Sfoglia per Autore
The Anti-Programmed Cell Death Protein-1/ Programmed Death-Ligand 1 Me-Too Drugs Tsunami: Hard To Be Millennials Among Baby Boomers
In corso di stampa Ferrara, Roberto; Ricciuti, Biagio; Ambrogio, Chiara; Trapani, Dario
Novel RAF‐directed approaches to overcome current clinical limits and block the RAS/RAF node
2024-01-01 Scardaci, Rossella; Berlinska, Ewa; Scaparone, Pietro; Vietti Michelina, Sandra; Garbo, Edoardo; Novello, Silvia; Santamaria, David; Ambrogio, Chiara
Biological and targeting differences between the rare KRAS A146T and canonical KRAS mutants in gastric cancer models
2024-01-01 Puliga, Elisabetta; De Bellis, Chiara; Vietti Michelina, Sandra; Capeloa, Tania; Migliore, Cristina; Orrù, Claudia; Baiocchi, Gian Luca; De Manzoni, Giovanni; Pietrantonio, Filippo; Reddavid, Rossella; Fumagalli Romario, Uberto; Ambrogio, Chiara; Corso, Simona; Giordano, Silvia
Cancer Hallmarks: Piecing the Puzzle Together
2024-01-01 Alcolea, Maria P.; Alonso-Curbelo, Direna; Ambrogio, Chiara; Bullman, Susan; Correia, Ana Luísa; Ernst, Aurélie; Halbrook, Christopher J.; Kelly, Gemma L.; Lund, Amanda W.; Quail, Daniela F.; Ruscetti, Marcus; Shema, Efrat; Stromnes, Ingunn M.; Tam, Wai Leong
Resistance to KRAS G12C Inhibition in Non-small Cell Lung Cancer
2023-01-01 Di Federico, Alessandro; Ricciotti, Ilaria; Favorito, Valentina; Michelina, Sandra Vietti; Scaparone, Pietro; Metro, Giulio; De Giglio, Andrea; Pecci, Federica; Lamberti, Giuseppe; Ambrogio, Chiara; Ricciuti, Biagio
YAP and TAZ orchestrate adaptive resistance to KRAS inhibitors
2023-01-01 Alessia Mira; Chiara Ambrogio
The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer
2023-01-01 Entrialgo-Cadierno, Rodrigo; Cueto-Ureña, Cristina; Welch, Connor; Feliu, Iker; Macaya, Irati; Vera, Laura; Morales, Xabier; Michelina, Sandra Vietti; Scaparone, Pietro; Lopez, Ines; Darbo, Elodie; Erice, Oihane; Vallejo, Adrian; Moreno, Haritz; Goñi-Salaverri, Ainhoa; Lara-Astiaso, David; Halberg, Nils; Cortes-Dominguez, Ivan; Guruceaga, Elizabeth; Ambrogio, Chiara; Lecanda, Fernando; Vicent, Silve
Exploiting signaling rewiring in cancer cells with co-existing oncogenic drivers
2023-01-01 Chiarle, Roberto; Ambrogio, Chiara
ALK peptide vaccination restores the immunogenicity of ALK-rearranged non-small cell lung cancer
2023-01-01 Mota, Ines; Patrucco, Enrico; Mastini, Cristina; Mahadevan, Navin R; Thai, Tran C; Bergaggio, Elisa; Cheong, Taek-Chin; Leonardi, Giulia; Karaca-Atabay, Elif; Campisi, Marco; Poggio, Teresa; Menotti, Matteo; Ambrogio, Chiara; Longo, Dario L; Klaeger, Susan; Keshishian, Hasmik; Sztupinszki, Zsófia M; Szallasi, Zoltan; Keskin, Derin B; Duke-Cohan, Jonathan S; Reinhold, Bruce; Carr, Steven A; Wu, Catherine J; Moynihan, Kelly D; Irvine, Darrell J; Barbie, David A; Reinherz, Ellis L; Voena, Claudia; Awad, Mark M; Blasco, Rafael B; Chiarle, Roberto
ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells
2023-01-01 Bergaggio, Elisa; Tai, Wei-Tien; Aroldi, Andrea; Mecca, Carmen; Landoni, Elisa; Nüesch, Manuel; Mota, Ines; Metovic, Jasna; Molinaro, Luca; Ma, Leyuan; Alvarado, Diego; Ambrogio, Chiara; Voena, Claudia; Blasco, Rafael B; Li, Tongqing; Klein, Daryl; Irvine, Darrell J; Papotti, Mauro; Savoldo, Barbara; Dotti, Gianpietro; Chiarle, Roberto
Targeting CCR7-PI3Kγ overcomes resistance to tyrosine kinase inhibitors in ALK-rearranged lymphoma
2023-01-01 Mastini, Cristina; Campisi, Marco; Patrucco, Enrico; Mura, Giulia; Ferreira, Antonio; Costa, Carlotta; Ambrogio, Chiara; Germena, Giulia; Martinengo, Cinzia; Peola, Silvia; Mota, Ines; Vissio, Elena; Molinaro, Luca; Arigoni, Maddalena; Olivero, Martina; Calogero, Raffaele; Prokoph, Nina; Tabbò, Fabrizio; Shoji, Brent; Brugieres, Laurence; Geoerger, Birgit; Turner, Suzanne D; Cuesta-Mateos, Carlos; D'Aliberti, Deborah; Mologni, Luca; Piazza, Rocco; Gambacorti-Passerini, Carlo; Inghirami, Giorgio G; Chiono, Valeria; Kamm, Roger D; Hirsch, Emilio; Koch, Raphael; Weinstock, David M; Aster, Jon C; Voena, Claudia; Chiarle, Roberto
