SASSI, FRANCESCO
SASSI, FRANCESCO
Dip. SCIENZE ONCOLOGICHE - Candiolo (attivo dal 01/01/2002 al 30/04/2013)
A molecularly annotated platform of patient-derived xenografts (‘xenopatients’) identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer
2011-01-01 Bertotti A; Migliardi G; Galimi F; Sassi F; Torti D; Isella C; Corà D; Di Nicolantonio F; Buscarino M; Petti C; Ribero D; Russolillo N; Muratore A; Massucco P; Pisacane A; Molinaro L; Valtorta E; Sartore-Bianchi A; Risio M; Capussotti L; Gambacorta M; Siena S; Medico E; Sapino A; Marsoni S; Comoglio PM; Bardelli A†; Trusolino L† (†Co-Senior authors)
A preclinical algorithm of soluble surrogate biomarkers that correlate with therapeutic inhibition of the MET oncogene in gastric tumors.
2012-01-01 D. Torti;F. Sassi;F. Galimi;S. Gastaldi;T. Perera;P. M. Comoglio;L. Trusolino*; A. Bertotti* (*Co-Senior Authors)
Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype
2020-01-01 Lupo, Barbara; Sassi, Francesco; Pinnelli, Marika; Galimi, Francesco; Zanella, Eugenia R.; Vurchio, Valentina; Migliardi, Giorgia; Gagliardi, Paolo Armando; Puliafito, Alberto; Manganaro, Daria; Luraghi, Paolo; Kragh, Michael; Pedersen, Mikkel W.; Horak, Ivan D.; Boccaccio, Carla; Medico, Enzo; Primo, Luca; Nichol, Daniel; Spiteri, Inmaculada; Heide, Timon; Vatsiou, Alexandra; Graham, Trevor A.; Élez, Elena; Argiles, Guillem; Nuciforo, Paolo; Sottoriva, Andrea; Dienstmann, Rodrigo; Pasini, Diego; Grassi, Elena; Isella, Claudio; Bertotti, Andrea; Trusolino, Livio
Efficacy of NEDD8 Pathway Inhibition in Preclinical Models of Poorly Differentiated, Clinically Aggressive Colorectal Cancer
2017-01-01 Picco, Gabriele; Petti, Consalvo; Sassi, Francesco; Grillone, Katia; Migliardi, Giorgia; Rossi, Teresa; Isella, Claudio; Di Nicolantonio, Federica; Sarotto, Ivana; Sapino, Anna; Bardelli, Alberto; Trusolino, Livio; Bertotti, Andrea; Medico, Enzo
Genetic and expression analysis of MET, MACC1 and HGF in metastatic colorectal cancer: Response to Met inhibition in patient xenografts and pathological correlations
2011-01-01 Francesco Galimi; Davide Torti; Francesco Sassi; Claudio Isella; Davide Corà; Stefania Gastaldi; Dario Ribero; Andrea Muratore; Paolo Massucco; Dimitrios Siatis; Gianluca Paraluppi; Federica Gonella; Francesca Maione; Alberto Pisacane; Ezio David; Bruno Torchio; Mauro Risio; Mauro Salizzoni; Lorenzo Capussotti; Tim Perera; Enzo Medico; M.F. Di Renzo; Paolo M. Comoglio; Livio Trusolino*; Andrea Bertotti* (*Co-Senior Authors)
The genomic landscape of response to EGFR blockade in colorectal cancer
2015-01-01 Bertotti, Andrea*; Papp, Eniko; Jones, Siân; Adleff, Vilmos; Anagnostou, Valsamo; Lupo, Barbara; Sausen, Mark; Phallen, Jillian; Hruban, Carolyn A.; Tokheim, Collin; Niknafs, Noushin; Nesselbush, Monica; Lytle, Karli; Sassi, Francesco; Cottino, Francesca; Migliardi, Giorgia; Zanella, Eugenia R.; Ribero, Dario; Russolillo, Nadia; Mellano, Alfredo; Muratore, Andrea; Paraluppi, Gianluca; Salizzoni, Mauro; Marsoni, Silvia; Kragh, Michael; Lantto, Johan; Cassingena, Andrea; Li, Qing Kay; Karchin, Rachel; Scharpf, Robert; Sartore-Bianchi, Andrea; Siena, Salvatore; Diaz, Luis A.; Trusolino, Livio*; Velculescu, Victor E*. (*Co-Senior e Corresponding Authors)
Heat-shock protein 27 (HSP27, HSPB1) is up-regulated by MET kinase inhibitors and confers resistance to MET-targeted therapy.
