Sfoglia per Autore
Intratumor heterogeneity of EGFR expression mediates targeted therapy resistance and formation of drug tolerant microenvironment
2025-01-01 Alsaed, Bassel; Lin, Linh; Son, Jieun; Li, Jiaqi; Smolander, Johannes; Lopez, Timothy; Eser, Pinar Ö.; Ogino, Atsuko; Ambrogio, Chiara; Eum, Yoonji; Thai, Tran; Wang, Haiyun; Sutinen, Eva; Mutanen, Hilma; Duàn, Hanna; Bobik, Nina; Borenius, Kristian; Feng, William W.; Nabet, Behnam; Mustjoki, Satu; Laaksonen, Sanna; Eschle, Benjamin K.; Poitras, Michael J.; Barbie, David; Ilonen, Ilkka; Gokhale, Prafulla; Jänne, Pasi A.; Haikala, Heidi M.
SOS1 inhibitor BI-3406 shows in vivo antitumor activity akin to genetic ablation and synergizes with a KRAS G12D inhibitor in KRAS LUAD
2025-01-01 Baltanás, Fernando C.; Kramer-Drauberg, Maximilian; García-Navas, Rósula; Patrucco, Enrico; Petrini, Ettore; Arnhof, Heribert; Olarte-San Juan, Andrea; Rodríguez-Ramos, Pablo; Borrajo, Javier; Calzada, Nuria; Castellano, Esther; Mair, Barbara; Kostyrko, Kaja; Hofmann, Marco H.; Ambrogio, Chiara; Santos, Eugenio
Oncogenic mutant KRAS inhibition through oxidation at cysteine 118
2025-01-01 Kramer-Drauberg, Maximilian; Petrini, Ettore; Mira, Alessia; Patrucco, Enrico; Scardaci, Rossella; Savinelli, Ilenia; Wang, Haiyun; Qiao, Keying; Carrà, Giovanna; Nokin, Marie-Julie; Zhou, Zhiwei; Westover, Kenneth D; Santamaria, David; Porporato, Paolo E; Ambrogio, Chiara
ALK in cancer: from function to therapeutic targeting
2025-01-01 Voena C.; Ambrogio C.; Iannelli F.; Chiarle R.
KRAS combination strategies: How well aligned is clinical and preclinical research?
2025-01-01 Nadal, Ernest; Ambrogio, Chiara; Santamaria, David; Lindsay, Colin R.
Circulating tumor DNA dynamic variation predicts sotorasib efficacy in KRASp.G12C-mutated advanced non-small cell lung cancer
2025-01-01 Passiglia, Francesco; Pepe, Francesco; Russo, Gianluca; Garbo, Edoardo; Listì, Angela; Benso, Federica; Scimone, Claudia; Palumbo, Lucia; Pluchino, Monica; Minari, Roberta; Bordi, Paola; Cani, Massimiliano; Ungaro, Antonio; Ambrogio, Chiara; Taulli, Riccardo; Capelletto, Enrica; Balbi, Maurizio; Righi, Luisella; Tiseo, Marcello; Giannarelli, Diana; Troncone, Giancarlo; Novello, Silvia; Malapelle, Umberto
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy
2024-01-01 Holderfield, Matthew; Lee, Bianca J.; Jiang, Jingjing; Tomlinson, Aidan; Seamon, Kyle J.; Mira, Alessia; Patrucco, Enrico; Goodhart, Grace; Dilly, Julien; Gindin, Yevgeniy; Dinglasan, Nuntana; Wang, Yingyun; Lai, Lick Pui; Cai, Shurui; Jiang, Lingyan; Nasholm, Nicole; Shifrin, Nataliya; Blaj, Cristina; Shah, Harshit; Evans, James W.; Montazer, Nilufar; Lai, Oliver; Shi, Jade; Ahler, Ethan; Quintana, Elsa; Chang, Stephanie; Salvador, Anthony; Marquez, Abby; Cregg, Jim; Liu, Yang; Milin, Anthony; Chen, Anqi; Ziv, Tamar Bar; Parsons, Dylan; Knox, John E.; Klomp, Jennifer E.; Roth, Jennifer; Rees, Matthew; Ronan, Melissa; Cuevas-Navarro, Antonio; Hu, Feng; Lito, Piro; Santamaria, David; Aguirre, Andrew J.; Waters, Andrew M.; Der, Channing J.; Ambrogio, Chiara; Wang, Zhengping; Gill, Adrian L.; Koltun, Elena S.; Smith, Jacqueline A. M.; Wildes, David; Singh, Mallika
scPharm: Identifying Pharmacological Subpopulations of Single Cells for Precision Medicine in Cancers
2024-01-01 Tian, Peng; Zheng, Jie; Qiao, Keying; Fan, Yuxiao; Xu, Yue; Wu, Tao; Chen, Shuting; Zhang, Yinuo; Zhang, Bingyue; Ambrogio, Chiara; Wang, Haiyun
In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma
2024-01-01 Nokin, Marie-Julie; Darbo, Elodie; Richard, Elodie; San José, Sonia; de Hita, Sergio; Prouzet-Mauleon, Valérie; Turcq, Béatrice; Gerardelli, Laura; Crake, Rebekah; Velasco, Valérie; Koopmansch, Benjamin; Lambert, Frederic; Xue, Jenny Y.; Sang, Ben; Horne, Julie; Ziemons, Eric; Villanueva, Alberto; Blomme, Arnaud; Herfs, Michael; Cataldo, Didier; Calvayrac, Olivier; Porporato, Paolo; Nadal, Ernest; Lito, Piro; Jänne, Pasi A.; Ricciuti, Biagio; Awad, Mark M.; Ambrogio, Chiara; Santamaría, David;
Type I interferon signaling pathway enhances immune-checkpoint inhibition in KRAS mutant lung tumors
2024-01-01 Fernández-García, Fernando; Fernández-Rodríguez, Ana; Fustero-Torre, Coral; Piñeiro-Yáñez, Elena; Wang, Haiyun; Lechuga, Carmen G.; Callejas, Sergio; Álvarez, Rebeca; López-García, Alejandra; Esteban-Burgos, Laura; Salmón, Marina; San Román, Marta; Guerra, Carmen; Ambrogio, Chiara; Drosten, Matthias; Santamaría, David; Al-Shahrour, Fátima; Dopazo, Ana; Barbacid, Mariano; Musteanu, Monica
