Sfoglia per Autore
Hydroxypyrazolol[1,5-a]pyridine as a fluorescent carboxylic acid isostere: development of new fluorescent 4-PHP analogues
2013-01-01 Stefano Sainas; Birgitte Nielsen; Donatella Boschi; Bente Frølund; Marco L. Lolli
SUBSTITUTED 4-HYDROXY-1H-1,2,3-TRIAZOLES: SYNTHESIS AND BIOISOSTERIC APPLICATIONS
2014-01-01 Agnese C. Pippione; Antonella Federico; Stefano Sainas; Alex Ducime; Marco L. Lolli; Donatella Boschi
TOWARD A BIOISOSTERIC ALKAEST – APPLICATION TO THE BIOISOSTERIC MODULATION OF IMD-0354
2014-01-01 Marco L. Lolli; Alex Ducime; Antonella Federico; Agnese Chiara Pippione; Stefano Sainas; Alessandro Barge; Katia Martina; Donatella Boschi; Elisa Lupino; Marco Piccinini; Michael Kubbutat; Christoph Schächtele; Jean Marie Contreras; Christophe Morice; Joel Sussman; Yoav Peleg; Bjorn Walse; Salam Kadaraghi
Synthesis and Structural Characterization of Regio Substituted 4-Hydroxy-1H-1,2,3-triazols as Possible Tool in Bioisosteric Applications
2014-01-01 A Federico; S.Sainas; A. Ducime;K. Martina; F. Bosca; D. Boschi; M.L. Lolli.
4-Hydroxy-1H-1,2,3-Triazol-5-yl moiety as bioisoster of carboxylic group. Synthesis and pharmacological ionotropic glutamate receptors characterization of Glu analogues
2014-01-01 S. Sainas; A. Federico;C. Bertolotti; B. Nielsen; D. Boschi; B. Frølund and M. L. Lolli
Towards a Bioisosteric Alkaest: application to the bioisosteric modulation of IMD-0354
2014-01-01 Lolli Marco L.; Federico Antonella; Ducime Alex; Pippione Agnese; Sainas Stefano; Barge Alessandro; Martina Katia; Boschi Donatella; Lupino Elisa; Piccinini Marco; Kubbutat Michael; Contreras Jean Marie; Morice Christophe; Sussman Joel; Peleg Yoav; Walse Bjorn; Al-Kadaraghi Salam
Toward a Bioisosteric Alkahest: Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by a Scaffold Hopping Bioisosteric approach using Hydroxylated Pentatomic Heterocycles
2015-01-01 Marco L. Lolli, Agnese Chiara Pippione, Stefano Sainas, Stefano Mensa, Marta Giorgis, Marco Piccinini, Elisa Lupino, Salam Al-Kadaraghi, Donatella Boschi
Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by combination of in-silico ligand/structural pharmacophore models and scaffold hopping bioisosteric approaches
2015-01-01 Mensa, Stefano; Carnovale, Irene M.; Pippione, Agnese Chiara; Sainas, Stefano; Giorgis, Marta; Piccinini, Marco; Lupino, Elisa; Al-Karadaghi, Salam; Boschi, Donatella; L. Lolli., Marco
Substituted 4-hydroxy-1,2,3-triazoles: synthesis, characterization and first drug design applications through bioisosteric modulation and scaffold hopping approaches
2015-01-01 Pippione, Agnese C; Dosio, Franco; Ducime, Alex; Federico, Antonella; Martina, Katia; Sainas, Stefano; Frølund, Bente; Gooyit, Major; Janda, Kim D.; Boschi, Donatella; Lolli, Marco L.
Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by a Scaffold Hopping Bioisosteric approach using Hydroxylated Pentaatomic Heterocycles
2016-01-01 Sainas, Stefano; Pippione, Agnese Chiara; Carnovale, IRENE MARIA; Giraudo, Alessandro; Giorgis, Marta; Braga Rodolpho Campos, ; Andrade Carolina Horta, ; Piccinini, Marco; Lupino, Elisa; Guedes, Rita; AL KARADAGHI, Salam; Boschi, Donatella; Lolli, Marco Lucio
Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by a Scaffold Hopping Bioisosteric approach using Hydroxylated Pentatomic Heterocycles
2016-01-01 Sainas Stefano; Pippione Agnese Chiara; Carnovale Irene Maria; Giraudo Alessandro; Giorgis Marta; de Campos Braga Rodolpho; Andrade Carolina H; Villella Noemi; Friemann Rosmarie; Piccinini Marco; Lupino Elisa; Al-karadaghi Salam; Boschi Donatella;Lolli Marco Lucio
Antileishmanial activity of some 4-phenyl-3-amino-1H-pyrazols designed as CRK3 kinase inhibitors
2016-01-01 Agnese Chiara Pippione, Piermichele Kobauri, Stefano Sainas, Alberto Gimenez, Antonella Federico, Rodolpho Campos Braga, Carolina Horta Andrade, Donatella Boschi, Efrain Salamanca, Juan Carlos Ticona, Marco Lucio Lolli
Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by a Scaffold Hopping Bioisosteric approach using Hydroxylated Pentatomic Heterocycles
2016-01-01 Stefano Sainas, Agnese Chiara Pippione, Irene Maria Carnovale, Alessandro Giraudo, Marta Giorgis, Rodolpho B. Braga, Carolina H. Andrade, Noemi Villella, Marco Piccinini, Elisa Lupino, Rosmarie Friemann, Salam Al-Kadaraghi, Donatella Boschi, Marco L. Lolli
4-Hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-κB cascade
2017-01-01 Pippione, Agnese C.; Federico, Antonella; Ducime, Alex; Sainas, Stefano; Boschi, Donatella; Barge, Alessandro; Lupino, Elisa; Piccinini, Marco; Kubbutat, Michael; Contreras, Jean-Marie; Morice, Christophe; Al-Karadaghi, Salam; Lolli, Marco L.
Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds
2017-01-01 Sainas, Stefano; Pippione, Agnese C.; Giorgis, Marta; Lupino, Elisa; Goyal, Parveen; Ramondetti, Cristina; Buccinnà, Barbara; Piccinini, Marco; Braga, Rodolpho C.; Andrade, Carolina H.; Andersson, Mikael; Moritzer, Ann-Christin; Friemann, Rosmarie; Mensa, Stefano; Al-Kadaraghi, Salam; Boschi, Donatella; Lolli, Marco L
In vitro myeloid differentiation using a new generation of potent human dihydroorotate dehydrogenase inhibitors
2018-01-01 Sainas S., Pippione A. C., Bonanni D., Giorgis Marta, Lupino E. , Circosta P. , Gaidano V. , Cignetti A. , Piccinini M. , Saglio G. , Al-Karadaghi S. , Boschi D., Lolli M.L.
Development of Potent Human Dihydroorotate Dehydrogenase Inhibitors Able to Induces Myeloid Differentiation
2018-01-01 Stefano Sainas, Agnese C. Pippione, Davide Bonanni, Marta Giorgis, Elisa Lupino, Enrico Giraudo, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Marco Piccinini, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco L. Lolli
New human dihydroorotate dehydrogenase inhibitors able to restore myeloid differentiation in AML
2018-01-01 Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Elisa Lupino, Enrico Giraudo, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Marco Piccinini, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
PROCEEDINGS OF THE MERCK & ELSEVIER YOUNG CHEMISTSSYMPOSIUM
2018-01-01 Stefano Sainas, Agnese C. Pippione, Davide Bonanni, Marta Giorgis, Elisa Lupino, Enrico Giraudo, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Marco Piccinini, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco L. Lolli
