This research aimed to improve the loading capacity and the physical stability of liposomes containing docetaxel in comparison with paclitaxel. Several formulations of docetaxel liposomes have been studied. Entrapment efficiency and docetaxel concentration of liposomal formulations have been increased. Growth inhibitory activity of taxanes on two different human cancer cell lines was compared to that of taxane-liposomes.
Preparazione e caratterizzazione di liposomi convenzionali ed a lunga circolazione contenenti taxani
IMMORDINO, Maria Laura;BRUSA, Paola;STELLA, Barbara;ARPICCO, Silvia Maria;DOSIO, Franco;CATTEL, Luigi
2001-01-01
Abstract
This research aimed to improve the loading capacity and the physical stability of liposomes containing docetaxel in comparison with paclitaxel. Several formulations of docetaxel liposomes have been studied. Entrapment efficiency and docetaxel concentration of liposomal formulations have been increased. Growth inhibitory activity of taxanes on two different human cancer cell lines was compared to that of taxane-liposomes.File in questo prodotto:
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