Sfoglia per Autore
Probing salicylamide bioisosteric replacement in the design of Plasmodium Falciparum dihydroorotate dehydrogenase (pfDHODH) inhibitors
2012-01-01 Lolli, Marco Lucio; Boschi, Donatella; Nilsson, U. J.; Fritzson, I.; Sundin, A. P.; Al-Karadaghi, S.
PROBING THE BICYCLIC HYDROXYPYRAZOLO[1,5-a]PYRIDINE SCAFFOLD AS A CARBOXYLIC ACID BIOISOSTERE IN THE GABAa RECEPTOR SYSTEM
2012-01-01 Ducime Alex; Nielsen Birgitte; Lolli Marco L. ;Frølund Bente
Probing the bicyclic hydroxypyrazolo[1,5-a]pyridine scaffold as a carboxylic acid bioisostere in theGABAA receptor system
2012-01-01 A. Ducime; B. Nielsen; B. Frølund; M. L. Lolli
New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold
2012-01-01 Lolli M. L.; Giorgis M.; Tosco P.; Foti A.; Fruttero R.; Gasco A.
Hydroxypyrazolol[1,5-a]pyridine as a fluorescent carboxylic acid isostere: development of new fluorescent 4-PHP analogues
2013-01-01 Stefano Sainas; Birgitte Nielsen; Donatella Boschi; Bente Frølund; Marco L. Lolli
Synthesis of new Plasmodium Falciparum dihydroorotate dehydrogenase inhibitors through the application of an isosteric portfolio
2013-01-01 Pippione A. C.;1 Federico A.;1 Boschi D.;S.2 Lolli M. L.1
Hydroxypyrazolo[1,5-a]pyridine as a fluorescent carboxylic acid isostere: introducing GABAA receptor system affinities in the scaffold
2013-01-01 A. Ducime; B. Nielsen; D. Boschi; B. Frølund; M. L. Lolli
The role of fluorine in stabilizing the bioactive conformation of dihydroorotate dehydrogenase inhibitors
2013-01-01 Bonomo S.; Tosco P.; Giorgis M.; Lolli M.; Fruttero R.
SUBSTITUTED 4-HYDROXY-1H-1,2,3-TRIAZOLES: SYNTHESIS AND BIOISOSTERIC APPLICATIONS
2014-01-01 Agnese C. Pippione; Antonella Federico; Stefano Sainas; Alex Ducime; Marco L. Lolli; Donatella Boschi
TOWARD A BIOISOSTERIC ALKAEST – APPLICATION TO THE BIOISOSTERIC MODULATION OF IMD-0354
2014-01-01 Marco L. Lolli; Alex Ducime; Antonella Federico; Agnese Chiara Pippione; Stefano Sainas; Alessandro Barge; Katia Martina; Donatella Boschi; Elisa Lupino; Marco Piccinini; Michael Kubbutat; Christoph Schächtele; Jean Marie Contreras; Christophe Morice; Joel Sussman; Yoav Peleg; Bjorn Walse; Salam Kadaraghi
A novel SWCNT platform bearing DOTA and b-cyclodextrin units. "One shot" multidecoration under microwave irradiation.
2014-01-01 CALCIO GAUDINO, Emanuela; Tagliapietra, Silvia Maria; Martina, Katia; Barge, Alessandro; Lolli, Marco Lucio; Terreno, Enzo; Lembo, D.; Cravotto, Giancarlo
Development of new hydroxypyrazole-based inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH)
2014-01-01 A.C. Pippione; A. Giraudo; I. Galleano; U.J. Nilsson; I. Fritzson; A.P. Sundin; S. Al-Karadaghi; D. Boschi; M.L. Lolli
Discovery and optimization of new OvCHT1 inhibitors based on the 4-hydroxy-1H-1,2,3-triazole ring
2014-01-01 A. Ducime; A. C. Pippione; A. Moreo; A. Piccinelli; M. Gooyit; K. D. Janda; D. Boschi; M. L. Lolli
Synthesis and Structural Characterization of Regio Substituted 4-Hydroxy-1H-1,2,3-triazols as Possible Tool in Bioisosteric Applications
2014-01-01 A Federico; S.Sainas; A. Ducime;K. Martina; F. Bosca; D. Boschi; M.L. Lolli.
