BOSCHI, Donatella
BOSCHI, Donatella
SCIENZA E TECNOLOGIA DEL FARMACO
1H-pyrazole-4-carboxylic acids active against Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH): discovery of a new scaffold for development of antimalarial agents
2014-01-01 Agnese Chiara Pippione; Ulf J. Nilsson; Ingela Fritzson; Anders P. Sundin; Salam Al-Karadaghi; Donatella Boschi; and Marco Lucio Lolli
4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric γ-aminobutyric acid receptor binding site
2018-01-01 Giraudo, Alessandro; Krall, Jacob; Nielsen, Birgitte; Sørensen, Troels E.; Kongstad, Kenneth T.; Rolando, Barbara; Boschi, Donatella; Frølund, Bente; Lolli, Marco L.
4-Hydroxy-1H-1,2,3-Triazol-5-yl moiety as bioisoster of carboxylic group. Synthesis and pharmacological ionotropic glutamate receptors characterization of Glu analogues
2014-01-01 S. Sainas; A. Federico;C. Bertolotti; B. Nielsen; D. Boschi; B. Frølund and M. L. Lolli
4-Hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-κB cascade
2017-01-01 Pippione, Agnese C.; Federico, Antonella; Ducime, Alex; Sainas, Stefano; Boschi, Donatella; Barge, Alessandro; Lupino, Elisa; Piccinini, Marco; Kubbutat, Michael; Contreras, Jean-Marie; Morice, Christophe; Al-Karadaghi, Salam; Lolli, Marco L.
6-Cyclohexylmethoxy-5-(cyano-NNO-azoxy)pyrimidine-4-amine: A new scaffold endowed with potent CDK2 inhibitory activity
2013-01-01 Boschi D.; Tosco P.; Chandra N.; Chaurasia S.; Fruttero R.*; Griffin R.; Wang L.-Z.; Gasco A.
A differentiating and apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor
2021-01-01 Stefano Sainas, Paola Circosta, Marta Giorgis, Agnese Chiara Pippione, Marilena Marraudino, Mohammad Houshmand, Brigitta Bonaldo, Valentina Gaidano, Alessandro Cignetti, Stefano Gotti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
A differentiating and apoptotic therapy for acute myeloid leukaemia using potent human dihydroorotate dehydrogenase inhibitors.
2019-01-01 Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
A new generation of AKR1C3 inhibitors on the horizon: the 3- hydroxybenzazole approach to target prostate cancer
2023-01-01 Chiara Vigato, Agnese Chiara Pippione, Stefano Sainas, Iole Mannella, Laura Bertarini, Sandra Kovachka, Barbara Rolando, Osman Asghar Mirza, Karla Frydenvang, Francesca Spyrakis, Simonetta Oliaro-Bosso, Marco Lucio Lolli, Donatella Boschi
A New NF-κB Inhibitor, MEDS-23, Reduces the Severity of Adverse Post-Ischemic Stroke Outcomes in Rats
2022-01-01 Rubin E.; Pippione A.C.; Boyko M.; Einaudi G.; Sainas S.; Collino M.; Cifani C.; Lolli M.L.; Abu-Freha N.; Kaplanski J.; Boschi D.; Azab A.N.
A new pro-apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor
2021-01-01 Sainas Sainas, Paola Circosta, Noemi Villella, Elena Martino, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Caterina Peraldo Neia, Giovanna Chiorino, Salam Al-Karadaghi, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli.
A New Synthetic Approach to Substituted β-Carboline Systems
1999-01-01 GIUSEPPE ERMONDI; SONJA VISENTIN; D. BOSCHI; ROBERTA FRUTTERO; ALBERTO GASCO
Activity of calvatic acid and its analogs against Helicobacter pylori
2001-01-01 BOSCHI D.; C. CENA; FRUTTERO R.; BRENCIAGLIA M. I.; SCALTRITO M. M.; DUBINI F.; GASCO A.
AI Based Discovery of a New AKR1C3 Inhibitor for Anticancer Applications
In corso di stampa Pippione, Agnese C.; Vigato, Chiara; Tucciarello, Cristina; Hussain, Samrina; Salladini, Edoardo; Truong, Ha H.; Henriksen, Niel M.; Vanzetti, Gaia; Giordano, Giorgia; Zonari, Daniele; Mirza, Osman Asghar; Frydenvang, Karla; Pignochino, Ymera; Oliaro-Bosso, Simonetta; Boschi, Donatella; Lolli, Marco L.
