CIRCOSTA, Paola
CIRCOSTA, Paola
SCIENZE CLINICHE E BIOLOGICHE
A differentiating and apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor
2021-01-01 Stefano Sainas, Paola Circosta, Marta Giorgis, Agnese Chiara Pippione, Marilena Marraudino, Mohammad Houshmand, Brigitta Bonaldo, Valentina Gaidano, Alessandro Cignetti, Stefano Gotti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
A differentiating and apoptotic therapy for acute myeloid leukaemia using potent human dihydroorotate dehydrogenase inhibitors.
2019-01-01 Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
A new pro-apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor
2021-01-01 Sainas Sainas, Paola Circosta, Noemi Villella, Elena Martino, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Caterina Peraldo Neia, Giovanna Chiorino, Salam Al-Karadaghi, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli.
Apoptotic and differentiating therapy for AML using potent human dihydroorotate dehydrogenase inhibitor
2021-01-01 Sainas Sainas, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lolli
Development of Potent Human Dihydroorotate Dehydrogenase Inhibitors Able to Induces Myeloid Differentiation
2018-01-01 Stefano Sainas, Agnese C. Pippione, Davide Bonanni, Marta Giorgis, Elisa Lupino, Enrico Giraudo, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Marco Piccinini, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco L. Lolli
Discovery of novel and potent human Dihydroorotate Dehydrogenase inhibitor that induces differentiation and apoptosis in Acute Myeloid Leukaemia
2024-01-01 Villella Noemi, Sainas Stefano, Circosta Paola, Caliandro Ileana, Fornaseri Federico, Alberti Marta, Miggiano Riccardo, Giorgis Marta, Vázquez Santiago, Boschi Donatella, Lolli Marco Lucio
Discovery of novel and potent human Dihydroorotate Dehydrogenase inhibitor that induces differentiation and apoptosis in Acute Myeloid Leukaemia
2024-01-01 Villella Noemi, Sainas Stefano, Circosta Paola, Caliandro Ileana, Fornaseri Federico, Alberti Marta, Miggiano Riccardo, Giorgis Marta, Vázquez Santiago, Boschi Donatella, Lolli Marco Lucio
Discovery of novel and potent human Dihydroorotate Dehydrogenase inhibitor that induces differentiation and apoptosis in Acute Myeloid Leukaemia
2024-01-01 Villella Noemi, Sainas Stefano, Circosta Paola, Caliandro Ileana, Fornaseri Federico, Alberti Marta, Miggiano Riccardo, Giorgis Marta, Vázquez Santiago, Boschi Donatella, Lolli Marco Lucio
Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors
2019-01-01 Sainas Stefano, Pippione Agnese Chiara, Bonanni Davide, Giorgis Marta, Lupino Elisa, Circosta Paola, Gaidano Valentina, Cignetti Alessandro, Piccinini Marco, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio
Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors able to restore in vitro and in vivo myeloid differentiation
2019-01-01 Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
Enhancement of the metabolic stability in 2-hydroxypyrazolo[1,5-a]pyridine scaffold-based inhibitors of human dihydroorotate dehydrogenase (hDHODH)
2024-01-01 Chiara Vigato, Stefano Sainas, Marta Giorgis, Agnese C. Pippione, Alice Passoni, Renzo Bagnati, Paola Circosta, Riccardo Miggiano, Marta Alberti , Donatella Boschi, and Marco L. Lolli
Functional phenotype of peripheral lymphocytes in Churg Strauss syndrome
2012-01-01 Boita, M; Guida, G; Circosta, P; Heffler, E; Stella, S; Elia, A; Geuna, M; Rolla, G; Cignetti, A
High basal γH2AX levels sustain self-renewal of mouse embryonic and induced pluripotent stem cells
2012-01-01 Turinetto, Valentina; Orlando, Luca; Sanchez Ripoll, Y.; Kumpfmuller, B.; Porcedda, P.; Minieri, Valentina; Saviozzi, Silvia; Accomasso, Lisa; CIBRARIO ROCCHIETTI, Elisa; Circosta, Paola; Cignetti, A.; Welham, M. J.; Giachino, Claudia
Hydroxylated heterocycles as a bioisosteric tool to Modulate the carboxylic function into design potent human Dihydroorotate Dehydrogenase inhibitors
2021-01-01 Stefano Sainas, Paola Circosta, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli
Identification of a potent and innovative inhibitor of human Dihydroorotate Dehydrogenase, triggering differentiation and apoptosis in Acute Myeloid Leukaemia
2024-01-01 Villella Noemi, Sainas Stefano, Circosta Paola, Caliandro Ileana, Fornaseri Federico, Alberti Marta, Miggiano Riccardo, Giorgis Marta, Vázquez Santiago, Boschi Donatella, Lolli Marco Lucio
Identification of a potent and innovative inhibitor of human Dihydroorotate Dehydrogenase, triggering differentiation and apoptosis in Acute Myeloid Leukaemia
2024-01-01 Villella Noemi, Sainas Stefano, Circosta Paola, Caliandro Ileana, Fornaseri Federico, Alberti Marta, Miggiano Riccardo, Giorgis Marta, Vázquez Santiago, Boschi Donatella, Lolli Marco Lucio
Important steps into drug development of MEDS433, a potent human dihydroorotate dehydrogenase inhibitor based on the 2-hydroxypyrazolo[1,5-a]pyridine scaffold
2022-01-01 Marta Giorgis, Stefano Sainas, Paola Circosta, Alice Passoni, Renzo Bagnati, Marilena Marraudino, Brigitta Bonaldo, Stefano Gotti, Chiara Vigato, Agnese Chiara Pippione, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli
Important Steps into Drug Development of MEDS433, a Potent Human Dihydroorotate Dehydrogenase Inhibitor based on the 2-hydroxypyrazolo[1,5-a] Pyridine Scaffold
2022-01-01 M. Giorgis, S. Sainas, P.Circosta, A. Passoni, R. Bagnati, M. Marraudino, B. Bonaldo, S. Gotti, C. Vigato, A.C.Pippione, D. Boschi, G. Saglio, M.L. Lolli
Improvement of in vivo pharmacokinetic profile of M433, a potent and innovative hDHODH inhibitor.
2019-01-01 Marta Alberti, Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli
Improvement of Metabolic Weakness of New Dihydroorotate Dehydrogenase Inhibitors Based on 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold to Target Myeloid Leukemias
2021-01-01 Chiara Vigato, Stefano Sainas, Marta Giorgis, Paola Circosta, Alice Passoni, Marta Alberti, Agnese Chiara Pippione, Riccardo Miggiano, Davide Ferraris, Renzo Bagnati, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A differentiating and apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor | 2021 | Stefano Sainas, Paola Circosta, Marta Giorgis, Agnese Chiara Pippione, Marilena Marraudino, Mohammad Houshmand, Brigitta Bonaldo, Valentina Gaidano, Alessandro Cignetti, Stefano Gotti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli | |
| A differentiating and apoptotic therapy for acute myeloid leukaemia using potent human dihydroorotate dehydrogenase inhibitors. | 2019 | Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli | |
| A new pro-apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor | 2021 | Sainas Sainas, Paola Circosta, Noemi Villella, Elena Martino, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Caterina Peraldo Neia, Giovanna Chiorino, Salam Al-Karadaghi, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli. | |
| Apoptotic and differentiating therapy for AML using potent human dihydroorotate dehydrogenase inhibitor | 2021 | Sainas Sainas, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lolli | |
| Development of Potent Human Dihydroorotate Dehydrogenase Inhibitors Able to Induces Myeloid Differentiation | 2018 | Stefano Sainas, Agnese C. Pippione, Davide Bonanni, Marta Giorgis, Elisa Lupino, Enrico Giraudo, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Marco Piccinini, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco L. Lolli | |
| Discovery of novel and potent human Dihydroorotate Dehydrogenase inhibitor that induces differentiation and apoptosis in Acute Myeloid Leukaemia | 2024 | Villella Noemi, Sainas Stefano, Circosta Paola, Caliandro Ileana, Fornaseri Federico, Alberti Marta, Miggiano Riccardo, Giorgis Marta, Vázquez Santiago, Boschi Donatella, Lolli Marco Lucio | |
| Discovery of novel and potent human Dihydroorotate Dehydrogenase inhibitor that induces differentiation and apoptosis in Acute Myeloid Leukaemia | 2024 | Villella Noemi, Sainas Stefano, Circosta Paola, Caliandro Ileana, Fornaseri Federico, Alberti Marta, Miggiano Riccardo, Giorgis Marta, Vázquez Santiago, Boschi Donatella, Lolli Marco Lucio | |