How to manage KRAS G12C-mutated advanced non-small-cell lung cancer
2022-01-01 Ricciuti, Biagio; Mira, Alessia; Andrini, Elisa; Scaparone, Pietro; Michelina, Sandra Vietti; Pecci, Federica; Cantini, Luca; De Giglio, Andrea; Lamberti, Giuseppe; Ambrogio, Chiara; Metro, Giulio
Dissecting the clinicopathologic, genomic, and immunophenotypic correlates of KRASG12D-mutated non-small-cell lung cancer
2022-01-01 Ricciuti, B; Alessi, J V; Elkrief, A; Wang, X; Cortellini, A; Li, Y Y; Vaz, V R; Gupta, H; Pecci, F; Barrichello, A; Lamberti, G; Nguyen, T; Lindsay, J; Sharma, B; Felt, K; Rodig, S J; Nishino, M; Sholl, L M; Barbie, D A; Negrao, M V; Zhang, J; Cherniack, A D; Heymach, J V; Meyerson, M; Ambrogio, C; Jänne, P A; Arbour, K C; Pinato, D J; Skoulidis, F; Schoenfeld, A J; Awad, M M; Luo, J
Tyrosine phosphatases regulate resistance to ALK inhibitors in ALK+ anaplastic large cell lymphoma
2022-01-01 Karaca Atabay, Elif; Mecca, Carmen; Wang, Qi; Ambrogio, Chiara; Mota, Ines; Prokoph, Nina; Mura, Giulia; Martinengo, Cinzia; Patrucco, Enrico; Leonardi, Giulia; Hossa, Jessica; Pich, Achille; Mologni, Luca; Gambacorti-Passerini, Carlo B; Brugieres, Laurence; Geoerger, Birgit; Turner, Suzanne D; Voena, Claudia; Cheong, Taek-Chin; Chiarle, Roberto
Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities of KRAS Mutations in Non-Small Cell Lung Cancer
2022-01-01 Ricciuti, Biagio; Son, Jieun; Okoro, Jeffrey J; Mira, Alessia; Patrucco, Enrico; Eum, Yoonji; Wang, Xinan; Paranal, Raymond; Wang, Haiyun; Lin, Mika; Haikala, Heidi M; Li, Jiaqi; Xu, Yue; Alessi, Joao Victor; Chhoeu, Chhayheng; Redig, Amanda J; Köhler, Jens; Dholakia, Kshiti H; Chen, Yunhan; Richard, Elodie; Nokin, Marie-Julie; Santamaria, David; Gokhale, Prafulla C; Awad, Mark M; Jänne, Pasi A; Ambrogio, Chiara
Regulation of CD45 phosphatase by oncogenic ALK in anaplastic large cell lymphoma
2022-01-01 Mura, Giulia; Karaca Atabay, Elif; Menotti, Matteo; Martinengo, Cinzia; Ambrogio, Chiara; Giacomello, Gloria; Arigoni, Maddalena; Olivero, Martina; Calogero, Raffaele A; Chiarle, Roberto; Voena, Claudia
How far we have come targeting BRAF-mutant non-small cell lung cancer (NSCLC)
2022-01-01 Tabbo F.; Pisano C.; Mazieres J.; Mezquita L.; Nadal E.; Planchard D.; Pradines A.; Santamaria D.; Swalduz A.; Ambrogio C.; Novello S.; Ortiz-Cuaran S.
Docking Protein p130Cas Regulates Acinar to Ductal Metaplasia During Pancreatic Adenocarcinoma Development and Pancreatitis
2022-01-01 Costamagna, Andrea; Natalini, Dora; Leal, Maria del Pilar Camacho; Simoni, Matilde; Gozzelino, Luca; Cappello, Paola; Novelli, Francesco; Ambrogio, Chiara; Defilippi, Paola; Turco, Emilia; Giovannetti, Elisa; Hirsch, Emilio; Cabodi, Sara; Martini, Miriam
Genomic Profiling Identifies Putative Pathogenic Alterations in NSCLC Brain Metastases
2022-01-01 Nicoś, Marcin; Harbers, Luuk; Patrucco, Enrico; Kramer-Drauberg, Maximilian; Zhang, Xiaolu; Voena, Claudia; Kowalczyk, Anna; Bożyk, Aleksandra; Pęksa, Rafał; Jarosz, Bożena; Szumiło, Justyna; Simonetti, Michele; Żuk, Monika; Wasąg, Bartosz; Reszka, Katarzyna; Duchnowska, Renata; Milanowski, Janusz; Chiarle, Roberto; Bienko, Magda; Krawczyk, Paweł; Jassem, Jacek; Ambrogio, Chiara; Crosetto, Nicola
ERK inhibitor LY3214996-based treatment strategies for RAS-driven lung cancer
2021-01-01 Köhler, Jens; Zhao, Yutong; Li, Jiaqi; Gokhale, Prafulla C; Tiv, Hong L; Knott, Aine R; Wilkens, Margaret K; Soroko, Kara M; Lin, Mika; Ambrogio, Chiara; Musteanu, Monica; Ogino, Atsuko; Choi, Jihyun; Bahcall, Magda; Bertram, Arrien A; Chambers, Emily S; Paweletz, Cloud P; Bhagwat, Shripad V; Manro, Jason R; Tiu, Ramon V; Janne, Pasi A
A structural model of a Ras–Raf signalosome
2021-01-01 Mysore V.P.; Zhou Z.-W.; Ambrogio C.; Li L.; Kapp J.N.; Lu C.; Wang Q.; Tucker M.R.; Okoro J.J.; Nagy-Davidescu G.; Bai X.; Pluckthun A.; Janne P.A.; Westover K.D.; Shan Y.; Shaw D.E.
