The gamma-chain structure of a homozygote for HPFH Negro type, previously described by Acquaye and co-workers, and of 3 heterozygotes of the same family has been evaluated. G gamma and A gamma chains were present in a ratio of fetal type (7/3) in the homozygote and in ratios of 2/3 and 1/1 in the heterozygotes, in agreement with data of the literature. T gamma chains were absent in all the cases. Our results, compared with those previously reported for Negro and Greek HPFH, suggest that the T gamma gene is never linked with the HPFH determinant.

Analysis of the gamma chains in a homozygote for HPFH Negro type and in three related heterozygotes.

GUERRASIO, Angelo;SAGLIO, Giuseppe;
1980-01-01

Abstract

The gamma-chain structure of a homozygote for HPFH Negro type, previously described by Acquaye and co-workers, and of 3 heterozygotes of the same family has been evaluated. G gamma and A gamma chains were present in a ratio of fetal type (7/3) in the homozygote and in ratios of 2/3 and 1/1 in the heterozygotes, in agreement with data of the literature. T gamma chains were absent in all the cases. Our results, compared with those previously reported for Negro and Greek HPFH, suggest that the T gamma gene is never linked with the HPFH determinant.
1980
63
146
150
GUERRASIO A ;ACQUAYE CT ;OLDHAM JH ;SARTORIS ML ;CAMASCHELLA C ;SAGLIO G ;MAZZA U
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/34818
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