RAS-ON inhibition overcomes clinical resistance to KRAS G12C-OFF covalent blockade
2024-01-01 Nokin, Marie-Julie; Mira, Alessia; Patrucco, Enrico; Ricciuti, Biagio; Cousin, Sophie; Soubeyran, Isabelle; San José, Sonia; Peirone, Serena; Caizzi, Livia; Vietti Michelina, Sandra; Bourdon, Aurelien; Wang, Xinan; Alvarez-Villanueva, Daniel; Martínez-Iniesta, María; Vidal, August; Rodrigues, Telmo; García-Macías, Carmen; Awad, Mark M.; Nadal, Ernest; Villanueva, Alberto; Italiano, Antoine; Cereda, Matteo; Santamaría, David; Ambrogio, Chiara
Biological and targeting differences between the rare KRAS A146T and canonical KRAS mutants in gastric cancer models
2024-01-01 Puliga, Elisabetta; De Bellis, Chiara; Vietti Michelina, Sandra; Capeloa, Tania; Migliore, Cristina; Orrù, Claudia; Baiocchi, Gian Luca; De Manzoni, Giovanni; Pietrantonio, Filippo; Reddavid, Rossella; Fumagalli Romario, Uberto; Ambrogio, Chiara; Corso, Simona; Giordano, Silvia
Active thymus in adult with lung cancer: preliminary results from the Adult Thymic Project
2024-01-01 Sobrero, Simona; Patrucco, Enrico; Napoli, Francesca; Ragazzini, Roberta; Milazzo, Rachele; Vaisitti, Federico; Ambrogio, Chiara; Bonfanti, Paola; Rena, Ottavio; Ruffini, Enrico; Righi, Luisella; Leo, Francesco
Experimental variables determine the outcome of RAS-RAS interactions
2024-01-01 Zhou, Zhiwei; Nguyen, Tra Ly; Li, Xingxiao; Poujol, Christel; Berlinska, Ewa; Michelina, Sandra Vietti; Kapp, Jonas N.; Plückthun, Andreas; Winslow, Monte M.; Ambrogio, Chiara; Shan, Yibing; Santamaría, David; Westover, Kenneth D.
Cancer Hallmarks: Piecing the Puzzle Together
2024-01-01 Alcolea, Maria P.; Alonso-Curbelo, Direna; Ambrogio, Chiara; Bullman, Susan; Correia, Ana Luísa; Ernst, Aurélie; Halbrook, Christopher J.; Kelly, Gemma L.; Lund, Amanda W.; Quail, Daniela F.; Ruscetti, Marcus; Shema, Efrat; Stromnes, Ingunn M.; Tam, Wai Leong
Novel RAF‐directed approaches to overcome current clinical limits and block the RAS/RAF node
2024-01-01 Scardaci, Rossella; Berlinska, Ewa; Scaparone, Pietro; Vietti Michelina, Sandra; Garbo, Edoardo; Novello, Silvia; Santamaria, David; Ambrogio, Chiara
ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells
2023-01-01 Bergaggio, Elisa; Tai, Wei-Tien; Aroldi, Andrea; Mecca, Carmen; Landoni, Elisa; Nüesch, Manuel; Mota, Ines; Metovic, Jasna; Molinaro, Luca; Ma, Leyuan; Alvarado, Diego; Ambrogio, Chiara; Voena, Claudia; Blasco, Rafael B; Li, Tongqing; Klein, Daryl; Irvine, Darrell J; Papotti, Mauro; Savoldo, Barbara; Dotti, Gianpietro; Chiarle, Roberto
ALK peptide vaccination restores the immunogenicity of ALK-rearranged non-small cell lung cancer
2023-01-01 Mota, Ines; Patrucco, Enrico; Mastini, Cristina; Mahadevan, Navin R; Thai, Tran C; Bergaggio, Elisa; Cheong, Taek-Chin; Leonardi, Giulia; Karaca-Atabay, Elif; Campisi, Marco; Poggio, Teresa; Menotti, Matteo; Ambrogio, Chiara; Longo, Dario L; Klaeger, Susan; Keshishian, Hasmik; Sztupinszki, Zsófia M; Szallasi, Zoltan; Keskin, Derin B; Duke-Cohan, Jonathan S; Reinhold, Bruce; Carr, Steven A; Wu, Catherine J; Moynihan, Kelly D; Irvine, Darrell J; Barbie, David A; Reinherz, Ellis L; Voena, Claudia; Awad, Mark M; Blasco, Rafael B; Chiarle, Roberto
The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer
2023-01-01 Entrialgo-Cadierno, Rodrigo; Cueto-Ureña, Cristina; Welch, Connor; Feliu, Iker; Macaya, Irati; Vera, Laura; Morales, Xabier; Michelina, Sandra Vietti; Scaparone, Pietro; Lopez, Ines; Darbo, Elodie; Erice, Oihane; Vallejo, Adrian; Moreno, Haritz; Goñi-Salaverri, Ainhoa; Lara-Astiaso, David; Halberg, Nils; Cortes-Dominguez, Ivan; Guruceaga, Elizabeth; Ambrogio, Chiara; Lecanda, Fernando; Vicent, Silve
Resistance to KRAS G12C Inhibition in Non-small Cell Lung Cancer
2023-01-01 Di Federico, Alessandro; Ricciotti, Ilaria; Favorito, Valentina; Michelina, Sandra Vietti; Scaparone, Pietro; Metro, Giulio; De Giglio, Andrea; Pecci, Federica; Lamberti, Giuseppe; Ambrogio, Chiara; Ricciuti, Biagio
Regulation of CD45 phosphatase by oncogenic ALK in anaplastic large cell lymphoma
2023-01-01 Mura, Giulia; Karaca Atabay, Elif; Menotti, Matteo; Martinengo, Cinzia; Ambrogio, Chiara; Giacomello, Gloria; Arigoni, Maddalena; Olivero, Martina; Calogero, Raffaele A; Chiarle, Roberto; Voena, Claudia
