Sfoglia per Autore
Investigation of the central core of MEDS433: A Bioisosteric voyage into the Amide's Role
2024-01-01 Elena Martino, Stefano Sainas, Iole Manella, Marta Alberti, Marta Giorgis, Paola Circosta, Donatella Boschi and Marco Lucio Lolli
Investigation of the central core of MEDS433: A Bioisosteric voyage into the Amide's Role.
2024-01-01 Elena Martino, Stefano Sainas, Marta Alberti, Iole Mannella, Marta Giorgis, Paola Circosta, Donatella Boschi, Marco Lucio Lolli
Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer
2024-01-01 Pippione, Agnese Chiara; Kovachka, Sandra; Vigato, Chiara; Bertarini, Laura; Mannella, Iole; Sainas, Stefano; Rolando, Barbara; Denasio, Enrica; Piercy-Mycock, Helen; Romalho, Linda; Salladini, Edoardo; Adinolfi, Salvatore; Zonari, Daniele; Peraldo-Neia, Caterina; Chiorino, Giovanna; Passoni, Alice; Mirza, Osman Asghar; Frydenvang, Karla; Pors, Klaus; Lolli, Marco Lucio; Spyrakis, Francesca; Oliaro-Bosso, Simonetta; Boschi, Donatella
Turning the light on with pyrazolo[1,5-A]pyridine: exploring it’s fluorescent properties for the design of new fluorosteric compounds
2023-01-01 Elena Martino, Stefano Sainas, Francesco Bavo, Claudio Garino, Marta Giorgis, Bente Frølund, Marco Lucio Lolli
HYDROXYLATED HETEROCYCLES AS BIOISOSTERES OF THE CARBOXYLIC FUNCTION: DESIGN OF NEW AKR1C3 INHIBITORS ACTIVE IN PROSTATE CANCER
2023-01-01 Agnese C. Pippione, Stefano Sainas, Chiara Vigato, Iole Mannella, Irene Castellino, Sandra Kovachka, Mariia Iakovleva, Barbara Rolando, Tomasz Wrobel, Osman A. Mirza, Karla Frydenvang, Francesca Spyrakis, Simonetta Oliaro-Bosso, Marco L. Lolli, Donatella Boschi
A new generation of AKR1C3 inhibitors on the horizon: the 3- hydroxybenzazole approach to target prostate cancer
2023-01-01 Chiara Vigato, Agnese Chiara Pippione, Stefano Sainas, Iole Mannella, Laura Bertarini, Sandra Kovachka, Barbara Rolando, Osman Asghar Mirza, Karla Frydenvang, Francesca Spyrakis, Simonetta Oliaro-Bosso, Marco Lucio Lolli, Donatella Boschi
Optimization of MEDS433 synthesis: scale-up for preclinical evaluation studies
2023-01-01 Iole Mannella, Chiara Vigato, Stefano Sainas, Marco Lucio Lolli, Donatella Boschi
Optimization of MEDS433 synthesis: scale-up for preclinical evaluation studies
2023-01-01 Iole Mannella, Chiara Vigato, Stefano Sainas, Marco Lucio Lolli, Donatella Boschi
Biochemical characterization of Mycobacterium tuberculosis dihydroorotate dehydrogenase and identification of a selective inhibitor
2023-01-01 Marta Alberti , Stefano Sainas , Erika Ronchi , Marco L Lolli , Donatella Boschi, Menico Rizzi, Davide M Ferraris , Riccardo Miggiano
Mechanisms of antiviral activity of the new hDHODH inhibitor MEDS433 against respiratory syncytial virus replication
2023-01-01 Luganini, Anna; Sibille, Giulia; Pavan, Marta; Mello Grand, Maurizia; Sainas, Stefano; Boschi, Donatella; Lolli, Marco L; Chiorino, Giovanna; Gribaudo, Giorgio
Important Steps into Drug Development of MEDS433, a Potent Human Dihydroorotate Dehydrogenase Inhibitor based on the 2-hydroxypyrazolo[1,5-a] Pyridine Scaffold
2022-01-01 M. Giorgis, S. Sainas, P.Circosta, A. Passoni, R. Bagnati, M. Marraudino, B. Bonaldo, S. Gotti, C. Vigato, A.C.Pippione, D. Boschi, G. Saglio, M.L. Lolli
Important steps into drug development of MEDS433, a potent human dihydroorotate dehydrogenase inhibitor based on the 2-hydroxypyrazolo[1,5-a]pyridine scaffold
