Efficient routes to DOTA-monoamide ligands bearing amino, hydroxyl, aldehyde and maleimido groups are described. These functional groups, which can be spaced at will from the coordination cage, will readily react with suitable groups of targeting moieties. Bioconjugates obtained in this way can be used for diagnostic imaging and therapeutic applications.

Bifunctional ligands based on the DOTA-monoamide cage

BARGE, Alessandro;STEFANIA, Rachele;AIME, Silvio;CRAVOTTO, Giancarlo
2008-01-01

Abstract

Efficient routes to DOTA-monoamide ligands bearing amino, hydroxyl, aldehyde and maleimido groups are described. These functional groups, which can be spaced at will from the coordination cage, will readily react with suitable groups of targeting moieties. Bioconjugates obtained in this way can be used for diagnostic imaging and therapeutic applications.
2008
6
1176
1184
DIETHYLENETRIAMINEPENTAACETIC ACID DTPA; MRI CONTRAST AGENTS; CHELATING-AGENT; CONVENIENT SYNTHESIS; GADOLINIUM; COMPLEXES; DERIVATIVES; ANTIBODY; PEPTIDE; PROBES
Barge A; Tei L; Upadhyaya D; Fedeli F; Beltrami L; Stefania R; Aime S; Cravotto G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/47068
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