| Nome |
# |
|
Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors able to restore in vitro and in vivo myeloid differentiation, file e27ce42e-e3ed-2581-e053-d805fe0acbaa
|
4.586
|
|
Use of the 4-hydroxy-triazole moiety as a bioisosteric tool in the development of selective ligands for subtypes AMPA receptor, file e27ce42e-e239-2581-e053-d805fe0acbaa
|
1.561
|
|
Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors, file e27ce42e-e3f2-2581-e053-d805fe0acbaa
|
1.371
|
|
Improvement of in vivo pharmacokinetic profile of M433, a potent and innovative hDHODH inhibitor., file e27ce42f-3286-2581-e053-d805fe0acbaa
|
369
|
|
4-Hydroxy-1,2,5-oxadiazol-3-yl Moiety as Bioisoster of the Carboxy Function. Synthesis, Ionization Constants, and Molecular Pharmacological Characterization at Ionotropic Glutamate Receptors of Compounds Related to Glutamate and Its Homologues, file e27ce426-cbfc-2581-e053-d805fe0acbaa
|
355
|
|
Effective deploying of a novel DHODH inhibitor against herpes simplex type 1 and type 2 replication, file e27ce431-a1a5-2581-e053-d805fe0acbaa
|
338
|
|
Substituted 4-hydroxy-1,2,3-triazoles: synthesis, characterization and first drug design applications through bioisosteric modulation and scaffold hopping approaches, file e27ce428-141b-2581-e053-d805fe0acbaa
|
307
|
|
Synthesis and preliminary pharmacological characterisation of a new class of nitrogen-containing bisphosphonates (N-BPs), file e27ce426-be80-2581-e053-d805fe0acbaa
|
306
|
|
A novel SWCNT platform bearing DOTA and b-cyclodextrin units. "One shot" multidecoration
under microwave irradiation., file e27ce427-1005-2581-e053-d805fe0acbaa
|
259
|
|
Targeting Human Onchocerciasis: Recent Advances Beyond Ivermectin, file e27ce42d-2e68-2581-e053-d805fe0acbaa
|
233
|
|
A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action, file e27ce42c-a1ed-2581-e053-d805fe0acbaa
|
216
|
|
ONE -POT ALKOXYMERCURATION-BROMODEMERCURIATION: A VERSATILE ACCESS TO 3-ALKOXY-2-BROMOPROPANOIC ESTERS, file e27ce426-a096-2581-e053-d805fe0acbaa
|
213
|
|
Searching for new NO-donor aspirin-like molecules: furoxanylacyl derivatives of salicylic acid and related furazans, file e27ce426-dd5a-2581-e053-d805fe0acbaa
|
202
|
|
Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: Application of a bioisosteric scaffold hopping approach to flufenamic acid, file e27ce42d-1c99-2581-e053-d805fe0acbaa
|
202
|
|
Androgen-AR axis in primary and metastatic prostate cancer: chasing steroidogenic enzymes for therapeutic intervention, file e27ce42c-7eda-2581-e053-d805fe0acbaa
|
201
|
|
MDP, a database linking drug response data to genomic information, identifies dasatinib and statins as a combinatorial strategy to inhibit YAP/TAZ in cancer cells, file e27ce428-1ed2-2581-e053-d805fe0acbaa
|
153
|
|
Dihydroorotate dehydrogenase inhibitors in anti-infective drug research, file e27ce432-a9b3-2581-e053-d805fe0acbaa
|
150
|
|
Investigation of the central core of MEDS433: A Bioisosteric voyage into the Amide's Role., file b671f2a7-d375-46b9-a955-083bbb561111
|
141
|
|
The synergism between DHODH inhibitors and dipyridamole leads to metabolic lethality in acute myeloid leukemia, file e27ce432-269b-2581-e053-d805fe0acbaa
|
141
|
|
1,2,5-Oxadiazole analogues of leflunomide and related compounds, file e27ce426-ca8a-2581-e053-d805fe0acbaa
|
124
|
|
Preliminary ADME/PK studies of new hDHODH inhibitors effective for treatment of acute myeloid leukaemia (AML), file e27ce42f-16a0-2581-e053-d805fe0acbaa
|
115
|
|
Synthesis, physiochemical proprieties and application of hydroxyazole systems as carboxylic acid isoster, file e27ce42f-15c0-2581-e053-d805fe0acbaa
|
108
|
|
Synthesis of [18F] Brequinar as PET Imaging probes for human dihydroorotate dehydrogenase, file e27ce42f-169d-2581-e053-d805fe0acbaa
|
98
|
|
