AMBROGIO, Chiara
AMBROGIO, Chiara
BIOTECNOLOGIE MOLECOLARI E SCIENZE PER LA SALUTE
A Braf kinase-inactive mutant induces lung adenocarcinoma
2017-01-01 Nieto P.; Ambrogio C.; Esteban-Burgos L.; Gomez-Lopez G.; Blasco M.T.; Yao Z.; Marais R.; Rosen N.; Chiarle R.; Pisano D.G.; Barbacid M.; Santamaria D.
A LIBRETTO to orchestrate targeted therapy
2020-01-01 Marmarelis, Melina E; Chiarle, Roberto; Ambrogio, Chiara; Aggarwal, Charu
A putative role for Discoidin Domain Receptor 1 in cancer chemoresistance
2018-01-01 Ambrogio C.; Darbo E.; Lee S.W.; Santamaria D.
A structural model of a Ras–Raf signalosome
2021-01-01 Mysore V.P.; Zhou Z.-W.; Ambrogio C.; Li L.; Kapp J.N.; Lu C.; Wang Q.; Tucker M.R.; Okoro J.J.; Nagy-Davidescu G.; Bai X.; Pluckthun A.; Janne P.A.; Westover K.D.; Shan Y.; Shaw D.E.
Ablation of oncogenic ALK is a viable therapeutic approach fAblation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas
2006-01-01 PIVA R; CHIARLE R; MANAZZA AD; TAULLI R; SIMMONS W; AMBROGIO C; D'ESCAMARD V; PELLEGRINO E; PONZETTO C; PALESTRO G; INGHIRAMI G
ALK-dependent control of hypoxia-inducible factors mediates tumor growth and metastasis
2014-01-01 Martinengo, Cinzia; Poggio, Teresa; Menotti, Matteo; Scalzo, Maria Stella; Mastini, Cristina; Ambrogio, Chiara; Pellegrino, Elisa; Riera, Ludovica; Piva, Roberto; Ribatti, Domenico; Pastorino, Fabio; Perri, Patrizia; Ponzoni, Mirco; Wang, Qi; Voena, Claudia; Chiarle, Roberto
An integrative pharmacogenomics analysis identifies therapeutic targets in KRAS-mutant lung cancer
2019-01-01 Wang H.; Lv Q.; Xu Y.; Cai Z.; Zheng J.; Cheng X.; Dai Y.; Janne P.A.; Ambrogio C.; Kohler J.
Assessing therapeutic efficacy of MEK inhibition in a KrasG12C-driven mouse model of lung cancer
2018-01-01 Li S.; Liu S.; Deng J.; Akbay E.A.; Hai J.; Ambrogio C.; Zhang L.; Zhou F.; Jenkins R.W.; Adeegbe D.O.; Gao P.; Wang X.; Paweletz C.P.; Herter-Sprie G.S.; Chen T.; Gutierrez-Quiceno L.; Zhang Y.; Merlino A.A.; Quinn M.M.; Zeng Y.; Yu X.; Liu Y.; Fan L.; Aguirre A.J.; Barbie D.A.; Yi X.; Wong K.-K.
Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma
2016-01-01 Ambrogio C.; Gomez-Lopez G.; Falcone M.; Vidal A.; Nadal E.; Crosetto N.; Blasco R.B.; Fernandez-Marcos P.J.; Sanchez-Cespedes M.; Ren X.; Wang Z.; Ding K.; Hidalgo M.; Serrano M.; Villanueva A.; Santamaraa D.; Barbacid M.
Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities of KRAS Mutations in Non-Small Cell Lung Cancer
2022-01-01 Ricciuti, Biagio; Son, Jieun; Okoro, Jeffrey J; Mira, Alessia; Patrucco, Enrico; Eum, Yoonji; Wang, Xinan; Paranal, Raymond; Wang, Haiyun; Lin, Mika; Haikala, Heidi M; Li, Jiaqi; Xu, Yue; Alessi, Joao Victor; Chhoeu, Chhayheng; Redig, Amanda J; Köhler, Jens; Dholakia, Kshiti H; Chen, Yunhan; Richard, Elodie; Nokin, Marie-Julie; Santamaria, David; Gokhale, Prafulla C; Awad, Mark M; Jänne, Pasi A; Ambrogio, Chiara
Discoveries in the redox regulation of KRAS
2021-01-01 Maximilian Kramer-Drauberg; Chiara Ambrogio
Dissecting the clinicopathologic, genomic, and immunophenotypic correlates of KRASG12D-mutated non-small-cell lung cancer
2022-01-01 Ricciuti, B; Alessi, J V; Elkrief, A; Wang, X; Cortellini, A; Li, Y Y; Vaz, V R; Gupta, H; Pecci, F; Barrichello, A; Lamberti, G; Nguyen, T; Lindsay, J; Sharma, B; Felt, K; Rodig, S J; Nishino, M; Sholl, L M; Barbie, D A; Negrao, M V; Zhang, J; Cherniack, A D; Heymach, J V; Meyerson, M; Ambrogio, C; Jänne, P A; Arbour, K C; Pinato, D J; Skoulidis, F; Schoenfeld, A J; Awad, M M; Luo, J
Docking Protein p130Cas Regulates Acinar to Ductal Metaplasia During Pancreatic Adenocarcinoma Development and Pancreatitis
2021-01-01 Costamagna, Andrea; Natalini, Dora; Leal, Maria del Pilar Camacho; Simoni, Matilde; Gozzelino, Luca; Cappello, Paola; Novelli, Francesco; Ambrogio, Chiara; Defilippi, Paola; Turco, Emilia; Giovannetti, Elisa; Hirsch, Emilio; Cabodi, Sara; Martini, Miriam
Efficacy of a Cancer Vaccine against ALK-Rearranged Lung Tumors
2015-01-01 Voena, Claudia; Menotti, Matteo; Mastini, Cristina; Di Giacomo, Filomena; Longo, Dario Livio; Castella, Barbara; Merlo, Maria Elena Boggio; Ambrogio, Chiara; Wang, Qi; Minero, Valerio Giacomo; Poggio, Teresa; Martinengo, Cinzia; D'Amico, Lucia; Panizza, Elena; Mologni, Luca; Cavallo, Federica; Altruda, Fiorella; Butaney, Mohit; Capelletti, Marzia; Inghirami, Giorgio; Jänne, Pasi A; Chiarle, Roberto
ERK inhibitor LY3214996-based treatment strategies for RAS-driven lung cancer
2021-01-01 Köhler, Jens; Zhao, Yutong; Li, Jiaqi; Gokhale, Prafulla C; Tiv, Hong L; Knott, Aine R; Wilkens, Margaret K; Soroko, Kara M; Lin, Mika; Ambrogio, Chiara; Musteanu, Monica; Ogino, Atsuko; Choi, Jihyun; Bahcall, Magda; Bertram, Arrien A; Chambers, Emily S; Paweletz, Cloud P; Bhagwat, Shripad V; Manro, Jason R; Tiu, Ramon V; Janne, Pasi A
Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency
2016-01-01 Ceccon, M; Merlo, M E Boggio; Mologni, L.; Poggio, T.; Varesio, L.M.; Menotti, M.; Bombelli, S.; Rigolio, R.; Manazza, A.D.; Di Giacomo, F.; Ambrogio, C.; Giudici, G.; Casati, C.; Mastini, C.; Compagno, M.; Turner, S.D.; Gambacorti-Passerini, C.; Chiarle, R. ; Voena, C.
Expression of IFNgammaR2 mutated in a dileucine internalization motif reinstates IFNgamma signaling and apoptosis in human T lymphocytes
2010-01-01 Boselli D; Ragimbeau J; Orlando L; Cappello P; Capello M; Ambrogio C; Chiarle R; Marsili G; Battistini A; Giovarelli M; Pellegrini S; Novelli F.
Genomic Profiling Identifies Putative Pathogenic Alterations in NSCLC Brain Metastases
2022-01-01 Nicoś, Marcin; Harbers, Luuk; Patrucco, Enrico; Kramer-Drauberg, Maximilian; Zhang, Xiaolu; Voena, Claudia; Kowalczyk, Anna; Bożyk, Aleksandra; Pęksa, Rafał; Jarosz, Bożena; Szumiło, Justyna; Simonetti, Michele; Żuk, Monika; Wasąg, Bartosz; Reszka, Katarzyna; Duchnowska, Renata; Milanowski, Janusz; Chiarle, Roberto; Bienko, Magda; Krawczyk, Paweł; Jassem, Jacek; Ambrogio, Chiara; Crosetto, Nicola
How far we have come targeting BRAF-mutant non-small cell lung cancer (NSCLC)
2022-01-01 Tabbo F.; Pisano C.; Mazieres J.; Mezquita L.; Nadal E.; Planchard D.; Pradines A.; Santamaria D.; Swalduz A.; Ambrogio C.; Novello S.; Ortiz-Cuaran S.
