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EnglishThe coordinate modulation of the cellular functions of cadherins and integrins plays an essential role in fundamental physiological and pathological processes, including morphogenesis, tissue differentiation and renewal, wound healing, immune surveillance, inflammatory response, tumor progression, and metastasis. However, the molecular mechanisms underlying the fine-tuned functional communication between cadherins and integrins are still elusive. This paper focuses on recent findings towards the involvement of reactive oxygen species (ROS) in the regulation of cell adhesion and signal transduction functions of integrins and cadherins, pointing to ROS as emerging strong candidates for modulating themolecular crosstalk between cell-matrix and cell-cell adhesion receptors.
| Titolo: | Molecular Crosstalk between Integrins and Cadherins: Do Reactive Oxygen Species Set the Talk? |
| Autori Riconosciuti: | |
| Autori: | Luca Goitre; Barbara Pergolizzi; Elisa Ferro; Lorenza Trabalzini; Saverio Francesco Retta |
| Data di pubblicazione: | 2012 |
| Abstract: | The coordinate modulation of the cellular functions of cadherins and integrins plays an essential role in fundamental physiological and pathological processes, including morphogenesis, tissue differentiation and renewal, wound healing, immune surveillance, inflammatory response, tumor progression, and metastasis. However, the molecular mechanisms underlying the fine-tuned functional communication between cadherins and integrins are still elusive. This paper focuses on recent findings towards the involvement of reactive oxygen species (ROS) in the regulation of cell adhesion and signal transduction functions of integrins and cadherins, pointing to ROS as emerging strong candidates for modulating themolecular crosstalk between cell-matrix and cell-cell adhesion receptors. |
| Volume: | 2012 |
| Pagina iniziale: | 1 |
| Pagina finale: | 12 |
| Digital Object Identifier (DOI): | 10.1155/2012/807682 |
| URL: | http://www.hindawi.com/journals/jst/2012/807682/ |
| Parole Chiave: | Reactive Oxygen Species (ROS); Signal Transduction; Integrins; Cadherins; Small GTPases; Cell-Matrix Adhesion; Cell-Cell Adhesion |
| Rivista: | JOURNAL OF SIGNAL TRANSDUCTION (ONLINE) |
| Appare nelle tipologie: | 03A-Articolo su Rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| 2012 JST - Molecular Crosstalk between Integrins and Cadherins- Do Reactive Oxygen Species Set the Talk.pdf | 1 Ver. finale autore | Accesso aperto | Open Access Visualizza/Apri |
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