2014-01-01 Musiani, Daniele; Konda, John David; Pavan, Simona; Torchiaro, Erica; Sassi, Francesco; Noghero, Alessio; Erriquez, Jessica; Perera, Timothy; Olivero, Martina; Di Renzo, Maria Flavia
High-dose Vitamin C enhances cancer immunotherapy
2020-01-01 Magri A.; Germano G.; Lorenzato A.; Lamba S.; Chila R.; Montone M.; Amodio V.; Ceruti T.; Sassi F.; Arena S.; Abrignani S.; D'Incalci M.; Zucchetti M.; Di Nicolantonio F. *; Bardelli A.*; *co-last and corresponding authors
Identification and pre-clinical validation of surrogate soluble biomarkers correlating with therapeutic response to met inhibition
2010-01-01 Torti D; Bertotti A; Galimi F; Gastaldi S; Sassi F; Trusolino L
IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies.
2015-01-01 Zanella ER;Galimi F;Sassi F;Migliardi G;Cottino F;Leto SM;Lupo B;Erriquez J;Isella C;Comoglio PM;Medico E;Tejpar S;Budinsk E;Trusolino L*;Bertotti A*(*Co-Senior e Corresponding Authors)
INHIBITION OF MEK AND PI3K/MTOR SUPPRESSES TUMOR GROWTH BUT DOES NOT CAUSE TUMOR REGRESSION IN PATIENT-DERIVED XENOGRAFTS OF RAS-MUTANT COLORECTAL CARCINOMAS
2012-01-01 Giorgia Migliardi; Francesco Sassi; Davide Torti; Francesco Galimi; Eugenia R. Zanella; Michela Buscarino; Dario Ribero; Andrea Muratore; Paolo Massucco; Alberto Pisacane; Mauro Risio; Lorenzo Capussotti; Silvia Marsoni; Federica Di Nicolantonio; Alberto Bardelli; Paolo M. Comoglio; Livio Trusolino*; Andrea Bertotti* (*Co-Senior Authors)
Met as a potential therapeutic target in basal-like breast cancer
2010-01-01 Gastaldi S; Bertotti A; Galimi F; Sassi F; Torti D; Smalley M; Trusolino L
MET signaling in colon cancer stem-like cells blunts the therapeutic response to EGFR inhibitors.
2014-01-01 Luraghi P;Reato G;Cipriano E;Sassi F;Orzan F;Bigatto V;De Bacco F;Menietti E;Han M;Rideout WM;Perera T;Bertotti A;Trusolino L;Comoglio PM;Boccaccio C
MET SIGNALING REGULATES GROWTH, REPOPULATING POTENTIAL AND BASAL CELL-FATE COMMITMENT OF MAMMARY LUMINAL PROGENITORS: IMPLICATIONS FOR BASAL-LIKE BREAST CANCER.
2012-01-01 Paolo Accornero; Stefania Gastaldi; Francesco Sassi; Davide Torti; Silvia Miretti; Eugenio Martignani; Mario Baratta; Matthew J Smalley; Andrea Bertotti; Livio Trusolino
Met signaling regulates growth, repopulating potential and basal cell-fate commitment of mammary luminal progenitors: implications for basal-like breast cancer.
2013-01-01 S. Gastaldi; F. Sassi; P. Accornero; D. Torti; F. Galimi; G. Migliardi; G. Molyneux; T. Perera; P. M. Comoglio; C. Boccaccio; M. J. Smalley; A. Bertotti*; L. Trusolino* (*Co-Senior Authors)
Mixed lineage kinase MLK4 is activated in colorectal cancers where it synergistically cooperates with activated RAS signaling in driving tumorigenesis
2013-01-01 M. Martini; M. Russo; S. Lamba; E. Vitiello; E. H. Crowley; F. Sassi; D. Romanelli; M. Frattini; A. Marchetti; A. Bardelli
Modeling tumor progression and identifying genotype-drug interactions by the sequential introduction of cancer mutations into the genome of human normal cells
2011-01-01 Davide Zecchin; Margherita Gallicchio; Valentina Boscaro; Francesco Sassi; Enzo Medico; Federica Di Nicolantonio; Alberto Bardelli.
