Sfoglia per Autore
Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer
2024-01-01 Pippione, Agnese Chiara; Kovachka, Sandra; Vigato, Chiara; Bertarini, Laura; Mannella, Iole; Sainas, Stefano; Rolando, Barbara; Denasio, Enrica; Piercy-Mycock, Helen; Romalho, Linda; Salladini, Edoardo; Adinolfi, Salvatore; Zonari, Daniele; Peraldo-Neia, Caterina; Chiorino, Giovanna; Passoni, Alice; Mirza, Osman Asghar; Frydenvang, Karla; Pors, Klaus; Lolli, Marco Lucio; Spyrakis, Francesca; Oliaro-Bosso, Simonetta; Boschi, Donatella
Intramolecular interactions and the neutral loss of ammonia from collisionally activated, protonated ω-aminoalkyl-3-hydroxyfurazans
2024-01-01 Grossert, J. Stuart; Boschi, Donatella; Lolli, Marco L.; White, Robert L.
Investigation of the central core of MEDS433: A Bioisosteric voyage into the Amide's Role.
2024-01-01 Elena Martino, Stefano Sainas, Marta Alberti, Iole Mannella, Marta Giorgis, Paola Circosta, Donatella Boschi, Marco Lucio Lolli
HYDROXYLATED HETEROCYCLES AS BIOISOSTERES OF THE CARBOXYLIC FUNCTION: DESIGN OF NEW AKR1C3 INHIBITORS ACTIVE IN PROSTATE CANCER
2023-01-01 Agnese C. Pippione, Stefano Sainas, Chiara Vigato, Iole Mannella, Irene Castellino, Sandra Kovachka, Mariia Iakovleva, Barbara Rolando, Tomasz Wrobel, Osman A. Mirza, Karla Frydenvang, Francesca Spyrakis, Simonetta Oliaro-Bosso, Marco L. Lolli, Donatella Boschi
Phenothiazines as anti-cancer agents: SAR overview and synthetic strategies
2023-01-01 Arun Kumar, Chiara Vigato, Donatella Boschi, Marco Lucio Lolli, Deepak Kumar
Biochemical characterization of Mycobacterium tuberculosis dihydroorotate dehydrogenase and identification of a selective inhibitor
2023-01-01 Marta Alberti , Stefano Sainas , Erika Ronchi , Marco L Lolli , Donatella Boschi, Menico Rizzi, Davide M Ferraris , Riccardo Miggiano
Exploring the Potential of Sulfur Moieties in Compounds Inhibiting Steroidogenesis
2023-01-01 Wróbel, Tomasz M; Sharma, Katyayani; Mannella, Iole; Oliaro-Bosso, Simonetta; Nieckarz, Patrycja; Du Toit, Therina; Voegel, Clarissa Daniela; Rojas Velazquez, Maria Natalia; Yakubu, Jibira; Matveeva, Anna; Therkelsen, Søren; Jørgensen, Flemming Steen; Pandey, Amit V; Pippione, Agnese C; Lolli, Marco L; Boschi, Donatella; Björkling, Fredrik
Mechanisms of antiviral activity of the new hDHODH inhibitor MEDS433 against respiratory syncytial virus replication
2023-01-01 Luganini, Anna; Sibille, Giulia; Pavan, Marta; Mello Grand, Maurizia; Sainas, Stefano; Boschi, Donatella; Lolli, Marco L; Chiorino, Giovanna; Gribaudo, Giorgio
A new generation of AKR1C3 inhibitors on the horizon: the 3- hydroxybenzazole approach to target prostate cancer
2023-01-01 Chiara Vigato, Agnese Chiara Pippione, Stefano Sainas, Iole Mannella, Laura Bertarini, Sandra Kovachka, Barbara Rolando, Osman Asghar Mirza, Karla Frydenvang, Francesca Spyrakis, Simonetta Oliaro-Bosso, Marco Lucio Lolli, Donatella Boschi
