DE SIMONE, Angela
DE SIMONE, Angela
SCIENZA E TECNOLOGIA DEL FARMACO
(±)- BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease
2021-01-01 Ismaili L.; Monnin J.; Etievant A.; Arribas R.L.; Viejo L.; Refouvelet B.; Soukup O.; Janockova J.; Hepnarova V.; Korabecny J.; Kucera T.; Jun D.; Andrys R.; Musilek K.; Baguet A.; Garcia-Frutos E.M.; De Simone A.; Andrisano V.; Bartolini M.; De Los Rios C.; Marco-Contelles J.; Haffen E.
- The role of Chromatography in Alzheimer’s Disease Drug Discovery
2017-01-01 Fiori J; De Simone A; Naldi M; Andrisano V
3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease
2015-01-01 Prati Federica; De Simone Angela; Armirotti Andrea; Summa Maria; Pizzirani Daniela; Scarpelli Rita; Bertozzi Sine Mandrup; Perez Daniel I.; Andrisano Vincenza; Perez-Castillo Ana; Monti Barbara; Massenzio Francesca; Polito Letizia; Racchi Marco; Sabatino Piera; Bottegoni Giovanni; Martinez Ana; Cavalli Andrea; Bolognesi Maria L.
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors
2019-01-01 Pérez-Areales, F Javier; Turcu, Andreea L; Barniol-Xicota, Marta; Pont, Caterina; Pivetta, Deborah; Espargaró, Alba; Bartolini, Manuela; De Simone, Angela; Andrisano, Vincenza; Pérez, Belén; Sabate, Raimon; Sureda, Francesc X; Vázquez, Santiago; Muñoz-Torrero, Diego
A patent review of butyrylcholinesterase inhibitors and reactivators 2010–2017
2018-01-01 Andrisano, Vincenza; Naldi, Marina; De Simone, Angela; Bartolini, Manuela
A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: structure-based design, synthesis, and biological evaluation
2012-01-01 G. P. Chiriano; A. De Simone; F. Mancini; D. I. Perez; A. Cavalli; M. L. Bolognesi; G. Legname; A. Martinez; V. Andrisano; P. Carloni; M. Roberti
Advanced analytical methodologies in Alzheimer's disease drug discovery
2020-01-01 De Simone A.; Naldi M.; Tedesco D.; Bartolini M.; Davani L.; Andrisano V.
Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3β Inhibitors
2018-01-01 Hulcová, Daniela; Breiterová, Kateřina; Siatka, Tomáš; Klímová, Kamila; Davani, Lara; Šafratová, Marcela; Hošťálková, Anna; De Simone, Angela; Andrisano, Vincenza; Cahlíková, Lucie
Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease
2019-01-01 Hulcova D.; Marikova J.; Korabecny J.; Hostalkova A.; Jun D.; Kunes J.; Chlebek J.; Opletal L.; De Simone A.; Novakova L.; Andrisano V.; Ruzicka A.; Cahlikova L.
Amyloid beta-Peptide 25-35 Self Assembly and Its Inhibition: A Model Undecapeptide System to Gain Atomistic and Secondary Structure Details of the Alzheimer's Disease Process and Treatment
2012-01-01 Naldi M.; Fiori J.; Pistolozzi M.; Drake A.F.; Bertucci C.; Wu R.; Mlynarczyk K.; Filipek S.; De Simone A.; Andrisano V.
Application of an ESI-QTOF method for the detailed characterization of GSK-3β inhibitors
2017-01-01 DE SIMONE, ANGELA; FIORI, JESSICA; NALDI, MARINA; D'URZO, ANNALISA; TUMIATTI, VINCENZO; MILELLI, ANDREA; ANDRISANO, VINCENZA
Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets
2016-01-01 Chlebek Jakub; De Simone Angela; Hoš͗álková Anna; Opletal Lubomír; Pérez Concepción; Pérez Daniel I.; Havlíková Lucie; Cahlíková Lucie; Andrisano Vincenza
Aβ1-42 peptide toxicity on neuronal cells: A lipidomic study
2022-01-01 Davani, Lara; Fu, Xiaoqing; De Simone, Angela; Li, Peng; Montanari, Serena; Lämmerhofer, Michael; Andrisano, Vincenza
Beta-secretase as a target for Alzheimer's disease drug discovery: an overview of in vitro methods for characterization of inhibitors
2011-01-01 F. Mancini; A. De Simone; V. Andrisano
Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6
2020-01-01 Perez-Areales F.J.; Garrido M.; Aso E.; Bartolini M.; De Simone A.; Espargaro A.; Ginex T.; Sabate R.; Perez B.; Andrisano V.; Puigoriol-Illamola D.; Pallas M.; Luque F.J.; Loza M.I.; Brea J.; Ferrer I.; Ciruela F.; Messeguer A.; Munoz-Torrero D.
