MORELLI, Eugenio
MORELLI, Eugenio
ONCOLOGIA
Inhibition of the LINE1-derived MET transcript induces apoptosis and oncoprotein knockdown in cancer cells
2025-01-01 Miglio, Umberto; Berrino, Enrico; Avanzato, Daniele; Molineris, Ivan; Miano, Valentina; Milan, Melissa; Lanzetti, Letizia; Morelli, Eugenio; Hughes, James M.; De Bortoli, Michele; Sapino, Anna; Venesio, Tiziana
Loss of BCL7A permits IRF4 transcriptional activity and cellular growth in multiple myeloma
2025-01-01 Chakraborty, Chandraditya; Talluri, Srikanth; Binder, Moritz; Morelli, Eugenio; Mayoral, Jessica Encinas; Derebail, Sanika; Samur, Anil Aktas; Epstein, Charles; Anderson, Kenneth C.; Shammas, Masood; Samur, Mehmet K.; Fulciniti, Mariateresa; Munshi, Nikhil C.
CRISPR-Cas13d functional transcriptomics reveals widespread isoform-selective cancer dependencies on lncRNAs
2025-01-01 Morelli, Eugenio; Aktas Samur, Anil; Maisano, Domenico; Gao, Claire; Favasuli, Vanessa Katia; Papaioannou, Dimitrios; De Nola, Giovanni; Henninger, Jonathan E; Liu, Na; Turi, Marcello; Folino, Pietro; Vreux, Laure; Cumerlato, Michela; Chen, Liang; Aifantis, Iannis; Fulciniti, Mariateresa; Anderson, Kenneth C.; Lytton-Jean, Abigail KR; Gulla, Annamaria; Young, Richard; Samur, Mehmet K.; Munshi, Nikhil C.
ID2 suppresses multiple myeloma cell proliferation by repressing the activity of the transcription factor TCF3
2025-01-01 Fulciniti, Mariateresa; Yao, Yao; Perini, Tommaso; Fong Ng, Jessica; Schavgoulidze, Anaïs; Deng, Shuhui; Cui, Jian; Encinas Mayoral, Jessica; Ladisa, Francesco; Young, Ryan M.; Epstein, Charles B.; White, Cassandra M.; Ott, Christopher J.; Gulla, Annamaria; Matulis, Shannon M.; Sperling, Adam S.; Morelli, Eugenio; Boise, Lawrence H.; Binder, Moritz; Szalat, Raphael; Samur, Mehmet K.; Anderson, Kenneth C.; Munshi, Nikhil C.
Targeting Acetyl-CoA Carboxylase Suppresses De Novo Lipogenesis and Tumor Cell Growth in Multiple Myeloma
2025-01-01 Morelli, Eugenio; Ribeiro, Caroline Fidalgo; Rodrigues, Silvia D.; Gao, Claire; Socciarelli, Fabio; Maisano, Domenico; Favasuli, Vanessa; Liu, Na; Todoerti, Katia; Chakraborty, Chandraditya; Yao, Yao; Fulciniti, Mariateresa; Samur, Mehmet; Aktas-Samur, Anil; Amodio, Nicola; Turi, Marcello; Barello, Francesca; Penailillo, Johany; Giallongo, Cesarina; Romano, Alessandra; Gulla, Annamaria; Anderson, Kenneth C.; Inghirami, Giorgio; Munshi, Nikhil C.; Loda, Massimo
Epigenetic regulation of CD38/CD48 by KDM6A mediates NK cell response in multiple myeloma
2024-01-01 Liu J.; Xing L.; Li J.; Wen K.; Liu N.; Liu Y.; Wu G.; Wang S.; Ogiya D.; Song T.-Y.; Kurata K.; Penailillo J.; Morelli E.; Wang T.; Hong X.; Gulla A.; Tai Y.-T.; Munshi N.; Richardson P.; Carrasco R.; Hideshima T.; Anderson K.C.
DIS3 depletion in multiple myeloma causes extensive perturbation in cell cycle progression and centrosome amplification
2024-01-01 Favasuli V.K.; Ronchetti D.; Silvestris I.; Puccio N.; Fabbiano G.; Traini V.; Todoerti K.; Erratico S.; Ciarrocchi A.; Fragliasso V.; Giannandrea D.; Tumiatti F.; Chiaramonte R.; Torrente Y.; Finelli P.; Morelli E.; Munshi N.C.; Bolli N.; Neri A.; Taiana E.