Targeting Infrequent Driver Alterations in Non-Small Cell Lung Cancer
2021-01-01 Nokin M.-J.; Ambrogio C.; Nadal E.; Santamaria D.
Discoveries in the redox regulation of KRAS
2021-01-01 Maximilian Kramer-Drauberg; Chiara Ambrogio
A LIBRETTO to orchestrate targeted therapy
2020-01-01 Marmarelis, Melina E; Chiarle, Roberto; Ambrogio, Chiara; Aggarwal, Charu
Inhibition of DDR1 enhances in vivo chemosensitivity in KRAS-mutant lung adenocarcinoma
2020-01-01 Nokin, Marie-Julie; Darbo, Elodie; Travert, Camille; Drogat, Benjamin; Lacouture, Aurélie; San José, Sonia; Cabrera, Nuria; Turcq, Béatrice; Prouzet-Mauleon, Valérie; Falcone, Mattia; Villanueva, Alberto; Wang, Haiyun; Herfs, Michael; Mosteiro, Miguel; Jänne, Pasi A.; Pujol, Jean-Louis; Maraver, Antonio; Barbacid, Mariano; Nadal, Ernest; Santamaría, David; Ambrogio, Chiara
KRASQ61H preferentially signals through MAPK in a RAF dimer-dependent manner in non-small cell lung cancer
2020-01-01 Zhi-Wei Zhou; Chiara Ambrogio; Asim K Bera; Qing Li; Xing-Xiao Li; Lianbo Li; Jieun Son; Sudershan Gondi; Jiaqi Li; Emily Campbell; Hua Jin; Jeffrey J. Okoro; Cheng-Xiong Xu; Pasi A Janne; Kenneth D. Westover
Impact of BRAF mutation class on disease characteristics and clinical outcomes in BRAF-mutant lung cancer
2019-01-01 Dagogo-Jack I.; Martinez P.; Yeap B.Y.; Ambrogio C.; Ferris L.A.; Lydon C.; Nguyen T.; Jessop N.A.; John Iafrate A.; Johnson B.E.; Lennerz J.K.; Shaw A.T.; Awad M.M.
Wiskott–Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma
2019-01-01 Menotti, Matteo; Ambrogio, Chiara; Cheong, Taek-Chin; Pighi, Chiara; Mota, Ines; Cassel, Seth H.; Compagno, Mara; Wang, Qi; Dall’Olio, Riccardo; Minero, Valerio G.; Poggio, Teresa; Sharma, Geeta Geeta; Patrucco, Enrico; Mastini, Cristina; Choudhari, Ramesh; Pich, Achille; Zamo, Alberto; Piva, Roberto; Giliani, Silvia; Mologni, Luca; Collings, Clayton K.; Kadoch, Cigall; Gambacorti-Passerini, Carlo; Notarangelo, Luigi D.; Anton, Ines M.; Voena, Claudia*; Chiarle, Roberto
An integrative pharmacogenomics analysis identifies therapeutic targets in KRAS-mutant lung cancer
2019-01-01 Wang H.; Lv Q.; Xu Y.; Cai Z.; Zheng J.; Cheng X.; Dai Y.; Janne P.A.; Ambrogio C.; Kohler J.
KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS
2018-01-01 Ambrogio C.; Kohler J.; Zhou Z.-W.; Wang H.; Paranal R.; Li J.; Capelletti M.; Caffarra C.; Li S.; Lv Q.; Gondi S.; Hunter J.C.; Lu J.; Chiarle R.; Santamaria D.; Westover K.D.; Janne P.A.
A putative role for Discoidin Domain Receptor 1 in cancer chemoresistance
2018-01-01 Ambrogio C.; Darbo E.; Lee S.W.; Santamaria D.
Assessing therapeutic efficacy of MEK inhibition in a KrasG12C-driven mouse model of lung cancer
2018-01-01 Li S.; Liu S.; Deng J.; Akbay E.A.; Hai J.; Ambrogio C.; Zhang L.; Zhou F.; Jenkins R.W.; Adeegbe D.O.; Gao P.; Wang X.; Paweletz C.P.; Herter-Sprie G.S.; Chen T.; Gutierrez-Quiceno L.; Zhang Y.; Merlino A.A.; Quinn M.M.; Zeng Y.; Yu X.; Liu Y.; Fan L.; Aguirre A.J.; Barbie D.A.; Yi X.; Wong K.-K.
Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells
2017-01-01 Compagno, Mara; Wang, Qi; Pighi, Chiara; Cheong, Taek-Chin; Meng, Fei-Long; Poggio, Teresa; Yeap, Leng-Siew; Karaca, Elif; Blasco, Rafael B.; Langellotto, Fernanda; Ambrogio, Chiara; Voena, Claudia; Wiestner, Adrian; Kasar, Siddha N.; Brown, Jennifer R.; Sun, Jing; Wu, Catherine J.; Gostissa, Monica; Alt, Frederick W.; Chiarle, Roberto
A Braf kinase-inactive mutant induces lung adenocarcinoma
2017-01-01 Nieto P.; Ambrogio C.; Esteban-Burgos L.; Gomez-Lopez G.; Blasco M.T.; Yao Z.; Marais R.; Rosen N.; Chiarle R.; Pisano D.G.; Barbacid M.; Santamaria D.
Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma
2016-01-01 Ambrogio C.; Gomez-Lopez G.; Falcone M.; Vidal A.; Nadal E.; Crosetto N.; Blasco R.B.; Fernandez-Marcos P.J.; Sanchez-Cespedes M.; Ren X.; Wang Z.; Ding K.; Hidalgo M.; Serrano M.; Villanueva A.; Santamaraa D.; Barbacid M.
Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency
2016-01-01 Ceccon, M; Merlo, M E Boggio; Mologni, L.; Poggio, T.; Varesio, L.M.; Menotti, M.; Bombelli, S.; Rigolio, R.; Manazza, A.D.; Di Giacomo, F.; Ambrogio, C.; Giudici, G.; Casati, C.; Mastini, C.; Compagno, M.; Turner, S.D.; Gambacorti-Passerini, C.; Chiarle, R. ; Voena, C.
Redundant and non-redundant roles for Cdc42 and Rac1 in lymphomas developed in NPM-ALK transgenic mice
2016-01-01 Choudhari, Ramesh; Minero, Valerio Giacomo; Menotti, Matteo; Pulito, Roberta; Brakebusch, Cord; Compagno, Mara; Voena, Claudia; Ambrogio, Chiara; Chiarle, Roberto
Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice
2015-01-01 Lopez-Contreras A.J.; Specks J.; Barlow J.H.; Ambrogio C.; Desler C.; Vikingsson S.; Rodrigo-Perez S.; Green H.; Rasmussen L.J.; Murga M.; Nussenzweig A.; Fernandez-Capetillo O.
Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage
2015-01-01 Garcia-Beccaria M.; Martinez P.; Mendez-Pertuz M.; Martinez S.; Blanco-Aparicio C.; Canamero M.; Mulero F.; Ambrogio C.; Flores J.M.; Megias D.; Barbacid M.; Pastor J.; Blasco M.A.
Efficacy of a Cancer Vaccine against ALK-Rearranged Lung Tumors
2015-01-01 Voena, Claudia; Menotti, Matteo; Mastini, Cristina; Di Giacomo, Filomena; Longo, Dario Livio; Castella, Barbara; Merlo, Maria Elena Boggio; Ambrogio, Chiara; Wang, Qi; Minero, Valerio Giacomo; Poggio, Teresa; Martinengo, Cinzia; D'Amico, Lucia; Panizza, Elena; Mologni, Luca; Cavallo, Federica; Altruda, Fiorella; Butaney, Mohit; Capelletti, Marzia; Inghirami, Giorgio; Jänne, Pasi A; Chiarle, Roberto
Simple and Rapid InVivo Generation of Chromosomal Rearrangements using CRISPR/Cas9 Technology
2014-01-01 Blasco, Rafael B; Karaca, Elif; Ambrogio, Chiara; Cheong, Taek-Chin; Karayol, Emre; Minero, Valerio G.; Voena, Claudia; Chiarle, Roberto
ALK-dependent control of hypoxia-inducible factors mediates tumor growth and metastasis
2014-01-01 Martinengo, Cinzia; Poggio, Teresa; Menotti, Matteo; Scalzo, Maria Stella; Mastini, Cristina; Ambrogio, Chiara; Pellegrino, Elisa; Riera, Ludovica; Piva, Roberto; Ribatti, Domenico; Pastorino, Fabio; Perri, Patrizia; Ponzoni, Mirco; Wang, Qi; Voena, Claudia; Chiarle, Roberto
Modeling lung cancer evolution and preclinical response by orthotopic mouse allografts
2014-01-01 Ambrogio, Chiara*; Carmona, Francisco J.; Vidal, August; Falcone, Mattia; Nieto, Patricia; Romero, Octavio A.; Puertas, Sara; Vizoso, Miguel; Nadal, Ernest; Poggio, Teresa; Sánchez-Céspedes, Montserrat; Esteller, Manel; Mulero, Francisca; Voena, Claudia; Chiarle, Roberto; Barbacid, Mariano; Santamaría, David; Villanueva, Alberto
Lentiviral-based approach for the validation of cancer therapeutic targets in vivo
2014-01-01 Ambrogio C.; Stern P.; Scuoppo C.; Kranz H.; Barbacid M.; Santamaria D.
The EGFR family members sustain the neoplastic phenotype of ALK+ lung adenocarcinoma via EGR1.