2022-01-01 Marta Giorgis, Stefano Sainas, Paola Circosta, Alice Passoni, Renzo Bagnati, Marilena Marraudino, Brigitta Bonaldo, Stefano Gotti, Chiara Vigato, Agnese Chiara Pippione, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli
Targeting Acute Myelogenous Leukemia using potent human dihydroorotate dehydrogenase inhibitors based on the 2- hydroxypyrazolo[1,5-a]pyridine scaffold: from academy to clinic
2022-01-01 Marta Giorgis, Stefano Sainas, Paola Circosta, Alice Passoni, Renzo Bagnati, Marilena Marraudino, Brigitta Bonaldo, Stefano Gotti, Riccardo Miggiano, Davide Ferraris, Marta Alberti, Agnese Chiara Pippione, Chiara Vigato, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli
Targeting Acute Myelogenous Leukemia using potent human dihydroorotate dehydrogenase inhibitors based on the 2-hydroxypyrazolo[1,5-a]pyridine scaffold: from academy to clinic
2022-01-01 Marta Giorgis, Stefano Sainas, Paola Circosta, Alice Passoni, Renzo Bagnati, Marilena Marraudino, Brigitta Bonaldo, Stefano Gotti, Riccardo Miggiano, Davide Ferraris, Marta Alberti, Agnese Chiara Pippione, Chiara Vigato, Donatella Boschi, Giuseppe Nicola Saglio, Marco Lucio Lolli
New Hydroxybenzoazole Inhibitors of Aldo-Keto Reductase 1C3 (AKR1C3): Disclosure of SAR Investigation to Target Prostate Cancer
2022-01-01 Chiara Vigato, Agnese Chiara Pippione, Iole Mannella, Mariia Iakovleva, Stefano Sainas, Simonetta Oliaro Bosso, Barbara Rolando, Sandra Kovachka, Francesca Spyrakis, Marco Lucio Lolli, Donatella Boschi
A New NF-κB Inhibitor, MEDS-23, Reduces the Severity of Adverse Post-Ischemic Stroke Outcomes in Rats
2022-01-01 Rubin E.; Pippione A.C.; Boyko M.; Einaudi G.; Sainas S.; Collino M.; Cifani C.; Lolli M.L.; Abu-Freha N.; Kaplanski J.; Boschi D.; Azab A.N.
NEW AKR1C3 INHIBITORS WITH BENZOISOXAZOLE CORE: DESIGN, SYNTHESIS AND BIOLOGICAL ACTIVITY TO TARGET PROSTATE CANCER
2022-01-01 Pippione Agnese Chiara , Iakovleva, M.; Vottero, C.; Sainas, S; Kilic-Kurt, Z.; Rolando, B; Kovachka, S; Spyrakis, F; Buschini, A.; Montalbano, S.; Oliaro Bosso, S.; Lolli, M.L, Boschi, D.
Improving the fluorescent profile of pyrazolo [1,5-a]pyridine fluorophores for developing new fluorescent probes
2022-01-01 Elena Martino, Noemi Villella, Stefano Sainas, Francesco Bavo, Claudio Garino, Simona Mattiussi, Agnese Chiara Pippione, Marta Giorgis, Donatella Boschi, Bente Frølund, Marco Lucio Lolli.
Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia
2022-01-01 Houshmand, Mohammad; Vitale, Nicoletta; Orso, Francesca; Cignetti, Alessandro; Molineris, Ivan; Gaidano, Valentina; Sainas, Stefano; Giorgis, Marta; Boschi, Donatella; Fava, Carmen; Passoni, Alice; Gai, Marta; Geuna, Massimo; Sora, Federica; Iurlo, Alessandra; Abruzzese, Elisabetta; Breccia, Massimo; Mulas, Olga; Caocci, Giovanni; Castagnetti, Fausto; Taverna, Daniela; Oliviero, Salvatore; Pane, Fabrizio; Lolli, Marco Lucio; Circosta, Paola; Saglio, Giuseppe
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety
2022-01-01 Sainas, Stefano; Giorgis, Marta; Circosta, Paola; Poli, Giulio; Alberti, Marta; Passoni, Alice; Gaidano, Valentina; Pippione, Agnese C; Vitale, Nicoletta; Bonanni, Davide; Rolando, Barbara; Cignetti, Alessandro; Ramondetti, Cristina; Lanno, Alessia; Ferraris, Davide M; Canepa, Barbara; Buccinnà, Barbara; Piccinini, Marco; Rizzi, Menico; Saglio, Giuseppe; Al-Karadaghi, Salam; Boschi, Donatella; Miggiano, Riccardo; Tuccinardi, Tiziano; Lolli, Marco L
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Investigation of the central core of MEDS433: A Bioisosteric voyage into the Amide's Role | 2024 | Elena Martino, Stefano Sainas, Iole Manella, Marta Alberti, Marta Giorgis, Paola Circosta, Donatella Boschi and Marco Lucio Lolli | |
