| Nome |
# |
|
In vitro pharmacological evaluation of multitarget agents for thromboxane prostanoid receptor antagonism and COX-2 inhibition, file e27ce428-5e9e-2581-e053-d805fe0acbaa
|
573
|
|
4-Hydroxy-1,2,5-oxadiazol-3-yl Moiety as Bioisoster of the Carboxy Function. Synthesis, Ionization Constants, and Molecular Pharmacological Characterization at Ionotropic Glutamate Receptors of Compounds Related to Glutamate and Its Homologues, file e27ce426-cbfc-2581-e053-d805fe0acbaa
|
355
|
|
Design and synthesis of SWIR emitters for optical imaging, file a3c77925-a20a-4f10-b791-18737969052f
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346
|
|
Multitarget Drugs: Focus on the NO-donor hybrid drugs, file e27ce426-b4e8-2581-e053-d805fe0acbaa
|
329
|
|
Synthesis and preliminary pharmacological characterisation of a new class of nitrogen-containing bisphosphonates (N-BPs), file e27ce426-be80-2581-e053-d805fe0acbaa
|
306
|
|
Nitrooxymethyl-Substituted Analogues of Rofecoxib: Synthesis and Pharmacological Characterization, file e27ce426-cbf4-2581-e053-d805fe0acbaa
|
261
|
|
Synthesis physicochemical profile and PAMPA study of new NO-donor edaravone co-drugs, file e27ce426-d83a-2581-e053-d805fe0acbaa
|
253
|
|
Mitochondrial-targeting nitrooxy-doxorubicin: a new approach to overcome drug resistance., file e27ce426-e3dd-2581-e053-d805fe0acbaa
|
252
|
|
Amodiaquine analogues containing NO-donor substructures: Synthesis and their preliminary evaluation as potential tools in the treatment of cerebral malaria, file e27ce426-bdc3-2581-e053-d805fe0acbaa
|
250
|
|
New nitric oxide or hydrogen sulfide releasing aspirins, file e27ce426-d99c-2581-e053-d805fe0acbaa
|
245
|
|
Carnosine analogues containing NO-donor substructures: Synthesis, physico-chemical characterization and preliminary pharmacological profile, file e27ce426-ead8-2581-e053-d805fe0acbaa
|
227
|
|
Nitrooxymethyl Substituted Analogues of Celecoxib: Synthesis and Pharmacological Characterization, file e27ce426-b8e0-2581-e053-d805fe0acbaa
|
223
|
|
An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells, file e27ce427-135c-2581-e053-d805fe0acbaa
|
208
|
|
Searching for new NO-donor aspirin-like molecules: furoxanylacyl derivatives of salicylic acid and related furazans, file e27ce426-dd5a-2581-e053-d805fe0acbaa
|
202
|
|
Water-Soluble Nitric-Oxide-Releasing Acetylsalicylic Acid
(ASA) Prodrugs, file e27ce426-f7b4-2581-e053-d805fe0acbaa
|
197
|
|
A molecular hybrid producing simultaneously singlet oxygen and nitric oxide by single photon excitation with green light, file e27ce42d-b04b-2581-e053-d805fe0acbaa
|
195
|
|
Novel Antioxidant Agents Deriving From Molecular Combination of Vitamin C and NO-donor moieties, file e27ce426-aaa3-2581-e053-d805fe0acbaa
|
179
|
|
NO-donor COX-2 inhibitors. New nitrooxy-substituted 1,5-diarylimidazoles endowed with COX-2 inhibitory and vasodilator properties, file e27ce426-ae93-2581-e053-d805fe0acbaa
|
172
|
|
Doxorubicin-antioxidant multitarget drugs, file e27ce426-f93b-2581-e053-d805fe0acbaa
|
144
|
|
Mitochondrial-targeting nitrooxy-doxorubicin: a new approach to overcome drug resistance., file e27ce426-e3df-2581-e053-d805fe0acbaa
|
138
|
|
Edaravone derivatives containing NO-donor functions, file e27ce426-bc77-2581-e053-d805fe0acbaa
|
133
|
|
1,2,5-Oxadiazole analogues of leflunomide and related compounds, file e27ce426-ca8a-2581-e053-d805fe0acbaa
|
124
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Curcumin-loaded solid lipid nanoparticles bypass p-glycoprotein mediated doxorubicin resistance in triple negative breast cancer cells, file e27ce42f-cff3-2581-e053-d805fe0acbaa
|
120
|
|
Preliminary ADME/PK studies of new hDHODH inhibitors effective for treatment of acute myeloid leukaemia (AML), file e27ce42f-16a0-2581-e053-d805fe0acbaa
