Breast cancer is a heterogeneous disease, encompassing a wide variety of histological types and clinical behaviours. Current histopathological classification systems for breast cancer are based on descriptive entities that are of prognostic significance. Few predictive biomarkers are currently available. High throughput molecular technologies are reshaping our understanding of breast cancer and a molecular taxonomy that has stronger predictive power is slowly emerging. Novel therapeutic targets and prognostic/predictive gene signatures have been identified. This review will address the contribution of molecular methods to our understanding of breast cancer and its precursors, their use in breast cancer translational research and their impact on diagnostic breast cancer histopathology.

The role of molecular analysis in breast cancer.

MARCHIO', Caterina;
2009-01-01

Abstract

Breast cancer is a heterogeneous disease, encompassing a wide variety of histological types and clinical behaviours. Current histopathological classification systems for breast cancer are based on descriptive entities that are of prognostic significance. Few predictive biomarkers are currently available. High throughput molecular technologies are reshaping our understanding of breast cancer and a molecular taxonomy that has stronger predictive power is slowly emerging. Novel therapeutic targets and prognostic/predictive gene signatures have been identified. This review will address the contribution of molecular methods to our understanding of breast cancer and its precursors, their use in breast cancer translational research and their impact on diagnostic breast cancer histopathology.
2009
41
77
88
Geyer FC; Marchio C; Reis-Filho JS.
File in questo prodotto:
File Dimensione Formato  
felipe and cate review.pdf

Accesso riservato

Descrizione: Geyer FC - Pathology review
Tipo di file: PDF EDITORIALE
Dimensione 999.94 kB
Formato Adobe PDF
999.94 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/64087
Citazioni
  • ???jsp.display-item.citation.pmc??? 18
  • Scopus 54
  • ???jsp.display-item.citation.isi??? 52
social impact