Targeting myeloid differentiation using potent human dihydroorotate dehydrogenase (hDHODH) inhibitors
2018-01-01 Sainas Stefano, Pippione Agnese Chiara, Bonanni Davide, Giorgis Marta, Lupino Elisa, Giraudo Enrico, Goyal Parveen, Circosta Paola, Gaidano Valentina, Cignetti Alessandro, Piccinini Marco, Friemann Rosmarie, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Hydroxypyrazolol[1,5-a]pyridine as a fluorescent carboxylic acid isostere: development of new fluorescent 4-PHP analogues | 2013 | Stefano Sainas; Birgitte Nielsen; Donatella Boschi; Bente Frølund; Marco L. Lolli | |
| SUBSTITUTED 4-HYDROXY-1H-1,2,3-TRIAZOLES: SYNTHESIS AND BIOISOSTERIC APPLICATIONS | 2014 | Agnese C. Pippione; Antonella Federico; Stefano Sainas; Alex Ducime; Marco L. Lolli; Donatella Boschi | |
| TOWARD A BIOISOSTERIC ALKAEST – APPLICATION TO THE BIOISOSTERIC MODULATION OF IMD-0354 | 2014 | Marco L. Lolli; Alex Ducime; Antonella Federico; Agnese Chiara Pippione; Stefano Sainas; Alessandro Barge; Katia Martina; Donatella Boschi; Elisa Lupino; Marco Piccinini; Michael Kubbutat; Christoph Schächtele; Jean Marie Contreras; Christophe Morice; Joel Sussman; Yoav Peleg; Bjorn Walse; Salam Kadaraghi | |
| Synthesis and Structural Characterization of Regio Substituted 4-Hydroxy-1H-1,2,3-triazols as Possible Tool in Bioisosteric Applications | 2014 | A Federico; S.Sainas; A. Ducime;K. Martina; F. Bosca; D. Boschi; M.L. Lolli. | |
| 4-Hydroxy-1H-1,2,3-Triazol-5-yl moiety as bioisoster of carboxylic group. Synthesis and pharmacological ionotropic glutamate receptors characterization of Glu analogues | 2014 | S. Sainas; A. Federico;C. Bertolotti; B. Nielsen; D. Boschi; B. Frølund and M. L. Lolli | |
| Towards a Bioisosteric Alkaest: application to the bioisosteric modulation of IMD-0354 | 2014 | Lolli Marco L.; Federico Antonella; Ducime Alex; Pippione Agnese; Sainas Stefano; Barge Alessandro; Martina Katia; Boschi Donatella; Lupino Elisa; Piccinini Marco; Kubbutat Michael; Contreras Jean Marie; Morice Christophe; Sussman Joel; Peleg Yoav; Walse Bjorn; Al-Kadaraghi Salam | |
| Toward a Bioisosteric Alkahest: Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by a Scaffold Hopping Bioisosteric approach using Hydroxylated Pentatomic Heterocycles | 2015 | Marco L. Lolli, Agnese Chiara Pippione, Stefano Sainas, Stefano Mensa, Marta Giorgis, Marco Piccinini, Elisa Lupino, Salam Al-Kadaraghi, Donatella Boschi | |
| Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by combination of in-silico ligand/structural pharmacophore models and scaffold hopping bioisosteric approaches | 2015 | Mensa, Stefano; Carnovale, Irene M.; Pippione, Agnese Chiara; Sainas, Stefano; Giorgis, Marta; Piccinini, Marco; Lupino, Elisa; Al-Karadaghi, Salam; Boschi, Donatella; L. Lolli., Marco | |
| Substituted 4-hydroxy-1,2,3-triazoles: synthesis, characterization and first drug design applications through bioisosteric modulation and scaffold hopping approaches | 2015 | Pippione, Agnese C; Dosio, Franco; Ducime, Alex; Federico, Antonella; Martina, Katia; Sainas, Stefano; Frølund, Bente; Gooyit, Major; Janda, Kim D.; Boschi, Donatella; Lolli, Marco L. | |
| Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by a Scaffold Hopping Bioisosteric approach using Hydroxylated Pentaatomic Heterocycles | 2016 | Sainas, Stefano; Pippione, Agnese Chiara; Carnovale, IRENE MARIA; Giraudo, Alessandro; Giorgis, Marta; Braga Rodolpho Campos, ; Andrade Carolina Horta, ; Piccinini, Marco; Lupino, Elisa; Guedes, Rita; AL KARADAGHI, Salam; Boschi, Donatella; Lolli, Marco Lucio | |
| Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by a Scaffold Hopping Bioisosteric approach using Hydroxylated Pentatomic Heterocycles | 2016 | Sainas Stefano; Pippione Agnese Chiara; Carnovale Irene Maria; Giraudo Alessandro; Giorgis Marta; de Campos Braga Rodolpho; Andrade Carolina H; Villella Noemi; Friemann Rosmarie; Piccinini Marco; Lupino Elisa; Al-karadaghi Salam; Boschi Donatella;Lolli Marco Lucio | |
| Antileishmanial activity of some 4-phenyl-3-amino-1H-pyrazols designed as CRK3 kinase inhibitors | 2016 | Agnese Chiara Pippione, Piermichele Kobauri, Stefano Sainas, Alberto Gimenez, Antonella Federico, Rodolpho Campos Braga, Carolina Horta Andrade, Donatella Boschi, Efrain Salamanca, Juan Carlos Ticona, Marco Lucio Lolli | |
| Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by a Scaffold Hopping Bioisosteric approach using Hydroxylated Pentatomic Heterocycles | 2016 | Stefano Sainas, Agnese Chiara Pippione, Irene Maria Carnovale, Alessandro Giraudo, Marta Giorgis, Rodolpho B. Braga, Carolina H. Andrade, Noemi Villella, Marco Piccinini, Elisa Lupino, Rosmarie Friemann, Salam Al-Kadaraghi, Donatella Boschi, Marco L. Lolli | |
| 4-Hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-κB cascade | 2017 | Pippione, Agnese C.; Federico, Antonella; Ducime, Alex; Sainas, Stefano; Boschi, Donatella; Barge, Alessandro; Lupino, Elisa; Piccinini, Marco; Kubbutat, Michael; Contreras, Jean-Marie; Morice, Christophe; Al-Karadaghi, Salam; Lolli, Marco L. | |
| Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds | 2017 | Sainas, Stefano; Pippione, Agnese C.; Giorgis, Marta; Lupino, Elisa; Goyal, Parveen; Ramondetti, Cristina; Buccinnà, Barbara; Piccinini, Marco; Braga, Rodolpho C.; Andrade, Carolina H.; Andersson, Mikael; Moritzer, Ann-Christin; Friemann, Rosmarie; Mensa, Stefano; Al-Kadaraghi, Salam; Boschi, Donatella; Lolli, Marco L | |
| In vitro myeloid differentiation using a new generation of potent human dihydroorotate dehydrogenase inhibitors | 2018 | Sainas S., Pippione A. C., Bonanni D., Giorgis Marta, Lupino E. , Circosta P. , Gaidano V. , Cignetti A. , Piccinini M. , Saglio G. , Al-Karadaghi S. , Boschi D., Lolli M.L. | |
| Development of Potent Human Dihydroorotate Dehydrogenase Inhibitors Able to Induces Myeloid Differentiation | 2018 | Stefano Sainas, Agnese C. Pippione, Davide Bonanni, Marta Giorgis, Elisa Lupino, Enrico Giraudo, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Marco Piccinini, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco L. Lolli | |
| New human dihydroorotate dehydrogenase inhibitors able to restore myeloid differentiation in AML | 2018 | Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Elisa Lupino, Enrico Giraudo, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Marco Piccinini, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli | |
| PROCEEDINGS OF THE MERCK & ELSEVIER YOUNG CHEMISTSSYMPOSIUM | 2018 | Stefano Sainas, Agnese C. Pippione, Davide Bonanni, Marta Giorgis, Elisa Lupino, Enrico Giraudo, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Marco Piccinini, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco L. Lolli | |
| Targeting myeloid differentiation using potent human dihydroorotate dehydrogenase (hDHODH) inhibitors | 2018 | Sainas Stefano, Pippione Agnese Chiara, Bonanni Davide, Giorgis Marta, Lupino Elisa, Giraudo Enrico, Goyal Parveen, Circosta Paola, Gaidano Valentina, Cignetti Alessandro, Piccinini Marco, Friemann Rosmarie, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio |
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