Loss of GABARAP mediates resistance to immunogenic chemotherapy in multiple myeloma
2024-01-01 Gulla, Annamaria; Morelli, Eugenio; Johnstone, Megan; Turi, Marcello; Samur, Mehmet K; Botta, Cirino; Cifric, Selma; Folino, Pietro; Vinaixa, Delaney; Barello, Francesca; Clericuzio, Cole; Favasuli, Vanessa Katia; Maisano, Domenico; Talluri, Srikanth; Prabhala, Rao H; Bianchi, Giada; Fulciniti, Mariateresa; Wen, Kenneth; Kurata, Keiji; Liu, Jiye; Penailillo, Johany; Bragoni, Alberto; Sapino, Anna; Richardson, Paul G; Chauhan, Dharminder; Carrasco, Ruben D; Hideshima, Teru; Munshi, Nikhil C; Anderson, Kenneth C
GPER1 Activation Exerts Anti-Tumor Activity in Multiple Myeloma
2023-01-01 Gallo Cantafio M.E.; Torcasio R.; Scionti F.; Mesuraca M.; Ronchetti D.; Pistoni M.; Bellizzi D.; Passarino G.; Morelli E.; Neri A.; Viglietto G.; Amodio N.
A MIR17HG-derived long noncoding RNA provides an essential chromatin scaffold for protein interaction and myeloma growth
2023-01-01 Morelli E.; Fulciniti M.; Samur M.K.; Ribeiro C.F.; Wert-Lamas L.; Henninger J.E.; Gulla A.; Aktas-Samur A.; Todoerti K.; Talluri S.; Park W.D.; Federico C.; Scionti F.; Amodio N.; Bianchi G.; Johnstone M.; Liu N.; Gramegna D.; Maisano D.; Russo N.A.; Lin C.; Tai Y.-T.; Neri A.; Chauhan D.; Hideshima T.; Shammas M.A.; Tassone P.; Gryaznov S.; Young R.A.; Anderson K.C.; Novina C.D.; Loda M.; Munshi N.C.
BRD9 Degradation Disrupts Ribosome Biogenesis in Multiple Myeloma
2023-01-01 Kurata K.; Samur M.K.; Liow P.; Wen K.; Yamamoto L.; Liu J.; Morelli E.; Gulla A.; Tai Y.-T.; Qi J.; Hideshima T.; Anderson K.C.
CDK7 controls E2F- and MYC-driven proliferative and metabolic vulnerabilities in multiple myeloma
2023-01-01 Yao Y.; Ng J.F.; Park W.D.; Samur M.; Morelli E.; Encinas Mayoral J.; Chyra Z.; Xu Y.; Derebail S.; Epstein C.; Nabet B.; Chesi M.; Gray N.S.; Young R.A.; Kwiatkowski N.; Mitsiades C.; Anderson K.C.; Lin C.Y.; Munshi N.C.; Fulciniti M.
Therapeutic activation of G protein-coupled estrogen receptor 1 in Waldenström Macroglobulinemia
2022-01-01 Morelli E.; Hunter Z.R.; Fulciniti M.; Gulla A.; Perrotta I.D.; Zuccala V.; Federico C.; Juli G.; Manzoni M.; Ronchetti D.; Romeo E.; Gallo Cantafio M.E.; Soncini D.; Maltese L.; Rossi M.; Roccaro A.M.; Cea M.; Tassone P.; Neri A.; Treon S.C.; Munshi N.C.; Viglietto G.; Amodio N.
Bortezomib Induces Anti–Multiple Myeloma Immune Response Mediated by cGAS/STING Pathway Activation
2021-01-01 Gulla A.; Morelli E.; Samur M.K.; Botta C.; Hideshima T.; Bianchi G.; Fulciniti M.; Malvestiti S.; Prabhala R.H.; Talluri S.; Wen K.; Tai Y.-T.; Richardson P.G.; Chauhan D.; Sewastianik T.; Carrasco R.D.; Munshi N.C.; Anderson K.C.
JunB is a key regulator of multiple myeloma bone marrow angiogenesis
2021-01-01 Fan F.; Malvestiti S.; Vallet S.; Lind J.; Garcia-Manteiga J.M.; Morelli E.; Jiang Q.; Seckinger A.; Hose D.; Goldschmidt H.; Stadlbauer A.; Sun C.; Mei H.; Pecherstorfer M.; Bakiri L.; Wagner E.F.; Tonon G.; Sattler M.; Hu Y.; Tassone P.; Jaeger D.; Podar K.
miR17~92 restrains pro-apoptotic BIM to ensure survival of haematopoietic stem and progenitor cells
2020-01-01 Brinkmann K.; Ng A.P.; de Graaf C.A.; Di Rago L.; Hyland C.D.; Morelli E.; Rautela J.; Huntington N.D.; Strasser A.; Alexander W.S.; Herold M.J.