Optimization of MEDS433 synthesis: scale-up for preclinical evaluation studies
2023-01-01 Iole Mannella, Chiara Vigato, Stefano Sainas, Marco Lucio Lolli, Donatella Boschi
Optimization of MEDS433 synthesis: scale-up for preclinical evaluation studies
2023-01-01 Iole Mannella, Chiara Vigato, Stefano Sainas, Marco Lucio Lolli, Donatella Boschi
Turning the light on with pyrazolo[1,5-A]pyridine: exploring it’s fluorescent properties for the design of new fluorosteric compounds
2023-01-01 Elena Martino, Stefano Sainas, Francesco Bavo, Claudio Garino, Marta Giorgis, Bente Frølund, Marco Lucio Lolli
Targeting Acute Myelogenous Leukemia using potent human dihydroorotate dehydrogenase inhibitors based on the 2-hydroxypyrazolo[1,5-a]pyridine scaffold: from academy to clinic
2022-01-01 Marta Giorgis, Stefano Sainas, Paola Circosta, Alice Passoni, Renzo Bagnati, Marilena Marraudino, Brigitta Bonaldo, Stefano Gotti, Riccardo Miggiano, Davide Ferraris, Marta Alberti, Agnese Chiara Pippione, Chiara Vigato, Donatella Boschi, Giuseppe Nicola Saglio, Marco Lucio Lolli
New Hydroxybenzoazole Inhibitors of Aldo-Keto Reductase 1C3 (AKR1C3): Disclosure of SAR Investigation to Target Prostate Cancer
2022-01-01 Chiara Vigato, Agnese Chiara Pippione, Iole Mannella, Mariia Iakovleva, Stefano Sainas, Simonetta Oliaro Bosso, Barbara Rolando, Sandra Kovachka, Francesca Spyrakis, Marco Lucio Lolli, Donatella Boschi
NEW AKR1C3 INHIBITORS WITH BENZOISOXAZOLE CORE: DESIGN, SYNTHESIS AND BIOLOGICAL ACTIVITY TO TARGET PROSTATE CANCER
2022-01-01 Pippione Agnese Chiara , Iakovleva, M.; Vottero, C.; Sainas, S; Kilic-Kurt, Z.; Rolando, B; Kovachka, S; Spyrakis, F; Buschini, A.; Montalbano, S.; Oliaro Bosso, S.; Lolli, M.L, Boschi, D.
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety
2022-01-01 Sainas, Stefano; Giorgis, Marta; Circosta, Paola; Poli, Giulio; Alberti, Marta; Passoni, Alice; Gaidano, Valentina; Pippione, Agnese C; Vitale, Nicoletta; Bonanni, Davide; Rolando, Barbara; Cignetti, Alessandro; Ramondetti, Cristina; Lanno, Alessia; Ferraris, Davide M; Canepa, Barbara; Buccinnà, Barbara; Piccinini, Marco; Rizzi, Menico; Saglio, Giuseppe; Al-Karadaghi, Salam; Boschi, Donatella; Miggiano, Riccardo; Tuccinardi, Tiziano; Lolli, Marco L
Develop of new fluorescent probe to target hDHODH enzyme
2022-01-01 Elena Martino, Stefano Sainas, Francesco Bavo, Claudio Garino, Agnese Chiara Pippione, Marta Giorgis, Donatella Boschi, Bente Frølund, Marco Lucio Lolli
New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold
2022-01-01 Pippione A.C.; Kilic-Kurt Z.; Kovachka S.; Sainas S.; Rolando B.; Denasio E.; Pors K.; Adinolfi S.; Zonari D.; Bagnati R.; Lolli M.L.; Spyrakis F.; Oliaro-Bosso S.; Boschi D.
