Sfoglia per Autore
Targeting Infrequent Driver Alterations in Non-Small Cell Lung Cancer
2021-01-01 Nokin M.-J.; Ambrogio C.; Nadal E.; Santamaria D.
A structural model of a Ras–Raf signalosome
2021-01-01 Mysore V.P.; Zhou Z.-W.; Ambrogio C.; Li L.; Kapp J.N.; Lu C.; Wang Q.; Tucker M.R.; Okoro J.J.; Nagy-Davidescu G.; Bai X.; Pluckthun A.; Janne P.A.; Westover K.D.; Shan Y.; Shaw D.E.
ERK inhibitor LY3214996-based treatment strategies for RAS-driven lung cancer
2021-01-01 Köhler, Jens; Zhao, Yutong; Li, Jiaqi; Gokhale, Prafulla C; Tiv, Hong L; Knott, Aine R; Wilkens, Margaret K; Soroko, Kara M; Lin, Mika; Ambrogio, Chiara; Musteanu, Monica; Ogino, Atsuko; Choi, Jihyun; Bahcall, Magda; Bertram, Arrien A; Chambers, Emily S; Paweletz, Cloud P; Bhagwat, Shripad V; Manro, Jason R; Tiu, Ramon V; Janne, Pasi A
Discoveries in the redox regulation of KRAS
2021-01-01 Maximilian Kramer-Drauberg; Chiara Ambrogio
Inhibition of DDR1 enhances in vivo chemosensitivity in KRAS-mutant lung adenocarcinoma
2020-01-01 Nokin, Marie-Julie; Darbo, Elodie; Travert, Camille; Drogat, Benjamin; Lacouture, Aurélie; San José, Sonia; Cabrera, Nuria; Turcq, Béatrice; Prouzet-Mauleon, Valérie; Falcone, Mattia; Villanueva, Alberto; Wang, Haiyun; Herfs, Michael; Mosteiro, Miguel; Jänne, Pasi A.; Pujol, Jean-Louis; Maraver, Antonio; Barbacid, Mariano; Nadal, Ernest; Santamaría, David; Ambrogio, Chiara
A LIBRETTO to orchestrate targeted therapy
2020-01-01 Marmarelis, Melina E; Chiarle, Roberto; Ambrogio, Chiara; Aggarwal, Charu
KRASQ61H preferentially signals through MAPK in a RAF dimer-dependent manner in non-small cell lung cancer
2020-01-01 Zhi-Wei Zhou; Chiara Ambrogio; Asim K Bera; Qing Li; Xing-Xiao Li; Lianbo Li; Jieun Son; Sudershan Gondi; Jiaqi Li; Emily Campbell; Hua Jin; Jeffrey J. Okoro; Cheng-Xiong Xu; Pasi A Janne; Kenneth D. Westover
Impact of BRAF mutation class on disease characteristics and clinical outcomes in BRAF-mutant lung cancer
2019-01-01 Dagogo-Jack I.; Martinez P.; Yeap B.Y.; Ambrogio C.; Ferris L.A.; Lydon C.; Nguyen T.; Jessop N.A.; John Iafrate A.; Johnson B.E.; Lennerz J.K.; Shaw A.T.; Awad M.M.
Wiskott–Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma
2019-01-01 Menotti, Matteo; Ambrogio, Chiara; Cheong, Taek-Chin; Pighi, Chiara; Mota, Ines; Cassel, Seth H.; Compagno, Mara; Wang, Qi; Dall’Olio, Riccardo; Minero, Valerio G.; Poggio, Teresa; Sharma, Geeta Geeta; Patrucco, Enrico; Mastini, Cristina; Choudhari, Ramesh; Pich, Achille; Zamo, Alberto; Piva, Roberto; Giliani, Silvia; Mologni, Luca; Collings, Clayton K.; Kadoch, Cigall; Gambacorti-Passerini, Carlo; Notarangelo, Luigi D.; Anton, Ines M.; Voena, Claudia*; Chiarle, Roberto
An integrative pharmacogenomics analysis identifies therapeutic targets in KRAS-mutant lung cancer
2019-01-01 Wang H.; Lv Q.; Xu Y.; Cai Z.; Zheng J.; Cheng X.; Dai Y.; Janne P.A.; Ambrogio C.; Kohler J.
KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS
2018-01-01 Ambrogio C.; Kohler J.; Zhou Z.-W.; Wang H.; Paranal R.; Li J.; Capelletti M.; Caffarra C.; Li S.; Lv Q.; Gondi S.; Hunter J.C.; Lu J.; Chiarle R.; Santamaria D.; Westover K.D.; Janne P.A.
Assessing therapeutic efficacy of MEK inhibition in a KrasG12C-driven mouse model of lung cancer
2018-01-01 Li S.; Liu S.; Deng J.; Akbay E.A.; Hai J.; Ambrogio C.; Zhang L.; Zhou F.; Jenkins R.W.; Adeegbe D.O.; Gao P.; Wang X.; Paweletz C.P.; Herter-Sprie G.S.; Chen T.; Gutierrez-Quiceno L.; Zhang Y.; Merlino A.A.; Quinn M.M.; Zeng Y.; Yu X.; Liu Y.; Fan L.; Aguirre A.J.; Barbie D.A.; Yi X.; Wong K.-K.
A putative role for Discoidin Domain Receptor 1 in cancer chemoresistance
2018-01-01 Ambrogio C.; Darbo E.; Lee S.W.; Santamaria D.
A Braf kinase-inactive mutant induces lung adenocarcinoma
2017-01-01 Nieto P.; Ambrogio C.; Esteban-Burgos L.; Gomez-Lopez G.; Blasco M.T.; Yao Z.; Marais R.; Rosen N.; Chiarle R.; Pisano D.G.; Barbacid M.; Santamaria D.
Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells
2017-01-01 Compagno, Mara; Wang, Qi; Pighi, Chiara; Cheong, Taek-Chin; Meng, Fei-Long; Poggio, Teresa; Yeap, Leng-Siew; Karaca, Elif; Blasco, Rafael B.; Langellotto, Fernanda; Ambrogio, Chiara; Voena, Claudia; Wiestner, Adrian; Kasar, Siddha N.; Brown, Jennifer R.; Sun, Jing; Wu, Catherine J.; Gostissa, Monica; Alt, Frederick W.; Chiarle, Roberto
Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency
2016-01-01 Ceccon, M; Merlo, M E Boggio; Mologni, L.; Poggio, T.; Varesio, L.M.; Menotti, M.; Bombelli, S.; Rigolio, R.; Manazza, A.D.; Di Giacomo, F.; Ambrogio, C.; Giudici, G.; Casati, C.; Mastini, C.; Compagno, M.; Turner, S.D.; Gambacorti-Passerini, C.; Chiarle, R. ; Voena, C.
Redundant and non-redundant roles for Cdc42 and Rac1 in lymphomas developed in NPM-ALK transgenic mice
2016-01-01 Choudhari, Ramesh; Minero, Valerio Giacomo; Menotti, Matteo; Pulito, Roberta; Brakebusch, Cord; Compagno, Mara; Voena, Claudia; Ambrogio, Chiara; Chiarle, Roberto
Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma
2016-01-01 Ambrogio C.; Gomez-Lopez G.; Falcone M.; Vidal A.; Nadal E.; Crosetto N.; Blasco R.B.; Fernandez-Marcos P.J.; Sanchez-Cespedes M.; Ren X.; Wang Z.; Ding K.; Hidalgo M.; Serrano M.; Villanueva A.; Santamaraa D.; Barbacid M.