Molecular Subtyping Combined with Biological Pathway Analyses to Study Regorafenib Response in Clinically Relevant Mouse Models of Colorectal Cancer
2021-01-01 Lafferty, Adam; O'Farrell, Alice C; Migliardi, Giorgia; Khemka, Niraj; Lindner, Andreas U; Sassi, Francesco; Zanella, Eugenia R; Salvucci, Manuela; Vanderheyden, Evy; Modave, Elodie; Boeckx, Bram; Halang, Luise; Betge, Johannes; Ebert, Matthias P A; Dicker, Patrick; Argilés, Guillem; Tabernero, Josep; Dienstmann, Rodrigo; Medico, Enzo; Lambrechts, Diether; Bertotti, Andrea; Isella, Claudio; Trusolino, Livio; Prehn, Jochen H M; Byrne, Annette T
A molecularly annotated model of patient-derived colon cancer stem-like cells to assess genetic and non-genetic mechanisms of resistance to anti-EGFR therapy
2018-01-01 Luraghi, Paolo; Bigatto, Viola; Cipriano, Elia; Reato, Gigliola; Orzan, Francesca; Sassi, Francesco; De Bacco, Francesca; Isella, Claudio; Bellomo, Sara Erika; Medico, Enzo; Comoglio, Paolo M; Bertotti, Andrea; Trusolino, Livio; Boccaccio, Carla
Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling
2021-01-01 Ponsioen B.; Post J.B.; Buissant des Amorie J.R.; Laskaris D.; van Ineveld R.L.; Kersten S.; Bertotti A.; Sassi F.; Sipieter F.; Cappe B.; Mertens S.; Verlaan-Klink I.; Boj S.F.; Vries R.G.J.; Rehmann H.; Vandenabeele P.; Riquet F.B.; Trusolino L.; Bos J.L.; Snippert H.J.G.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A molecularly annotated platform of patient-derived xenografts (‘xenopatients’) identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer | 2011 | Bertotti A; Migliardi G; Galimi F; Sassi F; Torti D; Isella C; Corà D; Di Nicolantonio F; Buscarino M; Petti C; Ribero D; Russolillo N; Muratore A; Massucco P; Pisacane A; Molinaro L; Valtorta E; Sartore-Bianchi A; Risio M; Capussotti L; Gambacorta M; Siena S; Medico E; Sapino A; Marsoni S; Comoglio PM; Bardelli A†; Trusolino L† (†Co-Senior authors) | |
| A preclinical algorithm of soluble surrogate biomarkers that correlate with therapeutic inhibition of the MET oncogene in gastric tumors. | 2012 | D. Torti;F. Sassi;F. Galimi;S. Gastaldi;T. Perera;P. M. Comoglio;L. Trusolino*; A. Bertotti* (*Co-Senior Authors) | |
| Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype | 2020 | Lupo, Barbara; Sassi, Francesco; Pinnelli, Marika; Galimi, Francesco; Zanella, Eugenia R.; Vurchio, Valentina; Migliardi, Giorgia; Gagliardi, Paolo Armando; Puliafito, Alberto; Manganaro, Daria; Luraghi, Paolo; Kragh, Michael; Pedersen, Mikkel W.; Horak, Ivan D.; Boccaccio, Carla; Medico, Enzo; Primo, Luca; Nichol, Daniel; Spiteri, Inmaculada; Heide, Timon; Vatsiou, Alexandra; Graham, Trevor A.; Élez, Elena; Argiles, Guillem; Nuciforo, Paolo; Sottoriva, Andrea; Dienstmann, Rodrigo; Pasini, Diego; Grassi, Elena; Isella, Claudio; Bertotti, Andrea; Trusolino, Livio | |
| Efficacy of NEDD8 Pathway Inhibition in Preclinical Models of Poorly Differentiated, Clinically Aggressive Colorectal Cancer | 2017 | Picco, Gabriele; Petti, Consalvo; Sassi, Francesco; Grillone, Katia; Migliardi, Giorgia; Rossi, Teresa; Isella, Claudio; Di Nicolantonio, Federica; Sarotto, Ivana; Sapino, Anna; Bardelli, Alberto; Trusolino, Livio; Bertotti, Andrea; Medico, Enzo | |
