A novel class of paramagnetic liposome-based systems acting as dual T 1 and CEST 1H-MRI contrast agents is described. The vesicles contain a shift reagent in the aqueous core and a Gd-complex on the external surface conjugated through a biodegradable linker. As such, the probe can generate T 1 contrast only, but after the cleavage and removal of the Gd-coating, the CEST contrast is switched on.
Gadolinium-doped LipoCEST agents: a potential novel class of dual (1)H-MRI probes
TERRENO, Enzo;BOFFA, CINZIA;CARRERA, CARLA;DELLI CASTELLI, Daniela;AIME, Silvio
2011-01-01
Abstract
A novel class of paramagnetic liposome-based systems acting as dual T 1 and CEST 1H-MRI contrast agents is described. The vesicles contain a shift reagent in the aqueous core and a Gd-complex on the external surface conjugated through a biodegradable linker. As such, the probe can generate T 1 contrast only, but after the cleavage and removal of the Gd-coating, the CEST contrast is switched on.
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