| Discovery of novel and potent human Dihydroorotate Dehydrogenase inhibitor that induces differentiation and apoptosis in Acute Myeloid Leukaemia | 2024 | Villella Noemi, Sainas Stefano, Circosta Paola, Caliandro Ileana, Fornaseri Federico, Alberti Marta, Miggiano Riccardo, Giorgis Marta, Vázquez Santiago, Boschi Donatella, Lolli Marco Lucio | |
| Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors | 2019 | Sainas Stefano, Pippione Agnese Chiara, Bonanni Davide, Giorgis Marta, Lupino Elisa, Circosta Paola, Gaidano Valentina, Cignetti Alessandro, Piccinini Marco, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio | |
| Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors able to restore in vitro and in vivo myeloid differentiation | 2019 | Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli | |
| Enhancement of the metabolic stability in 2-hydroxypyrazolo[1,5-a]pyridine scaffold-based inhibitors of human dihydroorotate dehydrogenase (hDHODH) | 2024 | Chiara Vigato, Stefano Sainas, Marta Giorgis, Agnese C. Pippione, Alice Passoni, Renzo Bagnati, Paola Circosta, Riccardo Miggiano, Marta Alberti , Donatella Boschi, and Marco L. Lolli | |
| Functional phenotype of peripheral lymphocytes in Churg Strauss syndrome | 2012 | Boita, M; Guida, G; Circosta, P; Heffler, E; Stella, S; Elia, A; Geuna, M; Rolla, G; Cignetti, A | |
| High basal γH2AX levels sustain self-renewal of mouse embryonic and induced pluripotent stem cells | 2012 | Turinetto, Valentina; Orlando, Luca; Sanchez Ripoll, Y.; Kumpfmuller, B.; Porcedda, P.; Minieri, Valentina; Saviozzi, Silvia; Accomasso, Lisa; CIBRARIO ROCCHIETTI, Elisa; Circosta, Paola; Cignetti, A.; Welham, M. J.; Giachino, Claudia | |
| Hydroxylated heterocycles as a bioisosteric tool to Modulate the carboxylic function into design potent human Dihydroorotate Dehydrogenase inhibitors | 2021 | Stefano Sainas, Paola Circosta, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli | |
| Identification of a potent and innovative inhibitor of human Dihydroorotate Dehydrogenase, triggering differentiation and apoptosis in Acute Myeloid Leukaemia | 2024 | Villella Noemi, Sainas Stefano, Circosta Paola, Caliandro Ileana, Fornaseri Federico, Alberti Marta, Miggiano Riccardo, Giorgis Marta, Vázquez Santiago, Boschi Donatella, Lolli Marco Lucio | |
| Identification of a potent and innovative inhibitor of human Dihydroorotate Dehydrogenase, triggering differentiation and apoptosis in Acute Myeloid Leukaemia | 2024 | Villella Noemi, Sainas Stefano, Circosta Paola, Caliandro Ileana, Fornaseri Federico, Alberti Marta, Miggiano Riccardo, Giorgis Marta, Vázquez Santiago, Boschi Donatella, Lolli Marco Lucio | |
| Important steps into drug development of MEDS433, a potent human dihydroorotate dehydrogenase inhibitor based on the 2-hydroxypyrazolo[1,5-a]pyridine scaffold | 2022 | Marta Giorgis, Stefano Sainas, Paola Circosta, Alice Passoni, Renzo Bagnati, Marilena Marraudino, Brigitta Bonaldo, Stefano Gotti, Chiara Vigato, Agnese Chiara Pippione, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli | |
| Important Steps into Drug Development of MEDS433, a Potent Human Dihydroorotate Dehydrogenase Inhibitor based on the 2-hydroxypyrazolo[1,5-a] Pyridine Scaffold | 2022 | M. Giorgis, S. Sainas, P.Circosta, A. Passoni, R. Bagnati, M. Marraudino, B. Bonaldo, S. Gotti, C. Vigato, A.C.Pippione, D. Boschi, G. Saglio, M.L. Lolli | |
| Improvement of in vivo pharmacokinetic profile of M433, a potent and innovative hDHODH inhibitor. | 2019 | Marta Alberti, Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli | |
| Improvement of Metabolic Weakness of New Dihydroorotate Dehydrogenase Inhibitors Based on 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold to Target Myeloid Leukemias | 2021 | Chiara Vigato, Stefano Sainas, Marta Giorgis, Paola Circosta, Alice Passoni, Marta Alberti, Agnese Chiara Pippione, Riccardo Miggiano, Davide Ferraris, Renzo Bagnati, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli |