINO BIOISOSTERES FOR THE GABAa RECEPTOR
2016-01-01 Giraudo, Alessandro; Jensen, Anders A.; Nielsen, Birgitte; Boschi, Donatella; Krall, Jacob; Marco L. Lolli, ; Frølund, Bente
NEW HYDROXYAZOLES INHIBITORS OF ALDO-KETO REDUCTASE 1C3 (AKR1C3) OBTAINED BY SCAFFOLD HOPPING FROM FLUFENAMIC ACID AND INDOMETHACIN FOR CASTRATE RESISTANT PROSTATE CANCER
2016-01-01 Boschi, Donatella; Pippione, Agnese Chiara; Giraudo, Alessandro; Carnovale, Irene Maria; Zorniotti, Sonia; Oliaro-Bosso, Simonetta; Ferrante, Terenzio; Marini, Elisabetta; Pors, Klaus; Festuccia, Claudio; Monache, Simona Delle; Zaffaroni, Nadia; Braga, Rodolpho Campos; Lucio, Marco; Lolli,
Targeting Castration Resistant Prostate Cancer (CRPC) by innovative AKR1C3 inhibitors based on the 3-hydroxybenzoisoxazole structure
2016-01-01 Carnovale, Irene Maria; Pippione, Agnese Chiara; Giraudo, Alessandro; Federico, Antonella; Zorniotti, Sonia; Simonetta Oliaro Bosso, ; Ferrante, Terenzio; Marini, Elisabetta; Pors, Klaus; Braga, Rodolpho Campos; Boschi, Donatella; Lucio Lolli, Marco
DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NOVEL GABAaR LIGANDS BEARING 4-HYDROXYTRIAZOLE MOIETY
2017-01-01 Giraudo, Alessandro
Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach
2017-01-01 Pippione, Agnese C.; Giraudo, Alessandro; Bonanni, Davide; Carnovale, Irene M.; Marini, Elisabetta; Cena, Clara; Costale, Annalisa; Zonari, Daniele; Pors, Klaus; Sadiq, Maria; Boschi, Donatella; Oliaro-Bosso, Simonetta; Lolli, Marco L
4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric γ-aminobutyric acid receptor binding site
2018-01-01 Giraudo, Alessandro; Krall, Jacob; Nielsen, Birgitte; Sørensen, Troels E.; Kongstad, Kenneth T.; Rolando, Barbara; Boschi, Donatella; Frølund, Bente; Lolli, Marco L.
Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with hydroxypyrazole core: new scaffolds against malaria disease
2019-01-01 Pippione AC, Sainas S, Giraudo A, Bonanni D, Villella N, Bertea C, Friemann R, Al-Karadaghi S, Boschi D, Lolli ML.
Regioselective N‐Alkylation of Ethyl 4‐Benzyloxy‐1,2,3‐triazolecarboxylate: A Useful Tool for the Synthesis of Carboxylic Acid Bioisosteres
2019-01-01 Sainas, Stefano; Pippione, Agnese C.; Giraudo, Alessandro; Martina, Katia; Bosca, Federica; Rolando, Barbara; Barge, Alessandro; Ducime, Alex; Federico, Antonella; Grossert, Stuart J.; White, Robert L.; Boschi, Donatella; Lolli, Marco L.
Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies
2019-01-01 Pippione, Agnese C; Sainas, Stefano; Goyal, Parveen; Fritzson, Ingela; Cassiano, Gustavo C; Giraudo, Alessandro; Giorgis, Marta; Tavella, Tatyana A; Bagnati, Renzo; Rolando, Barbara; Caing-Carlsson, Rhawnie; Costa, Fabio T M; Andrade, Carolina Horta; Al-Karadaghi, Salam; Boschi, Donatella; Friemann, Rosmarie; Lolli, Marco L
Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters
2019-01-01 Giraudo A.; Krall J.; Bavo F.; Nielsen B.; Kongstad K.T.; Rolando B.; De Blasio R.; Gloriam D.E.; Loffler R.; Thiesen L.; Harpsoe K.; Frydenvang K.; Boschi D.; Wellendorph P.; Lolli M.L.; Jensen A.A.; Frolund B.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Development of new hydroxypyrazole-based inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) | 2014 | A.C. Pippione; A. Giraudo; I. Galleano; U.J. Nilsson; I. Fritzson; A.P. Sundin; S. Al-Karadaghi; D. Boschi; M.L. Lolli | |
| Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by a Scaffold Hopping Bioisosteric approach using Hydroxylated Pentaatomic Heterocycles | 2016 | Sainas, Stefano; Pippione, Agnese Chiara; Carnovale, IRENE MARIA; Giraudo, Alessandro; Giorgis, Marta; Braga Rodolpho Campos, ; Andrade Carolina Horta, ; Piccinini, Marco; Lupino, Elisa; Guedes, Rita; AL KARADAGHI, Salam; Boschi, Donatella; Lolli, Marco Lucio | |
| Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by a Scaffold Hopping Bioisosteric approach using Hydroxylated Pentatomic Heterocycles | 2016 | Sainas Stefano; Pippione Agnese Chiara; Carnovale Irene Maria; Giraudo Alessandro; Giorgis Marta; de Campos Braga Rodolpho; Andrade Carolina H; Villella Noemi; Friemann Rosmarie; Piccinini Marco; Lupino Elisa; Al-karadaghi Salam; Boschi Donatella;Lolli Marco Lucio | |
| Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by a Scaffold Hopping Bioisosteric approach using Hydroxylated Pentatomic Heterocycles | 2016 | Stefano Sainas, Agnese Chiara Pippione, Irene Maria Carnovale, Alessandro Giraudo, Marta Giorgis, Rodolpho B. Braga, Carolina H. Andrade, Noemi Villella, Marco Piccinini, Elisa Lupino, Rosmarie Friemann, Salam Al-Kadaraghi, Donatella Boschi, Marco L. Lolli | |
| Design, synthesis, and biological evaluation of flufenamic acid derived bioisosteres as inhibitors of aldo-keto reductase 1C3 (AKR1C3) expressed in prostate cancer | 2016 | Lolli, Marco; Cena, Clara; Giraudo, Alessandro; Marini, Elisabetta; Pippione, Agnese; Oliaro-Bosso, Simonetta; Ferrante, Terenzio; Sadiq, Maria; Pors, Klaus; Boschi, Donatella; Braga, Rudolpho; Andrade, Carolina. | |
| NEW HYDROXYAZOLES INHIBITORS OF AKR1C3 OBTAINED FROM NSAIDS BY SCAFFOLD HOPPING APPROACH AGAINST CASTRATE RESISTANT PROSTATE CANCER | 2016 | Boschi, Donatella; Pippione, Agnese Chiara; Giraudo, Alessandro; Carnovale, Irene Maria; Zorniotti, Sonia; Oliaro-Bosso, Simonetta; Ferrante, Terenzio; Marini, Elisabetta; Pors, Klaus; Festuccia, Claudio; Monache, Simona Delle; Zaffaroni, Nadia; Braga, Rodolpho Campos; Lucio Lolli, Marco | |
| SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NOVEL AMINO BIOISOSTERES FOR THE GABAa RECEPTOR | 2016 | Giraudo, Alessandro; Jensen, Anders A.; Nielsen, Birgitte; Boschi, Donatella; Krall, Jacob; Marco L. Lolli, ; Frølund, Bente | |
| NEW HYDROXYAZOLES INHIBITORS OF ALDO-KETO REDUCTASE 1C3 (AKR1C3) OBTAINED BY SCAFFOLD HOPPING FROM FLUFENAMIC ACID AND INDOMETHACIN FOR CASTRATE RESISTANT PROSTATE CANCER | 2016 | Boschi, Donatella; Pippione, Agnese Chiara; Giraudo, Alessandro; Carnovale, Irene Maria; Zorniotti, Sonia; Oliaro-Bosso, Simonetta; Ferrante, Terenzio; Marini, Elisabetta; Pors, Klaus; Festuccia, Claudio; Monache, Simona Delle; Zaffaroni, Nadia; Braga, Rodolpho Campos; Lucio, Marco; Lolli, | |
| Targeting Castration Resistant Prostate Cancer (CRPC) by innovative AKR1C3 inhibitors based on the 3-hydroxybenzoisoxazole structure | 2016 | Carnovale, Irene Maria; Pippione, Agnese Chiara; Giraudo, Alessandro; Federico, Antonella; Zorniotti, Sonia; Simonetta Oliaro Bosso, ; Ferrante, Terenzio; Marini, Elisabetta; Pors, Klaus; Braga, Rodolpho Campos; Boschi, Donatella; Lucio Lolli, Marco | |
| DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NOVEL GABAaR LIGANDS BEARING 4-HYDROXYTRIAZOLE MOIETY | 2017 | Giraudo, Alessandro | |
| Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach | 2017 | Pippione, Agnese C.; Giraudo, Alessandro; Bonanni, Davide; Carnovale, Irene M.; Marini, Elisabetta; Cena, Clara; Costale, Annalisa; Zonari, Daniele; Pors, Klaus; Sadiq, Maria; Boschi, Donatella; Oliaro-Bosso, Simonetta; Lolli, Marco L | |
| 4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric γ-aminobutyric acid receptor binding site | 2018 | Giraudo, Alessandro; Krall, Jacob; Nielsen, Birgitte; Sørensen, Troels E.; Kongstad, Kenneth T.; Rolando, Barbara; Boschi, Donatella; Frølund, Bente; Lolli, Marco L. | |
| Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with hydroxypyrazole core: new scaffolds against malaria disease | 2019 | Pippione AC, Sainas S, Giraudo A, Bonanni D, Villella N, Bertea C, Friemann R, Al-Karadaghi S, Boschi D, Lolli ML. | |
| Regioselective N‐Alkylation of Ethyl 4‐Benzyloxy‐1,2,3‐triazolecarboxylate: A Useful Tool for the Synthesis of Carboxylic Acid Bioisosteres | 2019 | Sainas, Stefano; Pippione, Agnese C.; Giraudo, Alessandro; Martina, Katia; Bosca, Federica; Rolando, Barbara; Barge, Alessandro; Ducime, Alex; Federico, Antonella; Grossert, Stuart J.; White, Robert L.; Boschi, Donatella; Lolli, Marco L. | |
| Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies | 2019 | Pippione, Agnese C; Sainas, Stefano; Goyal, Parveen; Fritzson, Ingela; Cassiano, Gustavo C; Giraudo, Alessandro; Giorgis, Marta; Tavella, Tatyana A; Bagnati, Renzo; Rolando, Barbara; Caing-Carlsson, Rhawnie; Costa, Fabio T M; Andrade, Carolina Horta; Al-Karadaghi, Salam; Boschi, Donatella; Friemann, Rosmarie; Lolli, Marco L | |
| Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters | 2019 | Giraudo A.; Krall J.; Bavo F.; Nielsen B.; Kongstad K.T.; Rolando B.; De Blasio R.; Gloriam D.E.; Loffler R.; Thiesen L.; Harpsoe K.; Frydenvang K.; Boschi D.; Wellendorph P.; Lolli M.L.; Jensen A.A.; Frolund B. |
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