Refining the chemical toolbox to be fit for educational and practical purpose for drug discovery in the 21st Century, file e27ce428-28d1-2581-e053-d805fe0acbaa
|
91
|
|
4-Hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-κB cascade, file e27ce42c-8ae1-2581-e053-d805fe0acbaa
|
89
|
|
A novel SWCNT platform bearing DOTA and b-cyclodextrin units. "One shot" multidecoration
under microwave irradiation., file e27ce427-083e-2581-e053-d805fe0acbaa
|
82
|
|
Probing salicylamide bioisosteric replacement in the design of Plasmodium Falciparum dihydroorotate dehydrogenase (pfDHODH) inhibitors, file e27ce426-f003-2581-e053-d805fe0acbaa
|
81
|
|
Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters, file e27ce433-4d5c-2581-e053-d805fe0acbaa
|
81
|
|
PROCEEDINGS OF THE MERCK & ELSEVIER YOUNG CHEMISTSSYMPOSIUM, file e27ce42d-c4a1-2581-e053-d805fe0acbaa
|
79
|
|
The new generation hdhodh inhibitor meds433 hinders the in vitro replication of sars-cov-2 and other human coronaviruses [Calistri A.*, Luganini A.*, co-first author], file e27ce432-d08f-2581-e053-d805fe0acbaa
|
76
|
|
Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. A computational study on gamma-aminobutyric acid (GABA) related compounds, file e27ce426-a8d5-2581-e053-d805fe0acbaa
|
68
|
|
The role of fluorine in stabilizing the bioactive conformation of dihydroorotate dehydrogenase inhibitors, file e27ce426-e48a-2581-e053-d805fe0acbaa
|
65
|
|
Multiple catalytic activities of human 17β-hydroxysteroid dehydrogenase type 7 respond differently to inhibitors., file e27ce42f-993b-2581-e053-d805fe0acbaa
|
56
|
|
Use of human Dihydroorotate Dehydrogenase (hDHODH) Inhibitors in Autoimmune Diseases and New Perspectives in Cancer Therapy, file e27ce42c-b64e-2581-e053-d805fe0acbaa
|
54
|
|
NOVEL HUMAN DIHYDROOROTATE DEHYDROGENASE (HDHODH) INHIBITORS AND THEIR USE IN TARGETING ONCOLOGICAL DISEASES SENSITIVE TO PYRIMIDINE STARVATION, file e27ce42e-cc6b-2581-e053-d805fe0acbaa
|
52
|
|
New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold, file e27ce435-3b91-2581-e053-d805fe0acbaa
|
50
|
|
Bioisosteres of Indomethacin as Inhibitors of Aldo-Keto Reductase 1C3, file e27ce432-dedb-2581-e053-d805fe0acbaa
|
49
|
|
Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity, file e27ce42f-27bd-2581-e053-d805fe0acbaa
|
48
|
|
APPLICATION OF THE ARACHNO™ TECHNOLOGY FOR THE PARALLEL SYNTHESIS OF A LIBRARY OF ASPIRIN ANALOGUES, file e27ce428-9a39-2581-e053-d805fe0acbaa
|
47
|
|
Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors, file e27ce433-402c-2581-e053-d805fe0acbaa
|
47
|
|
Turning the light on with pyrazolo[1,5-A]pyridine: exploring it’s fluorescent properties for the design of new fluorosteric compounds, file 53e29924-2d0a-4034-86af-f13ff1d255b6
|
43
|
|
Meds433, a New Dihydroorotate Dehydrogenase Inhibitor, Induces Apoptosis and Differentiation in Acute Myeloid Leukemia, file e27ce434-529c-2581-e053-d805fe0acbaa
|
43
|
|
New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold, file e27ce426-edc2-2581-e053-d805fe0acbaa
|
37
|
|
Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies, file e27ce433-0b18-2581-e053-d805fe0acbaa
|
35
|
|
A differentiating and apoptotic therapy for acute myeloid leukaemia using potent human dihydroorotate dehydrogenase inhibitors., file e27ce42e-f84b-2581-e053-d805fe0acbaa
|
34
|
|
In vitro myeloid differentiation using a new generation of potent human dihydroorotate
dehydrogenase inhibitors, file e27ce42d-bf81-2581-e053-d805fe0acbaa
|
33
|
|
Application of the arachno™ technology inside Educational fields: the introduction of parallel
synthesis concepts inside an undergraduated lab, file e27ce42b-2f9e-2581-e053-d805fe0acbaa
|
32
|
|
Indomethacin Inhibits Proliferation In Cells Harbouring PIK3CA Mutations, file e27ce42f-25c5-2581-e053-d805fe0acbaa
|
28
|
|
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety, file 33b0c0fc-4948-4f36-822a-38bf37292599