|
112
|
|
NO-donor COX-2 inhibitors. New nitrooxy-substituted 1,5-diarylimidazoles endowed with COX-2 inhibitory and vasodilator properties, file e27ce426-ae92-2581-e053-d805fe0acbaa
|
111
|
|
Synthesis, physico-chemical characterization, andbiological activities of new carnosine derivatives stablein human serum as potential neuroprotective agents, file e27ce426-c650-2581-e053-d805fe0acbaa
|
100
|
|
Anti-pseudomonas activity of 3-nitro-4-phenylfuroxan, file e27ce42d-8dfe-2581-e053-d805fe0acbaa
|
97
|
|
Overcoming multidrug resistance by targeting mitochondria with NO-donating doxorubicins, file e27ce428-7e0a-2581-e053-d805fe0acbaa
|
95
|
|
Liposomal Nitrooxy-Doxorubicin: One Step over Caelyx in Drug-Resistant Human Cancer Cells, file e27ce426-f58a-2581-e053-d805fe0acbaa
|
94
|
|
H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance, file e27ce428-be10-2581-e053-d805fe0acbaa
|
92
|
|
(Nitrooxyacyloxy)methyl esters of aspirin as novel nitric oxide releasing aspirins, file e27ce426-b275-2581-e053-d805fe0acbaa
|
89
|
|
Mitochondrial delivery of phenol substructure triggers mitochondrial depolarization and apoptosis of cancer cells, file e27ce42c-f044-2581-e053-d805fe0acbaa
|
86
|
|
Hyperglycemia Promotes Chemoresistance Through the Reduction of the Mitochondrial DNA Damage, the Bax/Bcl-2 and Bax/Bcl-XL Ratio, and the Cells in Sub-G1 Phase Due to Antitumoral Drugs Induced-Cytotoxicity in Human Colon Adenocarcinoma Cells., file e27ce42d-3004-2581-e053-d805fe0acbaa
|
85
|
|
A multi-photoresponsive molecular-hybrid for dual-modal photoinactivation of cancer cells, file e27ce427-03dc-2581-e053-d805fe0acbaa
|
84
|
|
Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters, file e27ce433-4d5c-2581-e053-d805fe0acbaa
|
81
|
|
New praziquantel derivatives containing NO-donor furoxans and related furazans as active agents against Schistosoma mansoni, file e27ce427-03db-2581-e053-d805fe0acbaa
|
77
|
|
Extracellular matrix composition modulates the responsiveness of differentiated and stem pancreatic cancer cells to lipophilic derivate of gemcitabine, file e27ce431-2421-2581-e053-d805fe0acbaa
|
74
|
|
Searching for Balanced Hybrid NO-Donor 1,4-Dihydropyridines with Basic Properties, file e27ce426-aaf2-2581-e053-d805fe0acbaa
|
72
|
|
New nitric oxide or hydrogen sulfide releasing aspirins, file e27ce426-d99d-2581-e053-d805fe0acbaa
|
72
|
|
Searching for new NO-donor Aspirin-like molecules: a new class of nitrooxy-acyl derivatives of salicylic acid, file e27ce426-bbb7-2581-e053-d805fe0acbaa
|
71
|
|
Doxorubicin-antioxidant multitarget drugs, file e27ce426-f93a-2581-e053-d805fe0acbaa
|
70
|
|
One molecule two goals: A selective P-glycoprotein modulator increases drug transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer cells, file e27ce431-6e5a-2581-e053-d805fe0acbaa
|
69
|
|
Coencapsulation of disulfiram and doxorubicin in liposomes strongly reverses multidrug resistance in breast cancer cells, file e27ce430-524a-2581-e053-d805fe0acbaa
|
68
|
|
NO-donor thiacarbocyanines as multifunctional agents for Alzheimer’s disease, file e27ce427-2d2f-2581-e053-d805fe0acbaa
|
66
|
|
Ketogal safety profile in human primary colonic epithelial cells and in mice, file e27ce434-10e8-2581-e053-d805fe0acbaa
|
65
|
|
Nitrooxymethyl Substituted Analogues of Celecoxib: Synthesis and Pharmacological Characterization, file e27ce426-b8e1-2581-e053-d805fe0acbaa
|
60
|
|
H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance, file e27ce428-bf82-2581-e053-d805fe0acbaa
|
60
|
|
A Nonmetal-Containing Nitric Oxide Donor Activated with Single-Photon Green Light, file e27ce42c-1578-2581-e053-d805fe0acbaa
|
59
|
|