How to manage KRAS G12C-mutated advanced non-small-cell lung cancer
2022-01-01 Ricciuti, Biagio; Mira, Alessia; Andrini, Elisa; Scaparone, Pietro; Michelina, Sandra Vietti; Pecci, Federica; Cantini, Luca; De Giglio, Andrea; Lamberti, Giuseppe; Ambrogio, Chiara; Metro, Giulio
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A Braf kinase-inactive mutant induces lung adenocarcinoma | 2017 | Nieto P.; Ambrogio C.; Esteban-Burgos L.; Gomez-Lopez G.; Blasco M.T.; Yao Z.; Marais R.; Rosen N.; Chiarle R.; Pisano D.G.; Barbacid M.; Santamaria D. | |
| A LIBRETTO to orchestrate targeted therapy | 2020 | Marmarelis, Melina E; Chiarle, Roberto; Ambrogio, Chiara; Aggarwal, Charu | |
| A putative role for Discoidin Domain Receptor 1 in cancer chemoresistance | 2018 | Ambrogio C.; Darbo E.; Lee S.W.; Santamaria D. | |
| A structural model of a Ras–Raf signalosome | 2021 | Mysore V.P.; Zhou Z.-W.; Ambrogio C.; Li L.; Kapp J.N.; Lu C.; Wang Q.; Tucker M.R.; Okoro J.J.; Nagy-Davidescu G.; Bai X.; Pluckthun A.; Janne P.A.; Westover K.D.; Shan Y.; Shaw D.E. | |
| Ablation of oncogenic ALK is a viable therapeutic approach fAblation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas | 2006 | PIVA R; CHIARLE R; MANAZZA AD; TAULLI R; SIMMONS W; AMBROGIO C; D'ESCAMARD V; PELLEGRINO E; PONZETTO C; PALESTRO G; INGHIRAMI G | |
| ALK-dependent control of hypoxia-inducible factors mediates tumor growth and metastasis | 2014 | Martinengo, Cinzia; Poggio, Teresa; Menotti, Matteo; Scalzo, Maria Stella; Mastini, Cristina; Ambrogio, Chiara; Pellegrino, Elisa; Riera, Ludovica; Piva, Roberto; Ribatti, Domenico; Pastorino, Fabio; Perri, Patrizia; Ponzoni, Mirco; Wang, Qi; Voena, Claudia; Chiarle, Roberto | |
| An integrative pharmacogenomics analysis identifies therapeutic targets in KRAS-mutant lung cancer | 2019 | Wang H.; Lv Q.; Xu Y.; Cai Z.; Zheng J.; Cheng X.; Dai Y.; Janne P.A.; Ambrogio C.; Kohler J. | |
| Assessing therapeutic efficacy of MEK inhibition in a KrasG12C-driven mouse model of lung cancer | 2018 | Li S.; Liu S.; Deng J.; Akbay E.A.; Hai J.; Ambrogio C.; Zhang L.; Zhou F.; Jenkins R.W.; Adeegbe D.O.; Gao P.; Wang X.; Paweletz C.P.; Herter-Sprie G.S.; Chen T.; Gutierrez-Quiceno L.; Zhang Y.; Merlino A.A.; Quinn M.M.; Zeng Y.; Yu X.; Liu Y.; Fan L.; Aguirre A.J.; Barbie D.A.; Yi X.; Wong K.-K. | |
| Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma | 2016 | Ambrogio C.; Gomez-Lopez G.; Falcone M.; Vidal A.; Nadal E.; Crosetto N.; Blasco R.B.; Fernandez-Marcos P.J.; Sanchez-Cespedes M.; Ren X.; Wang Z.; Ding K.; Hidalgo M.; Serrano M.; Villanueva A.; Santamaraa D.; Barbacid M. | |
| Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities of KRAS Mutations in Non-Small Cell Lung Cancer | 2022 | Ricciuti, Biagio; Son, Jieun; Okoro, Jeffrey J; Mira, Alessia; Patrucco, Enrico; Eum, Yoonji; Wang, Xinan; Paranal, Raymond; Wang, Haiyun; Lin, Mika; Haikala, Heidi M; Li, Jiaqi; Xu, Yue; Alessi, Joao Victor; Chhoeu, Chhayheng; Redig, Amanda J; Köhler, Jens; Dholakia, Kshiti H; Chen, Yunhan; Richard, Elodie; Nokin, Marie-Julie; Santamaria, David; Gokhale, Prafulla C; Awad, Mark M; Jänne, Pasi A; Ambrogio, Chiara | |
| Discoveries in the redox regulation of KRAS | 2021 | Maximilian Kramer-Drauberg; Chiara Ambrogio | |
