BERTOTTI, Andrea
BERTOTTI, Andrea
ONCOLOGIA
A molecularly annotated platform of patient-derived xenografts (‘xenopatients’) identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer
2011-01-01 Bertotti A; Migliardi G; Galimi F; Sassi F; Torti D; Isella C; Corà D; Di Nicolantonio F; Buscarino M; Petti C; Ribero D; Russolillo N; Muratore A; Massucco P; Pisacane A; Molinaro L; Valtorta E; Sartore-Bianchi A; Risio M; Capussotti L; Gambacorta M; Siena S; Medico E; Sapino A; Marsoni S; Comoglio PM; Bardelli A†; Trusolino L† (†Co-Senior authors)
A preclinical algorithm of soluble surrogate biomarkers that correlate with therapeutic inhibition of the MET oncogene in gastric tumors.
2012-01-01 D. Torti;F. Sassi;F. Galimi;S. Gastaldi;T. Perera;P. M. Comoglio;L. Trusolino*; A. Bertotti* (*Co-Senior Authors)
A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth.
2001-01-01 L. TRUSOLINO; A. BERTOTTI; P.M. COMOGLIO
Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition.
2010-01-01 S. Corso;E. Ghiso;V. Cepero;J. R. Sierra;C. Migliore;A. Bertotti;L. Trusolino;P. M. Comoglio;S. Giordano
Adaptive mutability of colorectal cancers in response to targeted therapies
2019-01-01 Russo M.; Crisafulli G.; Sogari A.; Reilly N.M.; Arena S.; Lamba S.; Bartolini A.; Amodio V.; Magri A.; Novara L.; Sarotto I.; Nagel Z.D.; Piett C.G.; Amatu A.; Sartore-Bianchi A.; Siena S.; Bertotti A.; Trusolino L.; Corigliano M.; Gherardi M.; Lagomarsino M.C.; Di Nicolantonio F.; Bardelli A.
Amplification of the MET Receptor Drives Resistance to Anti-EGFR Therapies in Colorectal Cancer.
2013-01-01 Bardelli A*;Corso S*;Bertotti A*;Hobor S;Valtorta E;Siravegna G;Sartore-Bianchi A;Scala E;Cassingena A;Zecchin D;Apicella M;Migliardi G;Galimi F;Lauricella C;Zanon C;Perera T;Veronese S;Corti G;Amatu A;Gambacorta M;Diaz LA Jr;Sausen M;Velculescu VE;Comoglio P;Trusolino L;Di Nicolantonio F;Giordano S;Siena S (*Co-First Authors)
Animal research: Temper Italy's strict lab-animal law.
2013-01-01 Trusolino L;Bertotti A
Anti-cancer effect and gene modulation of ET-743 in human biliary tract carcinoma preclinical models.
2014-01-01 Peraldo-Neia C;Cavalloni G;Soster M;Gammaitoni L;Marchiò S;Sassi F;Trusolino L;Bertotti A;Medico E;Capussotti L;Aglietta M;Leone F
Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth.
2006-01-01 Bertotti A; Comoglio PM; Trusolino L
beta4 integrin is a transforming molecule that unleashes Met tyrosine kinase tumorigenesis.
