In the range of pH examined (5.2-10), variations of internal pH from high to low values result in a reversible decrease of the conductance of the open K channels, without significantly affecting the kinetics parameters. A linear plot of the conductance versus internal pH suggests the existence of a titratable group that has an apparent pKI of about 6.9, and that is accessible to protons only from the intracellular side of the membrane.
K+ conductance modified by a titratable group accessible to protons from the intracellular side of the squid axone membrane
CARBONE, Emilio;
1979-01-01
Abstract
In the range of pH examined (5.2-10), variations of internal pH from high to low values result in a reversible decrease of the conductance of the open K channels, without significantly affecting the kinetics parameters. A linear plot of the conductance versus internal pH suggests the existence of a titratable group that has an apparent pKI of about 6.9, and that is accessible to protons only from the intracellular side of the membrane.
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