GAIDANO, Valentina
GAIDANO, Valentina
A differentiating and apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor
2021-01-01 Stefano Sainas, Paola Circosta, Marta Giorgis, Agnese Chiara Pippione, Marilena Marraudino, Mohammad Houshmand, Brigitta Bonaldo, Valentina Gaidano, Alessandro Cignetti, Stefano Gotti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
A differentiating and apoptotic therapy for acute myeloid leukaemia using potent human dihydroorotate dehydrogenase inhibitors.
2019-01-01 Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
A new pro-apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor
2021-01-01 Sainas Sainas, Paola Circosta, Noemi Villella, Elena Martino, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Caterina Peraldo Neia, Giovanna Chiorino, Salam Al-Karadaghi, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli.
Apoptotic and differentiating therapy for AML using potent human dihydroorotate dehydrogenase inhibitor
2021-01-01 Sainas Sainas, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lolli
Design and Application of a Novel PNA Probe for the Detection At Single Cell Level of JAK2(V617F) Mutation
2012-01-01 Cilloni D; Rosso V; Torti D; Carnuccio F; Serra A; Nicoli P; Gaidano V; Campia V; Signorino E; Calabrese C; Carturan S; Favole A; Saglio G; Frassoni F; Bracco E
Development of Potent Human Dihydroorotate Dehydrogenase Inhibitors Able to Induces Myeloid Differentiation
2018-01-01 Stefano Sainas, Agnese C. Pippione, Davide Bonanni, Marta Giorgis, Elisa Lupino, Enrico Giraudo, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Marco Piccinini, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco L. Lolli
Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors
2019-01-01 Sainas Stefano, Pippione Agnese Chiara, Bonanni Davide, Giorgis Marta, Lupino Elisa, Circosta Paola, Gaidano Valentina, Cignetti Alessandro, Piccinini Marco, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio
Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors able to restore in vitro and in vivo myeloid differentiation
2019-01-01 Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
ERYTHROFERRONE EXPRESSION LEVELS IN MYELODYSPLATIC SYNDROMES SHOW CLINICAL RELEVANCE
2017-01-01 Di Savino, Augusta; Savi, Arianna; Gallo, Daniela; Gaidano, Valentina; Scaravaglio, Patrizia; Mezzabotta, Mauro; Saglio, Giuseppe; Cilloni, Daniela; Marco, De Gobbi
Hydroxylated heterocycles as a bioisosteric tool to Modulate the carboxylic function into design potent human Dihydroorotate Dehydrogenase inhibitors
2021-01-01 Stefano Sainas, Paola Circosta, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli
Improvement of in vivo pharmacokinetic profile of M433, a potent and innovative hDHODH inhibitor.
2019-01-01 Marta Alberti, Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli
In vitro myeloid differentiation using a new generation of potent human dihydroorotate dehydrogenase inhibitors
2018-01-01 Sainas S., Pippione A. C., Bonanni D., Giorgis Marta, Lupino E. , Circosta P. , Gaidano V. , Cignetti A. , Piccinini M. , Saglio G. , Al-Karadaghi S. , Boschi D., Lolli M.L.
In vitro myeloid differentiation using a new generation of potent human dihydroorotate dehydrogenase (hDHODH) inhibitors
2018-01-01 Sainas Stefano, Pippione Agnese Chiara, Bonanni Davide, Giorgis Marta, Lupino Elisa, Giraudo Enrico, Goyal Parveen, Circosta Paola, Gaidano Valentina, Cignetti Alessandro, Piccinini Marco, Friemann Rosmarie, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio
Meds433, a New Dihydroorotate Dehydrogenase Inhibitor, Induces Apoptosis and Differentiation in Acute Myeloid Leukemia
2019-01-01 Gaidano, Valentina; Circosta, Paola; Cignetti, Alessandro; Houshmand, Mohammad; Vitale, Nicoletta; Sainas, Stefano; Pippione, Agnese; Marraudino, Marilena; Bonaldo, Brigitta; Giorgis, Marta; Boschi, Donatella; Lolli, Marco Lucio; Saglio, Giuseppe
New human dihydroorotate dehydrogenase inhibitors able to restore myeloid differentiation in AML
2018-01-01 Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Elisa Lupino, Enrico Giraudo, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Marco Piccinini, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
PROCEEDINGS OF THE MERCK & ELSEVIER YOUNG CHEMISTSSYMPOSIUM
2018-01-01 Stefano Sainas, Agnese C. Pippione, Davide Bonanni, Marta Giorgis, Elisa Lupino, Enrico Giraudo, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Marco Piccinini, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco L. Lolli
Targeting myeloid differentiation using potent human dihydroorotate dehydrogenase (hDHODH) inhibitors
2018-01-01 Sainas Stefano, Pippione Agnese Chiara, Bonanni Davide, Giorgis Marta, Lupino Elisa, Giraudo Enrico, Goyal Parveen, Circosta Paola, Gaidano Valentina, Cignetti Alessandro, Piccinini Marco, Friemann Rosmarie, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio
TFR2 AND EpoR EXPRESSION AT DIAGNOSIS AS POSSIBLE PREDICTORS OF ERYTHROPOIETIN TREATMENT RESPONSE IN MDS PATIENTS
2015-01-01 Di Savino, A ; Familiari, U ; Palmieri, A ; Crasto, F ; Volpengo, A ; Scaravaglio, P ; Gaidano, V ; Nicoli, P ; Gottardi, E ; Papotti, M ; Roetto, A ; Saglio, G; Cilloni, D; De Gobbi, M
The inhibition of human DHODH by M433 leads to differentiation and apoptosis in acute myeloid leukemia
