The aetiological translocation, PAX3-FKHR, found in alveolar rabdomyosarcoma (ARMS), results in a very potent activator of transcription. Since c-Met is a transcriptional target of PAX3, we compared the effects of PAX3-FKHR on Met expression, cell-cycle regulators and myogenic markers in MEFs, NIH3T3 and C2C12. We observed that PAX3-FKHR induces terminal myogenic differentiation in MEFs and activates a myogenic program in NIH3T3; while in the myoblast cell line (C2C12), it inhibits differentiation. Our data indicate that the role of PAX3-FKHR depends on the cell context and the activation of a myogenic program is compatible with a transforming potential.
PAX3-FKHR at the cross-road between differentiation and transformation
SCHMITT-NEY, MICHAEL;ALLEGRA, Paola;CREPALDI, Tiziana;PONZETTO, Carola
2005-01-01
Abstract
The aetiological translocation, PAX3-FKHR, found in alveolar rabdomyosarcoma (ARMS), results in a very potent activator of transcription. Since c-Met is a transcriptional target of PAX3, we compared the effects of PAX3-FKHR on Met expression, cell-cycle regulators and myogenic markers in MEFs, NIH3T3 and C2C12. We observed that PAX3-FKHR induces terminal myogenic differentiation in MEFs and activates a myogenic program in NIH3T3; while in the myoblast cell line (C2C12), it inhibits differentiation. Our data indicate that the role of PAX3-FKHR depends on the cell context and the activation of a myogenic program is compatible with a transforming potential.
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