Discovery of new NIK inhibitors by Structure-Based Drug Design
2014-01-01 Jean-Marie Contreras; Bo Svensson; Bjorn Walse; Salam Al-Karadaghi; Frank Totzke; Michael H.G. Kubbutat; Christoph Schächtele; Marco Lolli; Donatella Boschi; Marco Piccinini; Elisa Lupino; Joel Sussmann; Israel Silman; Yoav Peleg; Christophe Morice; Thierry Langer
1H-pyrazole-4-carboxylic acids active against Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH): discovery of a new scaffold for development of antimalarial agents
2014-01-01 Agnese Chiara Pippione; Ulf J. Nilsson; Ingela Fritzson; Anders P. Sundin; Salam Al-Karadaghi; Donatella Boschi; and Marco Lucio Lolli
Towards a Bioisosteric Alkaest: application to the bioisosteric modulation of IMD-0354
2014-01-01 Lolli Marco L.; Federico Antonella; Ducime Alex; Pippione Agnese; Sainas Stefano; Barge Alessandro; Martina Katia; Boschi Donatella; Lupino Elisa; Piccinini Marco; Kubbutat Michael; Contreras Jean Marie; Morice Christophe; Sussman Joel; Peleg Yoav; Walse Bjorn; Al-Kadaraghi Salam
Toward a Bioisosteric Alkahest: Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by a Scaffold Hopping Bioisosteric approach using Hydroxylated Pentatomic Heterocycles
2015-01-01 Marco L. Lolli, Agnese Chiara Pippione, Stefano Sainas, Stefano Mensa, Marta Giorgis, Marco Piccinini, Elisa Lupino, Salam Al-Kadaraghi, Donatella Boschi
APPLICATION OF THE ARACHNO™ TECHNOLOGY FOR THE PARALLEL SYNTHESIS OF A LIBRARY OF ASPIRIN ANALOGUES
2015-01-01 Moreo, Angela; Barge, Alessandro; Boschi, Donatella; Costale, Annalisa; Dosio, Franco; Federico, Antonella; Stevanato, Livio; L. Lolli., Marco
Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by combination of in-silico ligand/structural pharmacophore models and scaffold hopping bioisosteric approaches
2015-01-01 Mensa, Stefano; Carnovale, Irene M.; Pippione, Agnese Chiara; Sainas, Stefano; Giorgis, Marta; Piccinini, Marco; Lupino, Elisa; Al-Karadaghi, Salam; Boschi, Donatella; L. Lolli., Marco
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Probing salicylamide bioisosteric replacement in the design of Plasmodium Falciparum dihydroorotate dehydrogenase (pfDHODH) inhibitors | 2012 | Lolli, Marco Lucio; Boschi, Donatella; Nilsson, U. J.; Fritzson, I.; Sundin, A. P.; Al-Karadaghi, S. | |
| PROBING THE BICYCLIC HYDROXYPYRAZOLO[1,5-a]PYRIDINE SCAFFOLD AS A CARBOXYLIC ACID BIOISOSTERE IN THE GABAa RECEPTOR SYSTEM | 2012 | Ducime Alex; Nielsen Birgitte; Lolli Marco L. ;Frølund Bente | |
| Probing the bicyclic hydroxypyrazolo[1,5-a]pyridine scaffold as a carboxylic acid bioisostere in theGABAA receptor system | 2012 | A. Ducime; B. Nielsen; B. Frølund; M. L. Lolli | |
| New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold | 2012 | Lolli M. L.; Giorgis M.; Tosco P.; Foti A.; Fruttero R.; Gasco A. | |
| Hydroxypyrazolol[1,5-a]pyridine as a fluorescent carboxylic acid isostere: development of new fluorescent 4-PHP analogues | 2013 | Stefano Sainas; Birgitte Nielsen; Donatella Boschi; Bente Frølund; Marco L. Lolli | |
| Synthesis of new Plasmodium Falciparum dihydroorotate dehydrogenase inhibitors through the application of an isosteric portfolio | 2013 | Pippione A. C.;1 Federico A.;1 Boschi D.;S.2 Lolli M. L.1 | |
| Hydroxypyrazolo[1,5-a]pyridine as a fluorescent carboxylic acid isostere: introducing GABAA receptor system affinities in the scaffold | 2013 | A. Ducime; B. Nielsen; D. Boschi; B. Frølund; M. L. Lolli | |
| The role of fluorine in stabilizing the bioactive conformation of dihydroorotate dehydrogenase inhibitors | 2013 | Bonomo S.; Tosco P.; Giorgis M.; Lolli M.; Fruttero R. | |
