SERAFINI, Marta
SERAFINI, Marta
SCIENZA E TECNOLOGIA DEL FARMACO
1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry
2021-01-01 Aprile, Silvio; Riva, Beatrice; Bhela, Irene Preet; Cordero-Sanchez, Celia; Avino, Giulia; Genazzani, Armando; Serafini, Marta; Pirali, Tracey
A capsaicinoid-based soft drug, AG1529, for attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability
2021-01-01 Nikolaeva-Koleva M.; Butron L.; Gonzalez-Rodriguez S.; Devesa I.; Valente P.; Serafini M.; Genazzani A.; Pirali T.; Ballester G. F.; Fernandez-Carvajal A.; Ferrer-Montiel A.
A multicomponent approach in the discovery of indoleamine 2,3-dioxygenase 1 inhibitors: Synthesis, biological investigation and docking studies
2018-01-01 Griglio A.; Torre E.; Serafini M.; Bianchi A.; Schmid R.; Coda Zabetta G.; Massarotti A.; Sorba G.; Pirali T.; Fallarini S.
A primer of deuterium in drug design
2019-01-01 Cargnin S.; Serafini M.; Pirali T.
A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs
2022-01-01 Bhela I.P.; Ranza A.; Balestrero F.C.; Serafini M.; Aprile S.; Di Martino R.M.C.; Condorelli F.; Pirali T.
An aryne-based three-component access to α-aroylamino amides
2017-01-01 Serafini M.; Griglio A.; Viarengo S.; Aprile S.; Pirali T.
An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline
2022-01-01 Aprile S.; Colombo G.; Serafini M.; Di Paola R.; Pisati F.; Bhela I.P.; Cuzzocrea S.; Grosa G.; Pirali T.
Applications of deuterium in medicinal chemistry
2019-01-01 Pirali, Tracey; Serafini, Marta; Cargnin, Sarah; Genazzani, Armando
Arynes and isocyanides: Two close-knit partners in multicomponent reactions
2018-01-01 Serafini M.; Pirali T.
CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy
2022-01-01 Cordero-Sanchez, Celia; Pessolano, Emanuela; Riva, Beatrice; Vismara, Mauro; Trivigno, Silvia Maria Grazia; Clemente, Nausicaa; Aprile, Silvio; Ruffinatti, Federico Alessandro; Portararo, Paola; Filigheddu, Nicoletta; Zaggia, Ivan; Bhela, Irene P; Serafini, Marta; Pirali, Tracey; Colombo, Mario P; Torti, Mauro; Sangaletti, Sabina; Bertoni, Alessandra; Genazzani, Armando A
Click 1,2,3-triazoles in drug discovery and development: From the flask to the clinic?
2021-01-01 Serafini M.; Pirali T.; Tron G.C.
Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity
2020-01-01 Serafini, M.; Torre, E.; Aprile, S.; Grosso, E.D.; Ges{\`u}, A.; Griglio, A.; Colombo, G.; Travelli, C.; Paiella, S.; Adamo, A.; Orecchini, E.; Coletti, A.; Pallotta, M.T.; Ugel, S.; Massarotti, A.; Pirali, T.; Fallarini, S.
Drug Discovery for Soft Drugs on TRPV1 and TRPM8 Channels Using the Passerini Reaction
2019-01-01 Pirali, Tracey; Galli, Ubaldina; Serafini, Marta; Griglio, Alessia; Genazzani, Armando; Tron, Gian Cesare
Erratum: An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline (ACS Medicinal Chemistry Letters (2022) 13: 8 (1278−1285) DOI: 10.1021/acsmedchemlett.2c00166)
2023-01-01 Silvio Aprile; Giorgia Colombo; Marta Serafini; Rosanna Di Paola; Federica Pisati; Irene Preet Bhela; Salvatore Cuzzocrea; Giorgio Grosa; Tracey Pirali
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs
2017-01-01 Pirali, Tracey; Ciraolo, Elisa; Aprile, Silvio; Massarotti, Alberto; Berndt, Alex; Griglio, Alessia; Serafini, Marta; Mercalli, Valentina; Landoni, Clarissa; Campa, Carlo Cosimo; Margaria, Jean Piero; Silva, Rangel L.; Grosa, Giorgio; Sorba, Giovanni; Williams, Roger; Hirsch, Emilio; Tron, Gian Cesare
Indolequinone-Based Hypoxia-Activated Proteolysis Targeting Chimeras Selectively Degrade BRD4 in Hypoxic Cancer Cells
2025-01-01 Serafini, Marta; Twigger, Sophie A.; Delfas, George; Mallerman, Maxim; Bailey, Elliot P.; Calder, Ewen D. D.; Hammond, Ester M.; Conway, Stuart J.
Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation
2023-01-01 Thomas A.M.; Serafini M.; Grant E.K.; Coombs E.A.J.; Bluck J.P.; Schiedel M.; McDonough M.A.; Reynolds J.K.; Lee B.; Platt M.; Sharlandjieva V.; Biggin P.C.; Duarte F.; Milne T.A.; Bush J.T.; Conway S.J.
Opportunities and Challenges of Arginase Inhibitors in Cancer: A Medicinal Chemistry Perspective
2024-01-01 Failla M.; Molaro M.C.; Schiano M.E.; Serafini M.; Tiburtini G.A.; Gianquinto E.; Scoccia R.; Battisegola C.; Rimoli M.G.; Chegaev K.; Ercolano G.; Lazzarato L.; Spyrakis F.; Sodano F.
Orthogonal IMiD-Degron Pairs Induce Selective Protein Degradation in Cells
2025-01-01 Brennan, Patrick J.; Saunders, Rebecca E.; Spanou, Mary; Singleton, Sarah E.; Serafini, Marta; Sun, Liang; Heger, Guillaume P.; Konopacka, Agnieszka; Beveridge, Ryan D.; Taylor, C. Cameron; DePaola, Peter; Gordon, Laurie; Bunally, Shenaz B.; Saudemont, Aurore; Benowitz, Andrew B.; Martinez-Fleites, Carlos; Schmitt, Danielle L.; Damoiseaux, Robert; Queisser, Markus A.; An, Heeseon; Deane, Charlotte M.; Hann, Michael M.; Brayshaw, Lewis L.; Conway, Stuart J.
Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis
2018-01-01 Riva, Beatrice; Griglio, Alessia; Serafini, Marta; CORDERO SANCHEZ, CELIA; Aprile, Silvio; Di Paola, Rosanna; Gugliandolo, Enrico; Alansary, Dalia; BIOCOTINO, Isabella; Lim, Dmitry; Grosa, Giorgio; Galli, Ubaldina; Niemeyer, Barbara; Sorba, Giovanni; Canonico, Pier Luigi; Cuzzocrea, Salvatore; Genazzani, Armando; Pirali, Tracey
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| 1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry | 2021 | Aprile, Silvio; Riva, Beatrice; Bhela, Irene Preet; Cordero-Sanchez, Celia; Avino, Giulia; Genazzani, Armando; Serafini, Marta; Pirali, Tracey | |
| A capsaicinoid-based soft drug, AG1529, for attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability | 2021 | Nikolaeva-Koleva M.; Butron L.; Gonzalez-Rodriguez S.; Devesa I.; Valente P.; Serafini M.; Genazzani A.; Pirali T.; Ballester G. F.; Fernandez-Carvajal A.; Ferrer-Montiel A. | |
| A multicomponent approach in the discovery of indoleamine 2,3-dioxygenase 1 inhibitors: Synthesis, biological investigation and docking studies | 2018 | Griglio A.; Torre E.; Serafini M.; Bianchi A.; Schmid R.; Coda Zabetta G.; Massarotti A.; Sorba G.; Pirali T.; Fallarini S. | |
| A primer of deuterium in drug design | 2019 | Cargnin S.; Serafini M.; Pirali T. | |
| A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs | 2022 | Bhela I.P.; Ranza A.; Balestrero F.C.; Serafini M.; Aprile S.; Di Martino R.M.C.; Condorelli F.; Pirali T. | |
| An aryne-based three-component access to α-aroylamino amides | 2017 | Serafini M.; Griglio A.; Viarengo S.; Aprile S.; Pirali T. | |
| An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline | 2022 | Aprile S.; Colombo G.; Serafini M.; Di Paola R.; Pisati F.; Bhela I.P.; Cuzzocrea S.; Grosa G.; Pirali T. | |
| Applications of deuterium in medicinal chemistry | 2019 | Pirali, Tracey; Serafini, Marta; Cargnin, Sarah; Genazzani, Armando | |
| Arynes and isocyanides: Two close-knit partners in multicomponent reactions | 2018 | Serafini M.; Pirali T. | |
| CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy | 2022 | Cordero-Sanchez, Celia; Pessolano, Emanuela; Riva, Beatrice; Vismara, Mauro; Trivigno, Silvia Maria Grazia; Clemente, Nausicaa; Aprile, Silvio; Ruffinatti, Federico Alessandro; Portararo, Paola; Filigheddu, Nicoletta; Zaggia, Ivan; Bhela, Irene P; Serafini, Marta; Pirali, Tracey; Colombo, Mario P; Torti, Mauro; Sangaletti, Sabina; Bertoni, Alessandra; Genazzani, Armando A | |
| Click 1,2,3-triazoles in drug discovery and development: From the flask to the clinic? | 2021 | Serafini M.; Pirali T.; Tron G.C. | |
| Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity | 2020 | Serafini, M.; Torre, E.; Aprile, S.; Grosso, E.D.; Ges{\`u}, A.; Griglio, A.; Colombo, G.; Travelli, C.; Paiella, S.; Adamo, A.; Orecchini, E.; Coletti, A.; Pallotta, M.T.; Ugel, S.; Massarotti, A.; Pirali, T.; Fallarini, S. | |
| Drug Discovery for Soft Drugs on TRPV1 and TRPM8 Channels Using the Passerini Reaction | 2019 | Pirali, Tracey; Galli, Ubaldina; Serafini, Marta; Griglio, Alessia; Genazzani, Armando; Tron, Gian Cesare | |
| Erratum: An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline (ACS Medicinal Chemistry Letters (2022) 13: 8 (1278−1285) DOI: 10.1021/acsmedchemlett.2c00166) | 2023 | Silvio Aprile; Giorgia Colombo; Marta Serafini; Rosanna Di Paola; Federica Pisati; Irene Preet Bhela; Salvatore Cuzzocrea; Giorgio Grosa; Tracey Pirali | |
| Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs | 2017 | Pirali, Tracey; Ciraolo, Elisa; Aprile, Silvio; Massarotti, Alberto; Berndt, Alex; Griglio, Alessia; Serafini, Marta; Mercalli, Valentina; Landoni, Clarissa; Campa, Carlo Cosimo; Margaria, Jean Piero; Silva, Rangel L.; Grosa, Giorgio; Sorba, Giovanni; Williams, Roger; Hirsch, Emilio; Tron, Gian Cesare | |
| Indolequinone-Based Hypoxia-Activated Proteolysis Targeting Chimeras Selectively Degrade BRD4 in Hypoxic Cancer Cells | 2025 | Serafini, Marta; Twigger, Sophie A.; Delfas, George; Mallerman, Maxim; Bailey, Elliot P.; Calder, Ewen D. D.; Hammond, Ester M.; Conway, Stuart J. | |
| Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation | 2023 | Thomas A.M.; Serafini M.; Grant E.K.; Coombs E.A.J.; Bluck J.P.; Schiedel M.; McDonough M.A.; Reynolds J.K.; Lee B.; Platt M.; Sharlandjieva V.; Biggin P.C.; Duarte F.; Milne T.A.; Bush J.T.; Conway S.J. | |
| Opportunities and Challenges of Arginase Inhibitors in Cancer: A Medicinal Chemistry Perspective | 2024 | Failla M.; Molaro M.C.; Schiano M.E.; Serafini M.; Tiburtini G.A.; Gianquinto E.; Scoccia R.; Battisegola C.; Rimoli M.G.; Chegaev K.; Ercolano G.; Lazzarato L.; Spyrakis F.; Sodano F. | |
| Orthogonal IMiD-Degron Pairs Induce Selective Protein Degradation in Cells | 2025 | Brennan, Patrick J.; Saunders, Rebecca E.; Spanou, Mary; Singleton, Sarah E.; Serafini, Marta; Sun, Liang; Heger, Guillaume P.; Konopacka, Agnieszka; Beveridge, Ryan D.; Taylor, C. Cameron; DePaola, Peter; Gordon, Laurie; Bunally, Shenaz B.; Saudemont, Aurore; Benowitz, Andrew B.; Martinez-Fleites, Carlos; Schmitt, Danielle L.; Damoiseaux, Robert; Queisser, Markus A.; An, Heeseon; Deane, Charlotte M.; Hann, Michael M.; Brayshaw, Lewis L.; Conway, Stuart J. | |
| Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis | 2018 | Riva, Beatrice; Griglio, Alessia; Serafini, Marta; CORDERO SANCHEZ, CELIA; Aprile, Silvio; Di Paola, Rosanna; Gugliandolo, Enrico; Alansary, Dalia; BIOCOTINO, Isabella; Lim, Dmitry; Grosa, Giorgio; Galli, Ubaldina; Niemeyer, Barbara; Sorba, Giovanni; Canonico, Pier Luigi; Cuzzocrea, Salvatore; Genazzani, Armando; Pirali, Tracey |