A new series of amodiaquine analogues modified in the basic side chain with in vitro antileishmanial and antiplasmodial activity, file e27ce426-b440-2581-e053-d805fe0acbaa
|
57
|
|
NO-Donor Melatonin Derivatives: Synthesis And In Vitro Pharmacological Characterization, file e27ce426-bbd1-2581-e053-d805fe0acbaa
|
56
|
|
Quinone based nitric oxide donating compounds, file e27ce427-a390-2581-e053-d805fe0acbaa
|
56
|
|
Tuning the Hydrophobicity of a Mitochondria-Targeted NO Photodonor, file e27ce42c-bcef-2581-e053-d805fe0acbaa
|
54
|
|
Designing Multitarget Anti-inflammatory Agents: Chemical Modulation of the Lumiracoxib Structure toward Dual Thromboxane Antagonists-COX-2 Inhibitors., file e27ce427-b2ad-2581-e053-d805fe0acbaa
|
51
|
|
Edaravone derivatives containing NO-donor functions, file e27ce426-bc79-2581-e053-d805fe0acbaa
|
50
|
|
Nitric Oxide Donor Doxorubicins Accumulate into Doxorubicin-Resistant Human Colon Cancer Cells Inducing Cytotoxicity, file e27ce426-c49d-2581-e053-d805fe0acbaa
|
50
|
|
New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold, file e27ce435-3b91-2581-e053-d805fe0acbaa
|
50
|
|
Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain-Blood Barrier and Glioblastoma Stem Cells, file e27ce42e-70b1-2581-e053-d805fe0acbaa
|
49
|
|
Bioisosteres of Indomethacin as Inhibitors of Aldo-Keto Reductase 1C3, file e27ce432-dedb-2581-e053-d805fe0acbaa
|
49
|
|
Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors, file e27ce433-402c-2581-e053-d805fe0acbaa
|
47
|
|
Endoplasmic reticulum-targeting doxorubicin: a new tool effective against doxorubicin-resistant osteosarcoma, file e27ce432-dd86-2581-e053-d805fe0acbaa
|
40
|
|
Multitarget antioxidant NO-donor organic nitrates: a novel ap-proach to overcome nitrates tolerance, an ex vivo study, file e27ce434-a776-2581-e053-d805fe0acbaa
|
37
|
|
Multitarget Drugs: No-Donor Doxorubicins, file e27ce427-664a-2581-e053-d805fe0acbaa
|
35
|
|
New furoxan derivatives for the treatment of ocular hypertension, file e27ce42b-615d-2581-e053-d805fe0acbaa
|
35
|
|
Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies, file e27ce433-0b18-2581-e053-d805fe0acbaa
|
35
|
|
Design, Biological Evaluation, and Molecular Modeling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-Glycoprotein Ligand Overcoming Multidrug Resistance in Cancer Stem Cells, file e27ce433-4651-2581-e053-d805fe0acbaa
|
35
|
|
Novel R-roscovitine NO-donor hybrid compounds as potential
pro-resolution of inflammation agents, file e27ce426-df67-2581-e053-d805fe0acbaa
|
34
|
|
New tetrahydroisoquinoline-based P-glycoprotein modulators: Decoration of the biphenyl core gives selective ligands, file e27ce42d-8df5-2581-e053-d805fe0acbaa
|
32
|
|
New furoxan derivatives for the treatment of ocular hypertension, file e27ce42b-15a7-2581-e053-d805fe0acbaa
|
30
|
|
Light-Regulated NO Release as a Novel Strategy To Overcome Doxorubicin Multidrug Resistance, file e27ce42b-3a6a-2581-e053-d805fe0acbaa
|
30
|
|
Hyaluronated liposomes containing H2S-releasing doxorubicin are effective against P-glycoprotein-positive/doxorubicin-resistant osteosarcoma cells and xenografts, file e27ce42e-af48-2581-e053-d805fe0acbaa
|
30
|
|
Paracetamol-Galactose Conjugate: A Novel Prodrug for an Old Analgesic Drug, file e27ce435-98a8-2581-e053-d805fe0acbaa
|
29
|
|
Furoxan nitric oxide donors disperse Pseudomonas aeruginosa biofilms, accelerate growth, and repress pyoverdine production, file e27ce42b-e9f3-2581-e053-d805fe0acbaa
|
28
|
|
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety, file 33b0c0fc-4948-4f36-822a-38bf37292599
|
27
|
|
Nitrooxymethyl-Substituted Analogues of Rofecoxib: Synthesis and Pharmacological Characterization, file e27ce426-cbf5-2581-e053-d805fe0acbaa
|
27
|
|