| Investigation of the central core of MEDS433: A Bioisosteric voyage into the Amide's Role. | 2024 | Elena Martino, Stefano Sainas, Marta Alberti, Iole Mannella, Marta Giorgis, Paola Circosta, Donatella Boschi, Marco Lucio Lolli | |
| Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer | 2024 | Pippione, Agnese Chiara; Kovachka, Sandra; Vigato, Chiara; Bertarini, Laura; Mannella, Iole; Sainas, Stefano; Rolando, Barbara; Denasio, Enrica; Piercy-Mycock, Helen; Romalho, Linda; Salladini, Edoardo; Adinolfi, Salvatore; Zonari, Daniele; Peraldo-Neia, Caterina; Chiorino, Giovanna; Passoni, Alice; Mirza, Osman Asghar; Frydenvang, Karla; Pors, Klaus; Lolli, Marco Lucio; Spyrakis, Francesca; Oliaro-Bosso, Simonetta; Boschi, Donatella | |
| Turning the light on with pyrazolo[1,5-A]pyridine: exploring it’s fluorescent properties for the design of new fluorosteric compounds | 2023 | Elena Martino, Stefano Sainas, Francesco Bavo, Claudio Garino, Marta Giorgis, Bente Frølund, Marco Lucio Lolli | |
| HYDROXYLATED HETEROCYCLES AS BIOISOSTERES OF THE CARBOXYLIC FUNCTION: DESIGN OF NEW AKR1C3 INHIBITORS ACTIVE IN PROSTATE CANCER | 2023 | Agnese C. Pippione, Stefano Sainas, Chiara Vigato, Iole Mannella, Irene Castellino, Sandra Kovachka, Mariia Iakovleva, Barbara Rolando, Tomasz Wrobel, Osman A. Mirza, Karla Frydenvang, Francesca Spyrakis, Simonetta Oliaro-Bosso, Marco L. Lolli, Donatella Boschi | |
| A new generation of AKR1C3 inhibitors on the horizon: the 3- hydroxybenzazole approach to target prostate cancer | 2023 | Chiara Vigato, Agnese Chiara Pippione, Stefano Sainas, Iole Mannella, Laura Bertarini, Sandra Kovachka, Barbara Rolando, Osman Asghar Mirza, Karla Frydenvang, Francesca Spyrakis, Simonetta Oliaro-Bosso, Marco Lucio Lolli, Donatella Boschi | |
| Optimization of MEDS433 synthesis: scale-up for preclinical evaluation studies | 2023 | Iole Mannella, Chiara Vigato, Stefano Sainas, Marco Lucio Lolli, Donatella Boschi | |
| Optimization of MEDS433 synthesis: scale-up for preclinical evaluation studies | 2023 | Iole Mannella, Chiara Vigato, Stefano Sainas, Marco Lucio Lolli, Donatella Boschi | |
| Biochemical characterization of Mycobacterium tuberculosis dihydroorotate dehydrogenase and identification of a selective inhibitor | 2023 | Marta Alberti , Stefano Sainas , Erika Ronchi , Marco L Lolli , Donatella Boschi, Menico Rizzi, Davide M Ferraris , Riccardo Miggiano | |
| Mechanisms of antiviral activity of the new hDHODH inhibitor MEDS433 against respiratory syncytial virus replication | 2023 | Luganini, Anna; Sibille, Giulia; Pavan, Marta; Mello Grand, Maurizia; Sainas, Stefano; Boschi, Donatella; Lolli, Marco L; Chiorino, Giovanna; Gribaudo, Giorgio | |
| Important Steps into Drug Development of MEDS433, a Potent Human Dihydroorotate Dehydrogenase Inhibitor based on the 2-hydroxypyrazolo[1,5-a] Pyridine Scaffold | 2022 | M. Giorgis, S. Sainas, P.Circosta, A. Passoni, R. Bagnati, M. Marraudino, B. Bonaldo, S. Gotti, C. Vigato, A.C.Pippione, D. Boschi, G. Saglio, M.L. Lolli | |
| Important steps into drug development of MEDS433, a potent human dihydroorotate dehydrogenase inhibitor based on the 2-hydroxypyrazolo[1,5-a]pyridine scaffold | 2022 | Marta Giorgis, Stefano Sainas, Paola Circosta, Alice Passoni, Renzo Bagnati, Marilena Marraudino, Brigitta Bonaldo, Stefano Gotti, Chiara Vigato, Agnese Chiara Pippione, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli | |
