Sfoglia per Autore
Investigation of the central core of MEDS433: A Bioisosteric voyage into the Amide's Role
2024-01-01 Elena Martino, Stefano Sainas, Iole Manella, Marta Alberti, Marta Giorgis, Paola Circosta, Donatella Boschi and Marco Lucio Lolli
Investigation of the central core of MEDS433: A Bioisosteric voyage into the Amide's Role.
2024-01-01 Elena Martino, Stefano Sainas, Marta Alberti, Iole Mannella, Marta Giorgis, Paola Circosta, Donatella Boschi, Marco Lucio Lolli
Full chimaeric CAR.CIK from patients engrafted after allogeneic haematopoietic cell transplant: Feasibility, anti-leukaemic potential and alloreactivity across major human leukocyte antigen barriers
2023-01-01 Circosta, Paola; Donini, Chiara; Gallo, Susanna; Giraudo, Lidia; Gammaitoni, Loretta; Rotolo, Ramona; Galvagno, Federica; Capellero, Sonia; Basiricò, Marco; Casucci, Monica; Aglietta, Massimo; Ferrero, Ivana; Fagioli, Franca; Cignetti, Alessandro; Carnevale-Schianca, Fabrizio; Leuci, Valeria; Sangiolo, Dario
Important Steps into Drug Development of MEDS433, a Potent Human Dihydroorotate Dehydrogenase Inhibitor based on the 2-hydroxypyrazolo[1,5-a] Pyridine Scaffold
2022-01-01 M. Giorgis, S. Sainas, P.Circosta, A. Passoni, R. Bagnati, M. Marraudino, B. Bonaldo, S. Gotti, C. Vigato, A.C.Pippione, D. Boschi, G. Saglio, M.L. Lolli
Important steps into drug development of MEDS433, a potent human dihydroorotate dehydrogenase inhibitor based on the 2-hydroxypyrazolo[1,5-a]pyridine scaffold
2022-01-01 Marta Giorgis, Stefano Sainas, Paola Circosta, Alice Passoni, Renzo Bagnati, Marilena Marraudino, Brigitta Bonaldo, Stefano Gotti, Chiara Vigato, Agnese Chiara Pippione, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli
Targeting Acute Myelogenous Leukemia using potent human dihydroorotate dehydrogenase inhibitors based on the 2- hydroxypyrazolo[1,5-a]pyridine scaffold: from academy to clinic
2022-01-01 Marta Giorgis, Stefano Sainas, Paola Circosta, Alice Passoni, Renzo Bagnati, Marilena Marraudino, Brigitta Bonaldo, Stefano Gotti, Riccardo Miggiano, Davide Ferraris, Marta Alberti, Agnese Chiara Pippione, Chiara Vigato, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli
Targeting Acute Myelogenous Leukemia using potent human dihydroorotate dehydrogenase inhibitors based on the 2-hydroxypyrazolo[1,5-a]pyridine scaffold: from academy to clinic
2022-01-01 Marta Giorgis, Stefano Sainas, Paola Circosta, Alice Passoni, Renzo Bagnati, Marilena Marraudino, Brigitta Bonaldo, Stefano Gotti, Riccardo Miggiano, Davide Ferraris, Marta Alberti, Agnese Chiara Pippione, Chiara Vigato, Donatella Boschi, Giuseppe Nicola Saglio, Marco Lucio Lolli
Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia
2022-01-01 Houshmand, Mohammad; Vitale, Nicoletta; Orso, Francesca; Cignetti, Alessandro; Molineris, Ivan; Gaidano, Valentina; Sainas, Stefano; Giorgis, Marta; Boschi, Donatella; Fava, Carmen; Passoni, Alice; Gai, Marta; Geuna, Massimo; Sora, Federica; Iurlo, Alessandra; Abruzzese, Elisabetta; Breccia, Massimo; Mulas, Olga; Caocci, Giovanni; Castagnetti, Fausto; Taverna, Daniela; Oliviero, Salvatore; Pane, Fabrizio; Lolli, Marco Lucio; Circosta, Paola; Saglio, Giuseppe
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety
2022-01-01 Sainas, Stefano; Giorgis, Marta; Circosta, Paola; Poli, Giulio; Alberti, Marta; Passoni, Alice; Gaidano, Valentina; Pippione, Agnese C; Vitale, Nicoletta; Bonanni, Davide; Rolando, Barbara; Cignetti, Alessandro; Ramondetti, Cristina; Lanno, Alessia; Ferraris, Davide M; Canepa, Barbara; Buccinnà, Barbara; Piccinini, Marco; Rizzi, Menico; Saglio, Giuseppe; Al-Karadaghi, Salam; Boschi, Donatella; Miggiano, Riccardo; Tuccinardi, Tiziano; Lolli, Marco L
Improvement of Metabolic Weakness of New Dihydroorotate Dehydrogenase Inhibitors Based on 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold to Target Myeloid Leukemias
2021-01-01 Chiara Vigato, Stefano Sainas, Marta Giorgis, Paola Circosta, Alice Passoni, Marta Alberti, Agnese Chiara Pippione, Riccardo Miggiano, Davide Ferraris, Renzo Bagnati, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli
The inhibition of human DHODH by M433 leads to differentiation and apoptosis in acute myeloid leukemia
2021-01-01 Sainas Stefano, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Gotti Stefano, Saglio Giuseppe., Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio
Hydroxylated heterocycles as a bioisosteric tool to Modulate the carboxylic function into design potent human Dihydroorotate Dehydrogenase inhibitors
2021-01-01 Stefano Sainas, Paola Circosta, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli
A differentiating and apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor
2021-01-01 Stefano Sainas, Paola Circosta, Marta Giorgis, Agnese Chiara Pippione, Marilena Marraudino, Mohammad Houshmand, Brigitta Bonaldo, Valentina Gaidano, Alessandro Cignetti, Stefano Gotti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
Improvement of metabolic weakness of new human Dihydroorotate Dehydrogenase inhibitors based on 2-hydroxypyrazolo[1,5-a]pyridine scaffold
2021-01-01 Chiara Vigato, Stefano Sainas, Marta Giorgis, Paola Circosta, Alice Passoni, Agnese Chiara Pippione, Renzo Bagnati, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli
Targeting myeloid leukemias using human Dihydroorotate Dehydrogenase inhibitors based on 2-hydroxypyrazolo[1,5-a]pyridine scaffold: overcoming of metabolic issues
2021-01-01 Chiara Vigato, Stefano Sainas, Marta Giorgis, Paola Circosta, Alice Passoni, Agnese Chiara Pippione, Renzo Bagnati, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli.
A new pro-apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor
2021-01-01 Sainas Sainas, Paola Circosta, Noemi Villella, Elena Martino, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Caterina Peraldo Neia, Giovanna Chiorino, Salam Al-Karadaghi, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli.
Apoptotic and differentiating therapy for AML using potent human dihydroorotate dehydrogenase inhibitor
2021-01-01 Sainas Sainas, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lolli
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold: SAR of the Biphenyl Moiety
2021-01-01 Sainas S.; Giorgis M.; Circosta P.; Gaidano V.; Bonanni D.; Pippione A.C.; Bagnati R.; Passoni A.; Qiu Y.; Cojocaru C.F.; Canepa B.; Bona A.; Rolando B.; Mishina M.; Ramondetti C.; Buccinna B.; Piccinini M.; Houshmand M.; Cignetti A.; Giraudo E.; Al-Karadaghi S.; Boschi D.; Saglio G.; Lolli M.L.
The synergism between DHODH inhibitors and dipyridamole leads to metabolic lethality in acute myeloid leukemia
2021-01-01 Gaidano V.; Houshmand M.; Vitale N.; Carra G.; Morotti A.; Tenace V.; Rapelli S.; Sainas S.; Pippione A.C.; Giorgis M.; Boschi D.; Lolli M.L.; Cilloni D.; Cignetti A.; Saglio G.; Circosta P.
