The ADP-ribosyl cyclases are unique enzymes that catalyse the cyclization of NAD/NADP to cyclic ADP ribose NAADP, two widely distributed second messengers involved in intracellular calcium mobilization and signalling. This review will focus on the group of well-characterized invertebrate and vertebrate ARCs whose common gene structure allows us to trace their origin to the ancestor of bilaterian animals. Behind a facade of gene and protein homology lies a family with a disparate functional repertoire dictated by the animal model and the physical trait under investigation. Here we present a phylogenetic view of the ARCs to better understand the evolution of function in this family.
The ADP-ribosyl cyclases - the current evolutionary state of the ARCs
FERRERO, Enza;LO BUONO, NICOLA;HORENSTEIN, ALBERTO;FUNARO, Ada;MALAVASI, Fabio
2014-01-01
Abstract
The ADP-ribosyl cyclases are unique enzymes that catalyse the cyclization of NAD/NADP to cyclic ADP ribose NAADP, two widely distributed second messengers involved in intracellular calcium mobilization and signalling. This review will focus on the group of well-characterized invertebrate and vertebrate ARCs whose common gene structure allows us to trace their origin to the ancestor of bilaterian animals. Behind a facade of gene and protein homology lies a family with a disparate functional repertoire dictated by the animal model and the physical trait under investigation. Here we present a phylogenetic view of the ARCs to better understand the evolution of function in this family.File | Dimensione | Formato | |
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