| Nome |
# |
|
Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors able to restore in vitro and in vivo myeloid differentiation, file e27ce42e-e3ed-2581-e053-d805fe0acbaa
|
4.586
|
|
Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors, file e27ce42e-e3f2-2581-e053-d805fe0acbaa
|
1.371
|
|
Development of covalent NLRP3 inflammasome inhibitors: chemistry and biological activity, file e27ce42f-1c04-2581-e053-d805fe0acbaa
|
612
|
|
NEW NON-COVALENT INHIBITORS OF NLRP3 INFLAMMASOME ATPASE ACTIVITY, file e27ce42f-32eb-2581-e053-d805fe0acbaa
|
544
|
|
A one-pot ultrasound-assisted water extraction/cyclodextrin encapsulation of resveratrol from Polygonum cuspidatum., file e27ce426-da30-2581-e053-d805fe0acbaa
|
393
|
|
Improvement of in vivo pharmacokinetic profile of M433, a potent and innovative hDHODH inhibitor., file e27ce42f-3286-2581-e053-d805fe0acbaa
|
366
|
|
Effective deploying of a novel DHODH inhibitor against herpes simplex type 1 and type 2 replication, file e27ce431-a1a5-2581-e053-d805fe0acbaa
|
338
|
|
Inhibition of NLRP3 ATPase activity: a new strategy to fight chronic inflammatory diseases, file e27ce42f-0b4e-2581-e053-d805fe0acbaa
|
314
|
|
The effect of hazelnut roasted skin from different cultivars on the quality attributes, polyphenol content and texture of fresh egg pasta, file e27ce429-3dbe-2581-e053-d805fe0acbaa
|
284
|
|
Synthesis physicochemical profile and PAMPA study of new NO-donor edaravone co-drugs, file e27ce426-d83a-2581-e053-d805fe0acbaa
|
253
|
|
Amodiaquine analogues containing NO-donor substructures: Synthesis and their preliminary evaluation as potential tools in the treatment of cerebral malaria, file e27ce426-bdc3-2581-e053-d805fe0acbaa
|
250
|
|
Electrophilic Warhead-Based Design of Compounds Preventing
NLRP3 Inflammasome-Dependent Pyroptosis, file e27ce427-0bb3-2581-e053-d805fe0acbaa
|
236
|
|
NO-Donor Phenols: A New Class of Products Endowed with Antioxidant and Vasodilator Properties, file e27ce426-aadd-2581-e053-d805fe0acbaa
|
228
|
|
Carnosine analogues containing NO-donor substructures: Synthesis, physico-chemical characterization and preliminary pharmacological profile, file e27ce426-ead8-2581-e053-d805fe0acbaa
|
227
|
|
Multitarget Drugs: Synthesis and Preliminary Pharmacological Characterization of Zileuton Analogues Endowed with Dual 5-LO Inhibitor and NO-Dependent Activities, file e27ce426-bf24-2581-e053-d805fe0acbaa
|
190
|
|
Novel Antioxidant Agents Deriving From Molecular Combination of Vitamin C and NO-donor moieties, file e27ce426-aaa3-2581-e053-d805fe0acbaa
|
179
|
|
α-ketoglutarate dehydrogenase inhibition counteracts breast cancer-associated lung metastasis, file e27ce42c-cfbd-2581-e053-d805fe0acbaa
|
169
|
|
In the search for new NLRP3 inhibitors: chemical modulation of the 1-(piperidin-4-yl)-1,3-dihydro-2 Hbenzo[d]imidazole-2-one scaffold, file 08889351-65f4-45f0-9414-657c773f233e
|
167
|
|
The synergism between DHODH inhibitors and dipyridamole leads to metabolic lethality in acute myeloid leukemia, file e27ce432-269b-2581-e053-d805fe0acbaa
|
141
|
|
Investigation of the central core of MEDS433: A Bioisosteric voyage into the Amide's Role., file b671f2a7-d375-46b9-a955-083bbb561111
|
136
|
|
A Comparative Study on the Efficacy of NLRP3 Inflammasome Signaling Inhibitors in a Pre-clinical Model of Bowel Inflammation, file e27ce42d-984c-2581-e053-d805fe0acbaa
|
134
|
|
Edaravone derivatives containing NO-donor functions, file e27ce426-bc77-2581-e053-d805fe0acbaa
|
133
|
|
1,2,5-Oxadiazole analogues of leflunomide and related compounds, file e27ce426-ca8a-2581-e053-d805fe0acbaa
|
124
|
|
Methotrexate-Loaded Solid Lipid Nanoparticles: Protein Functionalization to Improve Brain Biodistribution, file e27ce42d-a53b-2581-e053-d805fe0acbaa