Targeting chronic myeloid leukemia stem/progenitor cells using venetoclax-loaded immunoliposome
2021-01-01 Houshmand M.; Garello F.; Stefania R.; Gaidano V.; Cignetti A.; Spinelli M.; Fava C.; Zarif M.N.; Galimberti S.; Pungolino E.; Annunziata M.; Luciano L.; Specchia G.; Bocchia M.; Binotto G.; Bonifacio M.; Martino B.; Pregno P.; Stagno F.; Iurlo A.; Russo S.; Aime S.; Circosta P.; Saglio G.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Investigation of the central core of MEDS433: A Bioisosteric voyage into the Amide's Role | 2024 | Elena Martino, Stefano Sainas, Iole Manella, Marta Alberti, Marta Giorgis, Paola Circosta, Donatella Boschi and Marco Lucio Lolli | |
| Investigation of the central core of MEDS433: A Bioisosteric voyage into the Amide's Role. | 2024 | Elena Martino, Stefano Sainas, Marta Alberti, Iole Mannella, Marta Giorgis, Paola Circosta, Donatella Boschi, Marco Lucio Lolli | |
| Full chimaeric CAR.CIK from patients engrafted after allogeneic haematopoietic cell transplant: Feasibility, anti-leukaemic potential and alloreactivity across major human leukocyte antigen barriers | 2023 | Circosta, Paola; Donini, Chiara; Gallo, Susanna; Giraudo, Lidia; Gammaitoni, Loretta; Rotolo, Ramona; Galvagno, Federica; Capellero, Sonia; Basiricò, Marco; Casucci, Monica; Aglietta, Massimo; Ferrero, Ivana; Fagioli, Franca; Cignetti, Alessandro; Carnevale-Schianca, Fabrizio; Leuci, Valeria; Sangiolo, Dario | |
| Important Steps into Drug Development of MEDS433, a Potent Human Dihydroorotate Dehydrogenase Inhibitor based on the 2-hydroxypyrazolo[1,5-a] Pyridine Scaffold | 2022 | M. Giorgis, S. Sainas, P.Circosta, A. Passoni, R. Bagnati, M. Marraudino, B. Bonaldo, S. Gotti, C. Vigato, A.C.Pippione, D. Boschi, G. Saglio, M.L. Lolli | |
| Important steps into drug development of MEDS433, a potent human dihydroorotate dehydrogenase inhibitor based on the 2-hydroxypyrazolo[1,5-a]pyridine scaffold | 2022 | Marta Giorgis, Stefano Sainas, Paola Circosta, Alice Passoni, Renzo Bagnati, Marilena Marraudino, Brigitta Bonaldo, Stefano Gotti, Chiara Vigato, Agnese Chiara Pippione, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli | |
| Targeting Acute Myelogenous Leukemia using potent human dihydroorotate dehydrogenase inhibitors based on the 2- hydroxypyrazolo[1,5-a]pyridine scaffold: from academy to clinic | 2022 | Marta Giorgis, Stefano Sainas, Paola Circosta, Alice Passoni, Renzo Bagnati, Marilena Marraudino, Brigitta Bonaldo, Stefano Gotti, Riccardo Miggiano, Davide Ferraris, Marta Alberti, Agnese Chiara Pippione, Chiara Vigato, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli | |
| Targeting Acute Myelogenous Leukemia using potent human dihydroorotate dehydrogenase inhibitors based on the 2-hydroxypyrazolo[1,5-a]pyridine scaffold: from academy to clinic | 2022 | Marta Giorgis, Stefano Sainas, Paola Circosta, Alice Passoni, Renzo Bagnati, Marilena Marraudino, Brigitta Bonaldo, Stefano Gotti, Riccardo Miggiano, Davide Ferraris, Marta Alberti, Agnese Chiara Pippione, Chiara Vigato, Donatella Boschi, Giuseppe Nicola Saglio, Marco Lucio Lolli | |
| Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia | 2022 | Houshmand, Mohammad; Vitale, Nicoletta; Orso, Francesca; Cignetti, Alessandro; Molineris, Ivan; Gaidano, Valentina; Sainas, Stefano; Giorgis, Marta; Boschi, Donatella; Fava, Carmen; Passoni, Alice; Gai, Marta; Geuna, Massimo; Sora, Federica; Iurlo, Alessandra; Abruzzese, Elisabetta; Breccia, Massimo; Mulas, Olga; Caocci, Giovanni; Castagnetti, Fausto; Taverna, Daniela; Oliviero, Salvatore; Pane, Fabrizio; Lolli, Marco Lucio; Circosta, Paola; Saglio, Giuseppe | |
| Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety | 2022 | Sainas, Stefano; Giorgis, Marta; Circosta, Paola; Poli, Giulio; Alberti, Marta; Passoni, Alice; Gaidano, Valentina; Pippione, Agnese C; Vitale, Nicoletta; Bonanni, Davide; Rolando, Barbara; Cignetti, Alessandro; Ramondetti, Cristina; Lanno, Alessia; Ferraris, Davide M; Canepa, Barbara; Buccinnà, Barbara; Piccinini, Marco; Rizzi, Menico; Saglio, Giuseppe; Al-Karadaghi, Salam; Boschi, Donatella; Miggiano, Riccardo; Tuccinardi, Tiziano; Lolli, Marco L | |
| Improvement of Metabolic Weakness of New Dihydroorotate Dehydrogenase Inhibitors Based on 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold to Target Myeloid Leukemias | 2021 | Chiara Vigato, Stefano Sainas, Marta Giorgis, Paola Circosta, Alice Passoni, Marta Alberti, Agnese Chiara Pippione, Riccardo Miggiano, Davide Ferraris, Renzo Bagnati, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli | |
| The inhibition of human DHODH by M433 leads to differentiation and apoptosis in acute myeloid leukemia | 2021 | Sainas Stefano, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Gotti Stefano, Saglio Giuseppe., Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio | |
| Hydroxylated heterocycles as a bioisosteric tool to Modulate the carboxylic function into design potent human Dihydroorotate Dehydrogenase inhibitors | 2021 | Stefano Sainas, Paola Circosta, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli | |
| A differentiating and apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor | 2021 | Stefano Sainas, Paola Circosta, Marta Giorgis, Agnese Chiara Pippione, Marilena Marraudino, Mohammad Houshmand, Brigitta Bonaldo, Valentina Gaidano, Alessandro Cignetti, Stefano Gotti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli | |
| Improvement of metabolic weakness of new human Dihydroorotate Dehydrogenase inhibitors based on 2-hydroxypyrazolo[1,5-a]pyridine scaffold | 2021 | Chiara Vigato, Stefano Sainas, Marta Giorgis, Paola Circosta, Alice Passoni, Agnese Chiara Pippione, Renzo Bagnati, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli | |
| Targeting myeloid leukemias using human Dihydroorotate Dehydrogenase inhibitors based on 2-hydroxypyrazolo[1,5-a]pyridine scaffold: overcoming of metabolic issues | 2021 | Chiara Vigato, Stefano Sainas, Marta Giorgis, Paola Circosta, Alice Passoni, Agnese Chiara Pippione, Renzo Bagnati, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli. | |
| A new pro-apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor | 2021 | Sainas Sainas, Paola Circosta, Noemi Villella, Elena Martino, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Caterina Peraldo Neia, Giovanna Chiorino, Salam Al-Karadaghi, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli. | |
| Apoptotic and differentiating therapy for AML using potent human dihydroorotate dehydrogenase inhibitor | 2021 | Sainas Sainas, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lolli | |
| Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold: SAR of the Biphenyl Moiety | 2021 | Sainas S.; Giorgis M.; Circosta P.; Gaidano V.; Bonanni D.; Pippione A.C.; Bagnati R.; Passoni A.; Qiu Y.; Cojocaru C.F.; Canepa B.; Bona A.; Rolando B.; Mishina M.; Ramondetti C.; Buccinna B.; Piccinini M.; Houshmand M.; Cignetti A.; Giraudo E.; Al-Karadaghi S.; Boschi D.; Saglio G.; Lolli M.L. | |
| The synergism between DHODH inhibitors and dipyridamole leads to metabolic lethality in acute myeloid leukemia | 2021 | Gaidano V.; Houshmand M.; Vitale N.; Carra G.; Morotti A.; Tenace V.; Rapelli S.; Sainas S.; Pippione A.C.; Giorgis M.; Boschi D.; Lolli M.L.; Cilloni D.; Cignetti A.; Saglio G.; Circosta P. | |
| Targeting chronic myeloid leukemia stem/progenitor cells using venetoclax-loaded immunoliposome | 2021 | Houshmand M.; Garello F.; Stefania R.; Gaidano V.; Cignetti A.; Spinelli M.; Fava C.; Zarif M.N.; Galimberti S.; Pungolino E.; Annunziata M.; Luciano L.; Specchia G.; Bocchia M.; Binotto G.; Bonifacio M.; Martino B.; Pregno P.; Stagno F.; Iurlo A.; Russo S.; Aime S.; Circosta P.; Saglio G. |
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