Background: Investigation of immunologic values in children vertically exposed to hepatitis C virus (HCV) infection could help explain the higher risk of infection in girls and indicate mechanisms of spontaneous viral clearance and possible long-term immunologic effects. Methods: Prospective study of children born to HCV-infected women. Lymphocyte and neutrophil measurements were age-standardized using the LMS method (this summarizes the changing age distribution of a variable). Associations between maternal and infant characteristics and lymphocyte and neutrophil z-scores were quantified using linear regression allowing for repeated measures. Results: HCV-infected children, girls, and those born to HCV/human immunodeficiency virus (HIV)-coinfected women had significantly higher lymphocyte z-scores than HCV-uninfected children, boys, and children born to HCV-only-infected women, respectively. Peak absolute lymphocytes were significantly lower for infected children with evidence of viral clearance than for persistently infected children. Girls also had significantly higher neutrophil z-scores than boys but HCV-infected children had significantly lower neutrophil z-scores than uninfected children. Conclusions: The gender associations are in line with those observed among children born to HIV-infected women, suggesting general gender-based differences in response to infection. Age-related standards for uninfected children could be used to assess immune function in other pediatric diseases and these results suggest that gender-specific reference values should be used at least for the first 2 years of life. Copyright © 2008 by Lippincott Williams & Wilkins.

Age-related lymphocyte and neutrophil levels in children of hepatitis C-infected women

Tovo P. -A.;A Amoroso;
2008

Abstract

Background: Investigation of immunologic values in children vertically exposed to hepatitis C virus (HCV) infection could help explain the higher risk of infection in girls and indicate mechanisms of spontaneous viral clearance and possible long-term immunologic effects. Methods: Prospective study of children born to HCV-infected women. Lymphocyte and neutrophil measurements were age-standardized using the LMS method (this summarizes the changing age distribution of a variable). Associations between maternal and infant characteristics and lymphocyte and neutrophil z-scores were quantified using linear regression allowing for repeated measures. Results: HCV-infected children, girls, and those born to HCV/human immunodeficiency virus (HIV)-coinfected women had significantly higher lymphocyte z-scores than HCV-uninfected children, boys, and children born to HCV-only-infected women, respectively. Peak absolute lymphocytes were significantly lower for infected children with evidence of viral clearance than for persistently infected children. Girls also had significantly higher neutrophil z-scores than boys but HCV-infected children had significantly lower neutrophil z-scores than uninfected children. Conclusions: The gender associations are in line with those observed among children born to HIV-infected women, suggesting general gender-based differences in response to infection. Age-related standards for uninfected children could be used to assess immune function in other pediatric diseases and these results suggest that gender-specific reference values should be used at least for the first 2 years of life. Copyright © 2008 by Lippincott Williams & Wilkins.
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9
800
807
Gender; Hepatitis C virus; Lymphocytes; Mother-to-child transmission; Neutrophils; Age Factors; Child; Child, Preschool; Female; HIV Infections; Hepatitis C; Humans; Infant; Infant, Newborn; Leukocyte Count; Lymphocytes; Male; Mothers; Neutrophils; Pregnancy; Pregnancy Complications, Infectious; Prospective Studies; Sex Factors; Family Health
Pembrey L.; Newell M.-L.; Tovo P.-A., A Amoroso, F Asensi-Botet, A Pereda, V Balossini, G Bona, M Zaffaroni, A Bandelloni, A Coscia, C Fabris, S Aime, G Bossi, M Stronati, C Boucher, W Buffolano, K Butler, L Cabero Roura, J M Bertran Sanges, P Cigna, L M Ciria, C Servera Ginard, G Claret Teruel, C Fortuny, O Coll, A Corrias, R Ledda, S Floris, A De Maria, J Echeverria, G Cilla, G Faldella, M Lanari, E Tridapalli, V Venturi, B Fischler, A-B Bohlin, S Lindgren, G Lindh, V Giacomet, V Fabiano, S Stucchi, S Fasan, A Vigano, S Hannam, G Mieli-Vergani, A Hatzakis, C Inchley, H O Fjaerli, A Macca-bruni, M Marcellini, M R Sartorelli, P Martin Fontelos, A Mazza, J Y Q Mok, M Vinolas, A Mur, D M Paternoster, P Grella, S Polywka, I Quinti, A M Casadei, A Rojahn, A Berg, R Rosso, E Repetto, J Ruiz Contreras, A Manzanares, A Ruiz Extremera, F Falvini, G V Zucotti, T Schmitz, I Grosch-Worner, C Feiterna Sperling, T Piening, H Souayah, J Levy, A Vegnente, R Iorio, L Lazier, C Bertaina, E Antonielli d'Oulx, O Del-monte, S Brezzio, R Wejstal, G Norkrans, A Zanetti, E Tanzi
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1772813
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