|
117
|
|
Preliminary ADME/PK studies of new hDHODH inhibitors effective for treatment of acute myeloid leukaemia (AML), file e27ce42f-16a0-2581-e053-d805fe0acbaa
|
112
|
|
Synthesis, physico-chemical characterization, andbiological activities of new carnosine derivatives stablein human serum as potential neuroprotective agents, file e27ce426-c650-2581-e053-d805fe0acbaa
|
100
|
|
Design, Synthesis, and Evaluation of Acrylamide Derivatives as Direct NLRP3 Inflammasome Inhibitors, file e27ce42b-688b-2581-e053-d805fe0acbaa
|
95
|
|
Synthesis of Small Molecules as Potential DNA Methylation Modulators, file e27ce428-513c-2581-e053-d805fe0acbaa
|
82
|
|
PROCEEDINGS OF THE MERCK & ELSEVIER YOUNG CHEMISTSSYMPOSIUM, file e27ce42d-c4a1-2581-e053-d805fe0acbaa
|
79
|
|
Chemical modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2h-benzo[d]imidazole-2-one scaffold as a novel NLRP3 inhibitor, file e27ce432-3ce7-2581-e053-d805fe0acbaa
|
77
|
|
Non-conventional extractions and antioxidant properties evaluation of microalga Spirulina maxima, file e27ce426-f789-2581-e053-d805fe0acbaa
|
75
|
|
The role of fluorine in stabilizing the bioactive conformation of dihydroorotate dehydrogenase inhibitors, file e27ce426-e48a-2581-e053-d805fe0acbaa
|
65
|
|
Multitarget Drugs: Synthesis and Preliminary Pharmacological Characterization of Zileuton Analogues Endowed with Dual 5-LO Inhibitor and NO-Dependent Activities, file e27ce426-bf25-2581-e053-d805fe0acbaa
|
63
|
|
Quinone based nitric oxide donating compounds, file e27ce427-a390-2581-e053-d805fe0acbaa
|
56
|
|
Use of human Dihydroorotate Dehydrogenase (hDHODH) Inhibitors in Autoimmune Diseases and New Perspectives in Cancer Therapy, file e27ce42c-b64e-2581-e053-d805fe0acbaa
|
54
|
|
NOVEL HUMAN DIHYDROOROTATE DEHYDROGENASE (HDHODH) INHIBITORS AND THEIR USE IN TARGETING ONCOLOGICAL DISEASES SENSITIVE TO PYRIMIDINE STARVATION, file e27ce42e-cc6b-2581-e053-d805fe0acbaa
|
52
|
|
Edaravone derivatives containing NO-donor functions, file e27ce426-bc79-2581-e053-d805fe0acbaa
|
50
|
|
Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors, file e27ce433-402c-2581-e053-d805fe0acbaa
|
47
|
|
Meds433, a New Dihydroorotate Dehydrogenase Inhibitor, Induces Apoptosis and Differentiation in Acute Myeloid Leukemia, file e27ce434-529c-2581-e053-d805fe0acbaa
|
41
|
|
Design and synthesis of N-benzoyl amino acid derivatives as DNA methylation inhibitors, file e27ce42b-8f91-2581-e053-d805fe0acbaa
|
40
|
|
New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold, file e27ce426-edc2-2581-e053-d805fe0acbaa
|
37
|
|
Multitarget antioxidant NO-donor organic nitrates: a novel ap-proach to overcome nitrates tolerance, an ex vivo study, file e27ce434-a776-2581-e053-d805fe0acbaa
|
37
|
|
Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies, file e27ce433-0b18-2581-e053-d805fe0acbaa
|
35
|
|
Turning the light on with pyrazolo[1,5-A]pyridine: exploring it’s fluorescent properties for the design of new fluorosteric compounds, file 53e29924-2d0a-4034-86af-f13ff1d255b6
|
34
|
|
Targeting NLRP3 inflammasome: development of new covalent and non-covalent inhibitors of ATPase activity, file e27ce42e-c9c8-2581-e053-d805fe0acbaa
|
34
|
|
A differentiating and apoptotic therapy for acute myeloid leukaemia using potent human dihydroorotate dehydrogenase inhibitors., file e27ce42e-f84b-2581-e053-d805fe0acbaa
|
34
|
|
In vitro myeloid differentiation using a new generation of potent human dihydroorotate
dehydrogenase inhibitors, file e27ce42d-bf81-2581-e053-d805fe0acbaa
|
33
|
|
New tools for the development of direct NLRP3 inflammasome inhibitors, file e27ce42d-016a-2581-e053-d805fe0acbaa
|
31
|
|