2013-01-01 Voena C;Di Giacomo F;Panizza E;D'Amico L;Boccalatte FE;Pellegrino E;Todaro M;Recupero D;Tabbò F;Ambrogio C;Martinengo C;Bonello L;Pulito R;Hamm J;Chiarle R;Cheng M;Ruggeri B;Medico E;Inghirami G
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| The Anti-Programmed Cell Death Protein-1/ Programmed Death-Ligand 1 Me-Too Drugs Tsunami: Hard To Be Millennials Among Baby Boomers | In corso di stampa | Ferrara, Roberto; Ricciuti, Biagio; Ambrogio, Chiara; Trapani, Dario | |
| Novel RAF‐directed approaches to overcome current clinical limits and block the RAS/RAF node | 2024 | Scardaci, Rossella; Berlinska, Ewa; Scaparone, Pietro; Vietti Michelina, Sandra; Garbo, Edoardo; Novello, Silvia; Santamaria, David; Ambrogio, Chiara | |
| Biological and targeting differences between the rare KRAS A146T and canonical KRAS mutants in gastric cancer models | 2024 | Puliga, Elisabetta; De Bellis, Chiara; Vietti Michelina, Sandra; Capeloa, Tania; Migliore, Cristina; Orrù, Claudia; Baiocchi, Gian Luca; De Manzoni, Giovanni; Pietrantonio, Filippo; Reddavid, Rossella; Fumagalli Romario, Uberto; Ambrogio, Chiara; Corso, Simona; Giordano, Silvia | |
| Cancer Hallmarks: Piecing the Puzzle Together | 2024 | Alcolea, Maria P.; Alonso-Curbelo, Direna; Ambrogio, Chiara; Bullman, Susan; Correia, Ana Luísa; Ernst, Aurélie; Halbrook, Christopher J.; Kelly, Gemma L.; Lund, Amanda W.; Quail, Daniela F.; Ruscetti, Marcus; Shema, Efrat; Stromnes, Ingunn M.; Tam, Wai Leong | |
| Resistance to KRAS G12C Inhibition in Non-small Cell Lung Cancer | 2023 | Di Federico, Alessandro; Ricciotti, Ilaria; Favorito, Valentina; Michelina, Sandra Vietti; Scaparone, Pietro; Metro, Giulio; De Giglio, Andrea; Pecci, Federica; Lamberti, Giuseppe; Ambrogio, Chiara; Ricciuti, Biagio | |
| YAP and TAZ orchestrate adaptive resistance to KRAS inhibitors | 2023 | Alessia Mira; Chiara Ambrogio | |
| The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer | 2023 | Entrialgo-Cadierno, Rodrigo; Cueto-Ureña, Cristina; Welch, Connor; Feliu, Iker; Macaya, Irati; Vera, Laura; Morales, Xabier; Michelina, Sandra Vietti; Scaparone, Pietro; Lopez, Ines; Darbo, Elodie; Erice, Oihane; Vallejo, Adrian; Moreno, Haritz; Goñi-Salaverri, Ainhoa; Lara-Astiaso, David; Halberg, Nils; Cortes-Dominguez, Ivan; Guruceaga, Elizabeth; Ambrogio, Chiara; Lecanda, Fernando; Vicent, Silve | |
| Exploiting signaling rewiring in cancer cells with co-existing oncogenic drivers | 2023 | Chiarle, Roberto; Ambrogio, Chiara | |
| ALK peptide vaccination restores the immunogenicity of ALK-rearranged non-small cell lung cancer | 2023 | Mota, Ines; Patrucco, Enrico; Mastini, Cristina; Mahadevan, Navin R; Thai, Tran C; Bergaggio, Elisa; Cheong, Taek-Chin; Leonardi, Giulia; Karaca-Atabay, Elif; Campisi, Marco; Poggio, Teresa; Menotti, Matteo; Ambrogio, Chiara; Longo, Dario L; Klaeger, Susan; Keshishian, Hasmik; Sztupinszki, Zsófia M; Szallasi, Zoltan; Keskin, Derin B; Duke-Cohan, Jonathan S; Reinhold, Bruce; Carr, Steven A; Wu, Catherine J; Moynihan, Kelly D; Irvine, Darrell J; Barbie, David A; Reinherz, Ellis L; Voena, Claudia; Awad, Mark M; Blasco, Rafael B; Chiarle, Roberto | |
| ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells | 2023 | Bergaggio, Elisa; Tai, Wei-Tien; Aroldi, Andrea; Mecca, Carmen; Landoni, Elisa; Nüesch, Manuel; Mota, Ines; Metovic, Jasna; Molinaro, Luca; Ma, Leyuan; Alvarado, Diego; Ambrogio, Chiara; Voena, Claudia; Blasco, Rafael B; Li, Tongqing; Klein, Daryl; Irvine, Darrell J; Papotti, Mauro; Savoldo, Barbara; Dotti, Gianpietro; Chiarle, Roberto | |