2005-01-01 Bertotti A; Comoglio PM; Trusolino L
Chromatin Velocity reveals epigenetic dynamics by single-cell profiling of heterochromatin and euchromatin
2022-01-01 Tedesco, Martina; Giannese, Francesca; Lazarević, Dejan; Giansanti, Valentina; Rosano, Dalia; Monzani, Silvia; Catalano, Irene; Grassi, Elena; Zanella, Eugenia R; Botrugno, Oronza A; Morelli, Leonardo; Panina Bordignon, Paola; Caravagna, Giulio; Bertotti, Andrea; Martino, Gianvito; Aldrighetti, Luca; Pasqualato, Sebastiano; Trusolino, Livio; Cittaro, Davide; Tonon, Giovanni
Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype
2020-01-01 Lupo, Barbara; Sassi, Francesco; Pinnelli, Marika; Galimi, Francesco; Zanella, Eugenia R.; Vurchio, Valentina; Migliardi, Giorgia; Gagliardi, Paolo Armando; Puliafito, Alberto; Manganaro, Daria; Luraghi, Paolo; Kragh, Michael; Pedersen, Mikkel W.; Horak, Ivan D.; Boccaccio, Carla; Medico, Enzo; Primo, Luca; Nichol, Daniel; Spiteri, Inmaculada; Heide, Timon; Vatsiou, Alexandra; Graham, Trevor A.; Élez, Elena; Argiles, Guillem; Nuciforo, Paolo; Sottoriva, Andrea; Dienstmann, Rodrigo; Pasini, Diego; Grassi, Elena; Isella, Claudio; Bertotti, Andrea; Trusolino, Livio
Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models
2019-01-01 Belli, Valentina; Matrone, Nunzia; Napolitano, Stefania; Migliardi, Giorgia; Cottino, Francesca; Bertotti, Andrea; Trusolino, Livio; Martinelli, Erika; Morgillo, Floriana; Ciardiello, Davide; De Falco, Vincenzo; Giunta, Emilio Francesco; Bracale, Umberto; Ciardiello, Fortunato; Troiani, Teresa
Compensatory pathways in oncogenic kinase signaling and resistance to targeted therapies: Six degrees of separation
2012-01-01 Trusolino L; Bertotti A
Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts
2021-01-01 Woo, Xing Yi; Giordano, Jessica; Srivastava, Anuj; Zhao, Zi-Ming; Lloyd, Michael W.; de Bruijn, Roebi; Suh, Yun-Suhk; Patidar, Rajesh; Chen, Li; Scherer, Sandra; Bailey, Matthew H.; Yang, Chieh-Hsiang; Cortes-Sanchez, Emilio; Xi, Yuanxin; Wang, Jing; Wickramasinghe, Jayamanna; Kossenkov, Andrew V.; Rebecca, Vito W.; Sun, Hua; Mashl, R. Jay; Davies, Sherri R.; Jeon, Ryan; Frech, Christian; Randjelovic, Jelena; Rosains, Jacqueline; Galimi, Francesco; Bertotti, Andrea; Lafferty, Adam; O’Farrell, Alice C.; Modave, Elodie; Lambrechts, Diether; ter Brugge, Petra; Serra, Violeta; Marangoni, Elisabetta; El Botty, Rania; Kim, Hyunsoo; Kim, Jong-Il; Yang, Han-Kwang; Lee, Charles; Dean, Dennis A.; Davis-Dusenbery, Brandi; Evrard, Yvonne A.; Doroshow, James H.; Welm, Alana L.; Welm, Bryan E.; Lewis, Michael T.; Fang, Bingliang; Roth, Jack A.; Meric-Bernstam, Funda; Herlyn, Meenhard; Davies, Michael A.; Ding, Li; Li, Shunqiang; Govindan, Ramaswamy; Isella, Claudio; Moscow, Jeffrey A.; Trusolino, Livio; Byrne, Annette T.; Jonkers, Jos; Bult, Carol J.; Medico, Enzo; Chuang, Jeffrey H.; Giordano, Silvia; Corso, Simona;
Cytokine-induced killer cells eradicate bone and soft-tissue sarcomas.
2014-01-01 Sangiolo D; Mesiano G; Gammaitoni L; Leuci V; Todorovic M; Giraudo L; Cammarata C; Dell'aglio C; D'Ambrosio L; Pisacane A; Sarotto I; Miano S; Ferrero I; Carnevale-Schianca F; Pignochino Y; Sassi F; Bertotti A; Piacibello W; Fagioli F; Aglietta M; Grignani G.
