We describe the blastic transformation of a case of chronic myelocytic leukemia in which, among other abnormalities, one extra Philadelphia and one extra 9q+ were observed. Molecular studies and analysis of the clonal evolution of the karyotype led to the interpretation of such an unusual finding as the result of nondisjunction, rather than of a double t(9;22) translocation.

Duplication of Ph and of 9q+ chromosomes during the blastic transformation of a CML case.

SAGLIO, Giuseppe;GUERRASIO, Angelo;
1987-01-01

Abstract

We describe the blastic transformation of a case of chronic myelocytic leukemia in which, among other abnormalities, one extra Philadelphia and one extra 9q+ were observed. Molecular studies and analysis of the clonal evolution of the karyotype led to the interpretation of such an unusual finding as the result of nondisjunction, rather than of a double t(9;22) translocation.
1987
29
57
63
AVANZI GC ;GIOVINAZZO B ;SAGLIO G ;GUERRASIO A ;ROSSO A ;BERTINI M ;RESEGOTTI L ;PEGORARO L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/34816
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