CINECA IRIS Institutional Research Information System

TGF-β Inhibition Through Combinatory Strategies Suppresses Proliferation and Invasiveness in Malignant Pleural Mesothelioma.

Malignant pleural mesothelioma (MPM) is a rare and aggressive tumor associated with asbestos exposure, which represents a current problem. MPM is characterized by a poor prognosis and an unsatisfactory therapeutic approach. Therefore, improving MPM prognosis is the real challenge for research today. Regarding preclinical data, Transforming Growth Factor-beta (TGF-beta) plays a crucial role in cancer, and its alteration has been associated with tumor progression and invasiveness, in particular...

Exploring genomic analysis and methylome profiling in longitudinal series of p.G12C KRAS mutated NSCLC patients treated with sotorasib

Aims: in the genomic era, the advent of next generation sequencing (NGS) technologies has rapidly transformed the clinical paradigm of NSCLC patients who could benefit from a wide series of clinically approved biomarker driven therapies. Among them, KRAS p. G12C hotspot mutation became part of the mandatory testing gene panel by electing NSCLC patients to sotorasib. Epigenomic signatures, including hypermethylation of CpGs islands, may be relevant in tailoring therapeutic algorithms in oncoge...

Narrative strategies in a nondemocratic setting: Moscow’s urban policy debates

The Narrative Policy Framework (NPF) explains the role of narratives in policy processes. The NPF was developed for democratic contexts and has not been systematically applied in a nondemocratic setting. This study fills this gap with an empirical analysis of narrative strategies used by governmental and oppositional actors in urban policy debates in Moscow. Results show how governmental actors consistently use angel shifts, contain issues, and avoid using causal mechanisms, while actors oppo...

Comportement alimentaire des ânes dans les pâturages embroussaillés du Parc National du Grand Paradis, en Italie