2021-01-01 Sainas Stefano, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Gotti Stefano, Saglio Giuseppe., Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A differentiating and apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor | 2021 | Stefano Sainas, Paola Circosta, Marta Giorgis, Agnese Chiara Pippione, Marilena Marraudino, Mohammad Houshmand, Brigitta Bonaldo, Valentina Gaidano, Alessandro Cignetti, Stefano Gotti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli | |
| A differentiating and apoptotic therapy for acute myeloid leukaemia using potent human dihydroorotate dehydrogenase inhibitors. | 2019 | Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli | |
| A new pro-apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor | 2021 | Sainas Sainas, Paola Circosta, Noemi Villella, Elena Martino, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Caterina Peraldo Neia, Giovanna Chiorino, Salam Al-Karadaghi, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli. | |
| Apoptotic and differentiating therapy for AML using potent human dihydroorotate dehydrogenase inhibitor | 2021 | Sainas Sainas, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lolli | |
| Design and Application of a Novel PNA Probe for the Detection At Single Cell Level of JAK2(V617F) Mutation | 2012 | Cilloni D; Rosso V; Torti D; Carnuccio F; Serra A; Nicoli P; Gaidano V; Campia V; Signorino E; Calabrese C; Carturan S; Favole A; Saglio G; Frassoni F; Bracco E | |
| Development of Potent Human Dihydroorotate Dehydrogenase Inhibitors Able to Induces Myeloid Differentiation | 2018 | Stefano Sainas, Agnese C. Pippione, Davide Bonanni, Marta Giorgis, Elisa Lupino, Enrico Giraudo, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Marco Piccinini, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco L. Lolli | |
| Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors | 2019 | Sainas Stefano, Pippione Agnese Chiara, Bonanni Davide, Giorgis Marta, Lupino Elisa, Circosta Paola, Gaidano Valentina, Cignetti Alessandro, Piccinini Marco, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio | |
| Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors able to restore in vitro and in vivo myeloid differentiation | 2019 | Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli | |
| ERYTHROFERRONE EXPRESSION LEVELS IN MYELODYSPLATIC SYNDROMES SHOW CLINICAL RELEVANCE | 2017 | Di Savino, Augusta; Savi, Arianna; Gallo, Daniela; Gaidano, Valentina; Scaravaglio, Patrizia; Mezzabotta, Mauro; Saglio, Giuseppe; Cilloni, Daniela; Marco, De Gobbi | |
| Hydroxylated heterocycles as a bioisosteric tool to Modulate the carboxylic function into design potent human Dihydroorotate Dehydrogenase inhibitors | 2021 | Stefano Sainas, Paola Circosta, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli | |
| Improvement of in vivo pharmacokinetic profile of M433, a potent and innovative hDHODH inhibitor. | 2019 | Marta Alberti, Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli | |
| In vitro myeloid differentiation using a new generation of potent human dihydroorotate dehydrogenase inhibitors | 2018 | Sainas S., Pippione A. C., Bonanni D., Giorgis Marta, Lupino E. , Circosta P. , Gaidano V. , Cignetti A. , Piccinini M. , Saglio G. , Al-Karadaghi S. , Boschi D., Lolli M.L. | |
| In vitro myeloid differentiation using a new generation of potent human dihydroorotate dehydrogenase (hDHODH) inhibitors | 2018 | Sainas Stefano, Pippione Agnese Chiara, Bonanni Davide, Giorgis Marta, Lupino Elisa, Giraudo Enrico, Goyal Parveen, Circosta Paola, Gaidano Valentina, Cignetti Alessandro, Piccinini Marco, Friemann Rosmarie, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio | |
| Meds433, a New Dihydroorotate Dehydrogenase Inhibitor, Induces Apoptosis and Differentiation in Acute Myeloid Leukemia | 2019 | Gaidano, Valentina; Circosta, Paola; Cignetti, Alessandro; Houshmand, Mohammad; Vitale, Nicoletta; Sainas, Stefano; Pippione, Agnese; Marraudino, Marilena; Bonaldo, Brigitta; Giorgis, Marta; Boschi, Donatella; Lolli, Marco Lucio; Saglio, Giuseppe | |
| New human dihydroorotate dehydrogenase inhibitors able to restore myeloid differentiation in AML | 2018 | Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Elisa Lupino, Enrico Giraudo, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Marco Piccinini, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli | |
| PROCEEDINGS OF THE MERCK & ELSEVIER YOUNG CHEMISTSSYMPOSIUM | 2018 | Stefano Sainas, Agnese C. Pippione, Davide Bonanni, Marta Giorgis, Elisa Lupino, Enrico Giraudo, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Marco Piccinini, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco L. Lolli | |
| Targeting myeloid differentiation using potent human dihydroorotate dehydrogenase (hDHODH) inhibitors | 2018 | Sainas Stefano, Pippione Agnese Chiara, Bonanni Davide, Giorgis Marta, Lupino Elisa, Giraudo Enrico, Goyal Parveen, Circosta Paola, Gaidano Valentina, Cignetti Alessandro, Piccinini Marco, Friemann Rosmarie, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio | |
| TFR2 AND EpoR EXPRESSION AT DIAGNOSIS AS POSSIBLE PREDICTORS OF ERYTHROPOIETIN TREATMENT RESPONSE IN MDS PATIENTS | 2015 | Di Savino, A ; Familiari, U ; Palmieri, A ; Crasto, F ; Volpengo, A ; Scaravaglio, P ; Gaidano, V ; Nicoli, P ; Gottardi, E ; Papotti, M ; Roetto, A ; Saglio, G; Cilloni, D; De Gobbi, M | |
| The inhibition of human DHODH by M433 leads to differentiation and apoptosis in acute myeloid leukemia | 2021 | Sainas Stefano, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Gotti Stefano, Saglio Giuseppe., Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio |