The aim of the present study was to verify the hypothesis that SS receptor subtypes (SSTRs) are expressed by H9c2 cardiac muscle cells. SSTRs expression was investigated by RT-PCR and Western blot analysis at both mRNA and protein level. Our findings demonstrate that H9c2 cells express all SSTR subtypes I-5 (SSTRI-5) at the mRNA and protein level. Thus, H9c2 cells would represent a new model to study the direct biological activities of SS and its analogues at the cardiac level.

H9c2 cardiac muscle cells express all somatostatin receptor subtypes

GRANATA, Riccarda;TROVATO, Letizia;DESTEFANIS, SILVIA;SETTANNI, Fabio;GHIGO, Ezio
2004-01-01

Abstract

The aim of the present study was to verify the hypothesis that SS receptor subtypes (SSTRs) are expressed by H9c2 cardiac muscle cells. SSTRs expression was investigated by RT-PCR and Western blot analysis at both mRNA and protein level. Our findings demonstrate that H9c2 cells express all SSTR subtypes I-5 (SSTRI-5) at the mRNA and protein level. Thus, H9c2 cells would represent a new model to study the direct biological activities of SS and its analogues at the cardiac level.
2004
27
RC24
RC27
Somatostatin receptors; H9c2 cardiac cells.
GRANATA R; TROVATO L; DESTEFANIS S; SETTANNI F; GHIGO E
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/36373
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 102
  • ???jsp.display-item.citation.isi??? 7
social impact