| Targeting CCR7-PI3Kγ overcomes resistance to tyrosine kinase inhibitors in ALK-rearranged lymphoma | 2023 | Mastini, Cristina; Campisi, Marco; Patrucco, Enrico; Mura, Giulia; Ferreira, Antonio; Costa, Carlotta; Ambrogio, Chiara; Germena, Giulia; Martinengo, Cinzia; Peola, Silvia; Mota, Ines; Vissio, Elena; Molinaro, Luca; Arigoni, Maddalena; Olivero, Martina; Calogero, Raffaele; Prokoph, Nina; Tabbò, Fabrizio; Shoji, Brent; Brugieres, Laurence; Geoerger, Birgit; Turner, Suzanne D; Cuesta-Mateos, Carlos; D'Aliberti, Deborah; Mologni, Luca; Piazza, Rocco; Gambacorti-Passerini, Carlo; Inghirami, Giorgio G; Chiono, Valeria; Kamm, Roger D; Hirsch, Emilio; Koch, Raphael; Weinstock, David M; Aster, Jon C; Voena, Claudia; Chiarle, Roberto | |
| How to manage KRAS G12C-mutated advanced non-small-cell lung cancer | 2022 | Ricciuti, Biagio; Mira, Alessia; Andrini, Elisa; Scaparone, Pietro; Michelina, Sandra Vietti; Pecci, Federica; Cantini, Luca; De Giglio, Andrea; Lamberti, Giuseppe; Ambrogio, Chiara; Metro, Giulio | |
| Dissecting the clinicopathologic, genomic, and immunophenotypic correlates of KRASG12D-mutated non-small-cell lung cancer | 2022 | Ricciuti, B; Alessi, J V; Elkrief, A; Wang, X; Cortellini, A; Li, Y Y; Vaz, V R; Gupta, H; Pecci, F; Barrichello, A; Lamberti, G; Nguyen, T; Lindsay, J; Sharma, B; Felt, K; Rodig, S J; Nishino, M; Sholl, L M; Barbie, D A; Negrao, M V; Zhang, J; Cherniack, A D; Heymach, J V; Meyerson, M; Ambrogio, C; Jänne, P A; Arbour, K C; Pinato, D J; Skoulidis, F; Schoenfeld, A J; Awad, M M; Luo, J | |
| Tyrosine phosphatases regulate resistance to ALK inhibitors in ALK+ anaplastic large cell lymphoma | 2022 | Karaca Atabay, Elif; Mecca, Carmen; Wang, Qi; Ambrogio, Chiara; Mota, Ines; Prokoph, Nina; Mura, Giulia; Martinengo, Cinzia; Patrucco, Enrico; Leonardi, Giulia; Hossa, Jessica; Pich, Achille; Mologni, Luca; Gambacorti-Passerini, Carlo B; Brugieres, Laurence; Geoerger, Birgit; Turner, Suzanne D; Voena, Claudia; Cheong, Taek-Chin; Chiarle, Roberto | |
| Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities of KRAS Mutations in Non-Small Cell Lung Cancer | 2022 | Ricciuti, Biagio; Son, Jieun; Okoro, Jeffrey J; Mira, Alessia; Patrucco, Enrico; Eum, Yoonji; Wang, Xinan; Paranal, Raymond; Wang, Haiyun; Lin, Mika; Haikala, Heidi M; Li, Jiaqi; Xu, Yue; Alessi, Joao Victor; Chhoeu, Chhayheng; Redig, Amanda J; Köhler, Jens; Dholakia, Kshiti H; Chen, Yunhan; Richard, Elodie; Nokin, Marie-Julie; Santamaria, David; Gokhale, Prafulla C; Awad, Mark M; Jänne, Pasi A; Ambrogio, Chiara | |
| Regulation of CD45 phosphatase by oncogenic ALK in anaplastic large cell lymphoma | 2022 | Mura, Giulia; Karaca Atabay, Elif; Menotti, Matteo; Martinengo, Cinzia; Ambrogio, Chiara; Giacomello, Gloria; Arigoni, Maddalena; Olivero, Martina; Calogero, Raffaele A; Chiarle, Roberto; Voena, Claudia | |
| How far we have come targeting BRAF-mutant non-small cell lung cancer (NSCLC) | 2022 | Tabbo F.; Pisano C.; Mazieres J.; Mezquita L.; Nadal E.; Planchard D.; Pradines A.; Santamaria D.; Swalduz A.; Ambrogio C.; Novello S.; Ortiz-Cuaran S. | |
| Docking Protein p130Cas Regulates Acinar to Ductal Metaplasia During Pancreatic Adenocarcinoma Development and Pancreatitis | 2022 | Costamagna, Andrea; Natalini, Dora; Leal, Maria del Pilar Camacho; Simoni, Matilde; Gozzelino, Luca; Cappello, Paola; Novelli, Francesco; Ambrogio, Chiara; Defilippi, Paola; Turco, Emilia; Giovannetti, Elisa; Hirsch, Emilio; Cabodi, Sara; Martini, Miriam | |
| Genomic Profiling Identifies Putative Pathogenic Alterations in NSCLC Brain Metastases | 2022 | Nicoś, Marcin; Harbers, Luuk; Patrucco, Enrico; Kramer-Drauberg, Maximilian; Zhang, Xiaolu; Voena, Claudia; Kowalczyk, Anna; Bożyk, Aleksandra; Pęksa, Rafał; Jarosz, Bożena; Szumiło, Justyna; Simonetti, Michele; Żuk, Monika; Wasąg, Bartosz; Reszka, Katarzyna; Duchnowska, Renata; Milanowski, Janusz; Chiarle, Roberto; Bienko, Magda; Krawczyk, Paweł; Jassem, Jacek; Ambrogio, Chiara; Crosetto, Nicola | |