Chemical modifications of Tonda Gentile Trilobata hazelnut and derived processing products under different infrared and hot-air roasting conditions: a combined analytical study, file e27ce42d-82a6-2581-e053-d805fe0acbaa
|
31
|
|
Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease, file e27ce42b-95d4-2581-e053-d805fe0acbaa
|
28
|
|
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety, file 33b0c0fc-4948-4f36-822a-38bf37292599
|
27
|
|
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold: SAR of the Biphenyl Moiety, file e27ce432-fd74-2581-e053-d805fe0acbaa
|
20
|
|
Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds, file e27ce42b-83d6-2581-e053-d805fe0acbaa
|
19
|
|
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold: SAR of the Biphenyl Moiety, file e27ce432-bb56-2581-e053-d805fe0acbaa
|
19
|
|
Pharmacological characterization of new NLRP3 inflammasome inhibitors., file e27ce430-5aa6-2581-e053-d805fe0acbaa
|
17
|
|
Synthesis physicochemical profile and PAMPA study of new NO-donor edaravone co-drugs, file e27ce426-d83b-2581-e053-d805fe0acbaa
|
13
|
|
An evaluation of the antioxidant properties of Arthrospira maxima extracts obtained using non-conventional techniques, file e27ce42b-d0be-2581-e053-d805fe0acbaa
|
13
|
|
Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAFV600E Protein, file d8cded6f-e57e-4e8c-87da-877e19c5510e
|
11
|
|
Targeting NLRP3 inflammasome regulatory mechanisms: design of anti-pyroptotic compounds for autoinflammatory diseases, file e27ce427-065a-2581-e053-d805fe0acbaa
|
7
|
|
New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold, file e27ce426-edc1-2581-e053-d805fe0acbaa
|
6
|
|
Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors, file e27ce42d-ad8b-2581-e053-d805fe0acbaa
|
6
|
|
In vitro myeloid differentiation using a new generation of potent human dihydroorotate
dehydrogenase inhibitors, file e27ce42d-9ae6-2581-e053-d805fe0acbaa
|
5
|
|
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold: SAR of the Biphenyl Moiety, file e27ce432-bcf1-2581-e053-d805fe0acbaa
|
5
|
|
Electrophilic Warhead-Based Design of Compounds Preventing
NLRP3 Inflammasome-Dependent Pyroptosis, file e27ce427-0bb4-2581-e053-d805fe0acbaa
|
4
|
|
Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds, file e27ce42b-83d7-2581-e053-d805fe0acbaa
|
4
|
|
Multitarget drugs in cardiovascular diseases: New agents with antioxidant and vasodilating properties for chronic applications, file 79c097e7-f448-4202-811b-c49c5849d453
|
3
|
|
Multitarget antioxidant NO-donor organic nitrates: a novel approach to overcome nitrates tolerance, file 8a501c96-7179-442f-96a3-526d0ba798a8
|
3
|
|
Carnosine analogues containing NO-donor substructures: Synthesis, physico-chemical characterization and preliminary pharmacological profile, file e27ce426-ead9-2581-e053-d805fe0acbaa
|
3
|
|
In vitro myeloid differentiation using a new generation of potent human dihydroorotate dehydrogenase (hDHODH) inhibitors, file e27ce42d-2659-2581-e053-d805fe0acbaa
|
3
|
|
In vitro myeloid differentiation using a new generation of potent human dihydroorotate dehydrogenase (hDHODH) inhibitors, file e27ce42d-2aec-2581-e053-d805fe0acbaa
|
3
|
|
Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies, file e27ce42d-b072-2581-e053-d805fe0acbaa
|
3
|
|
Amodiaquine analogues containing NO-donor substructures: Synthesis and their preliminary evaluation as potential tools in the treatment of cerebral malaria, file e27ce426-bdc4-2581-e053-d805fe0acbaa
|
2
|
|
Synthesis, physico-chemical characterization, andbiological activities of new carnosine derivatives stablein human serum as potential neuroprotective agents, file e27ce426-c64f-2581-e053-d805fe0acbaa
|
2
|
|
1,2,5-Oxadiazole analogues of leflunomide and related compounds, file e27ce426-ca88-2581-e053-d805fe0acbaa