Targeting CCR7-PI3Kγ overcomes resistance to tyrosine kinase inhibitors in ALK-rearranged lymphoma
2023-01-01 Mastini, Cristina; Campisi, Marco; Patrucco, Enrico; Mura, Giulia; Ferreira, Antonio; Costa, Carlotta; Ambrogio, Chiara; Germena, Giulia; Martinengo, Cinzia; Peola, Silvia; Mota, Ines; Vissio, Elena; Molinaro, Luca; Arigoni, Maddalena; Olivero, Martina; Calogero, Raffaele; Prokoph, Nina; Tabbò, Fabrizio; Shoji, Brent; Brugieres, Laurence; Geoerger, Birgit; Turner, Suzanne D; Cuesta-Mateos, Carlos; D'Aliberti, Deborah; Mologni, Luca; Piazza, Rocco; Gambacorti-Passerini, Carlo; Inghirami, Giorgio G; Chiono, Valeria; Kamm, Roger D; Hirsch, Emilio; Koch, Raphael; Weinstock, David M; Aster, Jon C; Voena, Claudia; Chiarle, Roberto
YAP and TAZ orchestrate adaptive resistance to KRAS inhibitors
2023-01-01 Alessia Mira; Chiara Ambrogio
The Anti-Programmed Cell Death Protein-1/ Programmed Death-Ligand 1 Me-Too Drugs Tsunami: Hard To Be Millennials Among Baby Boomers
2023-01-01 Ferrara, Roberto; Ricciuti, Biagio; Ambrogio, Chiara; Trapani, Dario
Exploiting signaling rewiring in cancer cells with co-existing oncogenic drivers
2023-01-01 Chiarle, Roberto; Ambrogio, Chiara
Tyrosine phosphatases regulate resistance to ALK inhibitors in ALK+ anaplastic large cell lymphoma
2022-01-01 Atabay, Elif; Mecca, Carmen; Wang, Qi; Ambrogio, Chiara; Mota, Ines; Prokoph, Nina; Mura, Giulia; Martinengo, Cinzia; Patrucco, Enrico; Leonardi, Giulia; Hossa, Jessica; Pich, Achille; Mologni, Luca; Gambacorti-Passerini, Carlo B; Brugieres, Laurence; Geoerger, Birgit; Turner, Suzanne D; Voena, Claudia; Cheong, Taek-Chin; Chiarle, Roberto
Dissecting the clinicopathologic, genomic, and immunophenotypic correlates of KRASG12D-mutated non-small-cell lung cancer
2022-01-01 Ricciuti, B; Alessi, J V; Elkrief, A; Wang, X; Cortellini, A; Li, Y Y; Vaz, V R; Gupta, H; Pecci, F; Barrichello, A; Lamberti, G; Nguyen, T; Lindsay, J; Sharma, B; Felt, K; Rodig, S J; Nishino, M; Sholl, L M; Barbie, D A; Negrao, M V; Zhang, J; Cherniack, A D; Heymach, J V; Meyerson, M; Ambrogio, C; Jänne, P A; Arbour, K C; Pinato, D J; Skoulidis, F; Schoenfeld, A J; Awad, M M; Luo, J
How far we have come targeting BRAF-mutant non-small cell lung cancer (NSCLC)
2022-01-01 Tabbo F.; Pisano C.; Mazieres J.; Mezquita L.; Nadal E.; Planchard D.; Pradines A.; Santamaria D.; Swalduz A.; Ambrogio C.; Novello S.; Ortiz-Cuaran S.
Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities of KRAS Mutations in Non-Small Cell Lung Cancer
2022-01-01 Ricciuti, Biagio; Son, Jieun; Okoro, Jeffrey J; Mira, Alessia; Patrucco, Enrico; Eum, Yoonji; Wang, Xinan; Paranal, Raymond; Wang, Haiyun; Lin, Mika; Haikala, Heidi M; Li, Jiaqi; Xu, Yue; Alessi, Joao Victor; Chhoeu, Chhayheng; Redig, Amanda J; Köhler, Jens; Dholakia, Kshiti H; Chen, Yunhan; Richard, Elodie; Nokin, Marie-Julie; Santamaria, David; Gokhale, Prafulla C; Awad, Mark M; Jänne, Pasi A; Ambrogio, Chiara
Docking Protein p130Cas Regulates Acinar to Ductal Metaplasia During Pancreatic Adenocarcinoma Development and Pancreatitis
2022-01-01 Costamagna, Andrea; Natalini, Dora; Leal, Maria del Pilar Camacho; Simoni, Matilde; Gozzelino, Luca; Cappello, Paola; Novelli, Francesco; Ambrogio, Chiara; Defilippi, Paola; Turco, Emilia; Giovannetti, Elisa; Hirsch, Emilio; Cabodi, Sara; Martini, Miriam
Genomic Profiling Identifies Putative Pathogenic Alterations in NSCLC Brain Metastases
2022-01-01 Nicoś, Marcin; Harbers, Luuk; Patrucco, Enrico; Kramer-Drauberg, Maximilian; Zhang, Xiaolu; Voena, Claudia; Kowalczyk, Anna; Bożyk, Aleksandra; Pęksa, Rafał; Jarosz, Bożena; Szumiło, Justyna; Simonetti, Michele; Żuk, Monika; Wasąg, Bartosz; Reszka, Katarzyna; Duchnowska, Renata; Milanowski, Janusz; Chiarle, Roberto; Bienko, Magda; Krawczyk, Paweł; Jassem, Jacek; Ambrogio, Chiara; Crosetto, Nicola
How to manage KRAS G12C-mutated advanced non-small-cell lung cancer
2022-01-01 Ricciuti, Biagio; Mira, Alessia; Andrini, Elisa; Scaparone, Pietro; Michelina, Sandra Vietti; Pecci, Federica; Cantini, Luca; De Giglio, Andrea; Lamberti, Giuseppe; Ambrogio, Chiara; Metro, Giulio
A structural model of a Ras–Raf signalosome
2021-01-01 Mysore V.P.; Zhou Z.-W.; Ambrogio C.; Li L.; Kapp J.N.; Lu C.; Wang Q.; Tucker M.R.; Okoro J.J.; Nagy-Davidescu G.; Bai X.; Pluckthun A.; Janne P.A.; Westover K.D.; Shan Y.; Shaw D.E.
