Catecholamines trigger proximal tubular fluid retention and reduce renal excretion of solute-free water. In advanced cirrhosis, non-osmotic hypersecretion of vasopressin (ADH) is considered the cause of dilutional hyponatremia, but ADH V2 receptor antagonists are not beneficial in long-term treatment of ascites.
Pathogenesis of Solute-Free Water Retention in Experimental Ascitic Cirrhosis: Is Vasopressin the Only Culprit?
ARAGNO, Manuela;MASTROCOLA, Raffaella;PAROLA, Maurizio
Last
2016-01-01
Abstract
Catecholamines trigger proximal tubular fluid retention and reduce renal excretion of solute-free water. In advanced cirrhosis, non-osmotic hypersecretion of vasopressin (ADH) is considered the cause of dilutional hyponatremia, but ADH V2 receptor antagonists are not beneficial in long-term treatment of ascites.
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