Identification of Human Dihydroorotate Dehydrogenase Inhibitor by a Pharmacophore-Based Virtual Screening Study
2022-01-01 Galati, Salvatore; Sainas, Stefano; Giorgis, Marta; Boschi, Donatella; Lolli, Marco L; Ortore, Gabriella; Poli, Giulio; Tuccinardi, Tiziano
Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia
2022-01-01 Houshmand, Mohammad; Vitale, Nicoletta; Orso, Francesca; Cignetti, Alessandro; Molineris, Ivan; Gaidano, Valentina; Sainas, Stefano; Giorgis, Marta; Boschi, Donatella; Fava, Carmen; Passoni, Alice; Gai, Marta; Geuna, Massimo; Sora, Federica; Iurlo, Alessandra; Abruzzese, Elisabetta; Breccia, Massimo; Mulas, Olga; Caocci, Giovanni; Castagnetti, Fausto; Taverna, Daniela; Oliviero, Salvatore; Pane, Fabrizio; Lolli, Marco Lucio; Circosta, Paola; Saglio, Giuseppe
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer | 2024 | Pippione, Agnese Chiara; Kovachka, Sandra; Vigato, Chiara; Bertarini, Laura; Mannella, Iole; Sainas, Stefano; Rolando, Barbara; Denasio, Enrica; Piercy-Mycock, Helen; Romalho, Linda; Salladini, Edoardo; Adinolfi, Salvatore; Zonari, Daniele; Peraldo-Neia, Caterina; Chiorino, Giovanna; Passoni, Alice; Mirza, Osman Asghar; Frydenvang, Karla; Pors, Klaus; Lolli, Marco Lucio; Spyrakis, Francesca; Oliaro-Bosso, Simonetta; Boschi, Donatella | |
| Intramolecular interactions and the neutral loss of ammonia from collisionally activated, protonated ω-aminoalkyl-3-hydroxyfurazans | 2024 | Grossert, J. Stuart; Boschi, Donatella; Lolli, Marco L.; White, Robert L. | |
| Investigation of the central core of MEDS433: A Bioisosteric voyage into the Amide's Role. | 2024 | Elena Martino, Stefano Sainas, Marta Alberti, Iole Mannella, Marta Giorgis, Paola Circosta, Donatella Boschi, Marco Lucio Lolli | |
| HYDROXYLATED HETEROCYCLES AS BIOISOSTERES OF THE CARBOXYLIC FUNCTION: DESIGN OF NEW AKR1C3 INHIBITORS ACTIVE IN PROSTATE CANCER | 2023 | Agnese C. Pippione, Stefano Sainas, Chiara Vigato, Iole Mannella, Irene Castellino, Sandra Kovachka, Mariia Iakovleva, Barbara Rolando, Tomasz Wrobel, Osman A. Mirza, Karla Frydenvang, Francesca Spyrakis, Simonetta Oliaro-Bosso, Marco L. Lolli, Donatella Boschi | |
| Phenothiazines as anti-cancer agents: SAR overview and synthetic strategies | 2023 | Arun Kumar, Chiara Vigato, Donatella Boschi, Marco Lucio Lolli, Deepak Kumar | |
| Biochemical characterization of Mycobacterium tuberculosis dihydroorotate dehydrogenase and identification of a selective inhibitor | 2023 | Marta Alberti , Stefano Sainas , Erika Ronchi , Marco L Lolli , Donatella Boschi, Menico Rizzi, Davide M Ferraris , Riccardo Miggiano | |
| Exploring the Potential of Sulfur Moieties in Compounds Inhibiting Steroidogenesis | 2023 | Wróbel, Tomasz M; Sharma, Katyayani; Mannella, Iole; Oliaro-Bosso, Simonetta; Nieckarz, Patrycja; Du Toit, Therina; Voegel, Clarissa Daniela; Rojas Velazquez, Maria Natalia; Yakubu, Jibira; Matveeva, Anna; Therkelsen, Søren; Jørgensen, Flemming Steen; Pandey, Amit V; Pippione, Agnese C; Lolli, Marco L; Boschi, Donatella; Björkling, Fredrik | |
| Mechanisms of antiviral activity of the new hDHODH inhibitor MEDS433 against respiratory syncytial virus replication | 2023 | Luganini, Anna; Sibille, Giulia; Pavan, Marta; Mello Grand, Maurizia; Sainas, Stefano; Boschi, Donatella; Lolli, Marco L; Chiorino, Giovanna; Gribaudo, Giorgio | |
| A new generation of AKR1C3 inhibitors on the horizon: the 3- hydroxybenzazole approach to target prostate cancer | 2023 | Chiara Vigato, Agnese Chiara Pippione, Stefano Sainas, Iole Mannella, Laura Bertarini, Sandra Kovachka, Barbara Rolando, Osman Asghar Mirza, Karla Frydenvang, Francesca Spyrakis, Simonetta Oliaro-Bosso, Marco Lucio Lolli, Donatella Boschi | |