| Dissecting the clinicopathologic, genomic, and immunophenotypic correlates of KRASG12D-mutated non-small-cell lung cancer | 2022 | Ricciuti, B; Alessi, J V; Elkrief, A; Wang, X; Cortellini, A; Li, Y Y; Vaz, V R; Gupta, H; Pecci, F; Barrichello, A; Lamberti, G; Nguyen, T; Lindsay, J; Sharma, B; Felt, K; Rodig, S J; Nishino, M; Sholl, L M; Barbie, D A; Negrao, M V; Zhang, J; Cherniack, A D; Heymach, J V; Meyerson, M; Ambrogio, C; Jänne, P A; Arbour, K C; Pinato, D J; Skoulidis, F; Schoenfeld, A J; Awad, M M; Luo, J | |
| Docking Protein p130Cas Regulates Acinar to Ductal Metaplasia During Pancreatic Adenocarcinoma Development and Pancreatitis | 2021 | Costamagna, Andrea; Natalini, Dora; Leal, Maria del Pilar Camacho; Simoni, Matilde; Gozzelino, Luca; Cappello, Paola; Novelli, Francesco; Ambrogio, Chiara; Defilippi, Paola; Turco, Emilia; Giovannetti, Elisa; Hirsch, Emilio; Cabodi, Sara; Martini, Miriam | |
| Efficacy of a Cancer Vaccine against ALK-Rearranged Lung Tumors | 2015 | Voena, Claudia; Menotti, Matteo; Mastini, Cristina; Di Giacomo, Filomena; Longo, Dario Livio; Castella, Barbara; Merlo, Maria Elena Boggio; Ambrogio, Chiara; Wang, Qi; Minero, Valerio Giacomo; Poggio, Teresa; Martinengo, Cinzia; D'Amico, Lucia; Panizza, Elena; Mologni, Luca; Cavallo, Federica; Altruda, Fiorella; Butaney, Mohit; Capelletti, Marzia; Inghirami, Giorgio; Jänne, Pasi A; Chiarle, Roberto | |
| ERK inhibitor LY3214996-based treatment strategies for RAS-driven lung cancer | 2021 | Köhler, Jens; Zhao, Yutong; Li, Jiaqi; Gokhale, Prafulla C; Tiv, Hong L; Knott, Aine R; Wilkens, Margaret K; Soroko, Kara M; Lin, Mika; Ambrogio, Chiara; Musteanu, Monica; Ogino, Atsuko; Choi, Jihyun; Bahcall, Magda; Bertram, Arrien A; Chambers, Emily S; Paweletz, Cloud P; Bhagwat, Shripad V; Manro, Jason R; Tiu, Ramon V; Janne, Pasi A | |
| Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency | 2016 | Ceccon, M; Merlo, M E Boggio; Mologni, L.; Poggio, T.; Varesio, L.M.; Menotti, M.; Bombelli, S.; Rigolio, R.; Manazza, A.D.; Di Giacomo, F.; Ambrogio, C.; Giudici, G.; Casati, C.; Mastini, C.; Compagno, M.; Turner, S.D.; Gambacorti-Passerini, C.; Chiarle, R. ; Voena, C. | |
| Expression of IFNgammaR2 mutated in a dileucine internalization motif reinstates IFNgamma signaling and apoptosis in human T lymphocytes | 2010 | Boselli D; Ragimbeau J; Orlando L; Cappello P; Capello M; Ambrogio C; Chiarle R; Marsili G; Battistini A; Giovarelli M; Pellegrini S; Novelli F. | |
| Genomic Profiling Identifies Putative Pathogenic Alterations in NSCLC Brain Metastases | 2022 | Nicoś, Marcin; Harbers, Luuk; Patrucco, Enrico; Kramer-Drauberg, Maximilian; Zhang, Xiaolu; Voena, Claudia; Kowalczyk, Anna; Bożyk, Aleksandra; Pęksa, Rafał; Jarosz, Bożena; Szumiło, Justyna; Simonetti, Michele; Żuk, Monika; Wasąg, Bartosz; Reszka, Katarzyna; Duchnowska, Renata; Milanowski, Janusz; Chiarle, Roberto; Bienko, Magda; Krawczyk, Paweł; Jassem, Jacek; Ambrogio, Chiara; Crosetto, Nicola | |
| How far we have come targeting BRAF-mutant non-small cell lung cancer (NSCLC) | 2022 | Tabbo F.; Pisano C.; Mazieres J.; Mezquita L.; Nadal E.; Planchard D.; Pradines A.; Santamaria D.; Swalduz A.; Ambrogio C.; Novello S.; Ortiz-Cuaran S. | |
| How to manage KRAS G12C-mutated advanced non-small-cell lung cancer | 2022 | Ricciuti, Biagio; Mira, Alessia; Andrini, Elisa; Scaparone, Pietro; Michelina, Sandra Vietti; Pecci, Federica; Cantini, Luca; De Giglio, Andrea; Lamberti, Giuseppe; Ambrogio, Chiara; Metro, Giulio |