Sfoglia per Autore
Covalent NLRP3 inhibitors: design strategies, synthesis and pharmacological characterization
2018-01-01 Gastaldi S., Introvigne M.L., Marino M., Marini E., Bertinaria M. Giorgis M.
A Comparative Study on the Efficacy of NLRP3 Inflammasome Signaling Inhibitors in a Pre-clinical Model of Bowel Inflammation
2018-01-01 Carolina Pellegrini, Matteo Fornai, Rocchina Colucci, Laura Benvenuti, Vanessa D’Antongiovanni, Gianfranco Natale, Federica Fulceri, Marta Giorgis, Elisabetta Marini, Simone Gastaldi, Massimo Bertinaria, Corrado Blandizzi, Luca Antonioli
Targeting NLRP3 inflammasome: development of new covalent and non-covalent inhibitors of ATPase activity
2019-01-01 Elisabetta Marini, Simone Gastaldi, Marta Giorgis, Marco Marino, Valentina Boscaro, Margherita Gallicchio, Massimo Bertinaria
Pharmacological characterization of new NLRP3 inflammasome inhibitors.
2019-01-01 Valentina Boscaro, Simone Gastaldi, Marco Marino, Marta Giorgis, Elisabetta Marini, Massimo Bertinaria, Margherita Gallicchio
NEW NON-COVALENT INHIBITORS OF NLRP3 INFLAMMASOME ATPASE ACTIVITY
2019-01-01 Gastaldi, S; Marino, M.; Giorgis, M.; Marini, E.; Boscaro, V.; Gallicchio, M.; Bertinaria, M.
In silico study of NLRP3: towards selective inhibition with small molecules
2019-01-01 Alejandro Gómez García, Simone Gastaldi, Giulia Fumero, Massimo Bertinaria, José Luis Medina Franco
Inhibition of NLRP3 ATPase activity: a new strategy to fight chronic inflammatory diseases
2019-01-01 Simone Gastaldi, Federica Blua, Marta Giorgis, Elisabetta Marini, Massimo Bertinaria
Development of covalent NLRP3 inflammasome inhibitors: chemistry and biological activity
2019-01-01 Bertinaria Massimo, Gastaldi Simone, Marini Elisabetta, Giorgis Marta
EVALUATION OF THE ANTIPYROPTOTIC ACTIVITY OF NEW INFLAMMASOME INHIBITORS
2021-01-01 Boscaro Valentina, Gastaldi Simone, Bertinaria Massimo, Gallicchio Margherita
In the search for new NLRP3 inhibitors: chemical modulation of the 1-(piperidin-4-yl)-1,3-dihydro-2 Hbenzo[d]imidazole-2-one scaffold
2021-01-01 Simone Gastaldi, Valentina Boscaro, Eleonora Gianquinto, Christina F. Sandall, Marta Giorgis, Elisabetta Marini, Federica Blua, Margherita Gallicchio, Francesca Spyrakis, Justin A. MacDonald, Massimo Bertinaria
COMPOSTI INIBITORI DELL’INFLAMMASOMA NLRP3 E LORO USO
2021-01-01 BLANDIZZI CORRADO, PELLEGRINI CAROLINA, FORNAI MATTEO, ANTONIOLI LUCA, COLUCCI ROCCHINA, BERTINARIA MASSIMO, MARINI ELISABETTA, BOSCARO VALENTINA, GASTALDI SIMONE, COCCO MATTIA
Chemical modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2h-benzo[d]imidazole-2-one scaffold as a novel NLRP3 inhibitor
2021-01-01 Gastaldi S.; Boscaro V.; Gianquinto E.; Sandall C.F.; Giorgis M.; Marini E.; Blua F.; Gallicchio M.; Spyrakis F.; Macdonald J.A.; Bertinaria M.