|
27
|
|
4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric γ-aminobutyric acid receptor binding site, file e27ce433-34f7-2581-e053-d805fe0acbaa
|
27
|
|
Structure Activity Relationship of strigolactones via a novel, quantitative in planta bioassay, file e27ce432-5dc5-2581-e053-d805fe0acbaa
|
23
|
|
Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach, file e27ce42c-0963-2581-e053-d805fe0acbaa
|
22
|
|
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold: SAR of the Biphenyl Moiety, file e27ce432-fd74-2581-e053-d805fe0acbaa
|
20
|
|
Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds, file e27ce42b-83d6-2581-e053-d805fe0acbaa
|
19
|
|
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold: SAR of the Biphenyl Moiety, file e27ce432-bb56-2581-e053-d805fe0acbaa
|
19
|
|
The Novel hDHODH Inhibitor MEDS433 Prevents Influenza Virus Replication by Blocking Pyrimidine Biosynthesis, file d5a328c9-46b4-40cc-8df5-9819dc586cdd
|
16
|
|
A New NF-κB Inhibitor, MEDS-23, Reduces the Severity of Adverse Post-Ischemic Stroke Outcomes in Rats, file e27ce434-f7ae-2581-e053-d805fe0acbaa
|
15
|
|
Heterocyclic ring cleavage upon collision-induced dissociation of deprotonated 3-hydroxy-1,2,5-oxadiazoles (3-hydroxyfurazans), file e27ce428-13ad-2581-e053-d805fe0acbaa
|
13
|
|
4-Hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-κB cascade, file e27ce42c-b2ab-2581-e053-d805fe0acbaa
|
13
|
|
A New NF-κB Inhibitor, MEDS-23, Reduces the Severity of Adverse Post-Ischemic Stroke Outcomes in Rats, file e27ce434-eaaf-2581-e053-d805fe0acbaa
|
10
|
|
Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer, file 95bb6e43-8fbf-4e81-8b56-6ed88d7a749f
|
6
|
|
New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold, file e27ce426-edc1-2581-e053-d805fe0acbaa
|
6
|
|
Recent advances in the synthesis of analogues of phytohormones strigolactones with ring-closing metathesis as a key step, file e27ce42c-7f6c-2581-e053-d805fe0acbaa
|
6
|
|
Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors, file e27ce42d-ad8b-2581-e053-d805fe0acbaa
|
6
|
|
Bioisosteres of Indomethacin as Inhibitors of Aldo-Keto Reductase 1C3, file e27ce42e-164e-2581-e053-d805fe0acbaa
|
6
|
|
Multiple catalytic activities of human 17β-hydroxysteroid dehydrogenase type 7 respond differently to inhibitors., file e27ce42f-017f-2581-e053-d805fe0acbaa
|
6
|
|
Biochemical characterization of Mycobacterium tuberculosis dihydroorotate dehydrogenase and identification of a selective inhibitor, file 43afce03-8b9d-4b21-87b3-2966d93360a8
|
5
|
|
Intramolecular interactions and the neutral loss of ammonia from collisionally activated, protonated ω-aminoalkyl-3-hydroxyfurazans, file dd2512c3-dfd4-4af9-9e7b-fdbd9f9ed097
|
5
|
|
Structure Activity Relationship of strigolactones via a novel, quantitative in planta bioassay, file e27ce42c-ac06-2581-e053-d805fe0acbaa
|
5
|
|
Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach, file e27ce42c-b3e5-2581-e053-d805fe0acbaa
|
5
|
|
In vitro myeloid differentiation using a new generation of potent human dihydroorotate
dehydrogenase inhibitors, file e27ce42d-9ae6-2581-e053-d805fe0acbaa
|
5
|
|
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold: SAR of the Biphenyl Moiety, file e27ce432-bcf1-2581-e053-d805fe0acbaa
|
5
|
|
Exploring the Potential of Sulfur Moieties in Compounds Inhibiting Steroidogenesis, file 7e0db6d3-72c0-4e7f-af0f-e29bf3188734
|
4
|
|
Effects of new hydroxyazoles inhibitors of AKR1C3 on vitality of prostate and colorectal cancer cell lines, file db177078-0175-4d01-8ea6-c13a138fadbc
|
4
|
|
Searching for new NO-donor aspirin-like molecules: furoxanylacyl derivatives of salicylic acid and related furazans, file e27ce427-cd40-2581-e053-d805fe0acbaa
|
4
|
|
Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds, file e27ce42b-83d7-2581-e053-d805fe0acbaa
|
4
|
|
Computational Method for Structure-Based Analysis of SAR Transfer, file e27ce431-4e2c-2581-e053-d805fe0acbaa
|
4
|
|
PROBING THE BICYCLIC HYDROXYPYRAZOLO[1,5-a]PYRIDINE SCAFFOLD AS A CARBOXYLIC ACID BIOISOSTERE IN THE GABAa RECEPTOR SYSTEM, file e27ce433-7d3e-2581-e053-d805fe0acbaa
|
4
|
|
Mechanisms of antiviral activity of the new hDHODH inhibitor MEDS433 against respiratory syncytial virus replication, file 8df89195-a794-475a-8c47-eed69b7310e6
|
3
|
|
Heterocyclic ring cleavage upon collision-induced dissociation of deprotonated 3-hydroxy-1,2,5-oxadiazoles (3-hydroxyfurazans), file e27ce428-1341-2581-e053-d805fe0acbaa
|
3
|
|
In vitro myeloid differentiation using a new generation of potent human dihydroorotate dehydrogenase (hDHODH) inhibitors, file e27ce42d-2659-2581-e053-d805fe0acbaa
|
3
|
|
In vitro myeloid differentiation using a new generation of potent human dihydroorotate dehydrogenase (hDHODH) inhibitors, file e27ce42d-2aec-2581-e053-d805fe0acbaa
|
3
|
|
DHODH inhibitors and leukemia: an emergent interest for new myeloid differentiation agents, file e27ce42d-4cce-2581-e053-d805fe0acbaa
|
3
|
|
Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies, file e27ce42d-b072-2581-e053-d805fe0acbaa
|
3
|
|
New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold, file e27ce435-3998-2581-e053-d805fe0acbaa
|
3
|
|
HYDROXYLATED HETEROCYCLES AS BIOISOSTERES OF THE CARBOXYLIC FUNCTION: DESIGN OF NEW AKR1C3 INHIBITORS ACTIVE IN PROSTATE CANCER, file deffeefd-18ce-465e-8214-ab55208f9682
|
2
|
|
1,2,5-Oxadiazole analogues of leflunomide and related compounds, file e27ce426-ca88-2581-e053-d805fe0acbaa
|
2
|
|
The role of fluorine in stabilizing the bioactive conformation of dihydroorotate dehydrogenase inhibitors, file e27ce426-e489-2581-e053-d805fe0acbaa
|
2
|
|
Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by a Scaffold Hopping Bioisosteric approach using Hydroxylated Pentaatomic Heterocycles, file e27ce42c-1dab-2581-e053-d805fe0acbaa
|
2
|
|
N-Acetyl-3-aminopyrazoles block the non canonical NF-kB cascade by selectively inhibiting NIK, file e27ce42c-d131-2581-e053-d805fe0acbaa
|
2
|
|
Targeting myeloid differentiation using potent human dihydroorotate dehydrogenase (hDHODH) inhibitors, file e27ce42c-f112-2581-e053-d805fe0acbaa
|
2
|
|
4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric γ-aminobutyric acid receptor binding site, file e27ce42d-a8d9-2581-e053-d805fe0acbaa
|
2
|
|
Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters, file e27ce42f-27c0-2581-e053-d805fe0acbaa
|
2
|
|
Structure Activity Relationship of strigolactones via a novel, quantitative in planta bioassay, file e27ce431-9a68-2581-e053-d805fe0acbaa
|
2
|
|
N-Acetyl-3-aminopyrazoles block the non canonical NF-kB cascade by selectively inhibiting NIK, file e27ce432-5a21-2581-e053-d805fe0acbaa
|
2
|
|
Design of new human Dihydroorotate Dehydrogenase inhibitors: amide bioisosterism in MEDS433 optimization, file e27ce434-bed2-2581-e053-d805fe0acbaa
|
2
|
|
Targeting Acute Myelogenous Leukemia using potent human dihydroorotate dehydrogenase inhibitors based on the 2-hydroxypyrazolo[1,5-a]pyridine scaffold: from academy to clinic, file 0f183a53-b692-48a9-996c-fc7c1c008917
|
1
|
|
Improvement of Metabolic Weakness of New Dihydroorotate Dehydrogenase Inhibitors Based on 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold to Target Myeloid Leukemias, file 83388e83-ad81-4a04-93f3-2b0624b87ea4
|
1
|
|
Important Steps into Drug Development of MEDS433, a Potent Human Dihydroorotate Dehydrogenase Inhibitor based on the 2-hydroxypyrazolo[1,5-a] Pyridine Scaffold, file ba92237a-a9d9-4a82-8262-6f5eaf4c9219
|
1
|
|
Synthesis of NO-Donor Bisphosphonates and Their in Vitro Action on Bone Resorption, file e27ce426-a939-2581-e053-d805fe0acbaa
|
1
|
| Totale |
13.510 |