Derivation and charaterization of cancer initialling cells representative of metastatic colorectal cancer genetic heterogeneity
2015-01-01 V. Bigatto, P. Luraghi, E. Cipriano, G. _Reato, F.N.Orzan, R. Neggia, A. Bertotti, L. Trusolino, P.M.Comoglio, C. Boccaccio
A diphtheria toxin resistance marker for in vitro and in vivo selection of stably transduced human cells
2015-01-01 Picco, Gabriele; Petti, Consalvo; Trusolino, Livio; Bertotti, Andrea; Medico, Enzo
Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): A proof-of-concept, multicentre, open-label, phase 2 trial
2016-01-01 Sartore-Bianchi, Andrea; Trusolino, Livio*; Martino, Cosimo; Bencardino, Katia; Lonardi, Sara; Bergamo, Francesca; Zagonel, Vittorina; Leone, Francesco; Depetris, Ilaria; Martinelli, Erika; Troiani, Teresa; Ciardiello, Fortunato; Racca, Patrizia; Bertotti, Andrea; Siravegna, Giulia; Torri, Valter; Amatu, Alessio; Ghezzi, Silvia; Marrapese, Giovanna; Palmeri, Laura; Valtorta, Emanuele; Cassingena, Andrea; Lauricella, Calogero; Vanzulli, Angelo; Regge, Daniele; Veronese, Silvio; Comoglio, Paolo M.; Bardelli, Alberto*; Marsoni, Silvia*; Siena, Salvatore* (*Co-Senior Authors)
Effective drug combinations in breast, colon and pancreatic cancer cells
2022-01-01 Jaaks P.; Coker E.A.; Vis D.J.; Edwards O.; Carpenter E.F.; Leto S.M.; Dwane L.; Sassi F.; Lightfoot H.; Barthorpe S.; van der Meer D.; Yang W.; Beck A.; Mironenko T.; Hall C.; Hall J.; Mali I.; Richardson L.; Tolley C.; Morris J.; Thomas F.; Lleshi E.; Aben N.; Benes C.H.; Bertotti A.; Trusolino L.; Wessels L.; Garnett M.J.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A molecularly annotated platform of patient-derived xenografts (‘xenopatients’) identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer | 2011 | Bertotti A; Migliardi G; Galimi F; Sassi F; Torti D; Isella C; Corà D; Di Nicolantonio F; Buscarino M; Petti C; Ribero D; Russolillo N; Muratore A; Massucco P; Pisacane A; Molinaro L; Valtorta E; Sartore-Bianchi A; Risio M; Capussotti L; Gambacorta M; Siena S; Medico E; Sapino A; Marsoni S; Comoglio PM; Bardelli A†; Trusolino L† (†Co-Senior authors) | |
| A preclinical algorithm of soluble surrogate biomarkers that correlate with therapeutic inhibition of the MET oncogene in gastric tumors. | 2012 | D. Torti;F. Sassi;F. Galimi;S. Gastaldi;T. Perera;P. M. Comoglio;L. Trusolino*; A. Bertotti* (*Co-Senior Authors) | |
| A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth. | 2001 | L. TRUSOLINO; A. BERTOTTI; P.M. COMOGLIO | |
| Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition. | 2010 | S. Corso;E. Ghiso;V. Cepero;J. R. Sierra;C. Migliore;A. Bertotti;L. Trusolino;P. M. Comoglio;S. Giordano | |
| Adaptive mutability of colorectal cancers in response to targeted therapies | 2019 | Russo M.; Crisafulli G.; Sogari A.; Reilly N.M.; Arena S.; Lamba S.; Bartolini A.; Amodio V.; Magri A.; Novara L.; Sarotto I.; Nagel Z.D.; Piett C.G.; Amatu A.; Sartore-Bianchi A.; Siena S.; Bertotti A.; Trusolino L.; Corigliano M.; Gherardi M.; Lagomarsino M.C.; Di Nicolantonio F.; Bardelli A. | |