| Genetic and expression analysis of MET, MACC1 and HGF in metastatic colorectal cancer: Response to Met inhibition in patient xenografts and pathological correlations | 2011 | Francesco Galimi; Davide Torti; Francesco Sassi; Claudio Isella; Davide Corà; Stefania Gastaldi; Dario Ribero; Andrea Muratore; Paolo Massucco; Dimitrios Siatis; Gianluca Paraluppi; Federica Gonella; Francesca Maione; Alberto Pisacane; Ezio David; Bruno Torchio; Mauro Risio; Mauro Salizzoni; Lorenzo Capussotti; Tim Perera; Enzo Medico; M.F. Di Renzo; Paolo M. Comoglio; Livio Trusolino*; Andrea Bertotti* (*Co-Senior Authors) | |
| The genomic landscape of response to EGFR blockade in colorectal cancer | 2015 | Bertotti, Andrea*; Papp, Eniko; Jones, Siân; Adleff, Vilmos; Anagnostou, Valsamo; Lupo, Barbara; Sausen, Mark; Phallen, Jillian; Hruban, Carolyn A.; Tokheim, Collin; Niknafs, Noushin; Nesselbush, Monica; Lytle, Karli; Sassi, Francesco; Cottino, Francesca; Migliardi, Giorgia; Zanella, Eugenia R.; Ribero, Dario; Russolillo, Nadia; Mellano, Alfredo; Muratore, Andrea; Paraluppi, Gianluca; Salizzoni, Mauro; Marsoni, Silvia; Kragh, Michael; Lantto, Johan; Cassingena, Andrea; Li, Qing Kay; Karchin, Rachel; Scharpf, Robert; Sartore-Bianchi, Andrea; Siena, Salvatore; Diaz, Luis A.; Trusolino, Livio*; Velculescu, Victor E*. (*Co-Senior e Corresponding Authors) | |
| Heat-shock protein 27 (HSP27, HSPB1) is up-regulated by MET kinase inhibitors and confers resistance to MET-targeted therapy. | 2014 | Musiani, Daniele; Konda, John David; Pavan, Simona; Torchiaro, Erica; Sassi, Francesco; Noghero, Alessio; Erriquez, Jessica; Perera, Timothy; Olivero, Martina; Di Renzo, Maria Flavia | |
| High-dose Vitamin C enhances cancer immunotherapy | 2020 | Magri A.; Germano G.; Lorenzato A.; Lamba S.; Chila R.; Montone M.; Amodio V.; Ceruti T.; Sassi F.; Arena S.; Abrignani S.; D'Incalci M.; Zucchetti M.; Di Nicolantonio F. *; Bardelli A.*; *co-last and corresponding authors | |
| Identification and pre-clinical validation of surrogate soluble biomarkers correlating with therapeutic response to met inhibition | 2010 | Torti D; Bertotti A; Galimi F; Gastaldi S; Sassi F; Trusolino L | |
| IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies. | 2015 | Zanella ER;Galimi F;Sassi F;Migliardi G;Cottino F;Leto SM;Lupo B;Erriquez J;Isella C;Comoglio PM;Medico E;Tejpar S;Budinsk E;Trusolino L*;Bertotti A*(*Co-Senior e Corresponding Authors) | |
| INHIBITION OF MEK AND PI3K/MTOR SUPPRESSES TUMOR GROWTH BUT DOES NOT CAUSE TUMOR REGRESSION IN PATIENT-DERIVED XENOGRAFTS OF RAS-MUTANT COLORECTAL CARCINOMAS | 2012 | Giorgia Migliardi; Francesco Sassi; Davide Torti; Francesco Galimi; Eugenia R. Zanella; Michela Buscarino; Dario Ribero; Andrea Muratore; Paolo Massucco; Alberto Pisacane; Mauro Risio; Lorenzo Capussotti; Silvia Marsoni; Federica Di Nicolantonio; Alberto Bardelli; Paolo M. Comoglio; Livio Trusolino*; Andrea Bertotti* (*Co-Senior Authors) | |
