OLIARO BOSSO, Simonetta
 Distribuzione geografica
Continente #
NA - Nord America 4.201
EU - Europa 2.816
AS - Asia 1.162
AF - Africa 78
SA - Sud America 38
OC - Oceania 13
Continente sconosciuto - Info sul continente non disponibili 6
Totale 8.314
Nazione #
US - Stati Uniti d'America 4.099
IT - Italia 702
CN - Cina 592
SE - Svezia 447
IE - Irlanda 345
DE - Germania 290
FR - Francia 190
FI - Finlandia 149
GB - Regno Unito 137
UA - Ucraina 137
KR - Corea 136
AT - Austria 114
JP - Giappone 103
PL - Polonia 98
CA - Canada 85
VN - Vietnam 80
DK - Danimarca 79
IN - India 72
SN - Senegal 53
SG - Singapore 44
BE - Belgio 33
HK - Hong Kong 33
TW - Taiwan 24
RU - Federazione Russa 21
BR - Brasile 20
ID - Indonesia 17
AU - Australia 13
MX - Messico 13
ES - Italia 12
IR - Iran 12
NL - Olanda 12
RO - Romania 12
TH - Thailandia 12
CH - Svizzera 11
AR - Argentina 10
PT - Portogallo 10
NG - Nigeria 9
TR - Turchia 9
SK - Slovacchia (Repubblica Slovacca) 7
EG - Egitto 6
EU - Europa 6
UZ - Uzbekistan 6
SA - Arabia Saudita 5
CL - Cile 4
IL - Israele 4
PK - Pakistan 4
CO - Colombia 3
CU - Cuba 3
NO - Norvegia 3
PH - Filippine 3
ZA - Sudafrica 3
CZ - Repubblica Ceca 2
GH - Ghana 2
MA - Marocco 2
MY - Malesia 2
RS - Serbia 2
SC - Seychelles 2
BD - Bangladesh 1
BO - Bolivia 1
EE - Estonia 1
GR - Grecia 1
IQ - Iraq 1
MD - Moldavia 1
MO - Macao, regione amministrativa speciale della Cina 1
PR - Porto Rico 1
SY - Repubblica araba siriana 1
TN - Tunisia 1
Totale 8.314
Città #
Chandler 553
Dublin 339
Beijing 329
Ann Arbor 285
Houston 281
Fairfield 258
Torino 210
Ashburn 171
Woodbridge 136
Jacksonville 132
Wilmington 119
Los Angeles 116
Seattle 114
Vienna 113
Villeurbanne 113
Nyköping 112
Medford 101
Dearborn 99
Princeton 95
Redwood City 90
Cambridge 87
Turin 86
Warsaw 84
Pisa 64
Ottawa 52
Dong Ket 47
Milan 47
Boardman 44
Fremont 42
Brussels 32
Boston 31
New York 31
Düsseldorf 23
Hangzhou 23
San Diego 23
Guangzhou 21
Copenhagen 20
Shanghai 19
Nanjing 18
Norwalk 17
Singapore 16
Kunming 15
Hefei 14
Helsinki 14
Toronto 13
Washington 13
Buffalo 11
Taipei 11
Tokyo 11
Ypsilanti 11
Bradford 10
Braunschweig 10
Falls Church 10
London 10
Nürnberg 10
Verona 10
Changsha 9
Chengdu 9
Fuzhou 9
Phoenix 9
Pune 9
Rome 9
Taichung 9
Bucharest 8
Central 8
Jakarta 8
Mountain View 8
Bagnacavallo 7
Bratislava 7
Philadelphia 7
Piemonte 7
Abuja 6
Birmingham 6
Hebei 6
Jinan 6
Luzhou 6
Menlo Park 6
Musashino 6
Ogaki 6
Pittsburgh 6
Seongbuk-gu 6
Lachine 5
Leeds 5
Munich 5
Naples 5
Padova 5
Paris 5
Toledo 5
Upper Marlboro 5
Wuhan 5
Zhengzhou 5
Bangkok 4
Bonn 4
Delhi 4
Duncan 4
Ferrara 4
Hamburg 4
Ho Chi Minh City 4
Indianapolis 4
Lappeenranta 4
Totale 5.035
Nome #
Androgen-AR axis in primary and metastatic prostate cancer: chasing steroidogenic enzymes for therapeutic intervention 323
Mesoporous silica as topical nanocarriers for quercetin: characterization and in vitro studies 309
Regulation of HMGCoA reductase Activity by Policosanol and Octacosadienol, a New synthetic Analogue of Octacosanol 258
Cannabinoid Delivery Systems for Pain and Inflammation Treatment 193
The cholesterol biosynthesis enzyme oxidosqualene cyclase is a new target to impair tumour angiogenesis and metastasis dissemination 187
Ergosterol reduction impairs mitochondrial DNA maintenance in S. cerevisiae 186
Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: Application of a bioisosteric scaffold hopping approach to flufenamic acid 185
Nanomaterials-protein interactions: the case of pristine and functionalized carbon nanotubes and Porcine Gastric Mucin (PGM) 181
Predictive tests to evaluate oxidative potential of engineered nanomaterials 177
Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach 163
Multiple catalytic activities of human 17β-hydroxysteroid dehydrogenase type 7 respond differently to inhibitors. 163
Singlet oxygen plays a key role in the toxicity and DNA damage of nanometric TiO2 to human keratinocytes 147
Design, synthesis, and biological evaluation of flufenamic acid derived bioisosteres as inhibitors of aldo-keto reductase 1C3 (AKR1C3) expressed in prostate cancer 146
Thermosensitive nanocomposite hydrogels for intravitreal delivery of cefuroxime 145
Analogs of squalene and oxidosqualene inhibit oxidosqualene cyclase of Trypanosoma cruzi expressed in Saccharomyces cerevisiae 142
NEW HYDROXYAZOLES INHIBITORS OF ALDO-KETO REDUCTASE 1C3 (AKR1C3) OBTAINED BY SCAFFOLD HOPPING FROM FLUFENAMIC ACID AND INDOMETHACIN FOR CASTRATE RESISTANT PROSTATE CANCER 138
Interactions of oxidosqualene cyclase (Erg7p) with 3-keto reductase (Erg27p) and other enzymes of sterol biosynthesis in yeast 134
Aminopropylindenes derived from Grundmann’s ketone as a novel chemotype of oxidosqualene cyclase inhibitors. 134
Inhibition of the ROS-mediated cytotoxicity and genotoxicity of nano-TiO2 toward human keratinocyte cells by iron doping 133
Synthesis and preliminary pharmacological characterisation of a new class of nitrogen-containing bisphosphonates (N-BPs) 125
Thermoresponsive mesoporous silica nanoparticles as a carrier for skin delivery of quercetin 124
Indoor illumination: A possible pitfall in toxicological assessment of photo-active nanomaterials 117
New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold 115
Effect of inhibiting the sterol biosynthesis pathway and the cholesterol content in the regulation of angiogenesis in vitro and in vivo 110
New inhibitors of Aldo-Keto Reductase 1C3 (AKR1C3) based on benzoisoxazole scaffold and their potential application in cancer 109
Bioisosteres of Indomethacin as Inhibitors of Aldo-Keto Reductase 1C3 107
Evaluation of Porcine and Aspergillus oryzae α-Amylases as Possible Model for the Human Enzyme 106
Targeting Castration Resistant Prostate Cancer (CRPC) by innovative AKR1C3 inhibitors based on the 3-hydroxybenzoisoxazole structure 96
Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity 95
4-methyl zymosterone and other 4-methyl intermediates of sterol biosynthesis from yeast mutants engineered in the ERG27 gene encoding 3-ketosteroid reductase 92
Surface modified TiO2 nanopowders for sunscreen applications 91
Umbelliferone Aminoalkyl Derivatives asInhibitors of Human Oxidosqualene: Lanosterol Cyclase 90
Recent Cannabinoid Delivery Systems 90
Umbelliferone aminoalkyl derivatives as inhibitors of oxidosqualene cyclases from Saccharomyces cerevisiae, Trypanosoma cruzi and pneumocystis carinii 89
Sistemi nanocompositi termosensibili per la somministrazione intravitreale di cefuroxima 88
protein -protein interaction in sterol biosynthesis: the relationship between sterol-3-keto reductase and oxidosqualene cyclase 87
4-Methylzymosterone and Other Intermediates of Sterol Biosynthesis from Yeast Mutants Engineered in the ERG27 Gene Encoding 3-Ketosteroid Reductase 83
POLICOSANOLI DA PULA DI RISO 82
Studio del canale di accesso al sito attivo della ossidosqualene ciclasi di Saccharomyces cerevisiae. 78
NEW HYDROXYAZOLES INHIBITORS OF AKR1C3 OBTAINED FROM NSAIDS BY SCAFFOLD HOPPING APPROACH AGAINST CASTRATE RESISTANT PROSTATE CANCER 78
New Hydroxybenzoazole Inhibitors of Aldo-Keto Reductase 1C3 (AKR1C3): Disclosure of SAR Investigation to Target Prostate Cancer 77