| ERK inhibitor LY3214996-based treatment strategies for RAS-driven lung cancer | 2021 | Köhler, Jens; Zhao, Yutong; Li, Jiaqi; Gokhale, Prafulla C; Tiv, Hong L; Knott, Aine R; Wilkens, Margaret K; Soroko, Kara M; Lin, Mika; Ambrogio, Chiara; Musteanu, Monica; Ogino, Atsuko; Choi, Jihyun; Bahcall, Magda; Bertram, Arrien A; Chambers, Emily S; Paweletz, Cloud P; Bhagwat, Shripad V; Manro, Jason R; Tiu, Ramon V; Janne, Pasi A | |
| A structural model of a Ras–Raf signalosome | 2021 | Mysore V.P.; Zhou Z.-W.; Ambrogio C.; Li L.; Kapp J.N.; Lu C.; Wang Q.; Tucker M.R.; Okoro J.J.; Nagy-Davidescu G.; Bai X.; Pluckthun A.; Janne P.A.; Westover K.D.; Shan Y.; Shaw D.E. | |
| Targeting Infrequent Driver Alterations in Non-Small Cell Lung Cancer | 2021 | Nokin M.-J.; Ambrogio C.; Nadal E.; Santamaria D. | |
| Discoveries in the redox regulation of KRAS | 2021 | Maximilian Kramer-Drauberg; Chiara Ambrogio | |
| A LIBRETTO to orchestrate targeted therapy | 2020 | Marmarelis, Melina E; Chiarle, Roberto; Ambrogio, Chiara; Aggarwal, Charu | |
| Inhibition of DDR1 enhances in vivo chemosensitivity in KRAS-mutant lung adenocarcinoma | 2020 | Nokin, Marie-Julie; Darbo, Elodie; Travert, Camille; Drogat, Benjamin; Lacouture, Aurélie; San José, Sonia; Cabrera, Nuria; Turcq, Béatrice; Prouzet-Mauleon, Valérie; Falcone, Mattia; Villanueva, Alberto; Wang, Haiyun; Herfs, Michael; Mosteiro, Miguel; Jänne, Pasi A.; Pujol, Jean-Louis; Maraver, Antonio; Barbacid, Mariano; Nadal, Ernest; Santamaría, David; Ambrogio, Chiara | |
| KRASQ61H preferentially signals through MAPK in a RAF dimer-dependent manner in non-small cell lung cancer | 2020 | Zhi-Wei Zhou; Chiara Ambrogio; Asim K Bera; Qing Li; Xing-Xiao Li; Lianbo Li; Jieun Son; Sudershan Gondi; Jiaqi Li; Emily Campbell; Hua Jin; Jeffrey J. Okoro; Cheng-Xiong Xu; Pasi A Janne; Kenneth D. Westover | |
| Impact of BRAF mutation class on disease characteristics and clinical outcomes in BRAF-mutant lung cancer | 2019 | Dagogo-Jack I.; Martinez P.; Yeap B.Y.; Ambrogio C.; Ferris L.A.; Lydon C.; Nguyen T.; Jessop N.A.; John Iafrate A.; Johnson B.E.; Lennerz J.K.; Shaw A.T.; Awad M.M. | |
| Wiskott–Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma | 2019 | Menotti, Matteo; Ambrogio, Chiara; Cheong, Taek-Chin; Pighi, Chiara; Mota, Ines; Cassel, Seth H.; Compagno, Mara; Wang, Qi; Dall’Olio, Riccardo; Minero, Valerio G.; Poggio, Teresa; Sharma, Geeta Geeta; Patrucco, Enrico; Mastini, Cristina; Choudhari, Ramesh; Pich, Achille; Zamo, Alberto; Piva, Roberto; Giliani, Silvia; Mologni, Luca; Collings, Clayton K.; Kadoch, Cigall; Gambacorti-Passerini, Carlo; Notarangelo, Luigi D.; Anton, Ines M.; Voena, Claudia*; Chiarle, Roberto | |
| An integrative pharmacogenomics analysis identifies therapeutic targets in KRAS-mutant lung cancer | 2019 | Wang H.; Lv Q.; Xu Y.; Cai Z.; Zheng J.; Cheng X.; Dai Y.; Janne P.A.; Ambrogio C.; Kohler J. | |
| KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS | 2018 | Ambrogio C.; Kohler J.; Zhou Z.-W.; Wang H.; Paranal R.; Li J.; Capelletti M.; Caffarra C.; Li S.; Lv Q.; Gondi S.; Hunter J.C.; Lu J.; Chiarle R.; Santamaria D.; Westover K.D.; Janne P.A. | |
| A putative role for Discoidin Domain Receptor 1 in cancer chemoresistance | 2018 | Ambrogio C.; Darbo E.; Lee S.W.; Santamaria D. | |
| Assessing therapeutic efficacy of MEK inhibition in a KrasG12C-driven mouse model of lung cancer | 2018 | Li S.; Liu S.; Deng J.; Akbay E.A.; Hai J.; Ambrogio C.; Zhang L.; Zhou F.; Jenkins R.W.; Adeegbe D.O.; Gao P.; Wang X.; Paweletz C.P.; Herter-Sprie G.S.; Chen T.; Gutierrez-Quiceno L.; Zhang Y.; Merlino A.A.; Quinn M.M.; Zeng Y.; Yu X.; Liu Y.; Fan L.; Aguirre A.J.; Barbie D.A.; Yi X.; Wong K.-K. | |
| Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells | 2017 | Compagno, Mara; Wang, Qi; Pighi, Chiara; Cheong, Taek-Chin; Meng, Fei-Long; Poggio, Teresa; Yeap, Leng-Siew; Karaca, Elif; Blasco, Rafael B.; Langellotto, Fernanda; Ambrogio, Chiara; Voena, Claudia; Wiestner, Adrian; Kasar, Siddha N.; Brown, Jennifer R.; Sun, Jing; Wu, Catherine J.; Gostissa, Monica; Alt, Frederick W.; Chiarle, Roberto | |
