Aim: leptin and adiponectin are adipokines with important roles in energy homeostasis regulation. Recent evidences suggest that these hormones might be involved in perinatal development. The aim of our study was to evaluate the relation between serum leptin and adiponectin concentration in infants and the kind of feeding and to evaluate hormones levels in breast milk (BM). Methods: We enrolled 171 AGA healthy infants aged <6 months, without gastrointestinal disease, admitted to our Department. Serum leptin concentration has been determined by RIA test and with the same technique we evaluated leptin presence in 25 BM samples. Serum adiponectin concentration has been assessed by RIA test in 56 infants; and in 25 BM samples by ELISA. Results: Median (range) serum leptin concentration in infants was 3.85 ng/ml (0.5-36.6).Breastfed (BF) infants had statistically higher serum leptin concentration (n=95; 3.85 ng/ml; 0.5-36.6) than formula-fed (FF) infants (n=76; 2.5 ng/ml; 1.1-25.1). Median (range) serum adiponectin concentration was 135.7 ng/ml (38.5-260.0), without significant differences for adiponectin concentrations between BF (n=37; 136.8 ng/ml; 38.5-189.7) and FF (n=19; 130.3 ng/ml; 84.8-260). Median (range) leptin concentration in BM was 0.49 ng/ ml (0.13-1.92). Adiponectin concentration was 10.08 ng/ml (1.92; 18.5). No statistically significant correlations were found between hormones concentration in infants serum and in breast-milk. Conclusion: our findings support the possibility that human milk components influence appetite and feeding behaviour of breastfed infants and arise the question if hormones contained in mothers’ milk could be take in account for the beneficial effect of breast-feeding on obesity in children.
Leptin and adiponectin in the first six months of life.
LUPICA, MARIA MADDALENA;FISSORE, MARIA FRANCESCA;LIGUORI, STEFANIA ALFONSINA;TARASCO, VALENTINA;
2010-01-01
Abstract
Aim: leptin and adiponectin are adipokines with important roles in energy homeostasis regulation. Recent evidences suggest that these hormones might be involved in perinatal development. The aim of our study was to evaluate the relation between serum leptin and adiponectin concentration in infants and the kind of feeding and to evaluate hormones levels in breast milk (BM). Methods: We enrolled 171 AGA healthy infants aged <6 months, without gastrointestinal disease, admitted to our Department. Serum leptin concentration has been determined by RIA test and with the same technique we evaluated leptin presence in 25 BM samples. Serum adiponectin concentration has been assessed by RIA test in 56 infants; and in 25 BM samples by ELISA. Results: Median (range) serum leptin concentration in infants was 3.85 ng/ml (0.5-36.6).Breastfed (BF) infants had statistically higher serum leptin concentration (n=95; 3.85 ng/ml; 0.5-36.6) than formula-fed (FF) infants (n=76; 2.5 ng/ml; 1.1-25.1). Median (range) serum adiponectin concentration was 135.7 ng/ml (38.5-260.0), without significant differences for adiponectin concentrations between BF (n=37; 136.8 ng/ml; 38.5-189.7) and FF (n=19; 130.3 ng/ml; 84.8-260). Median (range) leptin concentration in BM was 0.49 ng/ ml (0.13-1.92). Adiponectin concentration was 10.08 ng/ml (1.92; 18.5). No statistically significant correlations were found between hormones concentration in infants serum and in breast-milk. Conclusion: our findings support the possibility that human milk components influence appetite and feeding behaviour of breastfed infants and arise the question if hormones contained in mothers’ milk could be take in account for the beneficial effect of breast-feeding on obesity in children.
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