| Amplification of the MET Receptor Drives Resistance to Anti-EGFR Therapies in Colorectal Cancer. | 2013 | Bardelli A*;Corso S*;Bertotti A*;Hobor S;Valtorta E;Siravegna G;Sartore-Bianchi A;Scala E;Cassingena A;Zecchin D;Apicella M;Migliardi G;Galimi F;Lauricella C;Zanon C;Perera T;Veronese S;Corti G;Amatu A;Gambacorta M;Diaz LA Jr;Sausen M;Velculescu VE;Comoglio P;Trusolino L;Di Nicolantonio F;Giordano S;Siena S (*Co-First Authors) | |
| Animal research: Temper Italy's strict lab-animal law. | 2013 | Trusolino L;Bertotti A | |
| Anti-cancer effect and gene modulation of ET-743 in human biliary tract carcinoma preclinical models. | 2014 | Peraldo-Neia C;Cavalloni G;Soster M;Gammaitoni L;Marchiò S;Sassi F;Trusolino L;Bertotti A;Medico E;Capussotti L;Aglietta M;Leone F | |
| Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth. | 2006 | Bertotti A; Comoglio PM; Trusolino L | |
| beta4 integrin is a transforming molecule that unleashes Met tyrosine kinase tumorigenesis. | 2005 | Bertotti A; Comoglio PM; Trusolino L | |
| Chromatin Velocity reveals epigenetic dynamics by single-cell profiling of heterochromatin and euchromatin | 2022 | Tedesco, Martina; Giannese, Francesca; Lazarević, Dejan; Giansanti, Valentina; Rosano, Dalia; Monzani, Silvia; Catalano, Irene; Grassi, Elena; Zanella, Eugenia R; Botrugno, Oronza A; Morelli, Leonardo; Panina Bordignon, Paola; Caravagna, Giulio; Bertotti, Andrea; Martino, Gianvito; Aldrighetti, Luca; Pasqualato, Sebastiano; Trusolino, Livio; Cittaro, Davide; Tonon, Giovanni | |
| Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype | 2020 | Lupo, Barbara; Sassi, Francesco; Pinnelli, Marika; Galimi, Francesco; Zanella, Eugenia R.; Vurchio, Valentina; Migliardi, Giorgia; Gagliardi, Paolo Armando; Puliafito, Alberto; Manganaro, Daria; Luraghi, Paolo; Kragh, Michael; Pedersen, Mikkel W.; Horak, Ivan D.; Boccaccio, Carla; Medico, Enzo; Primo, Luca; Nichol, Daniel; Spiteri, Inmaculada; Heide, Timon; Vatsiou, Alexandra; Graham, Trevor A.; Élez, Elena; Argiles, Guillem; Nuciforo, Paolo; Sottoriva, Andrea; Dienstmann, Rodrigo; Pasini, Diego; Grassi, Elena; Isella, Claudio; Bertotti, Andrea; Trusolino, Livio | |
| Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models | 2019 | Belli, Valentina; Matrone, Nunzia; Napolitano, Stefania; Migliardi, Giorgia; Cottino, Francesca; Bertotti, Andrea; Trusolino, Livio; Martinelli, Erika; Morgillo, Floriana; Ciardiello, Davide; De Falco, Vincenzo; Giunta, Emilio Francesco; Bracale, Umberto; Ciardiello, Fortunato; Troiani, Teresa | |
| Compensatory pathways in oncogenic kinase signaling and resistance to targeted therapies: Six degrees of separation | 2012 | Trusolino L; Bertotti A | |
| Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts | 2021 | Woo, Xing Yi; Giordano, Jessica; Srivastava, Anuj; Zhao, Zi-Ming; Lloyd, Michael W.; de Bruijn, Roebi; Suh, Yun-Suhk; Patidar, Rajesh; Chen, Li; Scherer, Sandra; Bailey, Matthew H.; Yang, Chieh-Hsiang; Cortes-Sanchez, Emilio; Xi, Yuanxin; Wang, Jing; Wickramasinghe, Jayamanna; Kossenkov, Andrew V.; Rebecca, Vito W.; Sun, Hua; Mashl, R. Jay; Davies, Sherri R.; Jeon, Ryan; Frech, Christian; Randjelovic, Jelena; Rosains, Jacqueline; Galimi, Francesco; Bertotti, Andrea; Lafferty, Adam; O’Farrell, Alice C.; Modave, Elodie; Lambrechts, Diether; ter Brugge, Petra; Serra, Violeta; Marangoni, Elisabetta; El Botty, Rania; Kim, Hyunsoo; Kim, Jong-Il; Yang, Han-Kwang; Lee, Charles; Dean, Dennis A.; Davis-Dusenbery, Brandi; Evrard, Yvonne A.; Doroshow, James H.; Welm, Alana L.; Welm, Bryan E.; Lewis, Michael T.; Fang, Bingliang; Roth, Jack A.; Meric-Bernstam, Funda; Herlyn, Meenhard; Davies, Michael A.; Ding, Li; Li, Shunqiang; Govindan, Ramaswamy; Isella, Claudio; Moscow, Jeffrey A.; Trusolino, Livio; Byrne, Annette T.; Jonkers, Jos; Bult, Carol J.; Medico, Enzo; Chuang, Jeffrey H.; Giordano, Silvia; Corso, Simona; | |
| Cytokine-induced killer cells eradicate bone and soft-tissue sarcomas. | 2014 | Sangiolo D; Mesiano G; Gammaitoni L; Leuci V; Todorovic M; Giraudo L; Cammarata C; Dell'aglio C; D'Ambrosio L; Pisacane A; Sarotto I; Miano S; Ferrero I; Carnevale-Schianca F; Pignochino Y; Sassi F; Bertotti A; Piacibello W; Fagioli F; Aglietta M; Grignani G. | |
| Derivation and charaterization of cancer initialling cells representative of metastatic colorectal cancer genetic heterogeneity | 2015 | V. Bigatto, P. Luraghi, E. Cipriano, G. _Reato, F.N.Orzan, R. Neggia, A. Bertotti, L. Trusolino, P.M.Comoglio, C. Boccaccio | |
| A diphtheria toxin resistance marker for in vitro and in vivo selection of stably transduced human cells | 2015 | Picco, Gabriele; Petti, Consalvo; Trusolino, Livio; Bertotti, Andrea; Medico, Enzo | |
| Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): A proof-of-concept, multicentre, open-label, phase 2 trial | 2016 | Sartore-Bianchi, Andrea; Trusolino, Livio*; Martino, Cosimo; Bencardino, Katia; Lonardi, Sara; Bergamo, Francesca; Zagonel, Vittorina; Leone, Francesco; Depetris, Ilaria; Martinelli, Erika; Troiani, Teresa; Ciardiello, Fortunato; Racca, Patrizia; Bertotti, Andrea; Siravegna, Giulia; Torri, Valter; Amatu, Alessio; Ghezzi, Silvia; Marrapese, Giovanna; Palmeri, Laura; Valtorta, Emanuele; Cassingena, Andrea; Lauricella, Calogero; Vanzulli, Angelo; Regge, Daniele; Veronese, Silvio; Comoglio, Paolo M.; Bardelli, Alberto*; Marsoni, Silvia*; Siena, Salvatore* (*Co-Senior Authors) | |
| Effective drug combinations in breast, colon and pancreatic cancer cells | 2022 | Jaaks P.; Coker E.A.; Vis D.J.; Edwards O.; Carpenter E.F.; Leto S.M.; Dwane L.; Sassi F.; Lightfoot H.; Barthorpe S.; van der Meer D.; Yang W.; Beck A.; Mironenko T.; Hall C.; Hall J.; Mali I.; Richardson L.; Tolley C.; Morris J.; Thomas F.; Lleshi E.; Aben N.; Benes C.H.; Bertotti A.; Trusolino L.; Wessels L.; Garnett M.J. |