| A Braf kinase-inactive mutant induces lung adenocarcinoma | 2017 | Nieto P.; Ambrogio C.; Esteban-Burgos L.; Gomez-Lopez G.; Blasco M.T.; Yao Z.; Marais R.; Rosen N.; Chiarle R.; Pisano D.G.; Barbacid M.; Santamaria D. | |
| Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma | 2016 | Ambrogio C.; Gomez-Lopez G.; Falcone M.; Vidal A.; Nadal E.; Crosetto N.; Blasco R.B.; Fernandez-Marcos P.J.; Sanchez-Cespedes M.; Ren X.; Wang Z.; Ding K.; Hidalgo M.; Serrano M.; Villanueva A.; Santamaraa D.; Barbacid M. | |
| Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency | 2016 | Ceccon, M; Merlo, M E Boggio; Mologni, L.; Poggio, T.; Varesio, L.M.; Menotti, M.; Bombelli, S.; Rigolio, R.; Manazza, A.D.; Di Giacomo, F.; Ambrogio, C.; Giudici, G.; Casati, C.; Mastini, C.; Compagno, M.; Turner, S.D.; Gambacorti-Passerini, C.; Chiarle, R. ; Voena, C. | |
| Redundant and non-redundant roles for Cdc42 and Rac1 in lymphomas developed in NPM-ALK transgenic mice | 2016 | Choudhari, Ramesh; Minero, Valerio Giacomo; Menotti, Matteo; Pulito, Roberta; Brakebusch, Cord; Compagno, Mara; Voena, Claudia; Ambrogio, Chiara; Chiarle, Roberto | |
| Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice | 2015 | Lopez-Contreras A.J.; Specks J.; Barlow J.H.; Ambrogio C.; Desler C.; Vikingsson S.; Rodrigo-Perez S.; Green H.; Rasmussen L.J.; Murga M.; Nussenzweig A.; Fernandez-Capetillo O. | |
| Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage | 2015 | Garcia-Beccaria M.; Martinez P.; Mendez-Pertuz M.; Martinez S.; Blanco-Aparicio C.; Canamero M.; Mulero F.; Ambrogio C.; Flores J.M.; Megias D.; Barbacid M.; Pastor J.; Blasco M.A. | |
| Efficacy of a Cancer Vaccine against ALK-Rearranged Lung Tumors | 2015 | Voena, Claudia; Menotti, Matteo; Mastini, Cristina; Di Giacomo, Filomena; Longo, Dario Livio; Castella, Barbara; Merlo, Maria Elena Boggio; Ambrogio, Chiara; Wang, Qi; Minero, Valerio Giacomo; Poggio, Teresa; Martinengo, Cinzia; D'Amico, Lucia; Panizza, Elena; Mologni, Luca; Cavallo, Federica; Altruda, Fiorella; Butaney, Mohit; Capelletti, Marzia; Inghirami, Giorgio; Jänne, Pasi A; Chiarle, Roberto | |
| Simple and Rapid InVivo Generation of Chromosomal Rearrangements using CRISPR/Cas9 Technology | 2014 | Blasco, Rafael B; Karaca, Elif; Ambrogio, Chiara; Cheong, Taek-Chin; Karayol, Emre; Minero, Valerio G.; Voena, Claudia; Chiarle, Roberto | |
| ALK-dependent control of hypoxia-inducible factors mediates tumor growth and metastasis | 2014 | Martinengo, Cinzia; Poggio, Teresa; Menotti, Matteo; Scalzo, Maria Stella; Mastini, Cristina; Ambrogio, Chiara; Pellegrino, Elisa; Riera, Ludovica; Piva, Roberto; Ribatti, Domenico; Pastorino, Fabio; Perri, Patrizia; Ponzoni, Mirco; Wang, Qi; Voena, Claudia; Chiarle, Roberto | |
| Modeling lung cancer evolution and preclinical response by orthotopic mouse allografts | 2014 | Ambrogio, Chiara*; Carmona, Francisco J.; Vidal, August; Falcone, Mattia; Nieto, Patricia; Romero, Octavio A.; Puertas, Sara; Vizoso, Miguel; Nadal, Ernest; Poggio, Teresa; Sánchez-Céspedes, Montserrat; Esteller, Manel; Mulero, Francisca; Voena, Claudia; Chiarle, Roberto; Barbacid, Mariano; Santamaría, David; Villanueva, Alberto | |
| Lentiviral-based approach for the validation of cancer therapeutic targets in vivo | 2014 | Ambrogio C.; Stern P.; Scuoppo C.; Kranz H.; Barbacid M.; Santamaria D. | |
| The EGFR family members sustain the neoplastic phenotype of ALK+ lung adenocarcinoma via EGR1. | 2013 | Voena C;Di Giacomo F;Panizza E;D'Amico L;Boccalatte FE;Pellegrino E;Todaro M;Recupero D;Tabbò F;Ambrogio C;Martinengo C;Bonello L;Pulito R;Hamm J;Chiarle R;Cheng M;Ruggeri B;Medico E;Inghirami G |
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