Sfoglia per Autore
Permeability prediction in the beyond-Rule-of 5 chemical space: Focus on cyclic hexapeptides
2021-01-01 Digiesi, Vito; de la Oliva Roque, Víctor; Vallaro, Maura; Caron, Giulia; Ermondi, Giuseppe
Pt(iv) complexes based on cyclohexanediamines and the histone deacetylase inhibitor 2-(2-propynyl)octanoic acid: synthesis, characterization, cell penetration properties and antitumor activity
2021-01-01 Gabano E.; Rangone B.; Perin E.; Caron G.; Ermondi G.; Vallaro M.; Gandin V.; Marzano C.; Barbanente A.; Margiotta N.; Ravera M.
Rifampicin as an example of beyond-rule-of-5 compound: Ionization beyond water and lipophilicity beyond octanol/water
2021-01-01 Ermondi G.; Vallaro M.; Saame J.; Toom L.; Leito I.; Ruiz R.; Caron G.
The block relevance (Br) analysis makes the choice of methods for measuring lipophilicity and permeability safer and speeds up drug candidate prioritization
2021-01-01 Caron G.; Vallaro M.; Ermondi G.
Are we ready to design oral PROTACs®?
2021-01-01 Jimenez D.G.; Sebastiano M.R.; Caron G.; Ermondi G.
Characterization of the new CelerisTM Arginine column: Retentive behaviour through a combination of chemometric tools and potential in drug analysis
2021-01-01 Russo, Giacomo; Vallaro, Maura; Cappelli, Luca; Anderson, Scott; Ermondi, Giuseppe; Caron, Giulia
Rational Control of Molecular Properties Is Mandatory to Exploit the Potential of PROTACs as Oral Drugs
2021-01-01 Ermondi, Giuseppe; Garcia Jimenez, Diego; Rossi Sebastiano, Matteo; Caron, Giulia
Steering New Drug Discovery Campaigns: Permeability, Solubility, and Physicochemical Properties in the bRo5 Chemical Space
2021-01-01 Caron G.; Kihlberg J.; Goetz G.; Ratkova E.; Poongavanam V.; Ermondi G.
IκBα targeting promotes oxidative stress-dependent cell death
2021-01-01 Carrà, Giovanna; Ermondi, Giuseppe; Riganti, Chiara; Righi, Luisella; Caron, Giulia; Menga, Alessio; Capelletto, Enrica; Maffeo, Beatrice; Lingua, Marcello Francesco; Fusella, Federica; Volante, Marco; Taulli, Riccardo; Guerrasio, Angelo; Novello, Silvia; Brancaccio, Mara; Piazza, Rocco; Morotti, Alessandro
Degraders early developability assessment: face-to-face with molecular properties
2020-01-01 Ermondi G.; Vallaro M.; Caron G.
Chromatographic HILIC indexes to characterize the lipophilicity of zwitterions
2020-01-01 Vallaro M.; Ermondi G.; Caron G.
Flexibility in early drug discovery: focus on the beyond-Rule-of-5 chemical space
2020-01-01 Caron G.; Digiesi V.; Solaro S.; Ermondi G.
Solubility prediction in the bRo5 chemical space: where are we right now?
2020-01-01 Ermondi G.; Vallaro M.; Caron G.; Poongavanam V.; Kihlberg J.
Updating the portfolio of physicochemical descriptors related to permeability in the beyond the rule of 5 chemical space
2020-01-01 Ermondi G.; Vallaro M.; Goetz G.; Shalaeva M.; Caron G.
Permeability prediction for zwitterions via chromatographic indexes and classification into 'certain' and 'uncertain'
2019-01-01 Caudana F.; Ermondi G.; Vallaro M.; Shalaeva M.; Caron G.
Log P in the bRo5 chemical space
2019-01-01 Maura Vallaro, Giuseppe Ermondi, Gilles Goetz, Marina Shalaeva, Sonja Visentin, Giulia Caron
Experimental lipophilicity for beyond Rule of 5 compounds
2019-01-01 Ermondi, Giuseppe; Vallaro, Maura; Goetz, Gilles; Shalaeva, Marina; Caron, Giulia
The NFKBIA’s amplification in cancer, emerging molecular targets for lung cancer therapy
2019-01-01 Giovanna Carrà, Rocco Piazza, Giuseppe Ermondi, Giulia Caron, Chiara Riganti, Beatrice Maffeo, Antonio Cartellà, Marcello Francesco Lingua, Mara Brancaccio, Riccardo Taulli, Silvia Novello; Alessandro Morotti
Translating unusual computational methods to drug discovery: Taking advantage of work in other fields
2019-01-01 Caron G.; Ermondi G.
MLR, PLSR-BR Analysis and MBPLSR to Interpret Multivariate QSPR Models. The Case of a Micellar Liquid Chromatography Descriptor (log K WSDS )
2019-01-01 Ermondi G.; Caron G.
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