In adult rodents, doublecortin (DCX) and polysialylated neural cell adhesion molecule (PSA-NCAM) expression is mostly restricted to newly generated neurons. These molecules have also been described in prenatally generated cells of the piriform cortex and, to a lesser extent, neocortex (NC) of the rat. In addition, PSA-NCAM+ cells have been identified in several telencephalic regions of the lizard. Here, through immunohistochemistry and 3-dimensional reconstruction, we have investigated distribution, morphology, and phenotype of DCX/PSA-NCAM-expressing cells in the pallium of different mammals and in lizard. In all species, a population of nonnewly-generated pallial DCX+/PSA-NCAM+ cells shows common morphological and phenotypic characteristics, including expression of Tbr-1, a transcription factor expressed in pallial projection neurons, and preferential distribution in associative areas. In the guinea pig and rabbit, DCX+/PSA-NCAM+ elements are also abundant in the NC, particularly in areas implicated in nonspatial learning and memory networks. In reptiles, DCX+/PSA-NCAM+ cells are located in the lateral and medial cortex and dorsal ventricular ridge but not in the dorsal cortex. These data support the fact that coexpression of DCX+/PSA-NCAM+/Tbr-1+ in the adult brain identifies evolutionary conserved cell populations shared by different pallial derivatives including the mammalian NC.

DCX and PSA-NCAM expression identifies a population of neurons preferentially distributed in associative areas of different pallial derivatives and vertebrate species

LUZZATI, FEDERICO;BONFANTI, Luca;FASOLO, Aldo;PERETTO, Paolo Marcello
2009-01-01

Abstract

In adult rodents, doublecortin (DCX) and polysialylated neural cell adhesion molecule (PSA-NCAM) expression is mostly restricted to newly generated neurons. These molecules have also been described in prenatally generated cells of the piriform cortex and, to a lesser extent, neocortex (NC) of the rat. In addition, PSA-NCAM+ cells have been identified in several telencephalic regions of the lizard. Here, through immunohistochemistry and 3-dimensional reconstruction, we have investigated distribution, morphology, and phenotype of DCX/PSA-NCAM-expressing cells in the pallium of different mammals and in lizard. In all species, a population of nonnewly-generated pallial DCX+/PSA-NCAM+ cells shows common morphological and phenotypic characteristics, including expression of Tbr-1, a transcription factor expressed in pallial projection neurons, and preferential distribution in associative areas. In the guinea pig and rabbit, DCX+/PSA-NCAM+ elements are also abundant in the NC, particularly in areas implicated in nonspatial learning and memory networks. In reptiles, DCX+/PSA-NCAM+ cells are located in the lateral and medial cortex and dorsal ventricular ridge but not in the dorsal cortex. These data support the fact that coexpression of DCX+/PSA-NCAM+/Tbr-1+ in the adult brain identifies evolutionary conserved cell populations shared by different pallial derivatives including the mammalian NC.
2009
19(5)
1028
1041
F. LUZZATI; L. BONFANTI; A. FASOLO; P. PERETTO
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/100831
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