In the range of pH examined (5.2-10), variations of internal pH from high to low values result in a reversible decrease of the conductance of the open K channels, without significantly affecting the kinetics parameters. A linear plot of the conductance versus internal pH suggests the existence of a titratable group that has an apparent pKI of about 6.9, and that is accessible to protons only from the intracellular side of the membrane.
K+ conductance modified by a titratable group accessible to protons from the intracellular side of the squid axone membrane / Enzo Wanke; Emilio Carbone; Pier Luigi Testa. - In: BIOPHYSICAL JOURNAL. - ISSN 0006-3495. - 26(1979), pp. 319-324.
Titolo: | K+ conductance modified by a titratable group accessible to protons from the intracellular side of the squid axone membrane |
Autori Riconosciuti: | |
Autori: | Enzo Wanke; Emilio Carbone; Pier Luigi Testa |
Data di pubblicazione: | 1979 |
Abstract: | In the range of pH examined (5.2-10), variations of internal pH from high to low values result in a reversible decrease of the conductance of the open K channels, without significantly affecting the kinetics parameters. A linear plot of the conductance versus internal pH suggests the existence of a titratable group that has an apparent pKI of about 6.9, and that is accessible to protons only from the intracellular side of the membrane. |
Volume: | 26 |
Pagina iniziale: | 319 |
Pagina finale: | 324 |
Parole Chiave: | Canali del K+ voltaggio-dipendenti; assone gigante di calamaro; protoni; permeabilità dei canali ionici |
Rivista: | BIOPHYSICAL JOURNAL |
Appare nelle tipologie: | 03A-Articolo su Rivista |
File in questo prodotto:
File | Descrizione | Tipologia | Licenza | |
---|---|---|---|---|
Wanke et al. Biophys J 1979.pdf | POSTPRINT (VERSIONE FINALE DELL’AUTORE) | Accesso riservato | Utenti riconosciuti Richiedi una copia |