| SUBSTITUTED 4-HYDROXY-1H-1,2,3-TRIAZOLES: SYNTHESIS AND BIOISOSTERIC APPLICATIONS | 2014 | Agnese C. Pippione; Antonella Federico; Stefano Sainas; Alex Ducime; Marco L. Lolli; Donatella Boschi | |
| TOWARD A BIOISOSTERIC ALKAEST – APPLICATION TO THE BIOISOSTERIC MODULATION OF IMD-0354 | 2014 | Marco L. Lolli; Alex Ducime; Antonella Federico; Agnese Chiara Pippione; Stefano Sainas; Alessandro Barge; Katia Martina; Donatella Boschi; Elisa Lupino; Marco Piccinini; Michael Kubbutat; Christoph Schächtele; Jean Marie Contreras; Christophe Morice; Joel Sussman; Yoav Peleg; Bjorn Walse; Salam Kadaraghi | |
| A novel SWCNT platform bearing DOTA and b-cyclodextrin units. "One shot" multidecoration under microwave irradiation. | 2014 | CALCIO GAUDINO, Emanuela; Tagliapietra, Silvia Maria; Martina, Katia; Barge, Alessandro; Lolli, Marco Lucio; Terreno, Enzo; Lembo, D.; Cravotto, Giancarlo | |
| Development of new hydroxypyrazole-based inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) | 2014 | A.C. Pippione; A. Giraudo; I. Galleano; U.J. Nilsson; I. Fritzson; A.P. Sundin; S. Al-Karadaghi; D. Boschi; M.L. Lolli | |
| Discovery and optimization of new OvCHT1 inhibitors based on the 4-hydroxy-1H-1,2,3-triazole ring | 2014 | A. Ducime; A. C. Pippione; A. Moreo; A. Piccinelli; M. Gooyit; K. D. Janda; D. Boschi; M. L. Lolli | |
| Synthesis and Structural Characterization of Regio Substituted 4-Hydroxy-1H-1,2,3-triazols as Possible Tool in Bioisosteric Applications | 2014 | A Federico; S.Sainas; A. Ducime;K. Martina; F. Bosca; D. Boschi; M.L. Lolli. | |
| Discovery of new NIK inhibitors by Structure-Based Drug Design | 2014 | Jean-Marie Contreras; Bo Svensson; Bjorn Walse; Salam Al-Karadaghi; Frank Totzke; Michael H.G. Kubbutat; Christoph Schächtele; Marco Lolli; Donatella Boschi; Marco Piccinini; Elisa Lupino; Joel Sussmann; Israel Silman; Yoav Peleg; Christophe Morice; Thierry Langer | |
| 1H-pyrazole-4-carboxylic acids active against Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH): discovery of a new scaffold for development of antimalarial agents | 2014 | Agnese Chiara Pippione; Ulf J. Nilsson; Ingela Fritzson; Anders P. Sundin; Salam Al-Karadaghi; Donatella Boschi; and Marco Lucio Lolli | |
| Towards a Bioisosteric Alkaest: application to the bioisosteric modulation of IMD-0354 | 2014 | Lolli Marco L.; Federico Antonella; Ducime Alex; Pippione Agnese; Sainas Stefano; Barge Alessandro; Martina Katia; Boschi Donatella; Lupino Elisa; Piccinini Marco; Kubbutat Michael; Contreras Jean Marie; Morice Christophe; Sussman Joel; Peleg Yoav; Walse Bjorn; Al-Kadaraghi Salam | |
| Toward a Bioisosteric Alkahest: Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by a Scaffold Hopping Bioisosteric approach using Hydroxylated Pentatomic Heterocycles | 2015 | Marco L. Lolli, Agnese Chiara Pippione, Stefano Sainas, Stefano Mensa, Marta Giorgis, Marco Piccinini, Elisa Lupino, Salam Al-Kadaraghi, Donatella Boschi | |
| APPLICATION OF THE ARACHNO™ TECHNOLOGY FOR THE PARALLEL SYNTHESIS OF A LIBRARY OF ASPIRIN ANALOGUES | 2015 | Moreo, Angela; Barge, Alessandro; Boschi, Donatella; Costale, Annalisa; Dosio, Franco; Federico, Antonella; Stevanato, Livio; L. Lolli., Marco | |
| Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by combination of in-silico ligand/structural pharmacophore models and scaffold hopping bioisosteric approaches | 2015 | Mensa, Stefano; Carnovale, Irene M.; Pippione, Agnese Chiara; Sainas, Stefano; Giorgis, Marta; Piccinini, Marco; Lupino, Elisa; Al-Karadaghi, Salam; Boschi, Donatella; L. Lolli., Marco |
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