YWHAE/14-3-3e expression impacts the protein load, contributing to proteasome inhibitor sensitivity in multiple myeloma
2020-01-01 Xu Y.; Fulciniti M.; Samur M.K.; Ho M.; Deng S.; Liu L.; Wen K.; Yu T.; Chyra Z.; Dereibal S.; Zhang L.; Yao Y.; Chakraborty C.; Morelli E.; Li N.; Lopez M.A.; Perini T.; Mu S.; An G.; Alonso R.; Bianchi G.; Tai Y.-T.; Anderson K.C.; Qiu L.; Munshi N.C.
Inhibition of haspin kinase promotes cell-intrinsic and extrinsic antitumor activity
2020-01-01 Melms J.C.; Vallabhaneni S.; Mills C.E.; Yapp C.; Chen J.-Y.; Morelli E.; Waszyk P.; Kumar S.; Deming D.; Moret N.; Rodriguez S.; Subramanian K.; Rogava M.; Cartwright A.N.R.; Luoma A.; Mei S.; Brinker T.J.; Miller D.M.; Spektor A.; Schadendorf D.; Riggi N.; Wucherpfennig K.W.; Sorger P.K.; Izar B.
Targeting histone deacetylase 3 (HDAC3) in the bone marrow microenvironment inhibits multiple myeloma proliferation by modulating exosomes and IL-6 trans-signaling
2020-01-01 Ho M.; Chen T.; Liu J.; Dowling P.; Hideshima T.; Zhang L.; Morelli E.; Camci-Unal G.; Wu X.; Tai Y.-T.; Wen K.; Samur M.; Schlossman R.L.; Mazitschek R.; Kavanagh E.L.; Lindsay S.; Harada T.; McCann A.; Anderson K.C.; O'Gorman P.; Bianchi G.
Inhibition of histone methyltransferase DOT1L silences ER gene and blocks proliferation of antiestrogen-resistant breast cancer cells
2019-01-01 Nassa G.; Salvati A.; Tarallo R.; Gigantino V.; Alexandrova E.; Memoli D.; Sellitto A.; Rizzo F.; Malanga D.; Mirante T.; Morelli E.; Nees M.; Akerfelt M.; Kangaspeska S.; Nyman T.A.; Milanesi L.; Giurato G.; Weisz A.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Inhibition of the LINE1-derived MET transcript induces apoptosis and oncoprotein knockdown in cancer cells | 2025 | Miglio, Umberto; Berrino, Enrico; Avanzato, Daniele; Molineris, Ivan; Miano, Valentina; Milan, Melissa; Lanzetti, Letizia; Morelli, Eugenio; Hughes, James M.; De Bortoli, Michele; Sapino, Anna; Venesio, Tiziana | |
| Loss of BCL7A permits IRF4 transcriptional activity and cellular growth in multiple myeloma | 2025 | Chakraborty, Chandraditya; Talluri, Srikanth; Binder, Moritz; Morelli, Eugenio; Mayoral, Jessica Encinas; Derebail, Sanika; Samur, Anil Aktas; Epstein, Charles; Anderson, Kenneth C.; Shammas, Masood; Samur, Mehmet K.; Fulciniti, Mariateresa; Munshi, Nikhil C. | |
| CRISPR-Cas13d functional transcriptomics reveals widespread isoform-selective cancer dependencies on lncRNAs | 2025 | Morelli, Eugenio; Aktas Samur, Anil; Maisano, Domenico; Gao, Claire; Favasuli, Vanessa Katia; Papaioannou, Dimitrios; De Nola, Giovanni; Henninger, Jonathan E; Liu, Na; Turi, Marcello; Folino, Pietro; Vreux, Laure; Cumerlato, Michela; Chen, Liang; Aifantis, Iannis; Fulciniti, Mariateresa; Anderson, Kenneth C.; Lytton-Jean, Abigail KR; Gulla, Annamaria; Young, Richard; Samur, Mehmet K.; Munshi, Nikhil C. | |
| ID2 suppresses multiple myeloma cell proliferation by repressing the activity of the transcription factor TCF3 | 2025 | Fulciniti, Mariateresa; Yao, Yao; Perini, Tommaso; Fong Ng, Jessica; Schavgoulidze, Anaïs; Deng, Shuhui; Cui, Jian; Encinas Mayoral, Jessica; Ladisa, Francesco; Young, Ryan M.; Epstein, Charles B.; White, Cassandra M.; Ott, Christopher J.; Gulla, Annamaria; Matulis, Shannon M.; Sperling, Adam S.; Morelli, Eugenio; Boise, Lawrence H.; Binder, Moritz; Szalat, Raphael; Samur, Mehmet K.; Anderson, Kenneth C.; Munshi, Nikhil C. | |