Discoveries in the redox regulation of KRAS
2021-01-01 Maximilian Kramer-Drauberg; Chiara Ambrogio
ERK inhibitor LY3214996-based treatment strategies for RAS-driven lung cancer
2021-01-01 Köhler, Jens; Zhao, Yutong; Li, Jiaqi; Gokhale, Prafulla C; Tiv, Hong L; Knott, Aine R; Wilkens, Margaret K; Soroko, Kara M; Lin, Mika; Ambrogio, Chiara; Musteanu, Monica; Ogino, Atsuko; Choi, Jihyun; Bahcall, Magda; Bertram, Arrien A; Chambers, Emily S; Paweletz, Cloud P; Bhagwat, Shripad V; Manro, Jason R; Tiu, Ramon V; Janne, Pasi A
Targeting Infrequent Driver Alterations in Non-Small Cell Lung Cancer
2021-01-01 Nokin M.-J.; Ambrogio C.; Nadal E.; Santamaria D.
Inhibition of DDR1 enhances in vivo chemosensitivity in KRAS-mutant lung adenocarcinoma
2020-01-01 Nokin, Marie-Julie; Darbo, Elodie; Travert, Camille; Drogat, Benjamin; Lacouture, Aurélie; San José, Sonia; Cabrera, Nuria; Turcq, Béatrice; Prouzet-Mauleon, Valérie; Falcone, Mattia; Villanueva, Alberto; Wang, Haiyun; Herfs, Michael; Mosteiro, Miguel; Jänne, Pasi A.; Pujol, Jean-Louis; Maraver, Antonio; Barbacid, Mariano; Nadal, Ernest; Santamaría, David; Ambrogio, Chiara
KRASQ61H preferentially signals through MAPK in a RAF dimer-dependent manner in non-small cell lung cancer
2020-01-01 Zhi-Wei Zhou; Chiara Ambrogio; Asim K Bera; Qing Li; Xing-Xiao Li; Lianbo Li; Jieun Son; Sudershan Gondi; Jiaqi Li; Emily Campbell; Hua Jin; Jeffrey J. Okoro; Cheng-Xiong Xu; Pasi A Janne; Kenneth D. Westover
A LIBRETTO to orchestrate targeted therapy
2020-01-01 Marmarelis, Melina E; Chiarle, Roberto; Ambrogio, Chiara; Aggarwal, Charu
Impact of BRAF mutation class on disease characteristics and clinical outcomes in BRAF-mutant lung cancer
2019-01-01 Dagogo-Jack I.; Martinez P.; Yeap B.Y.; Ambrogio C.; Ferris L.A.; Lydon C.; Nguyen T.; Jessop N.A.; John Iafrate A.; Johnson B.E.; Lennerz J.K.; Shaw A.T.; Awad M.M.
Wiskott–Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma
2019-01-01 Menotti, Matteo; Ambrogio, Chiara; Cheong, Taek-Chin; Pighi, Chiara; Mota, Ines; Cassel, Seth H.; Compagno, Mara; Wang, Qi; Dall’Olio, Riccardo; Minero, Valerio G.; Poggio, Teresa; Sharma, Geeta Geeta; Patrucco, Enrico; Mastini, Cristina; Choudhari, Ramesh; Pich, Achille; Zamo, Alberto; Piva, Roberto; Giliani, Silvia; Mologni, Luca; Collings, Clayton K.; Kadoch, Cigall; Gambacorti-Passerini, Carlo; Notarangelo, Luigi D.; Anton, Ines M.; Voena, Claudia*; Chiarle, Roberto
An integrative pharmacogenomics analysis identifies therapeutic targets in KRAS-mutant lung cancer
2019-01-01 Wang H.; Lv Q.; Xu Y.; Cai Z.; Zheng J.; Cheng X.; Dai Y.; Janne P.A.; Ambrogio C.; Kohler J.
KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS
2018-01-01 Ambrogio C.; Kohler J.; Zhou Z.-W.; Wang H.; Paranal R.; Li J.; Capelletti M.; Caffarra C.; Li S.; Lv Q.; Gondi S.; Hunter J.C.; Lu J.; Chiarle R.; Santamaria D.; Westover K.D.; Janne P.A.
Assessing therapeutic efficacy of MEK inhibition in a KrasG12C-driven mouse model of lung cancer
2018-01-01 Li S.; Liu S.; Deng J.; Akbay E.A.; Hai J.; Ambrogio C.; Zhang L.; Zhou F.; Jenkins R.W.; Adeegbe D.O.; Gao P.; Wang X.; Paweletz C.P.; Herter-Sprie G.S.; Chen T.; Gutierrez-Quiceno L.; Zhang Y.; Merlino A.A.; Quinn M.M.; Zeng Y.; Yu X.; Liu Y.; Fan L.; Aguirre A.J.; Barbie D.A.; Yi X.; Wong K.-K.
