Hepatocellular carcinoma (HCC) develops with high incidence in patients with chronic liver disease (CLD), and particularly in those with cirrhosis. Currently, diagnosis and surveillance are mainly based on imaging-methods. The aim of this study was to evaluate the diagnostic accuracy of highly sensitive measurement of alpha-fetoprotein (AFP), Lens culinaris agglutinin-reactive fraction of AFP (AFP-L3) and des-gamma-carboxy-prothrombin (DCP) alone and in combination, for HCC detection. In addition, a recently proposed statistical model, including these three biomarkers plus gender and age, the GALAD model was applied.
Highly sensitive alpha-fetoprotein, Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein and des-gamma-carboxy prothrombin for hepatocellular carcinoma detection
CAVIGLIA, GIAN PAOLO;ABATE, Maria Lorena;RIZZETTO, Mario;SMEDILE, Antonina
2015-01-01
Abstract
Hepatocellular carcinoma (HCC) develops with high incidence in patients with chronic liver disease (CLD), and particularly in those with cirrhosis. Currently, diagnosis and surveillance are mainly based on imaging-methods. The aim of this study was to evaluate the diagnostic accuracy of highly sensitive measurement of alpha-fetoprotein (AFP), Lens culinaris agglutinin-reactive fraction of AFP (AFP-L3) and des-gamma-carboxy-prothrombin (DCP) alone and in combination, for HCC detection. In addition, a recently proposed statistical model, including these three biomarkers plus gender and age, the GALAD model was applied.
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