Design and synthesis of encorafenib-based BRAF-V600E degraders
2022-01-01 Federica Blua, Marco Marino, Simone Gastaldi, Federica Maione, Eleonora Gianquinto, Federica Di Nicolantonio, Massimo Bertinaria
Inflammasome Biology Fundamentals, Role in Disease States, and Therapeutic Opportunities
2022-01-01 Massimo Bertinaria, Simone Gastaldi, Elisabetta Marini
NLRP3 INFLAMMASOME-inhibiting compounds and the use thereof
2022-01-01 Blandizzi Corrado, Pellegrini Carolina, Fornai Matteo, Antonioli Luca, Colucci Rocchina, Bertinaria Massimo, Marini Elisabetta, Boscaro Valentina, Gastaldi Simone, Cocco Mattia
New inhibitors of NLRP3 inflammasome activation: pharmacological characterization in differentiated THP-1.
2022-01-01 Valentina Boscaro, Simone Gastaldi, Federica Blua, Massimo Bertinaria, Margherita Gallicchio
Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAFV600E Protein
2022-01-01 Marini, Elisabetta; Marino, Marco; Gionfriddo, Giulia; Maione, Federica; Pandini, Marta; Oddo, Daniele; Giorgis, Marta; Rolando, Barbara; Blua, Federica; Gastaldi, Simone; Marchiò, Serena; Kovachka, Sandra; Spyrakis, Francesca; Gianquinto, Eleonora; Di Nicolantonio, Federica; Bertinaria, Massimo
Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation
2023-01-01 Gastaldi, Simone; Rocca, Carmine; Gianquinto, Eleonora; Granieri, Maria Concetta; Boscaro, Valentina; Blua, Federica; Rolando, Barbara; Marini, Elisabetta; Gallicchio, Margherita; De Bartolo, Anna; Romeo, Naomi; Mazza, Rosa; Fedele, Francesco; Pagliaro, Pasquale; Penna, Claudia; Spyrakis, Francesca; Bertinaria, Massimo; Angelone, Tommaso
Discovery of a septin-4 covalent binder with antimetastatic activity in a mouse model of melanoma
2024-01-01 Blua F.; Monge C.; Gastaldi S.; Clemente N.; Pizzimenti S.; Lazzarato L.; Senetta R.; Vittorio S.; Gigliotti C.L.; Boggio E.; Dianzani U.; Vistoli G.; Altomare A.A.; Aldini G.; Dianzani C.; Marini E.; Bertinaria M.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Covalent NLRP3 inhibitors: design strategies, synthesis and pharmacological characterization | 2018 | Gastaldi S., Introvigne M.L., Marino M., Marini E., Bertinaria M. Giorgis M. | |
| A Comparative Study on the Efficacy of NLRP3 Inflammasome Signaling Inhibitors in a Pre-clinical Model of Bowel Inflammation | 2018 | Carolina Pellegrini, Matteo Fornai, Rocchina Colucci, Laura Benvenuti, Vanessa D’Antongiovanni, Gianfranco Natale, Federica Fulceri, Marta Giorgis, Elisabetta Marini, Simone Gastaldi, Massimo Bertinaria, Corrado Blandizzi, Luca Antonioli | |
| Targeting NLRP3 inflammasome: development of new covalent and non-covalent inhibitors of ATPase activity | 2019 | Elisabetta Marini, Simone Gastaldi, Marta Giorgis, Marco Marino, Valentina Boscaro, Margherita Gallicchio, Massimo Bertinaria | |
| Pharmacological characterization of new NLRP3 inflammasome inhibitors. | 2019 | Valentina Boscaro, Simone Gastaldi, Marco Marino, Marta Giorgis, Elisabetta Marini, Massimo Bertinaria, Margherita Gallicchio | |
| NEW NON-COVALENT INHIBITORS OF NLRP3 INFLAMMASOME ATPASE ACTIVITY | 2019 | Gastaldi, S; Marino, M.; Giorgis, M.; Marini, E.; Boscaro, V.; Gallicchio, M.; Bertinaria, M. | |
| In silico study of NLRP3: towards selective inhibition with small molecules | 2019 | Alejandro Gómez García, Simone Gastaldi, Giulia Fumero, Massimo Bertinaria, José Luis Medina Franco | |