| Targeting Acetyl-CoA Carboxylase Suppresses De Novo Lipogenesis and Tumor Cell Growth in Multiple Myeloma | 2025 | Morelli, Eugenio; Ribeiro, Caroline Fidalgo; Rodrigues, Silvia D.; Gao, Claire; Socciarelli, Fabio; Maisano, Domenico; Favasuli, Vanessa; Liu, Na; Todoerti, Katia; Chakraborty, Chandraditya; Yao, Yao; Fulciniti, Mariateresa; Samur, Mehmet; Aktas-Samur, Anil; Amodio, Nicola; Turi, Marcello; Barello, Francesca; Penailillo, Johany; Giallongo, Cesarina; Romano, Alessandra; Gulla, Annamaria; Anderson, Kenneth C.; Inghirami, Giorgio; Munshi, Nikhil C.; Loda, Massimo | |
| Epigenetic regulation of CD38/CD48 by KDM6A mediates NK cell response in multiple myeloma | 2024 | Liu J.; Xing L.; Li J.; Wen K.; Liu N.; Liu Y.; Wu G.; Wang S.; Ogiya D.; Song T.-Y.; Kurata K.; Penailillo J.; Morelli E.; Wang T.; Hong X.; Gulla A.; Tai Y.-T.; Munshi N.; Richardson P.; Carrasco R.; Hideshima T.; Anderson K.C. | |
| DIS3 depletion in multiple myeloma causes extensive perturbation in cell cycle progression and centrosome amplification | 2024 | Favasuli V.K.; Ronchetti D.; Silvestris I.; Puccio N.; Fabbiano G.; Traini V.; Todoerti K.; Erratico S.; Ciarrocchi A.; Fragliasso V.; Giannandrea D.; Tumiatti F.; Chiaramonte R.; Torrente Y.; Finelli P.; Morelli E.; Munshi N.C.; Bolli N.; Neri A.; Taiana E. | |
| Loss of GABARAP mediates resistance to immunogenic chemotherapy in multiple myeloma | 2024 | Gulla, Annamaria; Morelli, Eugenio; Johnstone, Megan; Turi, Marcello; Samur, Mehmet K; Botta, Cirino; Cifric, Selma; Folino, Pietro; Vinaixa, Delaney; Barello, Francesca; Clericuzio, Cole; Favasuli, Vanessa Katia; Maisano, Domenico; Talluri, Srikanth; Prabhala, Rao H; Bianchi, Giada; Fulciniti, Mariateresa; Wen, Kenneth; Kurata, Keiji; Liu, Jiye; Penailillo, Johany; Bragoni, Alberto; Sapino, Anna; Richardson, Paul G; Chauhan, Dharminder; Carrasco, Ruben D; Hideshima, Teru; Munshi, Nikhil C; Anderson, Kenneth C | |
| GPER1 Activation Exerts Anti-Tumor Activity in Multiple Myeloma | 2023 | Gallo Cantafio M.E.; Torcasio R.; Scionti F.; Mesuraca M.; Ronchetti D.; Pistoni M.; Bellizzi D.; Passarino G.; Morelli E.; Neri A.; Viglietto G.; Amodio N. | |
| A MIR17HG-derived long noncoding RNA provides an essential chromatin scaffold for protein interaction and myeloma growth | 2023 | Morelli E.; Fulciniti M.; Samur M.K.; Ribeiro C.F.; Wert-Lamas L.; Henninger J.E.; Gulla A.; Aktas-Samur A.; Todoerti K.; Talluri S.; Park W.D.; Federico C.; Scionti F.; Amodio N.; Bianchi G.; Johnstone M.; Liu N.; Gramegna D.; Maisano D.; Russo N.A.; Lin C.; Tai Y.-T.; Neri A.; Chauhan D.; Hideshima T.; Shammas M.A.; Tassone P.; Gryaznov S.; Young R.A.; Anderson K.C.; Novina C.D.; Loda M.; Munshi N.C. | |
| BRD9 Degradation Disrupts Ribosome Biogenesis in Multiple Myeloma | 2023 | Kurata K.; Samur M.K.; Liow P.; Wen K.; Yamamoto L.; Liu J.; Morelli E.; Gulla A.; Tai Y.-T.; Qi J.; Hideshima T.; Anderson K.C. | |