Efficacy of a Cancer Vaccine against ALK-Rearranged Lung Tumors
2015-01-01 Voena, Claudia; Menotti, Matteo; Mastini, Cristina; Di Giacomo, Filomena; Longo, Dario Livio; Castella, Barbara; Merlo, Maria Elena Boggio; Ambrogio, Chiara; Wang, Qi; Minero, Valerio Giacomo; Poggio, Teresa; Martinengo, Cinzia; D'Amico, Lucia; Panizza, Elena; Mologni, Luca; Cavallo, Federica; Altruda, Fiorella; Butaney, Mohit; Capelletti, Marzia; Inghirami, Giorgio; Jänne, Pasi A; Chiarle, Roberto
Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage
2015-01-01 Garcia-Beccaria M.; Martinez P.; Mendez-Pertuz M.; Martinez S.; Blanco-Aparicio C.; Canamero M.; Mulero F.; Ambrogio C.; Flores J.M.; Megias D.; Barbacid M.; Pastor J.; Blasco M.A.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Targeting Infrequent Driver Alterations in Non-Small Cell Lung Cancer | 2021 | Nokin M.-J.; Ambrogio C.; Nadal E.; Santamaria D. | |
| A structural model of a Ras–Raf signalosome | 2021 | Mysore V.P.; Zhou Z.-W.; Ambrogio C.; Li L.; Kapp J.N.; Lu C.; Wang Q.; Tucker M.R.; Okoro J.J.; Nagy-Davidescu G.; Bai X.; Pluckthun A.; Janne P.A.; Westover K.D.; Shan Y.; Shaw D.E. | |
| ERK inhibitor LY3214996-based treatment strategies for RAS-driven lung cancer | 2021 | Köhler, Jens; Zhao, Yutong; Li, Jiaqi; Gokhale, Prafulla C; Tiv, Hong L; Knott, Aine R; Wilkens, Margaret K; Soroko, Kara M; Lin, Mika; Ambrogio, Chiara; Musteanu, Monica; Ogino, Atsuko; Choi, Jihyun; Bahcall, Magda; Bertram, Arrien A; Chambers, Emily S; Paweletz, Cloud P; Bhagwat, Shripad V; Manro, Jason R; Tiu, Ramon V; Janne, Pasi A | |
| Discoveries in the redox regulation of KRAS | 2021 | Maximilian Kramer-Drauberg; Chiara Ambrogio | |
| Inhibition of DDR1 enhances in vivo chemosensitivity in KRAS-mutant lung adenocarcinoma | 2020 | Nokin, Marie-Julie; Darbo, Elodie; Travert, Camille; Drogat, Benjamin; Lacouture, Aurélie; San José, Sonia; Cabrera, Nuria; Turcq, Béatrice; Prouzet-Mauleon, Valérie; Falcone, Mattia; Villanueva, Alberto; Wang, Haiyun; Herfs, Michael; Mosteiro, Miguel; Jänne, Pasi A.; Pujol, Jean-Louis; Maraver, Antonio; Barbacid, Mariano; Nadal, Ernest; Santamaría, David; Ambrogio, Chiara | |
| A LIBRETTO to orchestrate targeted therapy | 2020 | Marmarelis, Melina E; Chiarle, Roberto; Ambrogio, Chiara; Aggarwal, Charu | |
| KRASQ61H preferentially signals through MAPK in a RAF dimer-dependent manner in non-small cell lung cancer | 2020 | Zhi-Wei Zhou; Chiara Ambrogio; Asim K Bera; Qing Li; Xing-Xiao Li; Lianbo Li; Jieun Son; Sudershan Gondi; Jiaqi Li; Emily Campbell; Hua Jin; Jeffrey J. Okoro; Cheng-Xiong Xu; Pasi A Janne; Kenneth D. Westover | |
| Impact of BRAF mutation class on disease characteristics and clinical outcomes in BRAF-mutant lung cancer | 2019 | Dagogo-Jack I.; Martinez P.; Yeap B.Y.; Ambrogio C.; Ferris L.A.; Lydon C.; Nguyen T.; Jessop N.A.; John Iafrate A.; Johnson B.E.; Lennerz J.K.; Shaw A.T.; Awad M.M. | |
| Wiskott–Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma | 2019 | Menotti, Matteo; Ambrogio, Chiara; Cheong, Taek-Chin; Pighi, Chiara; Mota, Ines; Cassel, Seth H.; Compagno, Mara; Wang, Qi; Dall’Olio, Riccardo; Minero, Valerio G.; Poggio, Teresa; Sharma, Geeta Geeta; Patrucco, Enrico; Mastini, Cristina; Choudhari, Ramesh; Pich, Achille; Zamo, Alberto; Piva, Roberto; Giliani, Silvia; Mologni, Luca; Collings, Clayton K.; Kadoch, Cigall; Gambacorti-Passerini, Carlo; Notarangelo, Luigi D.; Anton, Ines M.; Voena, Claudia*; Chiarle, Roberto | |