| Inhibition of NLRP3 ATPase activity: a new strategy to fight chronic inflammatory diseases | 2019 | Simone Gastaldi, Federica Blua, Marta Giorgis, Elisabetta Marini, Massimo Bertinaria | |
| Development of covalent NLRP3 inflammasome inhibitors: chemistry and biological activity | 2019 | Bertinaria Massimo, Gastaldi Simone, Marini Elisabetta, Giorgis Marta | |
| EVALUATION OF THE ANTIPYROPTOTIC ACTIVITY OF NEW INFLAMMASOME INHIBITORS | 2021 | Boscaro Valentina, Gastaldi Simone, Bertinaria Massimo, Gallicchio Margherita | |
| In the search for new NLRP3 inhibitors: chemical modulation of the 1-(piperidin-4-yl)-1,3-dihydro-2 Hbenzo[d]imidazole-2-one scaffold | 2021 | Simone Gastaldi, Valentina Boscaro, Eleonora Gianquinto, Christina F. Sandall, Marta Giorgis, Elisabetta Marini, Federica Blua, Margherita Gallicchio, Francesca Spyrakis, Justin A. MacDonald, Massimo Bertinaria | |
| COMPOSTI INIBITORI DELL’INFLAMMASOMA NLRP3 E LORO USO | 2021 | BLANDIZZI CORRADO, PELLEGRINI CAROLINA, FORNAI MATTEO, ANTONIOLI LUCA, COLUCCI ROCCHINA, BERTINARIA MASSIMO, MARINI ELISABETTA, BOSCARO VALENTINA, GASTALDI SIMONE, COCCO MATTIA | |
| Chemical modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2h-benzo[d]imidazole-2-one scaffold as a novel NLRP3 inhibitor | 2021 | Gastaldi S.; Boscaro V.; Gianquinto E.; Sandall C.F.; Giorgis M.; Marini E.; Blua F.; Gallicchio M.; Spyrakis F.; Macdonald J.A.; Bertinaria M. | |
| Design and synthesis of encorafenib-based BRAF-V600E degraders | 2022 | Federica Blua, Marco Marino, Simone Gastaldi, Federica Maione, Eleonora Gianquinto, Federica Di Nicolantonio, Massimo Bertinaria | |
| Inflammasome Biology Fundamentals, Role in Disease States, and Therapeutic Opportunities | 2022 | Massimo Bertinaria, Simone Gastaldi, Elisabetta Marini | |
| NLRP3 INFLAMMASOME-inhibiting compounds and the use thereof | 2022 | Blandizzi Corrado, Pellegrini Carolina, Fornai Matteo, Antonioli Luca, Colucci Rocchina, Bertinaria Massimo, Marini Elisabetta, Boscaro Valentina, Gastaldi Simone, Cocco Mattia | |
| New inhibitors of NLRP3 inflammasome activation: pharmacological characterization in differentiated THP-1. | 2022 | Valentina Boscaro, Simone Gastaldi, Federica Blua, Massimo Bertinaria, Margherita Gallicchio | |
| Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAFV600E Protein | 2022 | Marini, Elisabetta; Marino, Marco; Gionfriddo, Giulia; Maione, Federica; Pandini, Marta; Oddo, Daniele; Giorgis, Marta; Rolando, Barbara; Blua, Federica; Gastaldi, Simone; Marchiò, Serena; Kovachka, Sandra; Spyrakis, Francesca; Gianquinto, Eleonora; Di Nicolantonio, Federica; Bertinaria, Massimo | |
| Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation | 2023 | Gastaldi, Simone; Rocca, Carmine; Gianquinto, Eleonora; Granieri, Maria Concetta; Boscaro, Valentina; Blua, Federica; Rolando, Barbara; Marini, Elisabetta; Gallicchio, Margherita; De Bartolo, Anna; Romeo, Naomi; Mazza, Rosa; Fedele, Francesco; Pagliaro, Pasquale; Penna, Claudia; Spyrakis, Francesca; Bertinaria, Massimo; Angelone, Tommaso | |
| Discovery of a septin-4 covalent binder with antimetastatic activity in a mouse model of melanoma | 2024 | Blua F.; Monge C.; Gastaldi S.; Clemente N.; Pizzimenti S.; Lazzarato L.; Senetta R.; Vittorio S.; Gigliotti C.L.; Boggio E.; Dianzani U.; Vistoli G.; Altomare A.A.; Aldini G.; Dianzani C.; Marini E.; Bertinaria M. |
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