Tailored preparation of modified TiO2 nanopowders for the study of the role of photo-reactivity in the toxicity toward keratinocytes 74
Yeast Oxidosqualene cyclase (Erg7p) Is a Major Component of Lipid Particles. J. Biol. Chem. (2002) 277, 2406-2412. 73
Exploring the access of the substrate to the active site of yeast oxidosqualene cyclase by site-directed mutagenesis 73
Oxidosqualene cyclase from Trypanosoma cruzi and Pneumocystis carinii expressed in Yeast: a model for the development of novel antiparasitic agents 73
Vinyl sulfide derivatives of oxidosqualene, as inhibitors of oxidosqualene cyclase of Trypanosoma cruzi expressed in Saccharomyces cerevisiae. 73
Different interaction between oxidosqualene cyclase and steroid-3-ketoreductase from yeasts to mammals 72
Assessment of in‐situ gelling microemulsion systems upon temperature and dilution condition for corneal delivery of bevacizumab 72
Exploring the access of the substrate to the active site of yeast oxidosqualene cyclase by site-directed mutagenesis. 71
Inhibitory Effect of Umbelliferone Aminoalkyl Derivatives on Oxidosqualene Cyclases from Saccharomyces cerevisiae, Trypanosoma cruzi, Pneumocystis carinii, Homo sapiens and Arabidopsis thaliana: a structure-activity study 71
A new bevacizumab carrier for intravitreal administration: Focus on stability 70
Design, Synthesis, and Biological Evaluation of New (2E,6E)-10-(Dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol Ethers as Inhibitors of Human and Trypanosoma cruzi Oxidosqualene Cyclase. 69
Yeast Oxidosqualene cyclase (Erg7p) Is a Major Component of Lipid Particles 69
Comparative characterization of yeast and human 3-ketosteroid reductase, two moonlighting proteins that share a job 69
Access of the substrate to the active site of yeast oxidosqualene cyclase: an inhibition and site-directed mutagenesis appoach. 69
Characterization of the Channel Constriction Allowingthe Access of the Substrate to the Active Site of YeastOxidosqualene Cyclase 68
Access of the substrate to the active site of yeast oxidosqualene cyclase: a modelling and site-directed mutagenesis approach 67
Subcellular localization of yeast oxidosqualene cyclase and other eukaryotic oxidosqualene cyclases expressed in yeast 67
Characterization of C-4 demethylation complex of cholesterol biosynthesis 67
Oxidosqualene cyclase from Saccharomyces cerevisiae: a model for the development of novel antifungal and antiparasitic agents 66
Umbelliferone aminoalkyl derivatives as inhibitors of oxidosqualene cyclases from Saccharomyces cerevisiae, Trypanosoma cruzi, and Pneumocystis carinii 66
Divergent interactions involving the oxidosqualene cyclase and thesteroid-3-ketoreductase in the sterol biosynthetic pathway ofmammals and yeasts 65
Access of the substrate to the active site of squalene and oxidosqualene cyclases: comparative inhibition, site-directed mutagenesis and homology-modelling studies. 64
polyclonal antibodies against a fragment of oxidosqualene cyclase(erg7p) overexpressed in E.coli recognize the enzyme of different sources 64
AKR1C3 is a biomarker and druggable target for oropharyngeal tumors 64
Access of the substrate to the active site of yeast oxidosqualene cyclase: an inhibition and site-directed mutagenesis approach. 63
Arylpiperidines as a new class of oxidosqualene cyclase inhibitors 63
Different Interaction between Oxidosqualene Cyclase and Steroid-3-ketoreductase in Yeast and Mammals 62
A mutation in yeast oxidosqualene cyclase (Erg7) makes it independent of 3-ketoreductase activity (Erg27) 61