4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric γ-aminobutyric acid receptor binding site, file e27ce433-34f7-2581-e053-d805fe0acbaa
|
27
|
|
gem-Dinitroalkyl Benzenes: A Novel Class of IOP-Lowering Agents for the Treatment of Ocular Hypertension, file e27ce42c-8ff0-2581-e053-d805fe0acbaa
|
25
|
|
EFFICIENTLY TARGETING DRUG EFFLUX THROUGH MODULATION OF P-GLYCOPROTEIN ACTIVITY BY SMALL MOLECULES: DESIGN, BIOLOGICAL AND COMPUTATIONAL STUDY., file e27ce42f-0382-2581-e053-d805fe0acbaa
|
25
|
|
A Molecular Hybrid for Mitochondria-Targeted NO Photodelivery, file e27ce42c-8ff2-2581-e053-d805fe0acbaa
|
23
|
|
Light-Regulated NO Release as a Novel Strategy To Overcome Doxorubicin Multidrug Resistance, file e27ce42b-59af-2581-e053-d805fe0acbaa
|
22
|
|
Fluorescent Nitric Oxide Photodonors Based on BODIPY and Rhodamine Antennae, file e27ce432-ebba-2581-e053-d805fe0acbaa
|
22
|
|
Folate-targeted liposomal nitrooxy-doxorubicin: An effective tool against P-glycoprotein-positive and folate receptor-positive tumors, file e27ce433-469a-2581-e053-d805fe0acbaa
|
22
|
|
Nitric Oxide Donor Doxorubicins Accumulate into Doxorubicin-Resistant Human Colon Cancer Cells Inducing Cytotoxicity, file e27ce426-c49c-2581-e053-d805fe0acbaa
|
21
|
|
Multitarget Drugs: No-Donor Doxorubicins, file e27ce427-664b-2581-e053-d805fe0acbaa
|
21
|
|
MODIFIED DOXORUBICINS: "GASEOUS APPROACH" TO OVERCOME CARDIOTOXICITY AND MULTIDRUG RESISTANCE, file e27ce429-dd38-2581-e053-d805fe0acbaa
|
21
|
|
Folate-targeted liposomal nitrooxy-doxorubicin: An effective tool against P-glycoprotein-positive and folate receptor-positive tumors, file e27ce42c-ef0f-2581-e053-d805fe0acbaa
|
20
|
|
A generator of peroxynitrite activatable with red light, file e27ce432-66d7-2581-e053-d805fe0acbaa
|
20
|
|
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold: SAR of the Biphenyl Moiety, file e27ce432-fd74-2581-e053-d805fe0acbaa
|
20
|
|
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold: SAR of the Biphenyl Moiety, file e27ce432-bb56-2581-e053-d805fe0acbaa
|
19
|
|
Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation, file dbbf1cec-92cb-4b59-a79b-a1e7780a8780
|
18
|
|
Galactosylated Prodrugs: A Strategy to Improve the Profile of Nonsteroidal Anti-Inflammatory Drugs, file 60b7fd36-6180-4e5a-b8f0-3745477faabf
|
16
|
|
(Nitrooxyacyloxy)methyl esters of aspirin as novel nitric oxide releasing aspirins, file e27ce426-b276-2581-e053-d805fe0acbaa
|
16
|
|
NO-donor thiacarbocyanines as multifunctional agents for Alzheimer’s disease, file e27ce427-2d32-2581-e053-d805fe0acbaa
|
15
|
|
Endoplasmic reticulum-targeting doxorubicin: a new tool effective against doxorubicin-resistant osteosarcoma, file e27ce42e-1c89-2581-e053-d805fe0acbaa
|
15
|
|
Synthesis physicochemical profile and PAMPA study of new NO-donor edaravone co-drugs, file e27ce426-d83b-2581-e053-d805fe0acbaa
|
13
|
|
INCAPSULATED NO-GEMCITABINE: GASEOUS SOLUTION FOR MDR PANCREATIC CANCER, file e27ce42e-7875-2581-e053-d805fe0acbaa
|
13
|
|
MRP5 nitration by NO-releasing gemcitabine encapsulated in liposomes confers sensitivity in chemoresistant pancreatic adenocarcinoma cells, file e27ce431-9d9c-2581-e053-d805fe0acbaa
|
13
|
|
Design, Biological Evaluation, and Molecular Modeling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-Glycoprotein Ligand Overcoming Multidrug Resistance in Cancer Stem Cells, file e27ce42e-114b-2581-e053-d805fe0acbaa
|
12
|
|
Fluorescent Nitric Oxide Photodonors Based on BODIPY and Rhodamine Antennae, file e27ce42e-af49-2581-e053-d805fe0acbaa
|
12
|
|
Paracetamol-Galactose Conjugate: A Novel Prodrug for an Old Analgesic Drug, file e27ce42e-df97-2581-e053-d805fe0acbaa
|
12
|
|
Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAFV600E Protein, file d8cded6f-e57e-4e8c-87da-877e19c5510e
|
11
|
| Totale |
8.968 |