AKR1C3 is a biomarker and druggable target for oropharyngeal tumors
2021-01-01 Peraldo-Neia C.; Ostano P.; Mello-Grand M.; Guana F.; Gregnanin I.; Boschi D.; Oliaro-Bosso S.; Pippione A.C.; Carenzo A.; De Cecco L.; Cavalieri S.; Micali A.; Perrone F.; Averono G.; Bagnasacco P.; Dosdegani R.; Masini L.; Krengli M.; Aluffi-Valletti P.; Valente G.; Chiorino G.
ALPHA(1)-ADRENOCEPTOR BLOCKING ACTIVITY OF SOME RING-OPEN ANALOGS OF PRAZOSIN
1994-01-01 D. BOSCHI; A. DI STILO; R. FRUTTERO; C. MEDANA; G. SORBA; A. GASCO
An alternative conformation of the N-terminal loop of human dihydroorotate dehydrogenase drives binding to a potent antiproliferative agent
2024-01-01 Alberti, Marta; Poli, Giulio; Broggini, Luca; Sainas, Stefano; Rizzi, Menico; Boschi, Donatella; Ferraris, Davide M.; Martino, Elena; Ricagno, Stefano; Tuccinardi, Tiziano; Lolli, Marco L.; Miggiano, Riccardo
Androgen-AR axis in primary and metastatic prostate cancer: chasing steroidogenic enzymes for therapeutic intervention
2017-01-01 Pippione, Agnese C.; Boschi, Donatella; Pors, Klaus; Oliaro-Bosso, Simonetta; Lolli, Marco L.
Antileishmanial activity of some 4-phenyl-3-amino-1H-pyrazols designed as CRK3 kinase inhibitors
2016-01-01 Agnese Chiara Pippione, Piermichele Kobauri, Stefano Sainas, Alberto Gimenez, Antonella Federico, Rodolpho Campos Braga, Carolina Horta Andrade, Donatella Boschi, Efrain Salamanca, Juan Carlos Ticona, Marco Lucio Lolli
Apoptotic and differentiating therapy for AML using potent human dihydroorotate dehydrogenase inhibitor
2021-01-01 Sainas Sainas, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lolli
Application of an in house bioisosteric approach to the design of innovative inhibitors of aldo-keto reductase 1C3 (AKR1C3)
2019-01-01 Chiara Vigato, Agnese Chiara Pippione, Sandra Kovachka, Francesca Spyrakis, Martina Daga, Simonetta Oliaro-Bosso, Marco Lucio Lolli, Donatella Boschi
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| 1H-pyrazole-4-carboxylic acids active against Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH): discovery of a new scaffold for development of antimalarial agents | 2014 | Agnese Chiara Pippione; Ulf J. Nilsson; Ingela Fritzson; Anders P. Sundin; Salam Al-Karadaghi; Donatella Boschi; and Marco Lucio Lolli | |
| 4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric γ-aminobutyric acid receptor binding site | 2018 | Giraudo, Alessandro; Krall, Jacob; Nielsen, Birgitte; Sørensen, Troels E.; Kongstad, Kenneth T.; Rolando, Barbara; Boschi, Donatella; Frølund, Bente; Lolli, Marco L. | |
| 4-Hydroxy-1H-1,2,3-Triazol-5-yl moiety as bioisoster of carboxylic group. Synthesis and pharmacological ionotropic glutamate receptors characterization of Glu analogues | 2014 | S. Sainas; A. Federico;C. Bertolotti; B. Nielsen; D. Boschi; B. Frølund and M. L. Lolli | |
| 4-Hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-κB cascade | 2017 | Pippione, Agnese C.; Federico, Antonella; Ducime, Alex; Sainas, Stefano; Boschi, Donatella; Barge, Alessandro; Lupino, Elisa; Piccinini, Marco; Kubbutat, Michael; Contreras, Jean-Marie; Morice, Christophe; Al-Karadaghi, Salam; Lolli, Marco L. | |
| 6-Cyclohexylmethoxy-5-(cyano-NNO-azoxy)pyrimidine-4-amine: A new scaffold endowed with potent CDK2 inhibitory activity | 2013 | Boschi D.; Tosco P.; Chandra N.; Chaurasia S.; Fruttero R.*; Griffin R.; Wang L.-Z.; Gasco A. | |
| A differentiating and apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor | 2021 | Stefano Sainas, Paola Circosta, Marta Giorgis, Agnese Chiara Pippione, Marilena Marraudino, Mohammad Houshmand, Brigitta Bonaldo, Valentina Gaidano, Alessandro Cignetti, Stefano Gotti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli | |
| A differentiating and apoptotic therapy for acute myeloid leukaemia using potent human dihydroorotate dehydrogenase inhibitors. | 2019 | Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli | |
| A new generation of AKR1C3 inhibitors on the horizon: the 3- hydroxybenzazole approach to target prostate cancer | 2023 | Chiara Vigato, Agnese Chiara Pippione, Stefano Sainas, Iole Mannella, Laura Bertarini, Sandra Kovachka, Barbara Rolando, Osman Asghar Mirza, Karla Frydenvang, Francesca Spyrakis, Simonetta Oliaro-Bosso, Marco Lucio Lolli, Donatella Boschi | |
| A New NF-κB Inhibitor, MEDS-23, Reduces the Severity of Adverse Post-Ischemic Stroke Outcomes in Rats | 2022 | Rubin E.; Pippione A.C.; Boyko M.; Einaudi G.; Sainas S.; Collino M.; Cifani C.; Lolli M.L.; Abu-Freha N.; Kaplanski J.; Boschi D.; Azab A.N. | |
| A new pro-apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor | 2021 | Sainas Sainas, Paola Circosta, Noemi Villella, Elena Martino, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Caterina Peraldo Neia, Giovanna Chiorino, Salam Al-Karadaghi, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli. | |
| A New Synthetic Approach to Substituted β-Carboline Systems | 1999 | GIUSEPPE ERMONDI; SONJA VISENTIN; D. BOSCHI; ROBERTA FRUTTERO; ALBERTO GASCO | |
| Activity of calvatic acid and its analogs against Helicobacter pylori | 2001 | BOSCHI D.; C. CENA; FRUTTERO R.; BRENCIAGLIA M. I.; SCALTRITO M. M.; DUBINI F.; GASCO A. | |
| AI Based Discovery of a New AKR1C3 Inhibitor for Anticancer Applications | In corso di stampa | Pippione, Agnese C.; Vigato, Chiara; Tucciarello, Cristina; Hussain, Samrina; Salladini, Edoardo; Truong, Ha H.; Henriksen, Niel M.; Vanzetti, Gaia; Giordano, Giorgia; Zonari, Daniele; Mirza, Osman Asghar; Frydenvang, Karla; Pignochino, Ymera; Oliaro-Bosso, Simonetta; Boschi, Donatella; Lolli, Marco L. | |
| AKR1C3 is a biomarker and druggable target for oropharyngeal tumors | 2021 | Peraldo-Neia C.; Ostano P.; Mello-Grand M.; Guana F.; Gregnanin I.; Boschi D.; Oliaro-Bosso S.; Pippione A.C.; Carenzo A.; De Cecco L.; Cavalieri S.; Micali A.; Perrone F.; Averono G.; Bagnasacco P.; Dosdegani R.; Masini L.; Krengli M.; Aluffi-Valletti P.; Valente G.; Chiorino G. | |
| ALPHA(1)-ADRENOCEPTOR BLOCKING ACTIVITY OF SOME RING-OPEN ANALOGS OF PRAZOSIN | 1994 | D. BOSCHI; A. DI STILO; R. FRUTTERO; C. MEDANA; G. SORBA; A. GASCO | |
| An alternative conformation of the N-terminal loop of human dihydroorotate dehydrogenase drives binding to a potent antiproliferative agent | 2024 | Alberti, Marta; Poli, Giulio; Broggini, Luca; Sainas, Stefano; Rizzi, Menico; Boschi, Donatella; Ferraris, Davide M.; Martino, Elena; Ricagno, Stefano; Tuccinardi, Tiziano; Lolli, Marco L.; Miggiano, Riccardo | |
| Androgen-AR axis in primary and metastatic prostate cancer: chasing steroidogenic enzymes for therapeutic intervention | 2017 | Pippione, Agnese C.; Boschi, Donatella; Pors, Klaus; Oliaro-Bosso, Simonetta; Lolli, Marco L. | |
| Antileishmanial activity of some 4-phenyl-3-amino-1H-pyrazols designed as CRK3 kinase inhibitors | 2016 | Agnese Chiara Pippione, Piermichele Kobauri, Stefano Sainas, Alberto Gimenez, Antonella Federico, Rodolpho Campos Braga, Carolina Horta Andrade, Donatella Boschi, Efrain Salamanca, Juan Carlos Ticona, Marco Lucio Lolli | |
| Apoptotic and differentiating therapy for AML using potent human dihydroorotate dehydrogenase inhibitor | 2021 | Sainas Sainas, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lolli | |
| Application of an in house bioisosteric approach to the design of innovative inhibitors of aldo-keto reductase 1C3 (AKR1C3) | 2019 | Chiara Vigato, Agnese Chiara Pippione, Sandra Kovachka, Francesca Spyrakis, Martina Daga, Simonetta Oliaro-Bosso, Marco Lucio Lolli, Donatella Boschi |