Characterizing sterol defect suppressors uncovers a novel transcriptional signaling pathway regulating zymosterol biosynthesis, 60
Mesoporous silica nanoparticles as a promising skin delivery system for methotrexate 60
Yeast oxidosqualene cyclase (Erg7p) is a major component of lipid particles 57
Soybean-germ oil inhibits oxidosqualene cyclase in 3T3 fibroblasts 56
Interaction of oxidosqualene cyclase with C-4 sterol demethylation complex 55
Functional characterization by site-directed mutagenesis of human oxidosqualene cyclase (OSC) expressed in Pichia pastoris 55
policosanol: updating and perspectives 55
Oxidosqualene cyclase from Saccharomyces cerevisiae, Trypanosoma cruzi, Pneumocystis carinii and Arabidopsis thaliana expressed in yeast: a model for the development of novel antiparasitic agents 54
Novel Squalene-Hopene Cyclase Inhibitors derived from Hydroxycoumarins and Hydroxyacetophenones 53
Subcellular localization of oxidosqualene cyclases from Arabidopsis thaliana, Trypanosoma cruzi and Pneumocystis carinii expressed in yeast 53
Multiple-targeting ligands for AKR1C3 enzyme and androgen receptor to target prostate cancer 50
Conjugated Methyl Sulfide and phenyl Sulfide Derivatives of Oxidosqualene as Inhibitors of Oxidosqualene and Squalene-Hopene Cyclases. 49
Access of the substrate to the active site of yeast oxidosqualene cyclase: an inhibition and site-directed mutagenesis approach. 47
Difference in the late ergosterol biosynthesis between yeast spheroplasts and intact cells 47
Subcellular distribution and selective inhibition of oxidosqualene cyclases of Trypanosoma cruzi and Pneumocystis carinii expressed in Saccharomyces cerevisiae 45
Enzymatic and Chemical In Vitro Reconstitution of Iron-Sulfur Cluster Proteins 44
Extraction and Characterization of Bromelain from Pineapple Core: A Strategy for Pineapple Waste Valorization 42
Farnesyloxycoumarins, a New Class of Squalene Hopene Cyclase Inhibitors 41
Towards a metabolomic approach to investigate iron-sulfur cluster biogenesis 40
New potent selective inhibitors of Trypanosoma cruzi oxidosqualene cyclase. 36
Application of an in house bioisosteric approach to the design of innovative inhibitors of aldo-keto reductase 1C3 (AKR1C3) 33
Mutagenesi sito-specifica per lo studio di analogie strutturali tra squalene-opene ciclasi e ossidosqualene ciclasi. 30
HYDROXYLATED HETEROCYCLES AS BIOISOSTERES OF THE CARBOXYLIC FUNCTION: DESIGN OF NEW AKR1C3 INHIBITORS ACTIVE IN PROSTATE CANCER 28
Application of an in house bioisosteric approach to the design of innovative inhibitors of aldo-keto reductase 1C3 (AKR1C3) 23
Effects of new hydroxyazoles inhibitors of AKR1C3 on vitality of prostate and colorectal cancer cell lines 15
A new generation of AKR1C3 inhibitors on the horizon: the 3- hydroxybenzazole approach to target prostate cancer 15
NEW AKR1C3 INHIBITORS WITH BENZOISOXAZOLE CORE: DESIGN, SYNTHESIS AND BIOLOGICAL ACTIVITY TO TARGET PROSTATE CANCER 9
Exploring the Potential of Sulfur Moieties in Compounds Inhibiting Steroidogenesis 7
Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer 5
Totale 8.642
Categoria #
all - tutte 24.194
article - articoli 0
book - libri 0
conference - conferenze 8.529
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 32.723


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/201996 0 0 0 0 0 0 0 0 0 0 0 96
2019/20201.307 60 51 64 138 96 242 151 105 131 103 96 70
2020/20211.136 123 80 70 75 116 92 52 58 152 80 106 132
2021/20221.211 55 58 90 114 58 46 50 52 55 107 294 232
2022/20231.685 179 165 44 159 163 388 145 103 150 31 98 60
2023/2024988 111 151 71 67 101 132 139 63 7 70 48 28
Totale 8.642