Inflammation is a process that underlies sight-threatening ocular surface diseases, and gene supplementation with the plasmid that encodes for p-IL10 will allow the sustained de novo synthesis of the cytokine to occur in corneal cells, and provide a long-term anti-inflammatory effect. This work describes the development of solid lipid nanoparticle systems for the delivery of p-IL10 to transfect the cornea.
Gene delivery in the cornea: in vitro & ex vivo evaluation of solid lipid nanoparticle-based vectors
Serpe, Loredana;Foglietta, Federica;Muntoni, Elisabetta;Battaglia, LuigiLast
2018-01-01
Abstract
Inflammation is a process that underlies sight-threatening ocular surface diseases, and gene supplementation with the plasmid that encodes for p-IL10 will allow the sustained de novo synthesis of the cytokine to occur in corneal cells, and provide a long-term anti-inflammatory effect. This work describes the development of solid lipid nanoparticle systems for the delivery of p-IL10 to transfect the cornea.
File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
articolo cornee plasmidi.pdf
Open Access dal 02/09/2019
Tipo di file:
POSTPRINT (VERSIONE FINALE DELL’AUTORE)
Dimensione
5.53 MB
Formato
Adobe PDF
|
5.53 MB | Adobe PDF | Visualizza/Apri |
|
articolo cornee plasmidi.pdf
Accesso riservato
Tipo di file:
PDF EDITORIALE
Dimensione
9.36 MB
Formato
Adobe PDF
|
9.36 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