| An integrative pharmacogenomics analysis identifies therapeutic targets in KRAS-mutant lung cancer | 2019 | Wang H.; Lv Q.; Xu Y.; Cai Z.; Zheng J.; Cheng X.; Dai Y.; Janne P.A.; Ambrogio C.; Kohler J. | |
| KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS | 2018 | Ambrogio C.; Kohler J.; Zhou Z.-W.; Wang H.; Paranal R.; Li J.; Capelletti M.; Caffarra C.; Li S.; Lv Q.; Gondi S.; Hunter J.C.; Lu J.; Chiarle R.; Santamaria D.; Westover K.D.; Janne P.A. | |
| Assessing therapeutic efficacy of MEK inhibition in a KrasG12C-driven mouse model of lung cancer | 2018 | Li S.; Liu S.; Deng J.; Akbay E.A.; Hai J.; Ambrogio C.; Zhang L.; Zhou F.; Jenkins R.W.; Adeegbe D.O.; Gao P.; Wang X.; Paweletz C.P.; Herter-Sprie G.S.; Chen T.; Gutierrez-Quiceno L.; Zhang Y.; Merlino A.A.; Quinn M.M.; Zeng Y.; Yu X.; Liu Y.; Fan L.; Aguirre A.J.; Barbie D.A.; Yi X.; Wong K.-K. | |
| A putative role for Discoidin Domain Receptor 1 in cancer chemoresistance | 2018 | Ambrogio C.; Darbo E.; Lee S.W.; Santamaria D. | |
| A Braf kinase-inactive mutant induces lung adenocarcinoma | 2017 | Nieto P.; Ambrogio C.; Esteban-Burgos L.; Gomez-Lopez G.; Blasco M.T.; Yao Z.; Marais R.; Rosen N.; Chiarle R.; Pisano D.G.; Barbacid M.; Santamaria D. | |
| Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells | 2017 | Compagno, Mara; Wang, Qi; Pighi, Chiara; Cheong, Taek-Chin; Meng, Fei-Long; Poggio, Teresa; Yeap, Leng-Siew; Karaca, Elif; Blasco, Rafael B.; Langellotto, Fernanda; Ambrogio, Chiara; Voena, Claudia; Wiestner, Adrian; Kasar, Siddha N.; Brown, Jennifer R.; Sun, Jing; Wu, Catherine J.; Gostissa, Monica; Alt, Frederick W.; Chiarle, Roberto | |
| Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency | 2016 | Ceccon, M; Merlo, M E Boggio; Mologni, L.; Poggio, T.; Varesio, L.M.; Menotti, M.; Bombelli, S.; Rigolio, R.; Manazza, A.D.; Di Giacomo, F.; Ambrogio, C.; Giudici, G.; Casati, C.; Mastini, C.; Compagno, M.; Turner, S.D.; Gambacorti-Passerini, C.; Chiarle, R. ; Voena, C. | |
| Redundant and non-redundant roles for Cdc42 and Rac1 in lymphomas developed in NPM-ALK transgenic mice | 2016 | Choudhari, Ramesh; Minero, Valerio Giacomo; Menotti, Matteo; Pulito, Roberta; Brakebusch, Cord; Compagno, Mara; Voena, Claudia; Ambrogio, Chiara; Chiarle, Roberto | |
| Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma | 2016 | Ambrogio C.; Gomez-Lopez G.; Falcone M.; Vidal A.; Nadal E.; Crosetto N.; Blasco R.B.; Fernandez-Marcos P.J.; Sanchez-Cespedes M.; Ren X.; Wang Z.; Ding K.; Hidalgo M.; Serrano M.; Villanueva A.; Santamaraa D.; Barbacid M. | |
| Efficacy of a Cancer Vaccine against ALK-Rearranged Lung Tumors | 2015 | Voena, Claudia; Menotti, Matteo; Mastini, Cristina; Di Giacomo, Filomena; Longo, Dario Livio; Castella, Barbara; Merlo, Maria Elena Boggio; Ambrogio, Chiara; Wang, Qi; Minero, Valerio Giacomo; Poggio, Teresa; Martinengo, Cinzia; D'Amico, Lucia; Panizza, Elena; Mologni, Luca; Cavallo, Federica; Altruda, Fiorella; Butaney, Mohit; Capelletti, Marzia; Inghirami, Giorgio; Jänne, Pasi A; Chiarle, Roberto | |
| Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage | 2015 | Garcia-Beccaria M.; Martinez P.; Mendez-Pertuz M.; Martinez S.; Blanco-Aparicio C.; Canamero M.; Mulero F.; Ambrogio C.; Flores J.M.; Megias D.; Barbacid M.; Pastor J.; Blasco M.A. |
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