Objective: Aim of the study was to check the relationship between carotid IMT (cIMT) and aorta IMT (aIMT) with biochemical risk markers of atherosclerosis in a children cohort. Methods: 329 healthy and dyslipidemic children/adolescents (age 10.10±3.40) underwent B-mode ultrasound. Among dyslipidemic children 88 resulted FH, 74 FCHL, 56 dominant Hypercholesterolemia, 43 Hyperlipoprotein(a), 10 FHTG and 1 sitosterolemia. 57 were unaffected control subjects. cIMT and aIMT were assessed by using B-mode ultrasound. Results: In all subjects IMT measurement increased with age independently from gender. Both cIMT and aIMT correlated respectively with LDL-C (ρ=0.129, p=0.020; ρ=0.124, p=0.041), ApoB (ρ=0.150, p=0.007; ρ=0.158, p=0.01), non-HDL-C (ρ=0.128, p=0.021; ρ=0.138, p=0.023) and ApoB/ApoA1 (ρ=0.185, p=0.001; ρ=0.141, p=0.022). A negative correlation was found between cIMT and ApoA1 (ρ=-0.179, p=0.01). Furthermore aIMT resulted significantly related to CT levels (ρ=0.128, p=0.034). Conclusion: The present study shows, for the first time in children, a correlation between cIMT and aIMT with LDL-C, ApoB, ApoB/apoA1, non-HDL-C, as well as aIMT with CT. ApoB and ApoA1, as well as non-HDL-C, are accurate summary of CVD risk factors and are considered new good marker risk as regards to the conventional ones. It should be underlined that non-HDL-C can be routinely assessed in the clinical practice because it results an easy and cheap measure already useful in hypertrigliceridemic patients. This study support the effectiveness of ApoB and non-HDL-C values, as well as cIMT and aIMT measurements, as preclinical markers of atherosclerosis in childhood.
Usefulness of intima media thickness, ApoB and nonHDL-C in primary dislipidemic children.
ABELLO, Francesca;GUARDAMAGNA, Ornella
2010-01-01
Abstract
Objective: Aim of the study was to check the relationship between carotid IMT (cIMT) and aorta IMT (aIMT) with biochemical risk markers of atherosclerosis in a children cohort. Methods: 329 healthy and dyslipidemic children/adolescents (age 10.10±3.40) underwent B-mode ultrasound. Among dyslipidemic children 88 resulted FH, 74 FCHL, 56 dominant Hypercholesterolemia, 43 Hyperlipoprotein(a), 10 FHTG and 1 sitosterolemia. 57 were unaffected control subjects. cIMT and aIMT were assessed by using B-mode ultrasound. Results: In all subjects IMT measurement increased with age independently from gender. Both cIMT and aIMT correlated respectively with LDL-C (ρ=0.129, p=0.020; ρ=0.124, p=0.041), ApoB (ρ=0.150, p=0.007; ρ=0.158, p=0.01), non-HDL-C (ρ=0.128, p=0.021; ρ=0.138, p=0.023) and ApoB/ApoA1 (ρ=0.185, p=0.001; ρ=0.141, p=0.022). A negative correlation was found between cIMT and ApoA1 (ρ=-0.179, p=0.01). Furthermore aIMT resulted significantly related to CT levels (ρ=0.128, p=0.034). Conclusion: The present study shows, for the first time in children, a correlation between cIMT and aIMT with LDL-C, ApoB, ApoB/apoA1, non-HDL-C, as well as aIMT with CT. ApoB and ApoA1, as well as non-HDL-C, are accurate summary of CVD risk factors and are considered new good marker risk as regards to the conventional ones. It should be underlined that non-HDL-C can be routinely assessed in the clinical practice because it results an easy and cheap measure already useful in hypertrigliceridemic patients. This study support the effectiveness of ApoB and non-HDL-C values, as well as cIMT and aIMT measurements, as preclinical markers of atherosclerosis in childhood.
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