| Targeting Acute Myelogenous Leukemia using potent human dihydroorotate dehydrogenase inhibitors based on the 2- hydroxypyrazolo[1,5-a]pyridine scaffold: from academy to clinic | 2022 | Marta Giorgis, Stefano Sainas, Paola Circosta, Alice Passoni, Renzo Bagnati, Marilena Marraudino, Brigitta Bonaldo, Stefano Gotti, Riccardo Miggiano, Davide Ferraris, Marta Alberti, Agnese Chiara Pippione, Chiara Vigato, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli | |
| Targeting Acute Myelogenous Leukemia using potent human dihydroorotate dehydrogenase inhibitors based on the 2-hydroxypyrazolo[1,5-a]pyridine scaffold: from academy to clinic | 2022 | Marta Giorgis, Stefano Sainas, Paola Circosta, Alice Passoni, Renzo Bagnati, Marilena Marraudino, Brigitta Bonaldo, Stefano Gotti, Riccardo Miggiano, Davide Ferraris, Marta Alberti, Agnese Chiara Pippione, Chiara Vigato, Donatella Boschi, Giuseppe Nicola Saglio, Marco Lucio Lolli | |
| New Hydroxybenzoazole Inhibitors of Aldo-Keto Reductase 1C3 (AKR1C3): Disclosure of SAR Investigation to Target Prostate Cancer | 2022 | Chiara Vigato, Agnese Chiara Pippione, Iole Mannella, Mariia Iakovleva, Stefano Sainas, Simonetta Oliaro Bosso, Barbara Rolando, Sandra Kovachka, Francesca Spyrakis, Marco Lucio Lolli, Donatella Boschi | |
| A New NF-κB Inhibitor, MEDS-23, Reduces the Severity of Adverse Post-Ischemic Stroke Outcomes in Rats | 2022 | Rubin E.; Pippione A.C.; Boyko M.; Einaudi G.; Sainas S.; Collino M.; Cifani C.; Lolli M.L.; Abu-Freha N.; Kaplanski J.; Boschi D.; Azab A.N. | |
| NEW AKR1C3 INHIBITORS WITH BENZOISOXAZOLE CORE: DESIGN, SYNTHESIS AND BIOLOGICAL ACTIVITY TO TARGET PROSTATE CANCER | 2022 | Pippione Agnese Chiara , Iakovleva, M.; Vottero, C.; Sainas, S; Kilic-Kurt, Z.; Rolando, B; Kovachka, S; Spyrakis, F; Buschini, A.; Montalbano, S.; Oliaro Bosso, S.; Lolli, M.L, Boschi, D. | |
| Improving the fluorescent profile of pyrazolo [1,5-a]pyridine fluorophores for developing new fluorescent probes | 2022 | Elena Martino, Noemi Villella, Stefano Sainas, Francesco Bavo, Claudio Garino, Simona Mattiussi, Agnese Chiara Pippione, Marta Giorgis, Donatella Boschi, Bente Frølund, Marco Lucio Lolli. | |
| Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia | 2022 | Houshmand, Mohammad; Vitale, Nicoletta; Orso, Francesca; Cignetti, Alessandro; Molineris, Ivan; Gaidano, Valentina; Sainas, Stefano; Giorgis, Marta; Boschi, Donatella; Fava, Carmen; Passoni, Alice; Gai, Marta; Geuna, Massimo; Sora, Federica; Iurlo, Alessandra; Abruzzese, Elisabetta; Breccia, Massimo; Mulas, Olga; Caocci, Giovanni; Castagnetti, Fausto; Taverna, Daniela; Oliviero, Salvatore; Pane, Fabrizio; Lolli, Marco Lucio; Circosta, Paola; Saglio, Giuseppe | |
| Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety | 2022 | Sainas, Stefano; Giorgis, Marta; Circosta, Paola; Poli, Giulio; Alberti, Marta; Passoni, Alice; Gaidano, Valentina; Pippione, Agnese C; Vitale, Nicoletta; Bonanni, Davide; Rolando, Barbara; Cignetti, Alessandro; Ramondetti, Cristina; Lanno, Alessia; Ferraris, Davide M; Canepa, Barbara; Buccinnà, Barbara; Piccinini, Marco; Rizzi, Menico; Saglio, Giuseppe; Al-Karadaghi, Salam; Boschi, Donatella; Miggiano, Riccardo; Tuccinardi, Tiziano; Lolli, Marco L |
Legenda icone
- file ad accesso aperto
- file disponibili sulla rete interna
- file disponibili agli utenti autorizzati
- file disponibili solo agli amministratori
- file sotto embargo
- nessun file disponibile