A putative role for Discoidin Domain Receptor 1 in cancer chemoresistance
2018-01-01 Ambrogio C.; Darbo E.; Lee S.W.; Santamaria D.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Intratumor heterogeneity of EGFR expression mediates targeted therapy resistance and formation of drug tolerant microenvironment | 2025 | Alsaed, Bassel; Lin, Linh; Son, Jieun; Li, Jiaqi; Smolander, Johannes; Lopez, Timothy; Eser, Pinar Ö.; Ogino, Atsuko; Ambrogio, Chiara; Eum, Yoonji; Thai, Tran; Wang, Haiyun; Sutinen, Eva; Mutanen, Hilma; Duàn, Hanna; Bobik, Nina; Borenius, Kristian; Feng, William W.; Nabet, Behnam; Mustjoki, Satu; Laaksonen, Sanna; Eschle, Benjamin K.; Poitras, Michael J.; Barbie, David; Ilonen, Ilkka; Gokhale, Prafulla; Jänne, Pasi A.; Haikala, Heidi M. | |
| SOS1 inhibitor BI-3406 shows in vivo antitumor activity akin to genetic ablation and synergizes with a KRAS G12D inhibitor in KRAS LUAD | 2025 | Baltanás, Fernando C.; Kramer-Drauberg, Maximilian; García-Navas, Rósula; Patrucco, Enrico; Petrini, Ettore; Arnhof, Heribert; Olarte-San Juan, Andrea; Rodríguez-Ramos, Pablo; Borrajo, Javier; Calzada, Nuria; Castellano, Esther; Mair, Barbara; Kostyrko, Kaja; Hofmann, Marco H.; Ambrogio, Chiara; Santos, Eugenio | |
| Oncogenic mutant KRAS inhibition through oxidation at cysteine 118 | 2025 | Kramer-Drauberg, Maximilian; Petrini, Ettore; Mira, Alessia; Patrucco, Enrico; Scardaci, Rossella; Savinelli, Ilenia; Wang, Haiyun; Qiao, Keying; Carrà, Giovanna; Nokin, Marie-Julie; Zhou, Zhiwei; Westover, Kenneth D; Santamaria, David; Porporato, Paolo E; Ambrogio, Chiara | |
| ALK in cancer: from function to therapeutic targeting | 2025 | Voena C.; Ambrogio C.; Iannelli F.; Chiarle R. | |
| KRAS combination strategies: How well aligned is clinical and preclinical research? | 2025 | Nadal, Ernest; Ambrogio, Chiara; Santamaria, David; Lindsay, Colin R. | |
| Circulating tumor DNA dynamic variation predicts sotorasib efficacy in KRASp.G12C-mutated advanced non-small cell lung cancer | 2025 | Passiglia, Francesco; Pepe, Francesco; Russo, Gianluca; Garbo, Edoardo; Listì, Angela; Benso, Federica; Scimone, Claudia; Palumbo, Lucia; Pluchino, Monica; Minari, Roberta; Bordi, Paola; Cani, Massimiliano; Ungaro, Antonio; Ambrogio, Chiara; Taulli, Riccardo; Capelletto, Enrica; Balbi, Maurizio; Righi, Luisella; Tiseo, Marcello; Giannarelli, Diana; Troncone, Giancarlo; Novello, Silvia; Malapelle, Umberto | |
| Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy | 2024 | Holderfield, Matthew; Lee, Bianca J.; Jiang, Jingjing; Tomlinson, Aidan; Seamon, Kyle J.; Mira, Alessia; Patrucco, Enrico; Goodhart, Grace; Dilly, Julien; Gindin, Yevgeniy; Dinglasan, Nuntana; Wang, Yingyun; Lai, Lick Pui; Cai, Shurui; Jiang, Lingyan; Nasholm, Nicole; Shifrin, Nataliya; Blaj, Cristina; Shah, Harshit; Evans, James W.; Montazer, Nilufar; Lai, Oliver; Shi, Jade; Ahler, Ethan; Quintana, Elsa; Chang, Stephanie; Salvador, Anthony; Marquez, Abby; Cregg, Jim; Liu, Yang; Milin, Anthony; Chen, Anqi; Ziv, Tamar Bar; Parsons, Dylan; Knox, John E.; Klomp, Jennifer E.; Roth, Jennifer; Rees, Matthew; Ronan, Melissa; Cuevas-Navarro, Antonio; Hu, Feng; Lito, Piro; Santamaria, David; Aguirre, Andrew J.; Waters, Andrew M.; Der, Channing J.; Ambrogio, Chiara; Wang, Zhengping; Gill, Adrian L.; Koltun, Elena S.; Smith, Jacqueline A. M.; Wildes, David; Singh, Mallika | |
| scPharm: Identifying Pharmacological Subpopulations of Single Cells for Precision Medicine in Cancers | 2024 | Tian, Peng; Zheng, Jie; Qiao, Keying; Fan, Yuxiao; Xu, Yue; Wu, Tao; Chen, Shuting; Zhang, Yinuo; Zhang, Bingyue; Ambrogio, Chiara; Wang, Haiyun | |
| In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma | 2024 | Nokin, Marie-Julie; Darbo, Elodie; Richard, Elodie; San José, Sonia; de Hita, Sergio; Prouzet-Mauleon, Valérie; Turcq, Béatrice; Gerardelli, Laura; Crake, Rebekah; Velasco, Valérie; Koopmansch, Benjamin; Lambert, Frederic; Xue, Jenny Y.; Sang, Ben; Horne, Julie; Ziemons, Eric; Villanueva, Alberto; Blomme, Arnaud; Herfs, Michael; Cataldo, Didier; Calvayrac, Olivier; Porporato, Paolo; Nadal, Ernest; Lito, Piro; Jänne, Pasi A.; Ricciuti, Biagio; Awad, Mark M.; Ambrogio, Chiara; Santamaría, David; | |
