Antibiotic adjustment in CRRT

The management of infection in Intensive Care Unit represents an imperative challenge for critical care clinicians. At present, antibiotic dosing regimens are derived from studies on healthy volunteers and do not account for these major differences in drug prescriptions. We summarized the pharmacokinetic/pharmacodynamics relationship changes in antimicrobial agents due to the typical homeostatic disturbance or altered end-organ function of the critical illness. We focused on how the renal clearance alterations or the Continuous Renal Replacement Therapy may affect individual antimicrobial dosage and dosing interval of the antimicrobial agents.