LETO, SIMONETTA MARIA
LETO, SIMONETTA MARIA
213 Design, characterization and preclinical validation of a combinatorial CAR-based immunotherapy against colorectal cancer with HER2 amplification
2022-01-01 Cortese, Marco; Torchiaro, Erica; Leto, Simonetta; Petti, Consalvo; D'Andrea, Alice; Degree, Master; Invrea, Federica; Arena, Sabrina; Medico, Enzo
Abstract 3998: Preclinical efficacy of a synthetic Notch-based combinatorial immunotherapy against colorectal cancer with HER2 amplification
2024-01-01 Cortese, Marco; Torchiaro, Erica; D'Andrea, Alice; Petti, Consalvo; Invrea, Federica; Franco, Letizia; Donini, Chiara; Leuci, Valeria; Leto, Simonetta M.; Vurchio, Valentina; Cottino, Francesca; Isella, Claudio; Arena, Sabrina; Vigna, Elisa; Bertotti, Andrea; Trusolino, Livio; Sangiolo, Dario; Medico, Enzo
Colorectal cancer patient-derived organoids and cell lines harboring ATRX and/or DAXX mutations lack Alternative Lengthening of Telomeres (ALT)
2023-01-01 Marta Falcinelli , Giulia Dell’Omo, Elena Grassi , Elisa Mariella, Simonetta Maria Leto, Sharon Scardellato, Annalisa Lorenzato, Sabrina Arena , Andrea Bertotti, Livio Trusolino , Alberto Bardelli, Fabrizio d’Adda di Fagagna
Effective drug combinations in breast, colon and pancreatic cancer cells
2022-01-01 Jaaks P.; Coker E.A.; Vis D.J.; Edwards O.; Carpenter E.F.; Leto S.M.; Dwane L.; Sassi F.; Lightfoot H.; Barthorpe S.; van der Meer D.; Yang W.; Beck A.; Mironenko T.; Hall C.; Hall J.; Mali I.; Richardson L.; Tolley C.; Morris J.; Thomas F.; Lleshi E.; Aben N.; Benes C.H.; Bertotti A.; Trusolino L.; Wessels L.; Garnett M.J.
HER2 Activating Mutations Are Targets for Colorectal Cancer Treatment
2015-01-01 Kavuri, Shyam M; Jain, Naveen; Galimi, Francesco; Cottino, Francesca; Leto, Simonetta M; Migliardi, Giorgia; Searleman, Adam C; Shen, Wei; Monsey, John; Trusolino, Livio; Jacobs, Samuel A; Bertotti, Andrea*; Bose, Ron* (*Corresponding Authors)
IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies.
2015-01-01 Zanella ER;Galimi F;Sassi F;Migliardi G;Cottino F;Leto SM;Lupo B;Erriquez J;Isella C;Comoglio PM;Medico E;Tejpar S;Budinsk E;Trusolino L*;Bertotti A*(*Co-Senior e Corresponding Authors)
Preclinical efficacy of a HER2 synNotch/CEA-CAR combinatorial immunotherapy against colorectal cancer with HER2 amplification
2024-01-01 Cortese, Marco; Torchiaro, Erica; D'Andrea, Alice; Petti, Consalvo; Invrea, Federica; Franco, Letizia; Donini, Chiara; Leuci, Valeria; Leto, Simonetta Maria; Vurchio, Valentina; Cottino, Francesca; Isella, Claudio; Arena, Sabrina; Vigna, Elisa; Bertotti, Andrea; Trusolino, Livio; Sangiolo, Dario; Medico, Enzo
Primary and acquired resistance to EGFR-targeted therapies in colorectal cancer: impact on future treatment strategies.
2014-01-01 Leto SM;Trusolino L
Rituximab-induced hypogammaglobulinemia in patients with neuromyelitis optica spectrum disorders
2018-01-01 Andrea Marcinnò; Fabiana Marnetto; Paola Valentino; Serena Martire; Alessia Balbo; Aurora Drago; Maria Leto; Marco Capobianco; Giancarlo Panzica; Antonio Bertolotto
Sustained Inhibition of HER3 and EGFR Is Necessary to Induce Regression of HER2-Amplified Gastrointestinal Carcinomas
2015-01-01 Leto, Simonetta M.; Sassi, Francesco; Catalano, Irene; Torri, Valter; Migliardi, Giorgia; Zanella, Eugenia R.; Throsby, Mark; Bertotti, Andrea; Trusolino, Livio
Synthetic Lethal Interaction with BCL-XL Blockade Deepens Response to Cetuximab in Patient-Derived Models of Metastatic Colorectal Cancer
2023-01-01 Leto, Simonetta M; Ferri, Martina; Sassi, Francesco; Zanella, Eugenia R; Cottino, Francesca; Vurchio, Valentina; Catalano, Irene; Ferrero, Alessandro; Zingaretti, Caterina C; Marchio', Caterina; Grassi, Elena; Trusolino, Livio; Bertotti, Andrea
XENTURION is a population-level multidimensional resource of xenografts and tumoroids from metastatic colorectal cancer patients
2024-01-01 Leto, Simonetta M.; Grassi, Elena; Avolio, Marco; Vurchio, Valentina; Cottino, Francesca; Ferri, Martina; Zanella, Eugenia R.; Borgato, Sofia; Corti, Giorgio; di Blasio, Laura; Somale, Desiana; Vara-Messler, Marianela; Galimi, Francesco; Sassi, Francesco; Lupo, Barbara; Catalano, Irene; Pinnelli, Marika; Viviani, Marco; Sperti, Luca; Mellano, Alfredo; Ferrero, Alessandro; Zingaretti, Caterina C.; Puliafito, Alberto; Primo, Luca; Bertotti, Andrea; Trusolino, Livio
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| 213 Design, characterization and preclinical validation of a combinatorial CAR-based immunotherapy against colorectal cancer with HER2 amplification | 2022 | Cortese, Marco; Torchiaro, Erica; Leto, Simonetta; Petti, Consalvo; D'Andrea, Alice; Degree, Master; Invrea, Federica; Arena, Sabrina; Medico, Enzo | |
| Abstract 3998: Preclinical efficacy of a synthetic Notch-based combinatorial immunotherapy against colorectal cancer with HER2 amplification | 2024 | Cortese, Marco; Torchiaro, Erica; D'Andrea, Alice; Petti, Consalvo; Invrea, Federica; Franco, Letizia; Donini, Chiara; Leuci, Valeria; Leto, Simonetta M.; Vurchio, Valentina; Cottino, Francesca; Isella, Claudio; Arena, Sabrina; Vigna, Elisa; Bertotti, Andrea; Trusolino, Livio; Sangiolo, Dario; Medico, Enzo | |
| Colorectal cancer patient-derived organoids and cell lines harboring ATRX and/or DAXX mutations lack Alternative Lengthening of Telomeres (ALT) | 2023 | Marta Falcinelli , Giulia Dell’Omo, Elena Grassi , Elisa Mariella, Simonetta Maria Leto, Sharon Scardellato, Annalisa Lorenzato, Sabrina Arena , Andrea Bertotti, Livio Trusolino , Alberto Bardelli, Fabrizio d’Adda di Fagagna | |
| Effective drug combinations in breast, colon and pancreatic cancer cells | 2022 | Jaaks P.; Coker E.A.; Vis D.J.; Edwards O.; Carpenter E.F.; Leto S.M.; Dwane L.; Sassi F.; Lightfoot H.; Barthorpe S.; van der Meer D.; Yang W.; Beck A.; Mironenko T.; Hall C.; Hall J.; Mali I.; Richardson L.; Tolley C.; Morris J.; Thomas F.; Lleshi E.; Aben N.; Benes C.H.; Bertotti A.; Trusolino L.; Wessels L.; Garnett M.J. | |
| HER2 Activating Mutations Are Targets for Colorectal Cancer Treatment | 2015 | Kavuri, Shyam M; Jain, Naveen; Galimi, Francesco; Cottino, Francesca; Leto, Simonetta M; Migliardi, Giorgia; Searleman, Adam C; Shen, Wei; Monsey, John; Trusolino, Livio; Jacobs, Samuel A; Bertotti, Andrea*; Bose, Ron* (*Corresponding Authors) | |
| IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies. | 2015 | Zanella ER;Galimi F;Sassi F;Migliardi G;Cottino F;Leto SM;Lupo B;Erriquez J;Isella C;Comoglio PM;Medico E;Tejpar S;Budinsk E;Trusolino L*;Bertotti A*(*Co-Senior e Corresponding Authors) | |
| Preclinical efficacy of a HER2 synNotch/CEA-CAR combinatorial immunotherapy against colorectal cancer with HER2 amplification | 2024 | Cortese, Marco; Torchiaro, Erica; D'Andrea, Alice; Petti, Consalvo; Invrea, Federica; Franco, Letizia; Donini, Chiara; Leuci, Valeria; Leto, Simonetta Maria; Vurchio, Valentina; Cottino, Francesca; Isella, Claudio; Arena, Sabrina; Vigna, Elisa; Bertotti, Andrea; Trusolino, Livio; Sangiolo, Dario; Medico, Enzo | |
| Primary and acquired resistance to EGFR-targeted therapies in colorectal cancer: impact on future treatment strategies. | 2014 | Leto SM;Trusolino L | |
| Rituximab-induced hypogammaglobulinemia in patients with neuromyelitis optica spectrum disorders | 2018 | Andrea Marcinnò; Fabiana Marnetto; Paola Valentino; Serena Martire; Alessia Balbo; Aurora Drago; Maria Leto; Marco Capobianco; Giancarlo Panzica; Antonio Bertolotto | |
| Sustained Inhibition of HER3 and EGFR Is Necessary to Induce Regression of HER2-Amplified Gastrointestinal Carcinomas | 2015 | Leto, Simonetta M.; Sassi, Francesco; Catalano, Irene; Torri, Valter; Migliardi, Giorgia; Zanella, Eugenia R.; Throsby, Mark; Bertotti, Andrea; Trusolino, Livio | |
| Synthetic Lethal Interaction with BCL-XL Blockade Deepens Response to Cetuximab in Patient-Derived Models of Metastatic Colorectal Cancer | 2023 | Leto, Simonetta M; Ferri, Martina; Sassi, Francesco; Zanella, Eugenia R; Cottino, Francesca; Vurchio, Valentina; Catalano, Irene; Ferrero, Alessandro; Zingaretti, Caterina C; Marchio', Caterina; Grassi, Elena; Trusolino, Livio; Bertotti, Andrea | |
| XENTURION is a population-level multidimensional resource of xenografts and tumoroids from metastatic colorectal cancer patients | 2024 | Leto, Simonetta M.; Grassi, Elena; Avolio, Marco; Vurchio, Valentina; Cottino, Francesca; Ferri, Martina; Zanella, Eugenia R.; Borgato, Sofia; Corti, Giorgio; di Blasio, Laura; Somale, Desiana; Vara-Messler, Marianela; Galimi, Francesco; Sassi, Francesco; Lupo, Barbara; Catalano, Irene; Pinnelli, Marika; Viviani, Marco; Sperti, Luca; Mellano, Alfredo; Ferrero, Alessandro; Zingaretti, Caterina C.; Puliafito, Alberto; Primo, Luca; Bertotti, Andrea; Trusolino, Livio |