Vaccines against oncoantigens halt early neoplastic lesions in several cancer-prone, genetically engineered mouse models, whereas their ability to prevent chemical carcinogenesis has not been explored. This is a significant issue since exposure to chemical mutagens is responsible for a substantial percentage of cancers worldwide. Here we show that the archetypal oncoantigen ERBB2 is transiently overexpressed in Syrian hamsters during the early stages of 7,12-dimethylbenz[α]anthracene (DMBA)-induced oral carcinogenesis. Repeated DNA vaccinations against ERBB2 significantly reduce the number, size and severity of oral lesions in a manner directly proportional to the anti-ERBB2 antibody response. These results support the prospects of vaccines as a fresh strategy in the management of individuals at risk for exposure to defined carcinogenic agents.

A DNA vaccine against ERBB2 impairs chemical carcinogenesis in random-bred hamsters

BERTA, Giovanni Nicolao;SPRIO, ANDREA ELIO;SPADARO, Michela;SALAMONE, PAOLINA;DI SCIPIO, FEDERICA;MOGNETTI, Barbara;PAPOTTI, Mauro Giulio;FORNI, Guido;CAVALLO, Federica
2011-01-01

Abstract

Vaccines against oncoantigens halt early neoplastic lesions in several cancer-prone, genetically engineered mouse models, whereas their ability to prevent chemical carcinogenesis has not been explored. This is a significant issue since exposure to chemical mutagens is responsible for a substantial percentage of cancers worldwide. Here we show that the archetypal oncoantigen ERBB2 is transiently overexpressed in Syrian hamsters during the early stages of 7,12-dimethylbenz[α]anthracene (DMBA)-induced oral carcinogenesis. Repeated DNA vaccinations against ERBB2 significantly reduce the number, size and severity of oral lesions in a manner directly proportional to the anti-ERBB2 antibody response. These results support the prospects of vaccines as a fresh strategy in the management of individuals at risk for exposure to defined carcinogenic agents.
2011
4
7
994
1001
ERBB2; Squamous cells carcinoma; Oral cancer
G N Berta; A E Sprio; M Iezzi; M Spadaro; S Cappia; P Salamone; F Di Scipio; B Mognetti; M Papotti; P Musiani; G Forni; F Cavallo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/86631
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