| Optimization of MEDS433 synthesis: scale-up for preclinical evaluation studies | 2023 | Iole Mannella, Chiara Vigato, Stefano Sainas, Marco Lucio Lolli, Donatella Boschi | |
| Optimization of MEDS433 synthesis: scale-up for preclinical evaluation studies | 2023 | Iole Mannella, Chiara Vigato, Stefano Sainas, Marco Lucio Lolli, Donatella Boschi | |
| Turning the light on with pyrazolo[1,5-A]pyridine: exploring it’s fluorescent properties for the design of new fluorosteric compounds | 2023 | Elena Martino, Stefano Sainas, Francesco Bavo, Claudio Garino, Marta Giorgis, Bente Frølund, Marco Lucio Lolli | |
| Targeting Acute Myelogenous Leukemia using potent human dihydroorotate dehydrogenase inhibitors based on the 2-hydroxypyrazolo[1,5-a]pyridine scaffold: from academy to clinic | 2022 | Marta Giorgis, Stefano Sainas, Paola Circosta, Alice Passoni, Renzo Bagnati, Marilena Marraudino, Brigitta Bonaldo, Stefano Gotti, Riccardo Miggiano, Davide Ferraris, Marta Alberti, Agnese Chiara Pippione, Chiara Vigato, Donatella Boschi, Giuseppe Nicola Saglio, Marco Lucio Lolli | |
| New Hydroxybenzoazole Inhibitors of Aldo-Keto Reductase 1C3 (AKR1C3): Disclosure of SAR Investigation to Target Prostate Cancer | 2022 | Chiara Vigato, Agnese Chiara Pippione, Iole Mannella, Mariia Iakovleva, Stefano Sainas, Simonetta Oliaro Bosso, Barbara Rolando, Sandra Kovachka, Francesca Spyrakis, Marco Lucio Lolli, Donatella Boschi | |
| NEW AKR1C3 INHIBITORS WITH BENZOISOXAZOLE CORE: DESIGN, SYNTHESIS AND BIOLOGICAL ACTIVITY TO TARGET PROSTATE CANCER | 2022 | Pippione Agnese Chiara , Iakovleva, M.; Vottero, C.; Sainas, S; Kilic-Kurt, Z.; Rolando, B; Kovachka, S; Spyrakis, F; Buschini, A.; Montalbano, S.; Oliaro Bosso, S.; Lolli, M.L, Boschi, D. | |
| Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety | 2022 | Sainas, Stefano; Giorgis, Marta; Circosta, Paola; Poli, Giulio; Alberti, Marta; Passoni, Alice; Gaidano, Valentina; Pippione, Agnese C; Vitale, Nicoletta; Bonanni, Davide; Rolando, Barbara; Cignetti, Alessandro; Ramondetti, Cristina; Lanno, Alessia; Ferraris, Davide M; Canepa, Barbara; Buccinnà, Barbara; Piccinini, Marco; Rizzi, Menico; Saglio, Giuseppe; Al-Karadaghi, Salam; Boschi, Donatella; Miggiano, Riccardo; Tuccinardi, Tiziano; Lolli, Marco L | |
| Develop of new fluorescent probe to target hDHODH enzyme | 2022 | Elena Martino, Stefano Sainas, Francesco Bavo, Claudio Garino, Agnese Chiara Pippione, Marta Giorgis, Donatella Boschi, Bente Frølund, Marco Lucio Lolli | |
| New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold | 2022 | Pippione A.C.; Kilic-Kurt Z.; Kovachka S.; Sainas S.; Rolando B.; Denasio E.; Pors K.; Adinolfi S.; Zonari D.; Bagnati R.; Lolli M.L.; Spyrakis F.; Oliaro-Bosso S.; Boschi D. | |
| Identification of Human Dihydroorotate Dehydrogenase Inhibitor by a Pharmacophore-Based Virtual Screening Study | 2022 | Galati, Salvatore; Sainas, Stefano; Giorgis, Marta; Boschi, Donatella; Lolli, Marco L; Ortore, Gabriella; Poli, Giulio; Tuccinardi, Tiziano | |
| Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia | 2022 | Houshmand, Mohammad; Vitale, Nicoletta; Orso, Francesca; Cignetti, Alessandro; Molineris, Ivan; Gaidano, Valentina; Sainas, Stefano; Giorgis, Marta; Boschi, Donatella; Fava, Carmen; Passoni, Alice; Gai, Marta; Geuna, Massimo; Sora, Federica; Iurlo, Alessandra; Abruzzese, Elisabetta; Breccia, Massimo; Mulas, Olga; Caocci, Giovanni; Castagnetti, Fausto; Taverna, Daniela; Oliviero, Salvatore; Pane, Fabrizio; Lolli, Marco Lucio; Circosta, Paola; Saglio, Giuseppe |
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