| Type I interferon signaling pathway enhances immune-checkpoint inhibition in KRAS mutant lung tumors | 2024 | Fernández-García, Fernando; Fernández-Rodríguez, Ana; Fustero-Torre, Coral; Piñeiro-Yáñez, Elena; Wang, Haiyun; Lechuga, Carmen G.; Callejas, Sergio; Álvarez, Rebeca; López-García, Alejandra; Esteban-Burgos, Laura; Salmón, Marina; San Román, Marta; Guerra, Carmen; Ambrogio, Chiara; Drosten, Matthias; Santamaría, David; Al-Shahrour, Fátima; Dopazo, Ana; Barbacid, Mariano; Musteanu, Monica | |
| RAS-ON inhibition overcomes clinical resistance to KRAS G12C-OFF covalent blockade | 2024 | Nokin, Marie-Julie; Mira, Alessia; Patrucco, Enrico; Ricciuti, Biagio; Cousin, Sophie; Soubeyran, Isabelle; San José, Sonia; Peirone, Serena; Caizzi, Livia; Vietti Michelina, Sandra; Bourdon, Aurelien; Wang, Xinan; Alvarez-Villanueva, Daniel; Martínez-Iniesta, María; Vidal, August; Rodrigues, Telmo; García-Macías, Carmen; Awad, Mark M.; Nadal, Ernest; Villanueva, Alberto; Italiano, Antoine; Cereda, Matteo; Santamaría, David; Ambrogio, Chiara | |
| Biological and targeting differences between the rare KRAS A146T and canonical KRAS mutants in gastric cancer models | 2024 | Puliga, Elisabetta; De Bellis, Chiara; Vietti Michelina, Sandra; Capeloa, Tania; Migliore, Cristina; Orrù, Claudia; Baiocchi, Gian Luca; De Manzoni, Giovanni; Pietrantonio, Filippo; Reddavid, Rossella; Fumagalli Romario, Uberto; Ambrogio, Chiara; Corso, Simona; Giordano, Silvia | |
| Active thymus in adult with lung cancer: preliminary results from the Adult Thymic Project | 2024 | Sobrero, Simona; Patrucco, Enrico; Napoli, Francesca; Ragazzini, Roberta; Milazzo, Rachele; Vaisitti, Federico; Ambrogio, Chiara; Bonfanti, Paola; Rena, Ottavio; Ruffini, Enrico; Righi, Luisella; Leo, Francesco | |
| Experimental variables determine the outcome of RAS-RAS interactions | 2024 | Zhou, Zhiwei; Nguyen, Tra Ly; Li, Xingxiao; Poujol, Christel; Berlinska, Ewa; Michelina, Sandra Vietti; Kapp, Jonas N.; Plückthun, Andreas; Winslow, Monte M.; Ambrogio, Chiara; Shan, Yibing; Santamaría, David; Westover, Kenneth D. | |
| Cancer Hallmarks: Piecing the Puzzle Together | 2024 | Alcolea, Maria P.; Alonso-Curbelo, Direna; Ambrogio, Chiara; Bullman, Susan; Correia, Ana Luísa; Ernst, Aurélie; Halbrook, Christopher J.; Kelly, Gemma L.; Lund, Amanda W.; Quail, Daniela F.; Ruscetti, Marcus; Shema, Efrat; Stromnes, Ingunn M.; Tam, Wai Leong | |
| Novel RAF‐directed approaches to overcome current clinical limits and block the RAS/RAF node | 2024 | Scardaci, Rossella; Berlinska, Ewa; Scaparone, Pietro; Vietti Michelina, Sandra; Garbo, Edoardo; Novello, Silvia; Santamaria, David; Ambrogio, Chiara | |
| ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells | 2023 | Bergaggio, Elisa; Tai, Wei-Tien; Aroldi, Andrea; Mecca, Carmen; Landoni, Elisa; Nüesch, Manuel; Mota, Ines; Metovic, Jasna; Molinaro, Luca; Ma, Leyuan; Alvarado, Diego; Ambrogio, Chiara; Voena, Claudia; Blasco, Rafael B; Li, Tongqing; Klein, Daryl; Irvine, Darrell J; Papotti, Mauro; Savoldo, Barbara; Dotti, Gianpietro; Chiarle, Roberto | |
| ALK peptide vaccination restores the immunogenicity of ALK-rearranged non-small cell lung cancer | 2023 | Mota, Ines; Patrucco, Enrico; Mastini, Cristina; Mahadevan, Navin R; Thai, Tran C; Bergaggio, Elisa; Cheong, Taek-Chin; Leonardi, Giulia; Karaca-Atabay, Elif; Campisi, Marco; Poggio, Teresa; Menotti, Matteo; Ambrogio, Chiara; Longo, Dario L; Klaeger, Susan; Keshishian, Hasmik; Sztupinszki, Zsófia M; Szallasi, Zoltan; Keskin, Derin B; Duke-Cohan, Jonathan S; Reinhold, Bruce; Carr, Steven A; Wu, Catherine J; Moynihan, Kelly D; Irvine, Darrell J; Barbie, David A; Reinherz, Ellis L; Voena, Claudia; Awad, Mark M; Blasco, Rafael B; Chiarle, Roberto | |
| The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer | 2023 | Entrialgo-Cadierno, Rodrigo; Cueto-Ureña, Cristina; Welch, Connor; Feliu, Iker; Macaya, Irati; Vera, Laura; Morales, Xabier; Michelina, Sandra Vietti; Scaparone, Pietro; Lopez, Ines; Darbo, Elodie; Erice, Oihane; Vallejo, Adrian; Moreno, Haritz; Goñi-Salaverri, Ainhoa; Lara-Astiaso, David; Halberg, Nils; Cortes-Dominguez, Ivan; Guruceaga, Elizabeth; Ambrogio, Chiara; Lecanda, Fernando; Vicent, Silve | |