| CDK7 controls E2F- and MYC-driven proliferative and metabolic vulnerabilities in multiple myeloma | 2023 | Yao Y.; Ng J.F.; Park W.D.; Samur M.; Morelli E.; Encinas Mayoral J.; Chyra Z.; Xu Y.; Derebail S.; Epstein C.; Nabet B.; Chesi M.; Gray N.S.; Young R.A.; Kwiatkowski N.; Mitsiades C.; Anderson K.C.; Lin C.Y.; Munshi N.C.; Fulciniti M. | |
| Therapeutic activation of G protein-coupled estrogen receptor 1 in Waldenström Macroglobulinemia | 2022 | Morelli E.; Hunter Z.R.; Fulciniti M.; Gulla A.; Perrotta I.D.; Zuccala V.; Federico C.; Juli G.; Manzoni M.; Ronchetti D.; Romeo E.; Gallo Cantafio M.E.; Soncini D.; Maltese L.; Rossi M.; Roccaro A.M.; Cea M.; Tassone P.; Neri A.; Treon S.C.; Munshi N.C.; Viglietto G.; Amodio N. | |
| Bortezomib Induces Anti–Multiple Myeloma Immune Response Mediated by cGAS/STING Pathway Activation | 2021 | Gulla A.; Morelli E.; Samur M.K.; Botta C.; Hideshima T.; Bianchi G.; Fulciniti M.; Malvestiti S.; Prabhala R.H.; Talluri S.; Wen K.; Tai Y.-T.; Richardson P.G.; Chauhan D.; Sewastianik T.; Carrasco R.D.; Munshi N.C.; Anderson K.C. | |
| JunB is a key regulator of multiple myeloma bone marrow angiogenesis | 2021 | Fan F.; Malvestiti S.; Vallet S.; Lind J.; Garcia-Manteiga J.M.; Morelli E.; Jiang Q.; Seckinger A.; Hose D.; Goldschmidt H.; Stadlbauer A.; Sun C.; Mei H.; Pecherstorfer M.; Bakiri L.; Wagner E.F.; Tonon G.; Sattler M.; Hu Y.; Tassone P.; Jaeger D.; Podar K. | |
| miR17~92 restrains pro-apoptotic BIM to ensure survival of haematopoietic stem and progenitor cells | 2020 | Brinkmann K.; Ng A.P.; de Graaf C.A.; Di Rago L.; Hyland C.D.; Morelli E.; Rautela J.; Huntington N.D.; Strasser A.; Alexander W.S.; Herold M.J. | |
| YWHAE/14-3-3e expression impacts the protein load, contributing to proteasome inhibitor sensitivity in multiple myeloma | 2020 | Xu Y.; Fulciniti M.; Samur M.K.; Ho M.; Deng S.; Liu L.; Wen K.; Yu T.; Chyra Z.; Dereibal S.; Zhang L.; Yao Y.; Chakraborty C.; Morelli E.; Li N.; Lopez M.A.; Perini T.; Mu S.; An G.; Alonso R.; Bianchi G.; Tai Y.-T.; Anderson K.C.; Qiu L.; Munshi N.C. | |
| Inhibition of haspin kinase promotes cell-intrinsic and extrinsic antitumor activity | 2020 | Melms J.C.; Vallabhaneni S.; Mills C.E.; Yapp C.; Chen J.-Y.; Morelli E.; Waszyk P.; Kumar S.; Deming D.; Moret N.; Rodriguez S.; Subramanian K.; Rogava M.; Cartwright A.N.R.; Luoma A.; Mei S.; Brinker T.J.; Miller D.M.; Spektor A.; Schadendorf D.; Riggi N.; Wucherpfennig K.W.; Sorger P.K.; Izar B. | |
| Targeting histone deacetylase 3 (HDAC3) in the bone marrow microenvironment inhibits multiple myeloma proliferation by modulating exosomes and IL-6 trans-signaling | 2020 | Ho M.; Chen T.; Liu J.; Dowling P.; Hideshima T.; Zhang L.; Morelli E.; Camci-Unal G.; Wu X.; Tai Y.-T.; Wen K.; Samur M.; Schlossman R.L.; Mazitschek R.; Kavanagh E.L.; Lindsay S.; Harada T.; McCann A.; Anderson K.C.; O'Gorman P.; Bianchi G. | |
| Inhibition of histone methyltransferase DOT1L silences ER gene and blocks proliferation of antiestrogen-resistant breast cancer cells | 2019 | Nassa G.; Salvati A.; Tarallo R.; Gigantino V.; Alexandrova E.; Memoli D.; Sellitto A.; Rizzo F.; Malanga D.; Mirante T.; Morelli E.; Nees M.; Akerfelt M.; Kangaspeska S.; Nyman T.A.; Milanesi L.; Giurato G.; Weisz A. |