Plasma aminoacids were evaluated by ion-exchange chromatography in 15 previously untreated subjects affected with primary generalized epilepsy and in some of their first grade relatives. Results were comparated to a group of 50 healthy controls. Epileptic patients were then put on valproic acid (VPA) therapy for one month, and then newly examined as before treatment. Statistical analysis of the aminoacid levels showed significant vriations for the four ones relevant for inibitory (taurine and glycine) and excitatory neurotrasmission (aspartate and glutamate), both in epileptics and in their first grade relatives (23 subjects). VPA medication did not influences the aminoacid pool. It is tempted to speculate that sucj an analysis may be used as a metabolic screening of the disease.

Aminoacidi plasmatici in pazienti con epilessia generalizzata primaria e loro parenti di primo grado: studio sull’influenza dell’acido valproico

TORTA, Riccardo;VERZE', Laura;MUTANI, Roberto
1991-01-01

Abstract

Plasma aminoacids were evaluated by ion-exchange chromatography in 15 previously untreated subjects affected with primary generalized epilepsy and in some of their first grade relatives. Results were comparated to a group of 50 healthy controls. Epileptic patients were then put on valproic acid (VPA) therapy for one month, and then newly examined as before treatment. Statistical analysis of the aminoacid levels showed significant vriations for the four ones relevant for inibitory (taurine and glycine) and excitatory neurotrasmission (aspartate and glutamate), both in epileptics and in their first grade relatives (23 subjects). VPA medication did not influences the aminoacid pool. It is tempted to speculate that sucj an analysis may be used as a metabolic screening of the disease.
1991
Congresso Nazionale, Riunione Primaverile, Lega Italiana contro l'epilessia
Parma
17-18 aprile 1991
74
183
187
MONACO F.; GIANELLI M.; NALDI P.; SCHIAVELLA P.; CANTELLO R.; TORTA R.; ZANALDA E.; VERZE' L.; MUTANI R.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/123278
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact