statistiche per DE SIMONE, Angela

Distribuzione geografica

Continente	#
AS - Asia	198
NA - Nord America	131
EU - Europa	97
Totale	426

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Nazione	#
CN - Cina	144
US - Stati Uniti d'America	128
IT - Italia	62
VN - Vietnam	23
SE - Svezia	13
HK - Hong Kong	9
GR - Grecia	7
KR - Corea	5
FR - Francia	4
IN - India	4
IR - Iran	4
PL - Polonia	4
TR - Turchia	4
CA - Canada	3
TW - Taiwan	3
NO - Norvegia	2
BG - Bulgaria	1
DK - Danimarca	1
GB - Regno Unito	1
MO - Macao, regione amministrativa speciale della Cina	1
PK - Pakistan	1
RO - Romania	1
RS - Serbia	1
Totale	426

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Città	#
Beijing	69
Torino	27
Fairfield	22
Dong Ket	17
Redwood City	16
Wilmington	16
Cambridge	15
Hangzhou	11
Bologna	9
Central District	9
Ashburn	8
Chengdu	8
Hefei	7
Seattle	7
Ann Arbor	6
Kunming	6
Woodbridge	6
Xian	6
Leinì	4
Nanjing	4
Norwalk	4
Seoul	4
Houston	3
Piemonte	3
Shanghai	3
Wroclaw	3
Ankara	2
Baotou	2
Cupertino	2
Guangzhou	2
Hebei	2
Izmir	2
Jinan	2
Kumar	2
Mountain View	2
Nanchang	2
Oslo	2
Pistoia	2
Rome	2
San Diego	2
Taipei	2
Toronto	2
Absecon	1
Brescia	1
Changchun	1
Chatsworth	1
Cluj-napoca	1
Dallas	1
Durham	1
Fuzhou	1
Genova	1
Guiyang	1
Gurgaon	1
Hanoi	1
Harbin	1
Imola	1
Jinhua	1
Kraków	1
Kundan	1
La Canada Flintridge	1
London	1
Macau	1
Monmouth Junction	1
Montegaldella	1
Ningbo	1
Odense	1
Ottawa	1
Pescara	1
Pishgaman	1
Quzhou	1
Ravenna	1
San Mateo	1
Santarcangelo	1
Shenyang	1
Shuozhou	1
Silver Spring	1
Tianjin	1
Zhengzhou	1
Totale	361

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Nome	#
Investigating in vitro amyloid peptide 1−42 aggregation: Impact of higher molecular weight stable adducts	54
Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids	34
Naturally inspired molecules as multifunctional agents for Alzheimer's disease treatment	34
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors	20
Advanced analytical methodologies in Alzheimer's disease drug discovery	18
3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease	16
Development and validation of an LC-ESI-MS/MS method for the quantification of D-84, reboxetine and citalopram for their use in MS Binding Assays addressing the monoamine transporters hDAT, hSERT and hNET	14
Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors	14
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimers Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography	13
From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold	13
Uleine disrupts key enzymatic and non-enzymatic biomarkers that leads to Alzheimer's disease	13
Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease	13
Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease	12
Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3β Inhibitors	11
A patent review of butyrylcholinesterase inhibitors and reactivators 2010–2017	11
Beta-secretase as a target for Alzheimer's disease drug discovery: an overview of in vitro methods for characterization of inhibitors	11
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease	11
Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6	11
Pyridinylimidazoles as GSK3β Inhibitors: The Impact of Tautomerism on Compound Activity via Water Networks	10
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors	9
Multifunctional activity of some isoquinoline alkaloids from Corydalis cava tubers on Alzheimer's disease targets	9
Structural characterization of recombinant therapeutic proteins by circular dichroism	8
Circular dichroism in drug discovery and development: an abridged review	8
Designing Dual Transglutaminase 2/Histone Deacetylase Inhibitors Effective at Halting Neuronal Death	8
Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer's disease	8
Protein Flexibility in Virtual Screening: The BACE-1 Case Study	7
Simultaneous Multiple MS Binding Assays for the Dopamine, Norepinephrine, and Serotonin Transporters	7
Human recombinant beta-secretase immobilized enzyme reactor for fast hits’ selection and characterization from a virtual screening library	7
Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease	6
Histone Deacetylase Inhibitors as Multitarget Ligands: New Players in Alzheimer's Disease Drug Discovery?	6
A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: structure-based design, synthesis, and biological evaluation	6
Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer’s disease	6
Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets	6
Application of an ESI-QTOF method for the detailed characterization of GSK-3β inhibitors	6
Direct determination of GSK-3β activity and inhibition by UHPLC-UV-vis diode arrays detector (DAD)	6
Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer	6
Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice	6
Development of an UHPLC-diode arrays detector (DAD) method for the analysis of polydatin in human plasma	6
- The role of Chromatography in Alzheimer’s Disease Drug Discovery	5
Reversible human serum albumin binding of lipocrine: a circular dichroism study	5
Structural characterization of p53 isoforms due to the polymorphism at codon 72 by Mass Spectrometry and Circular Dichroism	5
Amyloid beta-Peptide 25-35 Self Assembly and Its Inhibition: A Model Undecapeptide System to Gain Atomistic and Secondary Structure Details of the Alzheimer's Disease Process and Treatment	5
Surface plasmon resonance, fluorescence, and circular dichroism studies for the characterization of the binding of BACE-1 inhibitors	5
Design, synthesis, in silico and in vitro screening of 1,2,4-thiadiazole analogues as non-peptide inhibitors of beta-secretase	5
Immobilized Enzyme Reactors: an Overview of Applications in Drug Discovery from 2008 to 2018	5
(±)- BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease	5
Optical Biosensors and Applications to Drug Discovery and Development in Cancer Research	4
Tacrine-based Multifunctional Agents in Alzheimer's Disease: an Old Story in Continuous Development	4
Liquid chromatographic enzymatic studies with on-line Beta-secretase immobilized enzyme reactor and 4-(4-dimethylaminophenylazo) benzoic acid/5-[(2-aminoethyl) amino] naphthalene-1-sulfonic acid as fluorogenic substrate	4
Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents	4
Glycogen Synthase Kinase 3β: A New Gold Rush in Anti-Alzheimer's Disease Multitarget Drug Discovery?	3
From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects	3
Combined Methodologies for Determining In Vitro Bioavailability of Drugs and Prediction of In Vivo Bioequivalence From Pharmaceutical Oral Formulations	1
Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease	1
Totale	528

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Categoria	#
all - tutte	528
article - articoli	0
book - libri	0
conference - conferenze	0
curatela - curatele	0
other - altro	0
patent - brevetti	0
selected - selezionate	0
volume - volumi	0
Totale	528

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	Totale	Lug	Ago	Sett	Ott	Nov	Dic	Gen	Feb	Mar	Apr	Mag	Giu
2019/2020	245	0	0	0	0	0	73	75	13	8	20	50	6
2020/2021	137	7	17	5	6	17	9	8	13	9	6	2	38
2021/2022	146	10	4	17	17	25	7	14	19	15	11	7	0
Totale													528

CINECA IRIS Institutional Research Information System

statistiche per DE SIMONE, Angela