|
2
|
|
The role of fluorine in stabilizing the bioactive conformation of dihydroorotate dehydrogenase inhibitors, file e27ce426-e489-2581-e053-d805fe0acbaa
|
2
|
|
A one-pot ultrasound-assisted water extraction/cyclodextrin encapsulation of resveratrol from Polygonum cuspidatum., file e27ce428-48e5-2581-e053-d805fe0acbaa
|
2
|
|
The effect of hazelnut roasted skin from different cultivars on the quality attributes, polyphenol content and texture of fresh egg pasta, file e27ce42a-7522-2581-e053-d805fe0acbaa
|
2
|
|
Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by a Scaffold Hopping Bioisosteric approach using Hydroxylated Pentaatomic Heterocycles, file e27ce42c-1dab-2581-e053-d805fe0acbaa
|
2
|
|
Targeting myeloid differentiation using potent human dihydroorotate dehydrogenase (hDHODH) inhibitors, file e27ce42c-f112-2581-e053-d805fe0acbaa
|
2
|
|
Chemical modifications of Tonda Gentile Trilobata hazelnut and derived processing products under different infrared and hot-air roasting conditions: a combined analytical study, file e27ce42d-82a7-2581-e053-d805fe0acbaa
|
2
|
|
Development of covalent NLRP3 inflammasome inhibitors: chemistry and biological activity, file e27ce42f-1c05-2581-e053-d805fe0acbaa
|
2
|
|
Design of new human Dihydroorotate Dehydrogenase inhibitors: amide bioisosterism in MEDS433 optimization, file e27ce434-bed2-2581-e053-d805fe0acbaa
|
2
|
|
Targeting Acute Myelogenous Leukemia using potent human dihydroorotate dehydrogenase inhibitors based on the 2-hydroxypyrazolo[1,5-a]pyridine scaffold: from academy to clinic, file 0f183a53-b692-48a9-996c-fc7c1c008917
|
1
|
|
Improvement of Metabolic Weakness of New Dihydroorotate Dehydrogenase Inhibitors Based on 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold to Target Myeloid Leukemias, file 83388e83-ad81-4a04-93f3-2b0624b87ea4
|
1
|
|
Important Steps into Drug Development of MEDS433, a Potent Human Dihydroorotate Dehydrogenase Inhibitor based on the 2-hydroxypyrazolo[1,5-a] Pyridine Scaffold, file ba92237a-a9d9-4a82-8262-6f5eaf4c9219
|
1
|
|
Investigation of the central core of MEDS433: A Bioisosteric voyage into the Amide's Role, file de2f6890-765d-4b86-8326-f3677ffc1aed
|
1
|
|
Novel Antioxidant Agents Deriving From Molecular Combination of Vitamin C and NO-donor moieties, file e27ce426-aaa2-2581-e053-d805fe0acbaa
|
1
|
|
Edaravone derivatives containing NO-donor functions, file e27ce426-bc76-2581-e053-d805fe0acbaa
|
1
|
|
Synthesis physicochemical profile and PAMPA study of new NO-donor edaravone co-drugs, file e27ce426-d839-2581-e053-d805fe0acbaa
|
1
|
|
Design and synthesis of N-benzoyl amino acid derivatives as DNA methylation inhibitors, file e27ce42a-87e8-2581-e053-d805fe0acbaa
|
1
|
|
Design, Synthesis, and Evaluation of Acrylamide Derivatives as Direct NLRP3 Inflammasome Inhibitors, file e27ce42a-a55c-2581-e053-d805fe0acbaa
|
1
|
|
Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds, file e27ce42b-937e-2581-e053-d805fe0acbaa
|
1
|
|
An evaluation of the antioxidant properties of Arthrospira maxima extracts obtained using non-conventional techniques, file e27ce42b-a93a-2581-e053-d805fe0acbaa
|
1
|
|
Development of Potent Human Dihydroorotate Dehydrogenase Inhibitors Able to Induces Myeloid Differentiation, file e27ce42c-bb7d-2581-e053-d805fe0acbaa
|
1
|
|
Development of Potent Human Dihydroorotate Dehydrogenase Inhibitors Able to Induces Myeloid Differentiation, file e27ce42c-bb7e-2581-e053-d805fe0acbaa
|
1
|
|
GIFC-2018 - BOOK OF ABSTRACTS, file e27ce42d-c447-2581-e053-d805fe0acbaa
|
1
|
|
Apoptotic and differentiating therapy for AML using potent human dihydroorotate dehydrogenase inhibitor, file e27ce434-f61f-2581-e053-d805fe0acbaa
|
1
|
| Totale |
13.145 |