Human dihydroorotate dehydrogenase (hDHODH, EC 1.3.5.2), a flavin-dependent mitochondrial enzyme involved in de novo pyrimidine biosynthesis, is a validated therapeutic target for the treatment of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. However, human DHODH inhibitors have also been investigated as treatment for cancer, parasite infections (i.e. malaria) and viruses as well as in the agrochemicals industry.
Use of human Dihydroorotate Dehydrogenase (hDHODH) Inhibitors in Autoimmune Diseases and New Perspectives in Cancer Therapy
Lolli, Marco L
First
;Sainas, Stefano;Pippione, Agnese C;Giorgis, Marta;Boschi, Donatella;Dosio, Franco
2018-01-01
Abstract
Human dihydroorotate dehydrogenase (hDHODH, EC 1.3.5.2), a flavin-dependent mitochondrial enzyme involved in de novo pyrimidine biosynthesis, is a validated therapeutic target for the treatment of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. However, human DHODH inhibitors have also been investigated as treatment for cancer, parasite infections (i.e. malaria) and viruses as well as in the agrochemicals industry.
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