Circular dichroism in drug discovery and development: an abridged review
2010-01-01 Bertucci C; Pistolozzi M; De Simone A.
Combined Methodologies for Determining In Vitro Bioavailability of Drugs and Prediction of In Vivo Bioequivalence From Pharmaceutical Oral Formulations
2021-01-01 De Simone A.; Davani L.; Montanari S.; Tumiatti V.; Avanessian S.; Testi F.; Andrisano V.
Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids
2017-01-01 Pérez-Areales, Francisco Javier; Betari, Nibal; Viayna, Antonio; Pont, Caterina; Espargaró, Alba; Bartolini, Manuela; De Simone, Angela; Rinaldi Alvarenga, José Fernando; Pérez, Belén; Sabate, Raimon; Lamuela-Raventós, Rosa Maria; Andrisano, Vincenza; Luque, Francisco Javier; Muñoz-Torrero, Diego
Design, synthesis, in silico and in vitro screening of 1,2,4-thiadiazole analogues as non-peptide inhibitors of beta-secretase
2014-01-01 Gurjar AS; Andrisano V; De Simone A; Velingkar VS
Designing Dual Transglutaminase 2/Histone Deacetylase Inhibitors Effective at Halting Neuronal Death
2018-01-01 Manuela Basso; Huan Huan Chen; Debasmita Tripathy; Mariarosaria Conte; Kim Y. P. Apperley; Angela De Simone; Jeffrey W. Keillor; Rajiv Ratan; Angela Nebbioso; Federica Sarno; Lucia Altucci; Andrea Milelli.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| (±)- BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease | 2021 | Ismaili L.; Monnin J.; Etievant A.; Arribas R.L.; Viejo L.; Refouvelet B.; Soukup O.; Janockova J.; Hepnarova V.; Korabecny J.; Kucera T.; Jun D.; Andrys R.; Musilek K.; Baguet A.; Garcia-Frutos E.M.; De Simone A.; Andrisano V.; Bartolini M.; De Los Rios C.; Marco-Contelles J.; Haffen E. | |
| - The role of Chromatography in Alzheimer’s Disease Drug Discovery | 2017 | Fiori J; De Simone A; Naldi M; Andrisano V | |
| 3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease | 2015 | Prati Federica; De Simone Angela; Armirotti Andrea; Summa Maria; Pizzirani Daniela; Scarpelli Rita; Bertozzi Sine Mandrup; Perez Daniel I.; Andrisano Vincenza; Perez-Castillo Ana; Monti Barbara; Massenzio Francesca; Polito Letizia; Racchi Marco; Sabatino Piera; Bottegoni Giovanni; Martinez Ana; Cavalli Andrea; Bolognesi Maria L. | |
| A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors | 2019 | Pérez-Areales, F Javier; Turcu, Andreea L; Barniol-Xicota, Marta; Pont, Caterina; Pivetta, Deborah; Espargaró, Alba; Bartolini, Manuela; De Simone, Angela; Andrisano, Vincenza; Pérez, Belén; Sabate, Raimon; Sureda, Francesc X; Vázquez, Santiago; Muñoz-Torrero, Diego | |
| A patent review of butyrylcholinesterase inhibitors and reactivators 2010–2017 | 2018 | Andrisano, Vincenza; Naldi, Marina; De Simone, Angela; Bartolini, Manuela | |
| A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: structure-based design, synthesis, and biological evaluation | 2012 | G. P. Chiriano; A. De Simone; F. Mancini; D. I. Perez; A. Cavalli; M. L. Bolognesi; G. Legname; A. Martinez; V. Andrisano; P. Carloni; M. Roberti | |
| Advanced analytical methodologies in Alzheimer's disease drug discovery | 2020 | De Simone A.; Naldi M.; Tedesco D.; Bartolini M.; Davani L.; Andrisano V. | |
| Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3β Inhibitors | 2018 | Hulcová, Daniela; Breiterová, Kateřina; Siatka, Tomáš; Klímová, Kamila; Davani, Lara; Šafratová, Marcela; Hošťálková, Anna; De Simone, Angela; Andrisano, Vincenza; Cahlíková, Lucie | |
| Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease | 2019 | Hulcova D.; Marikova J.; Korabecny J.; Hostalkova A.; Jun D.; Kunes J.; Chlebek J.; Opletal L.; De Simone A.; Novakova L.; Andrisano V.; Ruzicka A.; Cahlikova L. | |
| Amyloid beta-Peptide 25-35 Self Assembly and Its Inhibition: A Model Undecapeptide System to Gain Atomistic and Secondary Structure Details of the Alzheimer's Disease Process and Treatment | 2012 | Naldi M.; Fiori J.; Pistolozzi M.; Drake A.F.; Bertucci C.; Wu R.; Mlynarczyk K.; Filipek S.; De Simone A.; Andrisano V. | |
| Application of an ESI-QTOF method for the detailed characterization of GSK-3β inhibitors | 2017 | DE SIMONE, ANGELA; FIORI, JESSICA; NALDI, MARINA; D'URZO, ANNALISA; TUMIATTI, VINCENZO; MILELLI, ANDREA; ANDRISANO, VINCENZA | |
| Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets | 2016 | Chlebek Jakub; De Simone Angela; Hoš͗álková Anna; Opletal Lubomír; Pérez Concepción; Pérez Daniel I.; Havlíková Lucie; Cahlíková Lucie; Andrisano Vincenza | |
| Aβ1-42 peptide toxicity on neuronal cells: A lipidomic study | 2022 | Davani, Lara; Fu, Xiaoqing; De Simone, Angela; Li, Peng; Montanari, Serena; Lämmerhofer, Michael; Andrisano, Vincenza | |
| Beta-secretase as a target for Alzheimer's disease drug discovery: an overview of in vitro methods for characterization of inhibitors | 2011 | F. Mancini; A. De Simone; V. Andrisano | |
| Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6 | 2020 | Perez-Areales F.J.; Garrido M.; Aso E.; Bartolini M.; De Simone A.; Espargaro A.; Ginex T.; Sabate R.; Perez B.; Andrisano V.; Puigoriol-Illamola D.; Pallas M.; Luque F.J.; Loza M.I.; Brea J.; Ferrer I.; Ciruela F.; Messeguer A.; Munoz-Torrero D. | |
| Circular dichroism in drug discovery and development: an abridged review | 2010 | Bertucci C; Pistolozzi M; De Simone A. | |
| Combined Methodologies for Determining In Vitro Bioavailability of Drugs and Prediction of In Vivo Bioequivalence From Pharmaceutical Oral Formulations | 2021 | De Simone A.; Davani L.; Montanari S.; Tumiatti V.; Avanessian S.; Testi F.; Andrisano V. | |
| Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids | 2017 | Pérez-Areales, Francisco Javier; Betari, Nibal; Viayna, Antonio; Pont, Caterina; Espargaró, Alba; Bartolini, Manuela; De Simone, Angela; Rinaldi Alvarenga, José Fernando; Pérez, Belén; Sabate, Raimon; Lamuela-Raventós, Rosa Maria; Andrisano, Vincenza; Luque, Francisco Javier; Muñoz-Torrero, Diego | |
| Design, synthesis, in silico and in vitro screening of 1,2,4-thiadiazole analogues as non-peptide inhibitors of beta-secretase | 2014 | Gurjar AS; Andrisano V; De Simone A; Velingkar VS | |
| Designing Dual Transglutaminase 2/Histone Deacetylase Inhibitors Effective at Halting Neuronal Death | 2018 | Manuela Basso; Huan Huan Chen; Debasmita Tripathy; Mariarosaria Conte; Kim Y. P. Apperley; Angela De Simone; Jeffrey W. Keillor; Rajiv Ratan; Angela Nebbioso; Federica Sarno; Lucia Altucci; Andrea Milelli. |