| Met as a potential therapeutic target in basal-like breast cancer | 2010 | Gastaldi S; Bertotti A; Galimi F; Sassi F; Torti D; Smalley M; Trusolino L | |
| MET signaling in colon cancer stem-like cells blunts the therapeutic response to EGFR inhibitors. | 2014 | Luraghi P;Reato G;Cipriano E;Sassi F;Orzan F;Bigatto V;De Bacco F;Menietti E;Han M;Rideout WM;Perera T;Bertotti A;Trusolino L;Comoglio PM;Boccaccio C | |
| MET SIGNALING REGULATES GROWTH, REPOPULATING POTENTIAL AND BASAL CELL-FATE COMMITMENT OF MAMMARY LUMINAL PROGENITORS: IMPLICATIONS FOR BASAL-LIKE BREAST CANCER. | 2012 | Paolo Accornero; Stefania Gastaldi; Francesco Sassi; Davide Torti; Silvia Miretti; Eugenio Martignani; Mario Baratta; Matthew J Smalley; Andrea Bertotti; Livio Trusolino | |
| Met signaling regulates growth, repopulating potential and basal cell-fate commitment of mammary luminal progenitors: implications for basal-like breast cancer. | 2013 | S. Gastaldi; F. Sassi; P. Accornero; D. Torti; F. Galimi; G. Migliardi; G. Molyneux; T. Perera; P. M. Comoglio; C. Boccaccio; M. J. Smalley; A. Bertotti*; L. Trusolino* (*Co-Senior Authors) | |
| Mixed lineage kinase MLK4 is activated in colorectal cancers where it synergistically cooperates with activated RAS signaling in driving tumorigenesis | 2013 | M. Martini; M. Russo; S. Lamba; E. Vitiello; E. H. Crowley; F. Sassi; D. Romanelli; M. Frattini; A. Marchetti; A. Bardelli | |
| Modeling tumor progression and identifying genotype-drug interactions by the sequential introduction of cancer mutations into the genome of human normal cells | 2011 | Davide Zecchin; Margherita Gallicchio; Valentina Boscaro; Francesco Sassi; Enzo Medico; Federica Di Nicolantonio; Alberto Bardelli. | |
| Molecular Subtyping Combined with Biological Pathway Analyses to Study Regorafenib Response in Clinically Relevant Mouse Models of Colorectal Cancer | 2021 | Lafferty, Adam; O'Farrell, Alice C; Migliardi, Giorgia; Khemka, Niraj; Lindner, Andreas U; Sassi, Francesco; Zanella, Eugenia R; Salvucci, Manuela; Vanderheyden, Evy; Modave, Elodie; Boeckx, Bram; Halang, Luise; Betge, Johannes; Ebert, Matthias P A; Dicker, Patrick; Argilés, Guillem; Tabernero, Josep; Dienstmann, Rodrigo; Medico, Enzo; Lambrechts, Diether; Bertotti, Andrea; Isella, Claudio; Trusolino, Livio; Prehn, Jochen H M; Byrne, Annette T | |
| A molecularly annotated model of patient-derived colon cancer stem-like cells to assess genetic and non-genetic mechanisms of resistance to anti-EGFR therapy | 2018 | Luraghi, Paolo; Bigatto, Viola; Cipriano, Elia; Reato, Gigliola; Orzan, Francesca; Sassi, Francesco; De Bacco, Francesca; Isella, Claudio; Bellomo, Sara Erika; Medico, Enzo; Comoglio, Paolo M; Bertotti, Andrea; Trusolino, Livio; Boccaccio, Carla | |
| Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling | 2021 | Ponsioen B.; Post J.B.; Buissant des Amorie J.R.; Laskaris D.; van Ineveld R.L.; Kersten S.; Bertotti A.; Sassi F.; Sipieter F.; Cappe B.; Mertens S.; Verlaan-Klink I.; Boj S.F.; Vries R.G.J.; Rehmann H.; Vandenabeele P.; Riquet F.B.; Trusolino L.; Bos J.L.; Snippert H.J.G. |