| Resistance to KRAS G12C Inhibition in Non-small Cell Lung Cancer | 2023 | Di Federico, Alessandro; Ricciotti, Ilaria; Favorito, Valentina; Michelina, Sandra Vietti; Scaparone, Pietro; Metro, Giulio; De Giglio, Andrea; Pecci, Federica; Lamberti, Giuseppe; Ambrogio, Chiara; Ricciuti, Biagio | |
| Regulation of CD45 phosphatase by oncogenic ALK in anaplastic large cell lymphoma | 2023 | Mura, Giulia; Karaca Atabay, Elif; Menotti, Matteo; Martinengo, Cinzia; Ambrogio, Chiara; Giacomello, Gloria; Arigoni, Maddalena; Olivero, Martina; Calogero, Raffaele A; Chiarle, Roberto; Voena, Claudia | |
| Targeting CCR7-PI3Kγ overcomes resistance to tyrosine kinase inhibitors in ALK-rearranged lymphoma | 2023 | Mastini, Cristina; Campisi, Marco; Patrucco, Enrico; Mura, Giulia; Ferreira, Antonio; Costa, Carlotta; Ambrogio, Chiara; Germena, Giulia; Martinengo, Cinzia; Peola, Silvia; Mota, Ines; Vissio, Elena; Molinaro, Luca; Arigoni, Maddalena; Olivero, Martina; Calogero, Raffaele; Prokoph, Nina; Tabbò, Fabrizio; Shoji, Brent; Brugieres, Laurence; Geoerger, Birgit; Turner, Suzanne D; Cuesta-Mateos, Carlos; D'Aliberti, Deborah; Mologni, Luca; Piazza, Rocco; Gambacorti-Passerini, Carlo; Inghirami, Giorgio G; Chiono, Valeria; Kamm, Roger D; Hirsch, Emilio; Koch, Raphael; Weinstock, David M; Aster, Jon C; Voena, Claudia; Chiarle, Roberto | |
| YAP and TAZ orchestrate adaptive resistance to KRAS inhibitors | 2023 | Alessia Mira; Chiara Ambrogio | |
| The Anti-Programmed Cell Death Protein-1/ Programmed Death-Ligand 1 Me-Too Drugs Tsunami: Hard To Be Millennials Among Baby Boomers | 2023 | Ferrara, Roberto; Ricciuti, Biagio; Ambrogio, Chiara; Trapani, Dario | |
| Exploiting signaling rewiring in cancer cells with co-existing oncogenic drivers | 2023 | Chiarle, Roberto; Ambrogio, Chiara | |
| Tyrosine phosphatases regulate resistance to ALK inhibitors in ALK+ anaplastic large cell lymphoma | 2022 | Atabay, Elif; Mecca, Carmen; Wang, Qi; Ambrogio, Chiara; Mota, Ines; Prokoph, Nina; Mura, Giulia; Martinengo, Cinzia; Patrucco, Enrico; Leonardi, Giulia; Hossa, Jessica; Pich, Achille; Mologni, Luca; Gambacorti-Passerini, Carlo B; Brugieres, Laurence; Geoerger, Birgit; Turner, Suzanne D; Voena, Claudia; Cheong, Taek-Chin; Chiarle, Roberto | |
| Dissecting the clinicopathologic, genomic, and immunophenotypic correlates of KRASG12D-mutated non-small-cell lung cancer | 2022 | Ricciuti, B; Alessi, J V; Elkrief, A; Wang, X; Cortellini, A; Li, Y Y; Vaz, V R; Gupta, H; Pecci, F; Barrichello, A; Lamberti, G; Nguyen, T; Lindsay, J; Sharma, B; Felt, K; Rodig, S J; Nishino, M; Sholl, L M; Barbie, D A; Negrao, M V; Zhang, J; Cherniack, A D; Heymach, J V; Meyerson, M; Ambrogio, C; Jänne, P A; Arbour, K C; Pinato, D J; Skoulidis, F; Schoenfeld, A J; Awad, M M; Luo, J | |
| How far we have come targeting BRAF-mutant non-small cell lung cancer (NSCLC) | 2022 | Tabbo F.; Pisano C.; Mazieres J.; Mezquita L.; Nadal E.; Planchard D.; Pradines A.; Santamaria D.; Swalduz A.; Ambrogio C.; Novello S.; Ortiz-Cuaran S. | |
| Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities of KRAS Mutations in Non-Small Cell Lung Cancer | 2022 | Ricciuti, Biagio; Son, Jieun; Okoro, Jeffrey J; Mira, Alessia; Patrucco, Enrico; Eum, Yoonji; Wang, Xinan; Paranal, Raymond; Wang, Haiyun; Lin, Mika; Haikala, Heidi M; Li, Jiaqi; Xu, Yue; Alessi, Joao Victor; Chhoeu, Chhayheng; Redig, Amanda J; Köhler, Jens; Dholakia, Kshiti H; Chen, Yunhan; Richard, Elodie; Nokin, Marie-Julie; Santamaria, David; Gokhale, Prafulla C; Awad, Mark M; Jänne, Pasi A; Ambrogio, Chiara | |
| Docking Protein p130Cas Regulates Acinar to Ductal Metaplasia During Pancreatic Adenocarcinoma Development and Pancreatitis | 2022 | Costamagna, Andrea; Natalini, Dora; Leal, Maria del Pilar Camacho; Simoni, Matilde; Gozzelino, Luca; Cappello, Paola; Novelli, Francesco; Ambrogio, Chiara; Defilippi, Paola; Turco, Emilia; Giovannetti, Elisa; Hirsch, Emilio; Cabodi, Sara; Martini, Miriam | |
| Genomic Profiling Identifies Putative Pathogenic Alterations in NSCLC Brain Metastases | 2022 | Nicoś, Marcin; Harbers, Luuk; Patrucco, Enrico; Kramer-Drauberg, Maximilian; Zhang, Xiaolu; Voena, Claudia; Kowalczyk, Anna; Bożyk, Aleksandra; Pęksa, Rafał; Jarosz, Bożena; Szumiło, Justyna; Simonetti, Michele; Żuk, Monika; Wasąg, Bartosz; Reszka, Katarzyna; Duchnowska, Renata; Milanowski, Janusz; Chiarle, Roberto; Bienko, Magda; Krawczyk, Paweł; Jassem, Jacek; Ambrogio, Chiara; Crosetto, Nicola | |
| How to manage KRAS G12C-mutated advanced non-small-cell lung cancer | 2022 | Ricciuti, Biagio; Mira, Alessia; Andrini, Elisa; Scaparone, Pietro; Michelina, Sandra Vietti; Pecci, Federica; Cantini, Luca; De Giglio, Andrea; Lamberti, Giuseppe; Ambrogio, Chiara; Metro, Giulio | |
| A structural model of a Ras–Raf signalosome | 2021 | Mysore V.P.; Zhou Z.-W.; Ambrogio C.; Li L.; Kapp J.N.; Lu C.; Wang Q.; Tucker M.R.; Okoro J.J.; Nagy-Davidescu G.; Bai X.; Pluckthun A.; Janne P.A.; Westover K.D.; Shan Y.; Shaw D.E. | |
| Discoveries in the redox regulation of KRAS | 2021 | Maximilian Kramer-Drauberg; Chiara Ambrogio | |
| ERK inhibitor LY3214996-based treatment strategies for RAS-driven lung cancer | 2021 | Köhler, Jens; Zhao, Yutong; Li, Jiaqi; Gokhale, Prafulla C; Tiv, Hong L; Knott, Aine R; Wilkens, Margaret K; Soroko, Kara M; Lin, Mika; Ambrogio, Chiara; Musteanu, Monica; Ogino, Atsuko; Choi, Jihyun; Bahcall, Magda; Bertram, Arrien A; Chambers, Emily S; Paweletz, Cloud P; Bhagwat, Shripad V; Manro, Jason R; Tiu, Ramon V; Janne, Pasi A | |
| Targeting Infrequent Driver Alterations in Non-Small Cell Lung Cancer | 2021 | Nokin M.-J.; Ambrogio C.; Nadal E.; Santamaria D. | |
| Inhibition of DDR1 enhances in vivo chemosensitivity in KRAS-mutant lung adenocarcinoma | 2020 | Nokin, Marie-Julie; Darbo, Elodie; Travert, Camille; Drogat, Benjamin; Lacouture, Aurélie; San José, Sonia; Cabrera, Nuria; Turcq, Béatrice; Prouzet-Mauleon, Valérie; Falcone, Mattia; Villanueva, Alberto; Wang, Haiyun; Herfs, Michael; Mosteiro, Miguel; Jänne, Pasi A.; Pujol, Jean-Louis; Maraver, Antonio; Barbacid, Mariano; Nadal, Ernest; Santamaría, David; Ambrogio, Chiara | |
| KRASQ61H preferentially signals through MAPK in a RAF dimer-dependent manner in non-small cell lung cancer | 2020 | Zhi-Wei Zhou; Chiara Ambrogio; Asim K Bera; Qing Li; Xing-Xiao Li; Lianbo Li; Jieun Son; Sudershan Gondi; Jiaqi Li; Emily Campbell; Hua Jin; Jeffrey J. Okoro; Cheng-Xiong Xu; Pasi A Janne; Kenneth D. Westover | |
| A LIBRETTO to orchestrate targeted therapy | 2020 | Marmarelis, Melina E; Chiarle, Roberto; Ambrogio, Chiara; Aggarwal, Charu | |
| Impact of BRAF mutation class on disease characteristics and clinical outcomes in BRAF-mutant lung cancer | 2019 | Dagogo-Jack I.; Martinez P.; Yeap B.Y.; Ambrogio C.; Ferris L.A.; Lydon C.; Nguyen T.; Jessop N.A.; John Iafrate A.; Johnson B.E.; Lennerz J.K.; Shaw A.T.; Awad M.M. | |
| Wiskott–Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma | 2019 | Menotti, Matteo; Ambrogio, Chiara; Cheong, Taek-Chin; Pighi, Chiara; Mota, Ines; Cassel, Seth H.; Compagno, Mara; Wang, Qi; Dall’Olio, Riccardo; Minero, Valerio G.; Poggio, Teresa; Sharma, Geeta Geeta; Patrucco, Enrico; Mastini, Cristina; Choudhari, Ramesh; Pich, Achille; Zamo, Alberto; Piva, Roberto; Giliani, Silvia; Mologni, Luca; Collings, Clayton K.; Kadoch, Cigall; Gambacorti-Passerini, Carlo; Notarangelo, Luigi D.; Anton, Ines M.; Voena, Claudia*; Chiarle, Roberto | |
| An integrative pharmacogenomics analysis identifies therapeutic targets in KRAS-mutant lung cancer | 2019 | Wang H.; Lv Q.; Xu Y.; Cai Z.; Zheng J.; Cheng X.; Dai Y.; Janne P.A.; Ambrogio C.; Kohler J. | |
| KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS | 2018 | Ambrogio C.; Kohler J.; Zhou Z.-W.; Wang H.; Paranal R.; Li J.; Capelletti M.; Caffarra C.; Li S.; Lv Q.; Gondi S.; Hunter J.C.; Lu J.; Chiarle R.; Santamaria D.; Westover K.D.; Janne P.A. | |
| Assessing therapeutic efficacy of MEK inhibition in a KrasG12C-driven mouse model of lung cancer | 2018 | Li S.; Liu S.; Deng J.; Akbay E.A.; Hai J.; Ambrogio C.; Zhang L.; Zhou F.; Jenkins R.W.; Adeegbe D.O.; Gao P.; Wang X.; Paweletz C.P.; Herter-Sprie G.S.; Chen T.; Gutierrez-Quiceno L.; Zhang Y.; Merlino A.A.; Quinn M.M.; Zeng Y.; Yu X.; Liu Y.; Fan L.; Aguirre A.J.; Barbie D.A.; Yi X.; Wong K.-K. | |
| A putative role for Discoidin Domain Receptor 1 in cancer chemoresistance | 2018 | Ambrogio C.; Darbo E.; Lee S.W.; Santamaria D. |
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